Article
Cell Biology
Romain Larrue, Sandy Fellah, Nihad Boukrout, Corentin De Sousa, Julie Lemaire, Carolane Leboeuf, Marine Goujon, Michael Perrais, Bernard Mari, Christelle Cauffiez, Nicolas Pottier, Cynthia van der Hauwaert
Summary: Non-small cell lung cancer is characterized by poor prognosis due to low diagnosis efficiency and drug resistance. Targeting a specific small RNA (miR-92a-3p) may be an effective strategy to overcome chemotherapy resistance in cancer cells.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Yu-Jie Dong, Wei Feng, Yan Li
Summary: The study identified the HOTTIP-miR-205-ZEB2 axis as a key player in cisplatin resistance in ovarian cancer cells. Inhibiting HOTTIP and increasing miR-205 levels can reverse resistance to cisplatin, indicating that modulation of this axis may improve drug efficacy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luca Dalle Carbonare, Jessica Bertacco, Arianna Minoia, Mattia Cominacini, Lekhana Bhandary, Rossella Elia, Giovanni Gambaro, Monica Mottes, Maria Teresa Valenti
Summary: RUNX2 and SOX9 are key transcriptional regulators in chondrogenesis, with their activities being reciprocally regulated. The miR-204-5p has been shown to play a role in chondrogenesis, negatively regulating osteochondrogenic commitment of MSCs and positively regulating chondrocyte maturation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jiancheng Lv, Zijian Zhou, Jingzi Wang, Xiao Yang, Hao Yu, Jie Han, Dexiang Feng, Baorui Yuan, Qikai Wu, Pengchao Li, Qiang Lu, Haiwei Yang
Summary: The study found that circFAM114A2 is downregulated in urothelial carcinoma, with higher expression associated with better survival in patients and histological grade. This circRNA inhibits cell proliferation and enhances cisplatin sensitivity by sponging miR-222-3p/miR-146a-5p to regulate P27/P21 expression. CircFAM114A2 shows potential as a prognostic biomarker and therapeutic target for urothelial carcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Jian Huang, Yumei Lai, Jun Li, Lan Zhao
Summary: Temporomandibular joint osteoarthritis (TMJ OA) is a common disorder causing pain and dysfunction in the jaw and surrounding tissues. This study found that the loss of microRNAs miR-204 and miR-211 led to an OA-like phenotype in the TMJ, including cartilage degradation and abnormal bone remodeling. The disruption of osteogenesis and chondrogenesis balance in the TMJ may underlie TMJ OA. Additionally, the loss of miR-204/-211 led to abnormal collagen components, cartilage-degrading enzymes, and increased pain.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Oncology
Lei Zou, Peng Sun, Lei Zhang
Summary: The study revealed that miR-651-3p was significantly downregulated in HCC tissues and cell lines, but its upregulation could inhibit cell proliferation and induce apoptosis, involving the autophagy pathway by targeting ATG3 in HCC cells.
JOURNAL OF ONCOLOGY
(2021)
Article
Cell Biology
Lijun Wang, Xiaojun Wang, Pengwei Yan, Yatian Liu, Xuesong Jiang
Summary: The study revealed that LINC00261 suppresses cisplatin (DDP) resistance in esophageal squamous cell carcinoma (ESCC) through the regulation of the miR-545-3p/MT1M axis, highlighting its potential therapeutic significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tao Liu, Fei Jiang, Li-Yuan Yu, You-Yang Wu
Summary: This study elucidated the inhibitory effects of lidocaine on cell proliferation and cisplatin resistance in A431 human cutaneous squamous cell carcinoma cells through the miR-30c/SIRT1 pathway. The findings suggest that lidocaine has promising potential as a treatment strategy for cSCC.
Article
Genetics & Heredity
Ruirui Zhang, Huanyu Zhao, Hongmei Yuan, Jian Wu, Haiyan Liu, Suan Sun, Zhengwei Zhang, Jiayang Wang
Summary: This study reveals that circARVCF enhances DDP resistance in GC by elevating FGFR1 through sponging miR-1205.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Yongxian Cao, Feng Zhang, Haotian Wang, Chunhua Bi, Jinpeng Cui, Fenghai Liu, Huazheng Pan
Summary: Research has shown that MALAT1 and Nova1 are upregulated in doxorubicin-resistant HCC tissues and cells, while miR-3129-5p expression is decreased. Knockdown of MALAT1 regulates doxorubicin resistance of HCC cells by inhibiting proliferation, migration, invasion, and promoting apoptosis, with Nova1 being a target gene of miR-3129-5p that can reverse the effects of miR-3129-5p expression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Xiangdong Liu, Bo Yang, Yan Zhang, Xiaorui Guo, Qianjuan Yang, Xiaojing Liu, Qingxia Bai, Qun Lu
Summary: The study demonstrated the overexpression of miR-30a-5p in a periodontitis model, and showed that miR-30a-5p inhibitors not only promoted osteogenesis but also alleviated inflammation, with Runx2 identified as a target of miR-30a-5p. These findings suggest that miR-30a-5p mediates its effects in periodontitis through targeting Runx2.
Article
Biochemistry & Molecular Biology
An Song, Yuanyuan Wu, Weiming Chu, Xueming Yang, Zaiou Zhu, Enshi Yan, Wei Zhang, Junbo Zhou, Xu Ding, Jie Liu, Hongxia Zhu, Jinhai Ye, Yunong Wu, Yang Zheng, Xiaomeng Song
Summary: The study revealed that miR-619-5p was down-regulated in OSCC and cisplatin-resistant cells, and it inhibited the biological behaviors of cisplatin-resistant cells by targeting ATXN3. Ectopic expression of miR-619-5p may serve as a potential therapeutic target for regulating cisplatin resistance in OSCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Shuang Wu, Shihai Liu, Yongxian Cao, Geng Chao, Peng Wang, Huazheng Pan
Summary: This study identifies ZC3H13 as a potential tumor suppressor gene in hepatocellular carcinoma (HCC) and reveals the miR-362-3p/miR-425-5p-ZC3H13 axis as a regulatory pathway. The expression of ZC3H13 is closely associated with the prognosis and tumor immune infiltration in HCC.
Article
Oncology
Yang Zhou, Chunyan Wang, Jinye Ding, Yingying Chen, Yaoqi Sun, Zhongping Cheng
Summary: The study found that miR-133a expression was decreased in cisplatin-resistant ovarian cancer cells, and overexpression of miR-133a reduced cisplatin resistance. MiR-133a binds to the 3'UTR of YES1 and downregulates its expression. YES1 expression was upregulated in cisplatin-resistant ovarian cancer tissue, and miR-133a downregulated YES1 to inhibit cell autophagy and reduce cisplatin resistance.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Qi Li, Mo Yan, Chunhui Wang, Kaibin Wang, Guochang Bao
Summary: CKAP2L is overexpressed in prostate cancer and is associated with higher Gleason grade and poor clinical outcomes. Silencing CKAP2L inhibits cell proliferation, impairs monolayer formation, and inhibits cell invasion. CKAP2L is a direct target of miR-326, which has a carcinostatic effect by binding to the 3' untranslated regions (3'UTRs) of CKAP2L mRNA. Deletion of CKAP2L reduces the expression of genes involved in the mitotic cell cycle and chromosome segregation.