Identification of Chalcone Derivatives as Inhibitors of Leishmania infantum Arginase and Promising Antileishmanial Agents

Forced degradation studies of norepinephrine and epinephrine from dental anesthetics: Development of stability‐indicating HPLC method and in silico toxicity evaluation

(2020) Letícia Coli Louvisse de Abreu et al.   BIOMEDICAL CHROMATOGRAPHY

Arginase and its mechanisms in Leishmania persistence

(2020) Gabriela Pessenda et al.   PARASITE IMMUNOLOGY

Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation

(2019) José C. Espinoza-Hicks et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chalcones and Flavanones Bearing Hydroxyl and/or Methoxyl Groups: Synthesis and Biological Assessments

(2019) Gonçalo P. Rosa et al.   Applied Sciences-Basel

Phenylhydrazides as inhibitors of Leishmania amazonensis arginase and antileishmanial activity

(2019) Evanoel Crizanto de Lima et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting pteridine reductase 1 and dihydrofolate reductase: the old is a new trend for leishmaniasis drug discovery

(2019) Gustavo Machado das Neves et al.   Future Medicinal Chemistry

The impact of arginase activity on virulence factors of Leishmania amazonensis

(2019) Juliana Ide Aoki et al.   CURRENT OPINION IN MICROBIOLOGY

DNA Topoisomerases of Leishmania parasites; druggable targets for drug discovery

(2018) Rosa Mª Reguer et al.   CURRENT MEDICINAL CHEMISTRY

A comprehensive review of chalcone derivatives as antileishmanial agents

(2018) Marcos Vinícius Palmeira de Mello et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of chalcone-based antileishmanial agents targeting trypanothione reductase

(2018) Margherita Ortalli et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The chemotherapeutic potential of chalcones against leishmaniases: a review

(2018) Nasir Tajuddeen et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synthesis and Bioactivity of Reduced Chalcones Containing Sulfonamide Side Chains

(2018) Anwar E. M. Noreljaleel et al.   JOURNAL OF NATURAL PRODUCTS

Study of degradation behaviour of montelukast sodium and its marketed formulation in oxidative and accelerated test conditions and prediction of physicochemical and ADMET properties of its degradation products using ADMET Predictor™

(2018) Shobhit Kumar Tiwari et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Arginine and Polyamines Fate in Leishmania Infection

(2018) Sandra M. Muxel et al.   Frontiers in Microbiology

Leishmanicidal activity of the alkaloid-rich fraction from Guatteria latifolia

(2017) C. Ferreira et al.   EXPERIMENTAL PARASITOLOGY

Polyamine-trypanothione pathway: an update

(2017) Andrea Ilari et al.   Future Medicinal Chemistry

Identification, characterization and in silico ADMET prediction of Roflumilast degradation products

(2017) Mariana S. Pinheiro et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Chalcone Derivatives: Promising Starting Points for Drug Design

(2017) Marcelo Gomes et al.   MOLECULES

Arginase Flavonoid Anti-Leishmanial in Silico Inhibitors Flagged against Anti-Targets

(2016) Sanja Glisic et al.   MOLECULES

Prenylated chalcones and flavonoids for the prevention and treatment of cancer

(2016) Sascha Venturelli et al.   NUTRITION

Crystal structures ofLeishmania mexicanaarginase complexed with α,α-disubstituted boronic amino-acid inhibitors

(2016) Yang Hai et al.   Acta Crystallographica Section F-Structural Biology Communications

The 2′,4′-dihydroxychalcone could be explored to develop new inhibitors against the glycerol-3-phosphate dehydrogenase from Leishmania species

(2015) Thais G. Passalacqua et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Promise of Plant-Derived Substances as Inhibitors of Arginase

(2015) C. Girard-Thernier et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Antimycobacterial and Anti-Inflammatory Activities of Substituted Chalcones Focusing on an Anti-Tuberculosis Dual Treatment Approach

(2015) Thatiana Ventura et al.   MOLECULES

Hit and lead criteria in drug discovery for infectious diseases of the developing world

(2015) Kei Katsuno et al.   NATURE REVIEWS DRUG DISCOVERY

Antileishmanial phytochemical phenolics: Molecular docking to potential protein targets

(2014) Ifedayo Victor Ogungbe et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections

(2013) Edward L. D’Antonio et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Synthesis of licochalcone analogues with increased anti-inflammatory activity

(2013) Si-Jun Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase

(2012) Edson Roberto da Silva et al.   EXPERIMENTAL PARASITOLOGY

Inhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils

(2011) M. Vijaya Bhaskar Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

YL-I-108, a synthetic chalcone derivative, inhibits lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 murine macrophages: Involvement of heme oxygenase-1 induction and blockade of activator protein-1

(2009) Pil-Hoon Park et al.   ARCHIVES OF PHARMACAL RESEARCH

KB-34, a newly synthesized chalcone derivative, inhibits lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages via heme oxygenase-1 induction and blockade of activator protein-1

(2009) Pil-Hoon Park et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Infection with Arginase-Deficient Leishmania major Reveals a Parasite Number-Dependent and Cytokine-Independent Regulation of Host Cellular Arginase Activity and Disease Pathogenesis

(2009) H. M. Muleme et al.   JOURNAL OF IMMUNOLOGY