Muscle spindle function in healthy and diseased muscle

Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this information, the CNS computes the position and movement of our extremities in space, which is a requirement for motor control, for maintaining posture and for a stable gait. Many neuromuscular diseases affect muscle spindle function contributing, among others, to an unstable gait, frequent falls and ataxic behavior in the affected patients. Nevertheless, muscle spindles are usually ignored during examination and analysis of muscle function and when designing therapeutic strategies for neuromuscular diseases. This review summarizes the development and function of muscle spindles and the changes observed under pathological conditions, in particular in the various forms of muscular dystrophies.

Automated summary

Muscle spindles are sensory receptors in muscles that inform the central nervous system about changes in muscle length and stretching speed, crucial for motor control and maintaining posture. Neuromuscular diseases can affect muscle spindle function, leading to unstable gait and other issues. However, muscle spindles are often overlooked in clinical examinations and therapeutic strategies.