FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells

A Glutathione Activatable Ion Channel Induces Apoptosis in Cancer Cells by Depleting Intracellular Glutathione Levels

(2020) Javid Ahmad Malla et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cysteine depletion induces pancreatic tumor ferroptosis in mice

(2020) Michael A. Badgley et al.   SCIENCE

Lymph protects metastasizing melanoma cells from ferroptosis

(2020) Jessalyn M. Ubellacker et al.   NATURE

Myeloid FBW7 deficiency disrupts redox homeostasis and aggravates dietary-induced insulin resistance

(2020) Cheng Wang et al.   Redox Biology

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Broadening the impact of immunotherapy to pancreatic cancer: Challenges and opportunities

(2019) Vinod P. Balachandran et al.   GASTROENTEROLOGY

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Redox properties and human serum albumin binding of nitro-oleic acid

(2019) Martina Zatloukalova et al.   Redox Biology

Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses

(2019) Boutaina Daher et al.   CANCER RESEARCH

Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death

(2019) Lia Tesfay et al.   CANCER RESEARCH

Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer

(2019) Zuzanna Tracz-Gaszewska et al.   Cancers

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer

(2018) Qiangsheng Hu et al.   CELL PROLIFERATION

An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice

(2018) Mouad Edderkaoui et al.   GASTROENTEROLOGY

FBW7 increases the chemosensitivity of pancreatic cancer cells to gemcitabine through upregulation of ENT1

(2017) Qiangsheng Hu et al.   ONCOLOGY REPORTS

Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells

(2016) Rohit Anthony Sinha et al.   Autophagy

FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer

(2016) S. Ji et al.   CLINICAL CANCER RESEARCH

Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids

(2015) A. D. Southam et al.   CANCER RESEARCH

ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer

(2015) Shunrong Ji et al.   CELL RESEARCH

Gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) Yoav Binenbaum et al.   DRUG RESISTANCE UPDATES

Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

(2014) Ryan J. Davis et al.   CANCER CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Molecular Pathways: The Role of NR4A Orphan Nuclear Receptors in Cancer

(2012) H. M. Mohan et al.   CLINICAL CANCER RESEARCH

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

(2010) S.-O. Lee et al.   CANCER RESEARCH

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

(2010) Ichiro Onoyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun

(2010) Joerg D Hoeck et al.   NATURE NEUROSCIENCE

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Gemcitabine Resistance in Pancreatic Cancer: Picking the Key Players

(2008) M. P. Kim et al.   CLINICAL CANCER RESEARCH

Nitro-fatty Acid Formation and Signaling

(2008) Bruce A. Freeman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY