Article
Biotechnology & Applied Microbiology
Ding Liu, Huilin Huang, Bingxia Zhao, Weihong Guo
Summary: Melanin, a natural product, has been utilized in nanomedicine due to its biocompatibility and light responsive property. In this study, polydopamine (PDA) was extracted from dopamine, encapsulated with doxorubicin (DOX), and the prepared nanoparticles exhibited excellent stability and biosafety. With near infrared (NIR) irradiation, the PDA-DOX NPs showed promising potential in tumor therapy, enhancing cell uptake of DOX and inducing immunogenic cell death.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Lea Miebach, Hager Mohamed, Kristian Wende, Vandana Miller, Sander Bekeschus
Summary: This study suggests that gas plasma-oxidized liquids enriched with free radicals can be used as an additive option for treating pancreatic cancer, inducing tumor toxicity and provoking immunogenicity.
Article
Oncology
Changlin Li, Ying Zhang, Siyuan Yan, Guoan Zhang, Wei Wei, Zhi Qi, Benyi Li
Summary: Alternol triggers immunogenic cell death in prostate cancer cells through the generation of reactive oxygen species (ROS), leading to an antitumor immune response. This immunogenic cell death induces delayed tumor growth and prolonged survival.
Review
Chemistry, Multidisciplinary
Lea Miebach, Broder Poschkamp, Julia van der Linde, Sander Bekeschus
Summary: Cold medical gas plasmas have the potential to serve as a non-invasive and gentle hemostatic agent in clinical procedures. Their ability to induce blood coagulation makes them particularly suitable for vulnerable tissues and preventing post-operative bleeding. However, despite promising results in experimental animal models, no clinical trials have been conducted yet.
APPLIED SCIENCES-BASEL
(2022)
Article
Pharmacology & Pharmacy
Xuejia Kang, Yuxin Cai, Qi Wang, Chuanyu Wang, Wu Chen, Wen Yang, Amol Suryawanshi, Gang Zhou, Pengyu Chen, Feng Li
Summary: The CDL therapy combines CuS NP, DQ prodrug, and NIR laser to effectively kill cancer cells through ROS amplification cascade and Cu(DDC)2 chemotherapy, while ensuring tumor-specificity and reducing systemic toxicity through NIR light-triggered nontoxic-to-toxic transition. Additionally, the therapy has the potential to induce immunogenic cell death and elicit antitumor immunity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Cell Biology
Nicole Rufo, Yihan Yang, Steven De Vleeschouwer, Patrizia Agostinis
Summary: Disrupted endoplasmic reticulum (ER) homeostasis in cancer cells is characterized by maladaptive unfolded protein response (UPR) signaling, which sustains proteostasis and metabolism reprogramming, and fosters proinflammatory pathways promoting tissue repair and protumorigenic immune responses. However, when cancer cells are exposed to conditions causing irreparable ER homeostasis, the UPR switches to a cell death program, eliciting immunogenic cell death (ICD) with proinflammatory traits.
Article
Biochemistry & Molecular Biology
Sander Bekeschus, Thomas von Woedtke, Steffen Emmert, Anke Schmidt
Summary: The use of reactive oxygen and nitrogen species (ROS/RNS) therapy has shown promise in targeting chronic wounds, with multiple mechanisms including increased oxygenation and vascularization, enhanced apoptosis, redox signaling, and microbial inactivation working in concert to stimulate healing. Gas plasma technology, operating at body temperature, has the potential to become a new option for therapy-resistant wounds, but current challenges need to be addressed to further improve its clinical utilization.
Article
Immunology
Shuang Wang, Guangsuo Wang, Weiqing Wu, Zhenglei Xu, Jing Yang, Min Cao, Qi Wang, Jigang Wang, Chuanbin Yang, Wei Zhang
Summary: This study finds that piceatannol, a dietary phenolic compound, can enhance the anticancer immune response induced by the chemotherapy drug oxaliplatin (OXA) through inducing autophagy. Piceatannol promotes the release of immune response-triggering substances and improves the efficacy of chemotherapy. Additionally, piceatannol induces endoplasmic reticulum stress, leading to increased cell surface exposure of calreticulin. The combination of piceatannol and OXA also enhances the anticancer effects in immunocompetent mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Fariba Saadati, Fahimeh Jahanbakhshi, Hamed Mahdikia, Fereshteh Abbasvandi, Hamid Ghomi, Nasrin Yazdani, Keyvan Aghazadeh, Steffen Emmert, Sander Bekeschus
Summary: Cold physical plasma shows potential as a therapeutic intervention for breast cancer (BC) and oral squamous cell carcinoma (OSCC), selectively killing cancer cells without genotoxic effects on non-malignant cells.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Multidisciplinary
Zhaoyun Liu, Xintong Xu, Kaining Liu, Jingtian Zhang, Dan Ding, Rong Fu
Summary: Although the treatment efficacy for hematological malignancies has improved, relapse or drug resistance remains a challenge. Microenvironment disorder plays a significant role in the pathogenesis of these malignancies. Immunogenic cell death (ICD) is a unique mechanism that triggers an adaptive immune response through danger signals or damage-associated molecular patterns, making it a potential immunotherapeutic approach for hematological malignancies. This review provides an overview of ICD induction in hematological malignancies and current research on combining ICD inducers with other treatment strategies.
Article
Chemistry, Multidisciplinary
Eun-Jin Go, Dasom Yang, WonHyoung Ryu, Hong Jae Chon, Chan Kim, Kyung-Soon Park, Dong-Hyun Kim, Dong Keun Han, Wooram Park
Summary: Electrical ablation (EA) is a non-thermal technique that induces immunogenic cell death and can synergize with cancer immunotherapy. This study identified optimal voltage and pulse conditions for inducing immunogenic cell death, which can be combined with cancer immunotherapy for potential clinical applications.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Ferrin Antony, Xuejia Kang, Chetan Pundkar, Chuanyu Wang, Amarjit Mishra, Pengyu Chen, R. Jayachandra Babu, Amol Suryawanshi
Summary: Tumors often dysregulate the Wnt/beta-catenin pathway to promote tumorigenesis, immunosuppression, and resistance to targeted cancer immunotherapies. In this study, a nanoparticle formulation for XAV939, a tankyrase inhibitor, was used to investigate the effect of beta-catenin inhibition on melanoma cell viability, migration, and tumor progression.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Si Chen, Piao Zhu, Lijie Mao, Wencheng Wu, Han Lin, Deliang Xu, Xiangyu Lu, Jianlin Shi
Summary: Emerging piezocatalysts show great potential in diverse medical fields. Apart from their high catalytic activities, their unique charge-carrier-releasing properties can initiate redox catalytic reactions, leading to promising medical applications. Piezocatalytic materials, triggered by mechanical energy, can promote the production of effector molecules for medical purposes, such as decontamination, sterilization, and therapy. The review provides an overview of the progress in piezocatalytic medicine, including the principle of piezocatalysis, preparation methods of piezoelectric materials, and medical applications in tumor treatment, antisepsis, organic degradation, tissue repair, regeneration, and biosensing. The challenges and future perspectives in piezocatalytic medicine are also discussed to fuel the development of this emerging discipline.
ADVANCED MATERIALS
(2023)
Article
Oncology
Ying Zhang, Ramar Thangam, Sung-Hwan You, Rukhsora D. Sultonova, Akhil Venu, Jung-Joon Min, Yeongjin Hong
Summary: Surface-exposed calreticulin (ecto-CRT) plays a critical role in the phagocytic removal of apoptotic cells during immunotherapy. Engineered human fibronectin domain III (FN3) monobodies fused with CRT-specific peptides can be used to detect immunogenic cell death (ICD) and potentially predict early therapeutic responses. The engineered monobodies show high affinity for ecto-CRT and effectively detect pre-apoptotic cancer cells after treatment with ICD-inducing agents, offering a potential method for early prediction of therapeutic efficiency during anticancer treatment.
Article
Oncology
Wen Wang, Xin Yang, Chong Li, Yandong Li, Haibo Wang, Xue Han
Summary: The study revealed that Lentinan has concentration-dependent cytotoxic and pro-apoptotic effects on H22 cells, significantly increasing the rate of apoptosis and inducing the expression of immunogenic death-related proteins. These findings suggest that the antitumor effect of Lentinan may be attributed to the regulation of immunogenic death-related protein expression, providing insights for the future development of liver cancer vaccines.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Oncology
Keivan Majidzadeh-A, Shiva Zarinfam, Nasrin Abdoli, Fatemeh Yadegari, Rezvan Esmaeili, Leila Farahmand, Azin Teimourzadeh, Mahdieh Taghizadeh, Mansoor Salehi, Mohamad Zamani
Summary: BRCA1 and BRCA2 are major genes in inherited breast cancer, with a study in Iran revealing 89 distinct pathogenic variants, including 16 previously unreported mutations globally. The research provides valuable insights into the frequency and spectrum of BRCA mutations in the Iranian population.
Review
Oncology
Behrad Darvishi, Mohammad Reza Eisavand, Keivan Majidzadeh-A, Leila Farahmand
Summary: The extracellular matrix (ECM) plays a crucial role in tumor development, affecting cellular behavior by activating mechanotransduction pathways and inducing chemoresistance. This study aims to elucidate the relationship between ECM stiffening and chemoresistance, and discuss pharmacological approaches to overcome ECM-induced chemoresistance.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Lea Miebach, Eric Freund, Ramona Clemen, Klaus-Dieter Weltmann, Hans-Robert Metelmann, Thomas von Woedtke, Torsten Gerling, Kristian Wende, Sander Bekeschus
Summary: Gas plasma jet technology has been found to have potential in palliative treatment for cancer patients. Direct contact with tumor tissue showed higher therapeutic efficacy compared to remote treatment with reactive oxygen and nitrogen species. The study emphasizes the importance of standardized treatment distances in gas plasma exposure to cancer therapy.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Parnaz Merikhian, Behrad Darvishi, Neda Jalili, Mohammad Reza Esmailinejad, Azadeh Sharif Khatibi, Shima Moradi Kalbolandi, Malihe Salehi, Marjan Mosayebzadeh, Mahdieh Shokrollahi Barough, Keivan Majidzadeh-A, Fatemeh Yadegari, Fatemeh Rahbarizadeh, Leila Farahmand
Summary: Alterations in glycosylation pattern of MUC1 mucin tandem repeats during carcinomas negatively affect adhesive properties of malignant cells and enhance tumor invasiveness and metastasis. MUC1 overexpression is closely related to angiogenesis, making it a significant target for immunotherapy. The recombinant nanobody targeting MUC1 tandem repeats showed promise in suppressing tumor growth, invasion, and metastasis.
MOLECULAR ONCOLOGY
(2022)
Article
Genetics & Heredity
Mitra Samadi, Laleh Beigi, Fatemeh Yadegari, Alireza Madjid Ansari, Keivan Majidzadeh-A, Maryam Eskordi, Leila Farahmand
Summary: This study predicts the effects of mutations on splicing in the CYP2C19/CYP2D6 genes using ESEs as a metric. The results show 18 variations within conserved ESEs for each gene, and experimental evidence confirms the accuracy of these predictions. The findings are important for understanding the functional changes and drug responses associated with these genes.
Article
Cell & Tissue Engineering
Hamid Reza Aghayan, Fatemeh Salimian, Atefeh Abedini, Samrand Fattah Ghazi, Masud Yunesian, Sepideh Alavi-Moghadam, Jalil Makarem, Keivan Majidzadeh-A, Ali Hatamkhani, Maryam Moghri, Abbas Danesh, Mohammad Reza Haddad-Marandi, Hassan Sanati, Fereshteh Abbasvandi, Babak Arjmand, Pourya Azimi, Ardeshir Ghavamzadeh, Ramin Sarrami-Forooshani
Summary: This study aimed to evaluate the safety of intravenous injection of placenta-derived mesenchymal stem cells (PL-MSCs) in patients with COVID-19-induced acute respiratory distress syndrome (ARDS). The results demonstrated that the administration of PL-MSCs was safe and feasible, with no adverse events observed. There were no significant differences in clinical and laboratory parameters between the treatment and control groups. Further studies are needed to evaluate the efficacy of this treatment modality using higher cell doses and repeated injections.
STEM CELL RESEARCH & THERAPY
(2022)
Correction
Biochemical Research Methods
Mitra Samadi, Keivan Majidzadeh-A, Malihe Salehi, Neda Jalili, Zeinab Noorinejad, Marjan Mosayebzadeh, Ahad Muhammadnejad, Azadeh Sharif Khatibi, Shima Moradi-Kalbolandi, Leila Farahmand
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Mehdi Rahmanian, Omid Sartipzadeh Hematabad, Esfandyar Askari, Farhad Shokati, Atin Bakhshi, Shiva Moghadam, Asiie Olfatbakhsh, Esmat Al Sadat Hashemi, Mohammad Khorsand Ahmadi, Seyed Morteza Naghib, Nidhi Sinha, Jurjen Tel, Hossein Eslami Amirabadi, Jaap M. J. den Toonder, Keivan Majidzadeh-A
Summary: This study demonstrates the use of a novel micropillar array-based microfluidic chip (MPA-Chip) for isolating circulating tumor cells (CTCs) from the blood of cancer patients, providing prognostic information and monitoring treatment efficacy. The lozenge geometry of the MPA-Chip was found to be the most effective design, with high capture efficiency (>85%), purity (>90%), and viability (97%).
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Oncology
Mohsen Abbasi-Kangevari, Sahar Saeedi Moghaddam, Seyyed-Hadi Ghamari, Mohammadreza Azangou-Khyavy, Mohammad-Reza Malekpour, Negar Rezaei, Nazila Rezaei, Ali-Asghar Kolahi, Erfan Amini, Ali H. Mokdad, Hamidreza Jamshidi, Mohsen Naghavi, Bagher Larijani, Farshad Farzadfar
Summary: The incidence and prevalence rates of prostate cancer increased in North Africa and the Middle East from 1990 to 2019, while the death rate remained stable. The rise in incidence was primarily due to an increase in the age-specific incidence rate rather than population growth or aging.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Ilka Scheer, Ina Becker, Charlotte Schmitter, Sabine Semrau, Rainer Fietkau, Udo S. Gaipl, Benjamin Frey, Anna-Jasmina Donaubauer
Summary: The study investigates the reactivation of CMV during radiotherapy for brain tumors. It is found that patients with CMV reactivation have significantly higher levels of CD8+ T-EMRA cells. Additionally, the expression of CD27, CD28, and CD57 is associated with CMV infection status. The percentage of CD8+ T-EMRA cells may serve as a biomarker for predicting the risk of CMV reactivation during radiotherapy.
Article
Oncology
Thomas Weissmann, Sina Mansoorian, Matthias Stefan May, Sebastian Lettmaier, Daniel Hoefler, Lisa Deloch, Stefan Speer, Matthias Balk, Benjamin Frey, Udo S. Gaipl, Christoph Bert, Luitpold Valentin Distel, Franziska Walter, Claus Belka, Sabine Semrau, Heinrich Iro, Rainer Fietkau, Yixing Huang, Florian Putz
Summary: This study introduces two novel methods for automatically analyzing the distribution of nodal metastases in head and neck cancer patients. The deep learning method accurately assigns lymph node metastases to different levels, while the registration-based method allows for the analysis and visualization of the 3D probability distribution of metastases without predefined level boundaries.
Article
Medicine, Research & Experimental
Mohammad Ahmadvand, Mahdieh Shokrollahi Barough, Zahra Sadat Hashemi, Hassan Sanati, Fereshteh Abbasvandi, Masud Yunesian, Keivan A. Majidzadeh, Jalil Makarem, Hamid Reza Aghayan, Atefeh Abedini, Ardeshir Ghavamzadeh, Ramin Sarrami Forooshani
Summary: This study aimed to evaluate the feasibility and safety of allogeneic NK cell infusion as an intervention for respiratory viral disease. The results showed that intravenous infusion of ex vivo-expanded allogeneic NK cells was safe and feasible. However, the efficacy of this approach in reducing the severity of disease in COVID-19 patients could not be determined.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Chemistry, Multidisciplinary
Hamide Hosseinjani-Pirdehi, Soode Amigh, Afshan Mohajeri, Elahe Nazeri, Amir Taheri, Keivan Majidzadeh-A, Zahra Mohammadpour, Rezvan Esmaeili
Summary: In this study, fluorogenic coumarin-based probes were synthesized by condensation reaction of 4-hydroxy coumarin with malondialdehyde bis(diethyl acetal)/triethyl orthoformate. The absorption and fluorescence emission properties of probes 2b and 3 in different solvents were investigated, showing significant solvatochromic effect. Chemosensors 2b and 3 exhibited selectivity towards various cations and anions, with compound 3 showing distinct selectivity towards Sn2+ via chelation enhanced quenching mechanism. The fluorescence signal of compound 3 was quenched in the concentration range of 6.6-120 μM, with a detection limit of 3.89 μM. The non-toxicity and successful application of compound 3 in cellular imaging were demonstrated. The probe not only responded to tin ions through fluorescence quenching, but also showed colorimetric signal change, which could be observed in ambient conditions and inside living cells.
Article
Biochemistry & Molecular Biology
Anastazja Poczta, Piotr Krzeczynski, Maksim Ionov, Aneta Rogalska, Udo S. Gaipl, Agnieszka Marczak, Dorota Lubgan
Summary: This study synthesized a series of new derivatives by modifying the molecular structure of melphalan, and proved that EM-MOR-MEL and EM-T-MEL have better anti-cancer activity. These derivatives achieve their effects on multiple myeloma cells by affecting DNA conformation, increasing DNA damage, arresting cell cycle, and activating mitotic catastrophe.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Azzaya Sengedorj, Michael Hader, Benjamin Frey, Rainer Fietkau, Oliver J. Ott, Udo S. Gaipl, Michael Rueckert
Summary: Radiotherapy is a crucial standard cancer therapy that not only achieves local tumor control but also induces systemic anti-tumor immunity. However, the effects of radiotherapy on the immune system can be both immunostimulatory and immunosuppressive. Combining radiotherapy with additional therapies such as hyperthermia and immune checkpoint inhibitors shows promising approaches to effectively induce anti-tumor immunity.
CURRENT STEM CELL REPORTS
(2022)