Review
Neurosciences
Zhe Li, Yang Liu, Ruixue Wei, Suliman Khan, Ruiyi Zhang, Yan Zhang, Voon Wee Yong, Mengzhou Xue
Summary: This review summarizes recent progress in understanding the mechanisms by which deferoxamine may alleviate intracerebral hemorrhage (ICH) and discusses the potential clinical utility of deferoxamine.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jinyang Wen, Jinhan Qiao, Yuanyuan Tang, Yun Zhao, Zhaoxia Yang, Luyun Wang, Xinwei Tao, Xiaoyue Zhou, Liming Xia, Lu Huang, Dazhong Tang
Summary: This study evaluated the image quality and diagnostic performance of susceptibility-weighted imaging (SWI) and T1/T2 mapping in detecting reperfusion intramyocardial hemorrhage (IMH) in patients with ST-segment elevation myocardial infarction (STEMI). The results showed that both SWI and T1/T2 mapping had excellent diagnostic performance for detecting IMH, and can be considered as feasible approaches for clinical diagnosis of IMH.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Clinical Neurology
Angela Napolitano, Alberto Arrigoni, Anna Caroli, Mariangela Cava, Andrea Remuzzi, Luca Giovanni Longhi, Antonino Barletta, Rosalia Zangari, Ferdinando Luca Lorini, Maria Sessa, Simonetta Gerevini
Summary: There is increasing evidence that COVID-19 can cause neurological symptoms and cerebral microbleeds (CMBs) have been observed in patients with this condition. This study aimed to characterize CMBs patterns using susceptibility-weighted imaging (SWI) in hospitalized COVID-19 patients with neurological manifestations. The study found that CMBs are a frequent imaging finding in these patients and are associated with a pro-inflammatory state.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Sung-Ho Ahn, Angela Burkett, Atzhiry Paz, Jude P. Savarraj, Sarah Hinds, Georgene Hergenroeder, Aaron M. Gusdon, Xuefeng Ren, Jeong-Ho Hong, Huimahn A. Choi
Summary: The study identified serum cytokines at different time points that were independently associated with persistent CE, particularly persistent elevations of Eotaxin were associated with persistent CE after SAH.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Jie Wang, Xiao-qin Tang, Min Xia, Cheng-cheng Li, Chao Guo, Hong-fei Ge, Yi Yin, Bo Wang, Wei-xiang Chen, Hua Feng
Summary: Iron overload plays a key role in secondary bleeding after ICH in Ang II-induced hypertensive mice. Iron chelation during the process of Ang II-induced hypertension suppresses secondary bleeding after ICH.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Geriatrics & Gerontology
Chenyang Li, Henry Rusinek, Jingyun Chen, Louisa Bokacheva, Alok Vedvyas, Arjun V. Masurkar, E. Mark Haacke, Thomas Wisniewski, Yulin Ge
Summary: High-resolution susceptibility weighted imaging (SWI) can be a sensitive marker for characterizing cerebral oxygen metabolism and different stages of cognitive and functional status in neurodegenerative diseases, by quantifying white matter venous density and its associations with neurodegenerative features, WMHs, and clinical measures.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Veterinary Sciences
Nadja Wolfer, Adriano Wang-Leandro, Katrin M. Beckmann, Henning Richter, Matthias Dennler
Summary: SWI is more effective than T2*WI in detecting ASV in dogs, with the ability to differentiate between hemorrhagic and calcified lesions. Frontal sinus conformation can impact image interpretation, with brachycephalic dogs showing less severe artifacts in both sequences.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Mathematical & Computational Biology
Vaanathi Sundaresan, Christoph Arthofer, Giovanna Zamboni, Robert A. Dineen, Peter M. Rothwell, Stamatios N. Sotiropoulos, Dorothee P. Auer, Daniel J. Tozer, Hugh S. Markus, Karla L. Miller, Iulius Dragonu, Nikola Sprigg, Fidel Alfaro-Almagro, Mark Jenkinson, Ludovica Griffanti
Summary: The study aimed to detect CMB candidate subjects from the UK Biobank dataset using a machine learning-based, computationally light pipeline. Evaluation results showed that our method achieved subject-level detection accuracy of over 80% on all datasets, and demonstrated good generalisability across datasets.
FRONTIERS IN NEUROINFORMATICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tzu-Chao Chuang, Yen-Lin Chen, Wan-Pin Shui, Hsiao-Wen Chung, Shu-Shong Hsu, Ping-Hong Lai
Summary: By quantitatively measuring the sensitivity signals on SWI, high-grade and low-grade astrocytoma can be reliably differentiated.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Clinical Neurology
Chong-xi Xu, Hui Xu, Tong Yi, Xing-yang Yi, Jun-peng Ma
Summary: The study found that age and hypertension are highly correlated with cerebral microbleeds, and in acute ischemic stroke patients, the number of cerebral microbleeds increases the incidence of intracranial hemorrhage. Cerebral microbleeds >= 10 are independent predictors of ICH.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Lindsey R. Kuohn, Jens Witsch, Thorsten Steiner, Kevin N. Sheth, Hooman Kamel, Babak B. Navi, Alexander E. Merkler, Santosh B. Murthy, Stephan A. Mayer
Summary: This study examined the relationship between different locations (deep versus lobar) of intracerebral hemorrhage (ICH) and early neurological deterioration, hematoma expansion (HE), and outcome. The results showed that lobar ICH location was associated with more common HE and early neurological deterioration, while deep ICH location was associated with smaller hematoma size. However, after adjusting for prognostic variables, deep ICH was associated with worse outcome.
Article
Neurosciences
Haojie Wang, Shufa Zheng, Yibin Zhang, Wenjian Fan, Bingsen Xie, Fuxiang Chen, Yuanxiang Lin, Dezhi Kang
Summary: The study found that decreased serum iron levels serve as an important indicator for predicting postoperative cerebral edema and poor prognosis in patients with aSAH.
Article
Critical Care Medicine
Benjamin E. E. Zusman, Yijen Wu, Patrick M. M. Kochanek, Vincent E. E. Vagni, Keri Janesko-Feldman, Volodymyr Gerzanich, J. Marc Simard, Katherine Karahalios, Sandra Mihaljevic, Sudhanshu Raikwar, Anupama Rani, Jarrod Rulney, Shashvat M. M. Desai, Joshua Catapano, Ruchira M. M. Jha
Summary: This study evaluated the differential effects of glibenclamide on dose, TBI type, and imaging endophenotype. High-dose glibenclamide showed benefits in reducing hematoma volume, vasogenic edema, cytotoxic edema, and maintaining blood-brain barrier integrity after isolated brain contusion. However, its anti-edema effects were not robust in the presence of concomitant hemorrhagic shock.
CRITICAL CARE MEDICINE
(2023)
Article
Clinical Neurology
Faiza Boukerche, Sivasubramanian Balakrishnan, Paul Kalapos, Krishnamoorthy Thamburaj
Summary: This retrospective study reviewed 51 consecutive cases and 27 controls to investigate the ability of susceptibility-weighted imaging to distinguish cerebral venous clots from other structures. The results showed that susceptibility-weighted imaging can successfully differentiate the majority of clots from patent dural sinuses, cortical veins, and calvarium with excellent inter-rater agreements.
Article
Neurosciences
Nemanja Novakovic, Zachary M. Wilseck, Thomas L. Chenevert, Guohua Xi, Richard F. Keep, Aditya S. Pandey, Neeraj Chaudhary
Summary: This study investigated the time course of red blood cell lysis in ICH patients using MRI, revealing correlations between perihematomal iron accumulation and white matter loss with erythrolysis extent and hematoma volume in the early and subacute periods after ICH. MRI may be a reliable tool for assessing hematoma lysis over time and its impact on surrounding tissues.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Wei Cui, Ran Liu, Haiqiang Jin, Pu Lv, Yuyao Sun, Xi Men, Saina Yang, Xiaozhong Qu, Zhenzhong Yang, Yining Huang
JOURNAL OF CONTROLLED RELEASE
(2016)
Article
Clinical Neurology
Yuyao Sun, Malgorzata M. Miller, Shadi Yaghi, Brian Silver, Nils Henninger
Editorial Material
Clinical Neurology
Goun Je, Yuyao Sun, Kiandokht Keyhanian, Shadi Yaghi, Nils Henninger
Summary: This study aimed to determine the anatomical structures related to QTc-prolongation in patients with acute medullary infarction, and found that the dorsal vagal nucleus (DVN) is a key anatomical substrate for QTc-prolongation. Further studies with more patients and high-resolution, volumetric MRI are needed to confirm these findings.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Sakhaa Hanoun, Yuyao Sun, Farzad Ebrahimi, Mehdi Ghasemi
Summary: Myotonic dystrophy (DM) is a neuromuscular disease that can cause speech and language abnormalities related to cognitive dysfunction, muscle weakness, and myotonia. Understanding these abnormalities can provide markers for disease characterization and evaluation.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Yuyao Sun, Malgorzata M. Miller, Shadi Yaghi, Nils Henninger
Summary: This study investigates the link between cardiac injury markers and atrial fibrillation detected after stroke (AFDAS). The presence of non-AF stroke heart syndrome (SHS) features and left atrial volume index were independently associated with AFDAS. This understanding may aid in identifying modifiable risk factors and making treatment decisions for patients at risk of new-onset atrial fibrillation and ischemic stroke.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Review
Clinical Neurology
Yuyao Sun, Richard Bedlack, Carmel Armon, Morgan Beauchamp, Tulio Bertorini, Robert Bowser, Mark Bromberg, James Caress, Gregory Carter, Jesse Crayle, Merit E. Cudkowicz, Jonathan D. Glass, Carlayne Jackson, Isaac Lund, Sarah Martin, Sabrina Paganoni, Gary Pattee, Dylan Ratner, Kristiana Salmon, Paul Wicks
Summary: The article reviews the potential use of butyrates in the treatment of amyotrophic lateral sclerosis (ALS), with a focus on one trial involving sodium phenylbutyrate (NaPB) and Tauroursodeoxycholic acid (TUDCA). The results suggest that this combination can slow ALS progression and prolong survival, but the specific contribution of NaPB is unclear. However, more research is needed to determine the efficacy of butyrates as a treatment for ALS.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2022)
Article
Clinical Neurology
Jill Ann Goslinga, Mark Terrelonge, Richard Bedlack, Paul Barkhaus, Benjamin Barnes, Tulio Bertorini, Mark Bromberg, Gregory Carter, Amy Chen, Jesse Crayle, Mazen Dimachkie, Leanne Jiang, Gleb Levitsky, Isaac Lund, Sarah Martin, Christopher Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Lenka Slachtova, Yuyao Sun, Paul Wicks
Summary: This article reviews the evidence of glucocorticoids in ALS treatment and concludes that they do not provide clinical benefits and have serious risks.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Yuyao Sun, Xiaoyan Li, Richard Bedlack
Summary: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, fatal neurodegenerative motor neuron disease. Prior to 2022, there were only two FDA-approved disease-modifying therapies for ALS. The CENTAUR trial demonstrated the safety and efficacy of sodium phenylbutyrate-taurursodiol (PB-TURSO) in ALS patients, leading to its approval in Canada and the USA.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Clinical Neurology
Yuyao Sun, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T. T. Carter, Jesse Crayle, Merit Cudkowicz, Mazen Dimachkie, Eva L. L. Feldman, Timothy Fullam, Terry Heiman-Patterson, Sartaj Jhooty, Isaac Lund, Christopher Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Paul Wicks, Richard Bedlack
Summary: ALSUntangled reviews the use of ozone therapy in ALS patients, as it has potential mechanisms to slow down ALS progression. Although a non-peer-reviewed report suggests that ozone treatment may slow down ALS progression in a mouse model, there are no clinical trials using ozone in PALS. One verified case of ALS reversal was observed with a combination of alternative treatments including ozone. However, potential serious side effects associated with ozone therapy need to be further investigated before recommending it as a treatment for PALS.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Review
Clinical Neurology
Yuyao Sun, Michael Benatar, Javier Mascias Cadavid, Dave Ennist, Paul Wicks, Kim Staats, Morgan Beauchamp, Sartaj Jhooty, Gary Pattee, Andrew Brown, Tulio Bertorini, Paul Barkhaus, Mark Bromberg, Greg Carter, Richard Bedlack, Xiaoyan Li
Summary: Nuedexta, a combination of dextromethorphan hydrobromide and quinidine sulfate, was approved by FDA in 2010 for treating PBA. There are anecdotal case reports of improved bulbar function after Nuedexta treatment in ALS patients. Recent clinical trials support that Nuedexta can improve bulbar function in PALS, with or without PBA. It causes mild to moderate side effects. Considering Nuedexta treatment for bulbar dysfunction in ALS patients with or without PBA is supported based on this information.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
