Article
Oncology
Aviad Hoffman, Itamar Ashkenazi
Summary: This study evaluated the application of Margin Probe in patients undergoing lumpectomy for breast cancer and found that it has a relatively low sensitivity in detecting positive margins and a high false-positive rate, resulting in unnecessary margin shavings.
Article
Oncology
Rong Zhao, Jun Xing, Jinnan Gao
Summary: A nomogram was developed and validated to predict the status of breast-conserving margins in patients undergoing breast-conserving surgery. The nomogram, based on multiple indicators, showed good discrimination and calibration in both the modeling and validation groups.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Francesca Magnoni, Virgilio Sacchini, Paolo Veronesi, Beatrice Bianchi, Elisa Bottazzoli, Valentina Tagliaferri, Erica Mazzotta, Giulia Castelnovo, Giulia Deguidi, Elisabetta Maria Cristina Rossi, Giovanni Corso
Summary: The optimal surgical approach to hereditary breast cancer and the management of patients carrying mutations in high-penetrance genes are significant current clinical and scientific issues. Studies have shown that breast-conserving surgery is oncologically safe in BRCA carriers in terms of overall survival, despite an increased risk of ipsilateral recurrence.
Article
Oncology
Ashley Cairns, Anees B. Chagpar, Elisabeth Dupont, Edward A. Levine, Jennifer S. Gass, Akiko Chiba, David W. Ollila, Marissa Howard-McNatt
Summary: A study involving 631 patients found that preoperative MRI was not associated with margin status for breast cancer patients undergoing BCS. Instead, age and tumor size were the only factors associated with margin status.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Hakyoung Kim, Sae Byul Lee, Seok-Jin Nam, Eun Sook Lee, Byeong-Woo Park, Ho Yong Park, Hyouk Jin Lee, Jisun Kim, Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn
Summary: This study evaluated the long-term outcomes of Korean women with early breast cancer undergoing breast-conserving surgery plus radiotherapy or total mastectomy. Findings showed that the breast-conserving surgery plus radiotherapy group had better overall survival and breast cancer-specific survival than the total mastectomy group in both the Korean Breast Cancer Registry and Asan Medical Center cohorts. The results suggest that breast-conserving surgery plus radiotherapy is at least equivalent to total mastectomy in terms of overall survival and may influence treatment decisions for early breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jiameng Liu, Zhanlin Zhu, Zhipeng Hua, Weijie Lin, Yiyin Weng, Juli Lin, Hehui Mao, Lifen Lin, Xuming Chen, Jujiang Guo
Summary: The aim of this study is to identify risk factors for refusal of radiotherapy after breast-conserving surgery. The study found that patients with old age, low income, divorce, white race, advanced stage, and no chemotherapy were more likely to refuse radiotherapy.
RADIATION ONCOLOGY
(2023)
Review
Oncology
Caiqin Mo, Weihong Ruan, Junyu Lin, Huaying Chen, Xiangjin Chen
Summary: Repeat breast-conserving surgery (RBCS) has a higher secondary local recurrence rate compared to salvage mastectomy (SM) for patients with ipsilateral breast tumour recurrence (IBTR), but it does not significantly affect survival rates. RBCS may be considered as an alternative method for IBTR patients after breast-conserving surgery (BCS).
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
M. Luke Marinovich, Christobel M. Saunders, Gavin Pereira, Nehmat Houssami
Summary: This study investigated whether the introduction of the 2014 surgical margins guideline was associated with a reduction in reoperation rates for breast cancer patients in Western Australia. The results showed that the post-guideline reoperation rates did decrease, but this decline was already observed before the guideline was introduced.
Article
Health Care Sciences & Services
Alba Di Leone, Antonio Franco, Francesca Zotta, Lorenzo Scardina, Margherita Sicignano, Enrico Di Guglielmo, Virginia Castagnetta, Stefano Magno, Daniela Terribile, Alejandro Martin Sanchez, Gianluca Franceschini, Riccardo Masetti
Summary: Triple-negative breast cancer (TNBC) refers to a subtype of breast cancer that lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). A population-based study was conducted to compare the outcomes of breast-conserving surgery (BCS) and mastectomy (M) in 289 TNBC patients. The study found no significant differences in locoregional disease-free survival, distant disease-free survival, and overall survival between the two surgical treatments. These findings suggest that TNBC should not be considered a contraindication for breast-conserving surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Yu-Chun Song, Zhou Huang, Hui Fang, Yu Tang, Hao Jing, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Bo Chen, Yuan Tang, Shu-Nan Qi, Ning-Ning Lu, Ning Li, Ye-Xiong Li, Shu-Lian Wang
Summary: This study compares the recurrence and survival outcomes between breast-conserving surgery (BCS) and mastectomy after neoadjuvant chemotherapy (NACT). The results show that there is no significant difference in the 5-year locoregional recurrence rate, distant metastasis rate, and disease-free survival rate between the BCS and mastectomy groups. However, the BCS group has significantly higher 5-year breast cancer-specific survival rate and overall survival rate compared to the mastectomy group. Multivariate analysis also demonstrates that BCS significantly improves breast cancer-specific survival and overall survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hyunjung Kim, Tae Gyu Kim, Byungdo Park, Jeong Ho Kim, Si-Youl Jun, Jun Ho Lee, Hee Jun Choi, Chang Shin Jung, Yoon Ju Bang, Hyoun Wook Lee, Jae Seok Lee, Hyun Yeol Nam, Seunghyeon Shin, Sung Min Kim, Haeyoung Kim
Summary: This study aimed to evaluate the effectiveness of high-dose radiation therapy for positive margins in breast cancer surgery and compare the local recurrence between patients with positive and negative margins. The results showed that positive margins were not associated with poor local control in older patients after a high-dose boost, but had higher risk of local recurrence in younger patients.
Article
Oncology
Florin-Catalin Pop, Isabelle Veys, Sophie Vankerckhove, Romain Barbieux, Marie Chintinne, Michel Moreau, Vincent Donckier, Denis Larsimont, Pierre Bourgeois, Gabriel Liberale
Summary: This study investigates the feasibility and accuracy of indocyanine green fluorescence imaging for assessing surgical margins in breast cancer patients undergoing breast-conserving surgery. The results show that ICG-FI has a high negative predictive value for surgical margin assessment, helping surgeons predict clear margins intraoperatively and reducing the need for further analysis during surgery.
Article
Medicine, Research & Experimental
Piero Fregatti, Marco Gipponi, Giulia Atzori, Raffaele De Rosa, Raquel Diaz, Chiara Cornacchia, Marco Sparavigna, Alessandro Garlaschi, Liliana Belgioia, Alessandra Fozza, Francesca Pitto, Luca Boni, Eva Blondeaux, Francesca Depaoli, Federica Murelli, Simonetta Franchelli, Gabriele Zoppoli, Matteo Lambertini, Daniele Friedman
Summary: By analyzing the clinicopathological features of patients undergoing margin enlargement after lumpectomy for early breast cancer, it can be determined whether a re-operative procedure could have been avoided. Furthermore, a standardized protocol of specimen orientation was adopted to optimize both the widening procedure and the oncologic outcome.
Review
Oncology
Mohammed Tarek Hasan, Mohamed Hamouda, Mohammad. K. El Khashab, Ahmed Bostamy Elsnhory, Abdullah Mohamed Elghamry, Obada Atef Hassan, Aya Mamdouh Fayoud, Abdelrahman H. Hafez, Mohammed Al-kafarna, Abdulrahman Ibrahim Hagrass, Randa Kamal Rabea, Mohamed Ibrahim Gbreel
Summary: This study compared conventional breast-conserving surgery (CBCS) with oncoplastic breast-conserving surgery (OPBCS) for breast cancer interventions. The results showed that OPBCS was significantly better than CBCS in most outcomes. However, there was no significant difference between the two techniques in terms of local recurrence, surgical margins, and risk of mastectomy. Overall, oncoplastic surgery is recommended for females with breast cancer.
Article
Oncology
Mingdi Zhang, Kejin Wu, Peng Zhang, Maoli Wang, Fang Bai, Hongliang Chen
Summary: BCS shows independent favorable prognostic factor and can be acceptable and preferable alternative to mastectomy for well-selected early-stage T1 or T2 CLBC patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
M. J. Cardoso, L. Wyld, I. T. Rubio, M. Leidenius, G. Curigliano, B. Cutuli, L. Marotti, L. Biganzoli
Article
Oncology
Antonio Esgueva, Roberto Rodriguez-Revuelto, Martin Espinosa-Bravo, Juan Pablo Salazar, Isabel T. Rubio
Editorial Material
Oncology
Isabel T. Rubio, Michalis Kontos, M. T. F. D. Vrancken-Peeters, Roman Rouzier, Anita R. Skandarajah, Viviana Galimberti, Niels Kroman, Carmela Caballero, Shinji Ohno
Article
Oncology
Laura Biganzoli, Fatima Cardoso, Marc Beishon, David Cameron, Luigi Cataliotti, Charlotte E. Coles, Roberto C. Delgado Bolton, Maria Die Trill, Sema Erdem, Maria Fjell, Romain Geiss, Mathijs Goossens, Christiane Kuhl, Lorenza Marotti, Peter Naredi, Simon Oberst, Jean Palussiere, Antonio Ponti, Marco Rosselli Del Turco, Isabel T. Rubio, Anna Sapino, Elzbieta Senkus-Konefka, Arko Skelin, Berta Sousa, Tiina Saarto, Alberto Costa, Philip Poortmans
Review
Obstetrics & Gynecology
Nina Ditsch, Isabel T. Rubio, Maria L. Gasparri, Jana de Boniface, Thorsten Kuehn
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
(2020)
Article
Oncology
Tibor Kovacs, Isabel T. Rubio, Christos Markopoulos, Riccardo A. Audisio, Susan Knox, Thorsten Kuehn, Robert Mansel, Zoltan Matrai, Francesco Meani, Maurizio Nava, Lynda Wyld
Article
Oncology
Suzette Delaloge, Martine Piccart, Emiel Rutgers, Saskia Litiere, Laura J. van't Veer, Franchette van den Berkmortel, Etienne Brain, Aleksandra Dudek-Peric, Miguel Gil-Gil, Patricia Gomez, Florentine S. Hilbers, Zaman Khalil, Susan Knox, Sherko Kuemmel, Georg Kunz, Anne Lesur, Jean-Yves Pierga, Peter Ravdin, Isabel T. Rubio, Mahasti Saghatchian, Tineke J. Smilde, Alastair M. Thompson, Giuseppe Viale, Gabriele Zoppoli, Peter Vuylsteke, Konstantinos Tryfonidis, Coralie Poncet, Jan Bogaerts, Fatima Cardoso
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Antonio Esgueva, Christian Siso, Martin Espinosa-Bravo, Carolina Sobrido, Ignacio Miranda, Juan P. Salazar, Isabel T. Rubio
Summary: This study demonstrates that achieving a pathologic complete response is beneficial for breast conservative surgery and sentinel lymph node biopsy. In selected subgroups, avoiding any axillary surgery after neoadjuvant treatment may be feasible. In cN+ patients, any pathologic complete response is associated with improved survival.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Miriam Cuatrecasas, Inigo Gorostiaga, Cristina Riera, Esteban Saperas, Gemma Llort, Irmgard Costa, Xavier Matias-Guiu, Cristina Carrato, Matilde Navarro, Marta Pineda, Nuria Duenas, Joan Brunet, Vicente Marco, Isabel Trias, Jose Ignacio Busteros, Gemma Mateu, Francesc Balaguer, Maria-Teresa Fernandez-Figueras, Manel Esteller, Eva Musulen
Article
Immunology
Andrea Aran, Gonzalo Lazaro, Vicente Marco, Elisa Molina, Ferran Abanco, Vicente Peg, Maria Gion, Laia Garrigos, Jose Perez-Garcia, Javier Cortes, Merce Marti
Summary: Tumor-infiltrating lymphocytes (TILs) have predictive and prognostic value in breast cancer. TCR differences between CD4+ and CD8+ TILs were observed, and a more restricted TCR repertoire with higher similarity was found in CD4+ TILs.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Oncology
Fatima Cardoso, Laura van't Veer, Coralie Poncet, Josephine Lopes Cardozo, Suzette Delaloge, Jean-Yves Pierga, Peter Vuylsteke, Etienne Brain, Giuseppe Viale, Sherko Kuemmel, Isabel T. Rubio, Gabriele Zoppoli, Alastair Mark Thompson, Erika Matos, Khalil Zaman, Florentine Hilbers, Aleksandra Dudek-Peric, Bart Meulemans, Martine J. Piccart-Gebhart, Emiel J. Rutgers
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Raghavan Vidya, Isabel T. Rubio, Regis Resende Paulinelli, Alberto Rancati, Agnieszka Kolacinska-Voytkuv, Marzia Salgarello, Hilton Becker
ECANCERMEDICALSCIENCE
(2020)
Meeting Abstract
Oncology
Jane Bayani, Coralie Poncet, Cheryl Crozier, Quang M. Trinh, Megan Hopkins, Aime Lambert Uwimana, Tammy Piper, Carrie Cunningham, Monika Sobol, Stefan Aebi, Kim Benstead, Oliver Bogler, Lissandra Dal Lago, Florentine Hilbers, Ingrid Hedenfalk, Larissa Korde, Barbro Linderholm, John Martens, Lavinia Middleton, Melissa Murray, Catherine Kelly, Cecilia Nilsson, Monika Nowaczyk, Stephanie Peeters, Aleks Andra Peric, Peggy Porter, Carolien Schroder, Isabel T. Rubio, Kathryn J. Ruddy, Christi van Asperen, Danielle van den Weyngaert, Carolien H. M. van Deurzen, Elise van Leeuwen-Stok, Joanna Vermeij, Eric Winer, Lincoln D. Stein, Sharon H. Giordano, Fatima Cardoso, John M. S. Bartlett
Meeting Abstract
Oncology
C. Siso, A. Esgueva, I. Miranda, C. Sobrido, J. Salazar, M. Espinosa-Bravo, I. T. Rubio
ANNALS OF SURGICAL ONCOLOGY
(2020)
Meeting Abstract
Oncology
Andreas Karakatsanis, Theodoros Foukakis, Per Karlsson, Eleftherios Mamounas, Anees Chagpar, John Boyages, Isabel Rubio, Bjorn Naume, Davide Mauri, Elsken van der Wall, Chirag Shah, Ava Kwong, Priscilla McAuliffe, Oreste Gentilini, Michail Ignatiadis, Ellen Schlichting, Janez Zgajnar, Francesco Meani, Marios Konstantinos Tasoulis, Pat Whitworth, Walter Weber, Petros Charalampoudis, Bahadir Gulluoglu, Lida Pistioli, Tove Filtenborg Tvedskov, Marjut Leidenius, Bruce Mann, Arjen Witkamp, Lynda Wyld, Rosa di Micco, Christos Markopoulos, Antonios Valachis, Fredrik Warnberg
ANNALS OF SURGICAL ONCOLOGY
(2020)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.