Article
Biochemistry & Molecular Biology
Alberto Lozano-Ros, Maria L. Martinez-Gines, Jose M. Garcia-Dominguez, Sara Salvador-Martin, Haydee Goicochea-Briceno, Juan P. Cuello, Ariana Meldana-Rivera, Yolanda Higueras-Hernandez, Maria Sanjurjo-Saez, Luis A. Alvarez-Sala-Walther, Luis A. Lopez-Fernandez
Summary: Vitamin D plays a significant role in regulating multiple sclerosis. This study analyzed the regulatory effect of vitamin D on the TGF-beta signaling pathway in patients with relapsing-remitting multiple sclerosis. The results showed that the regulation of TGF-beta pathway genes by vitamin D is indirect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Weronika Galus, Anna Walawska-Hrycek, Michalina Rzepka, Ewa Krzystanek
Summary: This study assessed the vitamin D status and practices among MS patients and professionals in the clinical setting. Results showed that while most patients confirmed vitamin D supplementation, only a small percentage achieved optimal vitamin D levels. Lack of doctor's recommendation was the most common reason for the absence of supplementation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Ashvin Kuri, Nicola Vickaryous, Amine Awad, Benjamin Meir Jacobs, Ruth Dobson
Summary: This study demonstrates that vD supplementation is the major determinant of vD levels in people with MS, with genetic factors playing a smaller role.
JOURNAL OF NEUROLOGY
(2023)
Review
Nutrition & Dietetics
Julie Langlois, Damien Denimal
Summary: This systematic review examined the effects of vitamin D supplementation on clinical and imaging outcomes in patients with multiple sclerosis (MS). The results showed no significant impact of vitamin D supplementation on relapse events, disability progression, and magnetic resonance imaging (MRI) lesions. However, recent studies found a significant reduction in new MRI lesions in the central nervous system of MS patients during supplementation with vitamin D3.
Review
Cell Biology
Carsten Carlberg, Marcin P. Mycko
Summary: Environmental factors, such as low vitamin D levels, contribute to the susceptibility of multiple sclerosis (MS), an autoimmune disease affecting the central nervous system. Vitamin D3, through its metabolite 1,25(OH)2D3, modulates the epigenome and transcriptome of immune cells, reducing inflammatory reactions and promoting immunological tolerance in T cells, thus preventing MS.
Article
Nutrition & Dietetics
Michaela Tanja Haindl, Muammer Ucal, Willibald Wonisch, Michaela Lang, Marta Nowakowska, Milena Z. Z. Adzemovic, Michael Khalil, Christian Enzinger, Sonja Hochmeister
Summary: Vitamin D is an antioxidant supplement that has been widely discussed in relation to multiple sclerosis (MS). This study investigates the effects of vitamin D on cortical pathology, oxidative stress, and neurofilament light chain levels in a rat model of demyelination. The findings suggest a positive impact of vitamin D on cellular features of cortical pathology.
Article
Multidisciplinary Sciences
Majid Ghareghani, Kazem Zibara, Serge Rivest
Summary: Previous studies have shown that the prevalence of multiple sclerosis (MS) increases as one moves from the equator to the poles. This is due to variations in exposure to sunlight, which activates vitamin D synthesis, and absence of light, which activates melatonin synthesis. Deficiencies or excesses in vitamin D or melatonin can occur at any latitude due to specific lifestyles and diets. Northern countries with higher melatonin levels were expected to have lower MS prevalence, but this is not the case. Vitamin D deficiency and a higher MS prevalence persist in high latitudes even with supplementation. Darkness increases MS melatonin levels, causing negative effects that can be alleviated by light therapy. This review discusses the roles of melatonin and vitamin D in MS prevalence, possible causes in northern countries, and suggests strategies to treat MS using sunlight or darkness instead of supplements.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Franca Rosa Guerini, Cristina Agliardi, Letizia Oreni, Elisabetta Groppo, Elisabetta Bolognesi, Milena Zanzottera, Domenico Caputo, Marco Rovaris, Mario Clerici
Summary: The association between VDR gene polymorphisms and rehabilitation outcome in MS patients was evaluated. It was found that certain VDR gene variations were associated with better rehabilitation outcomes, suggesting that genetic profiling could be useful in identifying patients with a higher chance of recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Anna Walawska-Hrycek, Weronika Galus, Eugeniusz Hrycek, Aleksandra Kaczmarczyk, Ewa Krzystanek
Summary: The study indicated that low-dose vitamin D supplementation can normalize serum levels in patients with RRMS and increase levels of anti-inflammatory cytokines, maintaining a beneficial anti-inflammatory cytokine profile.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Michaela Tanja Haindl, Sonja Hochmeister
Summary: Multiple sclerosis is a multifactorial disease of the central nervous system with unclear disease mechanisms, and studies suggest that vitamin D may be a potential treatment approach. Animal models are essential for researching disease mechanisms and developing drugs for multiple sclerosis. When clinical studies present conflicting findings, standardized settings and mechanistic background information are necessary for further research.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Viktor Grut, Martin Bistrom, Jonatan Salzer, Pernilla Stridh, Anna Lindam, Lucia Alonso-Magdalena, Oluf Andersen, Daniel Jons, Martin Gunnarsson, Magnus Vrethem, Johan Hultdin, Peter Sundstrom
Summary: This study found that high levels of free vitamin D3 at a young age reduce the risk of MS later in life, and also implicate a role for DBP in MS etiology.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Fatima A. H. Al-Jaberi, Martin Kongsbak-Wismann, Alejandro Aguayo-Orozco, Nicolai Krogh, Terkild B. Buus, Daniel V. Lopez, Anna K. O. Rode, Eva Gravesen, Klaus Olgaard, Soren Brunak, Anders Woetmann, Niels odum, Charlotte M. Bonefeld, Carsten Geisler
Summary: This study reveals the impact of a point mutation in the DNA-binding domain of VDR on 1,25(OH)(2)D-3 signaling, with effects on VDR subcellular localization and transcriptional activity. The study also demonstrates that the expression level of wild-type VDR determines the responsiveness of T cells to 1,25(OH)(2)D-3. Additionally, the study shows that vitamin A inhibits the translocation of VDR to the nucleus and upregulation of CYP24A1 induced by 1,25(OH)(2)D-3.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Fatemeh Saheb Sharif-Askari, Narjes Saheb Sharif-Askari, Shirin Hafezi, Hawra Ali Hussain Alsayed, Balachandar Selvakumar, Mariam Wed Abdelaziz Eladham, Bushra Mdkhana, Ola Salam Bayram, Mohamad-Hani Temsah, Rabih Halwani
Summary: The levels of regulatory T and B cells are altered in severe COVID-19, especially in the presence of autoantibodies to type I IFNs. Treatment with tocilizumab and/or high dose of Vitamin D can increase the levels of these regulatory cells and improve control of inflammation.
SCIENTIFIC REPORTS
(2023)
Review
Clinical Neurology
Sara E. Gombash, Priscilla W. Lee, Elizabeth Sawdai, Amy E. Lovett-Racke
Summary: Vitamin D insufficiency during childhood is associated with the development of multiple sclerosis (MS), possibly due to abnormal immune responses and vulnerability of the central nervous system.
FRONTIERS IN NEUROLOGY
(2022)
Review
Nutrition & Dietetics
Mattia Perazzi, Enrico Gallina, Giulia Francesca Manfredi, Filippo Patrucco, Antonio Acquaviva, Donato Colangelo, Mario Pirisi, Mattia Bellan
Summary: This paper reviews the potential role of vitamin D in the pathogenesis and management of systemic sclerosis (SSc). Pre-clinical data suggest that vitamin D and its analogs may suppress fibrogenesis, while clinical data show a high prevalence of hypovitaminosis D and osteoporosis in SSc patients, but inconsistent findings regarding the association with clinical manifestations and phenotypes of SSc.
Article
Allergy
Calum T. Robb, You Zhou, Jennifer M. Felton, Birong Zhang, Marie Goepp, Privjyot Jheeta, Danielle J. Smyth, Rodger Duffin, Sonja Vermeren, Richard M. Breyer, Shuh Narumiya, Henry J. McSorley, Rick M. Maizels, Jurgen K. J. Schwarze, Adriano G. Rossi, Chengcan Yao
Summary: The study found that deficient EP2 receptor increases ILC2 responses and eosinophilic inflammation, while exogenous activation of EP4 and EP2 or inhibition of phosphodiesterase restricts IL-33-induced ILC2 responses.
Letter
Hematology
Matthias H. Busch, Sjoerd A. M. E. G. Timmermans, Sander M. J. van Kuijk, Joop P. Aendekerk, Renee Ysermans, Daan P. C. van Doorn, Judith Potjewijd, Marcel C. G. van de Poll, Iwan C. C. van der Horst, Jan G. M. C. Damoiseaux, Henri M. H. Spronk, Hugo ten Cate, Chris P. Reutelingsperger, Magdolna Nagy, Pieter van Paassen
Article
Nutrition & Dietetics
Ilse H. de Lange, Charlotte van Gorp, Kimberly R. I. Massy, Lilian Kessels, Nico Kloosterboer, Ann Bjornshave, Marie Stampe Ostenfeld, Jan G. M. C. Damoiseaux, Joep P. M. Derikx, Wim G. van Gemert, Tim G. A. M. Wolfs
Summary: Many whey proteins, peptides, and protein-derived amino acids can improve gut health through their anti-oxidant, anti-microbial, barrier-protective, and immune-modulating effects. This study investigated the effects of whey protein fractions with different degrees of enzymatic hydrolysis on the intestinal epithelium, as well as their anti-microbial and immune effects. The results highlight the importance of hydrolysis degree in influencing the biological effects of whey protein fractions, and provide new insights for improving immune tolerance and promoting intestinal health.
Article
Immunology
Jan Damoiseaux, Joyce van Beers
Summary: Autoantibodies, especially anti-dsDNA antibodies, are increasingly used in the diagnosis, classification, and follow-up of SLE patients. Standardizing autoantibody assays is a major challenge, and more attention should be given to harmonization initiatives and defining the required test characteristics for classification criteria. Separate multi-center studies are needed to establish the test characteristics of distinct immuno-assays for diagnosis and follow-up purposes. Additionally, these studies should not solely evaluate SLE as a single disease, but as a disease with distinct subtypes.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Article
Immunology
Renee Ysermans, Matthias H. Busch, Joop P. Aendekerk, Jan G. M. C. Damoiseaux, Pieter van Paassen
Summary: This retrospective study compared the outcomes of patients with ANCA-associated vasculitis (AAV) treated with a combination of Rituximab and low dose cyclophosphamide (RTX-CYC) or with Rituximab only. It was found that the RTX-CYC group had significantly lower major relapse rates within two years after remission-induction.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Article
Public, Environmental & Occupational Health
Sophie Kienhorst, Moniek H. D. van Aarle, Quirijn Jobsis, Michiel A. G. E. Bannier, Elin T. G. H. Kersten, Jan Damoiseaux, Onno C. P. van Schayck, Peter J. F. M. Merkus, Gerard Koppelman, Frederik-Jan van Schooten, Agnieszka Smolinska, Edward Dompeling
Summary: This study evaluates the application of a breath test in preschool children with asthma-like symptoms. The test predicts a diagnosis of asthma by analyzing the exhaled breath. The study also explores the relationship between other biological parameters and the odors in the breath.
Article
Medical Laboratory Technology
Daan A. R. Castelijn, A. H. Leontine Mulder, Pieter van der Pol, Jolien C. Hollander, Tietie Kuiper, Caroline Bijnens, Jan Damoiseaux, Hetty J. Bontkes
Summary: This study compared the diagnostic performance of three tTG-IgA assay methods for the diagnosis of celiac disease. The results showed that the chemiluminescence immunoassays (CLIA) were more sensitive compared to the fluorescence enzyme-linked immunoassay (FEIA). Lowering the cut-off threshold of the FEIA improved its diagnostic accuracy in adult cases. There were also differences in tTG-IgA levels between different age groups of patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Carolien Bonroy, Martine Vercammen, Walter Fierz, Luis E. C. Andrade, Lieve Van Hoovels, Maria Infantino, Marvin J. Fritzler, Dimitrios Bogdanos, Ana Kozmar, Benoit Nespola, Sylvia Broeders, Dina Patel, Manfred Herold, Bing Zheng, Eric Y. T. Chan, Raivo Uibo, Anna-Maija Haapala, Lucile Musset, Ulrich Sack, Gabor Nagy, Tatjana Sundic, Katarzyna Fischer, Maria-Jose Rego de Sousa, Maria Luisa Vargas, Catharina Eriksson, Ingmar Heijnen, Ignacio Garcia-De La Torre, Orlando Gabriel Carballo, Minoru Satoh, Kyeong-Hee Kim, Edward K. L. Chan, Jan Damoiseaux, Marcos Lopez-Hoyos, Xavier Bossuyt
Summary: This article summarizes the recommendations and suggestions on the methodological aspects of antinuclear antibody (ANA) testing, including the influence of various factors and the application of new methods such as automated computer-assisted diagnosis (CAD) systems and solid phase assays (SPA). These recommendations, supported by international experts, provide important guidance for high-quality ANA testing.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Clinical Neurology
Juliette Brenner, Sara Mariotto, Anna E. M. Bastiaansen, Manuela Paunovic, Sergio Ferrari, Daniela Alberti, Marienke A. A. M. de Bruijn, Yvette S. Crijnen, Marco W. J. Schreurs, Rinze F. Neuteboom, Jan G. M. C. Damoiseaux, Juna M. de Vries, Maarten J. Titulaer
Summary: This study aimed to investigate the value of serum NfL levels as a biomarker for disease severity and prognosis in patients with anti-NMDA receptor encephalitis. The results showed that increased NfL levels were associated with neuroaxonal damage in patients, but not with disease severity. However, the association with outcome was confounded by age. Therefore, the applicability of NfL as a prognostic marker is limited.
Editorial Material
Immunology
Anne L. Astier, David M. Kofler
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Shenghua Zong, Anita M. M. Vinke, Peng Du, Carolin Hoffmann, Marina Mane-Damas, Peter C. C. Molenaar, Jan G. M. C. Damoiseaux, Mario Losen, Rob P. W. Rouhl, Pilar Martinez-Martinez
Summary: The clinical significance of anti-GAD65 autoantibodies (GAD65-Abs) in patients with epilepsy and other neurological disorders is still unclear. High levels of GAD65-Abs are considered pathogenic, while low or moderate levels are seen as bystanders in diseases like diabetes mellitus type 1 (DM1). The value of cell-based assays (CBA) and immunohistochemistry (IHC) for detecting GAD65-Abs has not been clearly evaluated in this context.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemical Research Methods
Jules T. J. Teuwen, Lucas F. L. Ritzen, Yvon M. Knapen-Portz, Patricia K. Ludwiczek, Jan G. M. C. Damoiseaux, Joyce J. B. C. van Beers, Douwe de Boer
Summary: We developed a new reflex assay, T-CIERA, for identifying therapeutic monoclonal antibodies that interfere with IFE results. We demonstrated the applicability of T-CIERA to a variety of t-mAbs and its ability to distinguish multiple t-mAbs sharing a common target protein. T-CIERA showed an adequate limit of detection for all tested t-mAbs.
JOURNAL OF IMMUNOLOGICAL METHODS
(2023)
Letter
Immunology
Xiaochun Susan Zhang, Nicola Bizzaro, Anne E. Tebo, Vijayalakshmi Nandakumar, Maria Infantino, Teresa Carbone, Xavier Bossuyt, Jan Damoiseaux
IMMUNOLOGIC RESEARCH
(2023)
Article
Medicine, General & Internal
Judith Potjewijd, Rachid Tobal, Karin A. Boomars, Vanessa V. P. M. van Empel, Femke de Vries, Jan G. M. C. Damoiseaux, Leon J. Schurgers, Pieter van Paassen
Summary: The study found that elevated levels of dp-ucMGP in early-diagnosed SSc patients are associated with an increased risk of cardiovascular disease and mortality.
Meeting Abstract
Clinical Neurology
J. Kerstens, M. Schreurs, J. De Vries, E. Hoff, J. Damoiseaux, A. Van de Mortel, C. Delnooz, R. Neuteboom, D. Bastiaansen, Y. Crijnen, J. Brenner, R. Van Steenhoven, M. De Bruijn, A. Van Sonderen, M. Vermeiren, P. Sillevis Smitt, M. Titulaer
EUROPEAN JOURNAL OF NEUROLOGY
(2023)