Article
Nanoscience & Nanotechnology
Colleen R. McCollum, John R. Bertram, Prashant Nagpal, Anushree Chatterjee
Summary: InP QDs present a promising alternative to traditional small-molecule antibiotics for treating drug-resistant bacterial infections, as demonstrated in mouse experiments. The method effectively kills resistant bacteria by generating superoxide without being toxic to the animal.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Public, Environmental & Occupational Health
Hak-Jae Kim, Sae Won Na, Hissah Abdulrahman Alodaini, Munirah Abdullah Al-Dosary, P. Nandhakumari, L. Dyona
Summary: The study revealed a high prevalence of antibiotic resistance among bacterial strains isolated from wound infections, with some showing sensitivity to vancomycin. Specifically, Enterococcus faecalis and Proteus species exhibited resistance to various antibiotics.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Review
Infectious Diseases
Oskar A. Palacios, Jaime Raul Adame-Gallegos, Blanca Estela Rivera-Chavira, Guadalupe Virginia Nevarez-Moorillon
Summary: Monitoring multidrug-resistant bacteria and antibiotic resistance genes in mangroves can provide insights into environmental contamination. While mangrove ecosystems may act as reservoirs for dispersing antibiotic resistance to human pathogens, they also have the potential to filter out drug-resistant genes. However, the mechanisms by which mangroves reduce emerging contaminants like antibiotics and antibiotic resistance genes require further study.
Review
Infectious Diseases
Xiangyi Cui, Yuhong Lu, Changwu Yue
Summary: Bacterial resistance due to antibiotic overuse has become a serious global issue, necessitating stronger control measures and development of new drugs targeting resistant bacteria.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Dafna Yahav, Noam Tau, Daniel Shepshelovich
Summary: The study assessed the data supporting FDA approval of new drugs to treat MDR bacterial infections, as well as postmarketing studies. Results showed that most drugs were initially approved based on trials evaluating infections caused by non-MDR organisms, with limited postmarketing efficacy data available.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Summary: The indiscriminate use of antibiotics in poultry farming has led to the emergence of antibiotic-resistant bacteria in poultry products and the surrounding environment. This study found high rates of multidrug-resistant Gram-negative bacteria in the environment of poultry farms, with some strains exhibiting resistance to multiple antibiotics. The presence of these bacteria poses a significant threat to the effectiveness of available antibiotics in treating infectious diseases. Efforts to regulate antibiotic use and conduct research on One Health issues are necessary to combat and prevent the spread of antibiotic-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2022)
Article
Chemistry, Multidisciplinary
Dana F. Stamo, Prashant Nagpal, Anushree Chatterjee
Summary: CdTe-2.4 eV quantum dots in combination with antibiotics have the potential to nearly eradicate biofilms formed by various drug-resistant bacteria.
NANOSCALE ADVANCES
(2021)
Article
Infectious Diseases
Yessica Enciso-Martinez, Edwin Barrios-Villa, Cesar O. Sepulveda-Moreno, Manuel G. Ballesteros-Monrreal, Dora E. Valencia-Rivera, Gustavo A. Gonzalez-Aguilar, Miguel A. Martinez-Tellez, Jesus Fernando Ayala-Zavala
Summary: This research investigated the antibiotic resistance of Escherichia coli isolated from the Honeydew melon production system in Hermosillo, Sonora, Mexico. The results showed a high prevalence of antibiotic-resistant, ESBL, and non-ESBL genes in E. coli strains isolated from irrigation water, packing workers' hands, and discarded melons in a farm and packing facility of Honeydew melon in Hermosillo, Sonora.
Article
Chemistry, Physical
Ya-Qi Zhu, Wei-Qiang Huang, Guang Chen, Lei Xia, Ye-Zi You, Yue Yu
Summary: Researchers have developed a novel gel that can capture and trap bacteria, preventing their invasion, and the gel has the ability to generate reactive oxygen species (ROS) that can effectively kill bacteria. Experimental results have shown that this gel can accelerate the healing of infected wounds.
Article
Biochemistry & Molecular Biology
Deok-Gyun You, Hye-Ra Lee, Hong-Kyu Kim, Gi-Young Lee, Young-Do Yoo
Summary: The emergence of multidrug-resistant bacteria due to antibiotic abuse is a global health problem. AmpR-22, derived from the Romo1 protein, has been optimized for enhanced antimicrobial activity against a broad spectrum of bacteria, including MDR strains, showing significant survival rates in mice models of sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Joakim Bjerketorp, Jolanta J. Levenfors, Christina Nord, Bengt Guss, Bo Oberg, Anders Broberg
Summary: Twenty-eight multidrug-resistant bacterial strains closely related or identical to Pedobacter cryoconitis, Pedobacter lusitanus, and Pedobacter steynii were isolated from soil samples by selection for multidrug-resistance. These strains produced a wide array of novel compounds, with Pedobacter strain UP508 producing isopedopeptins and other strains producing different peptides.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
William Ndugire, Dang Truong, N. G. Hasitha Raviranga, Jingzhe Lao, Olof Ramstrom, Mingdi Yan
Summary: The addition of thiourea (TU) enhances the broad-spectrum antimicrobial activity of D-maltose-capped gold nanoclusters (AuNC-Mal). AuNC-Mal/TU exhibits effective inhibition against multidrug-resistant Pseudomonas aeruginosa with low cytotoxicity. The antimicrobial activity is attributed to the generation of [Au(TU)(2)](+) and smaller AuNCs, increased accumulation of Au in bacteria, and inhibition of thioredoxin reductase.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Plant Sciences
Anna Herman, Andrzej P. Herman
Summary: This review summarizes the current knowledge on the antimicrobial activity of herbal products and their active constituents used alone and in combination with antibiotics against multidrug-resistant bacteria. Promising herbal products and active constituents used alone include Piper betle, Glycyrrhiza glabra, and berberine. The synergistic effect of combining herbal products and antibiotics against multidrug-resistant bacteria is also discussed. The review suggests that combination therapy could expand the spectrum of antimicrobial action and represents a potential area for future research in the treatment of infectious diseases.
Article
Infectious Diseases
Lenka Doubravska, Miroslava Htoutou Sedlakova, Katerina Fiserova, Vendula Pudova, Karel Urbanek, Jana Petrzelova, Magdalena Roderova, Katerina Langova, Kristyna Mezerova, Pavla Kucova, Karel Axmann, Milan Kolar
Summary: This observational retrospective study analyzed the changes in bacterial pathogens and their resistance to antibiotics among intensive care patients in a Czech hospital during the COVID-19 pandemic. The study found that there were shifts in the distribution and resistance of bacterial pathogens, possibly due to antibiotic selection pressure and clonal spread of bacteria.
Article
Food Science & Technology
Winnie Mukuna, Abdullah Ibn Mafiz, Bharat Pokharel, Aniume Tobenna, Agnes Kilonzo-Nthenge
Summary: The study investigated the antimicrobial resistance of bacteria isolated from non-dairy milk alternatives, revealing that these substitutes may serve as reservoirs for multidrug-resistant opportunistic pathogens.
Review
Biochemical Research Methods
Max Levy, Partha P. Chowdhury, Prashant Nagpal
JOURNAL OF BIOLOGICAL ENGINEERING
(2019)
Article
Materials Science, Biomaterials
Max Levy, Partha P. Chowdhury, Kristen A. Eller, Anushree Chatterjee, Prashant Nagpal
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Nanoscience & Nanotechnology
Qi-C. Sun, Yuchen Ding, Prashant Nagpal
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Chemistry, Multidisciplinary
Max Levy, John R. Bertram, Kristen A. Eller, Anushree Chatterjee, Prashant Nagpal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Materials Science, Biomaterials
Thomas R. Aunins, Kristen A. Eller, Colleen M. Courtney, Max Levy, Samuel M. Goodman, Prashant Nagpal, Anushree Chatterjee
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Materials Science, Multidisciplinary
Ibrahim Khalifa Saleh, Yuchen Ding, Prashant Nagpal
MATERIALS RESEARCH EXPRESS
(2019)
Article
Cell Biology
J. Tyson McDonald, Francisco J. Enguita, Deanne Taylor, Robert J. Griffin, Waldemar Priebe, Mark R. Emmett, Mohammad M. Sajadi, Anthony D. Harris, Jean Clement, Joseph M. Dybas, Nukhet Aykin-Burns, Joseph W. Guarnieri, Larry N. Singh, Peter Grabham, Stephen B. Baylin, Aliza Yousey, Andrea N. Pearson, Peter M. Corry, Amanda Saravia-Butler, Thomas R. Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain Costes, Gustavo Gastao Davanzo, Diego Galeano, Alberto Paccanaro, Suzanne L. Meinig, Robert S. Hagan, Natalie M. Bowman, Matthew C. Wolfgang, Selin Altinok, Nicolae Sapoval, Todd J. Treangen, Pedro M. Moraes-Vieira, Charles Vanderburg, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Anushree Chatterjee, Robert Meller, Afshin Beheshti
Summary: The research demonstrates that miR-2392 is associated with SARS-CoV-2 infection, with potential for use in COVID-19 detection and as a target for antiviral therapy. Targeting miR-2392 can significantly reduce SARS-CoV-2 viability, indicating a potential treatment for COVID-19.
Article
Astronomy & Astrophysics
Colleen M. Courtney, Sadhana Sharma, Christina Fallgren, Michael M. Weil, Anushree Chatterjee, Prashant Nagpal
Summary: Radiation-induced immune suppression is a significant health challenge for cancer patients, space travelers, and astronauts. We developed a high-throughput drug discovery and target validation method using nucleic acids to reverse radiation-induced immunosuppression. We identified a NanoligomerTM molecule that can regulate gene expression and counter immune suppression. This approach has broad applicability in drug discovery and may be a potential reversible gene therapy for adverse health outcomes caused by radiation exposure.
LIFE SCIENCES IN SPACE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A. Garcia, Christopher D. Link, Charles Hoeffer, Anushree Chatterjee, Prashant Nagpal
Summary: Neuroinflammation can provide protection but chronic neuroinflammation is detrimental and linked to neurodegenerative diseases. Current treatments for neuroinflammation are limited and have limitations. This study presents a novel therapeutic approach using a nanoligomer discovery engine, which identified and validated a treatment option by screening upstream regulators and canonical pathways. The lead neurotherapeutic showed significant suppression of neuroinflammation in a mouse model, indicating its potential as a treatment for chronic neuroinflammation-linked diseases.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Materials Science, Biomaterials
Colleen R. McCollum, Colleen M. Courtney, Nolan J. O'Connor, Thomas R. Aunins, Tristan X. Jordan, Keegan L. Rogers, Stephen Brindley, Jared M. Brown, Prashant Nagpal, Anushree Chatterjee
Summary: A compound called SBCoV202 has been developed as a potential treatment for COVID-19. It inhibits viral replication and has shown efficacy against SARS-CoV-2 in vitro. The compound is safe and nontoxic, with favorable biodistribution and adaptability, making it a promising option for COVID-19 treatment.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yuchen Ding, Chi Chung Lee, Yilin Hu, Markus M. M. Ribbe, Prashant Nagpal, Anushree Chatterjee
Summary: Using visible light-activated CdS@ZnS quantum dots as a reducing agent, we have developed an efficient photocatalytic system for converting CO into hydrocarbon fuels. This method achieves high selectivity and does not require ATP as an energy source, making it a promising alternative to traditional inorganic photocatalysts.
Article
Nanoscience & Nanotechnology
Yuchen Ding, John R. Bertram, Prashant Nagpal
Summary: The study demonstrates that nickel-functionalized graphene quantum dots can effectively couple to nonphotosynthetic bacteria, creating nanobiohybrid organisms that convert carbon dioxide, air, and water into high-value-added chemicals using sunlight, with high efficiency and selectivity. These findings have important implications for the development of sustainable processes for making carbon-negative materials.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
John R. Bertram, Yuchen Ding, Prashant Nagpal
NANOSCALE ADVANCES
(2020)
Article
Chemistry, Multidisciplinary
Gary R. Abel, Lee E. Korshoj, Peter B. Otoupal, Sajida Khan, Anushree Chatterjee, Prashant Nagpal