Article
Chemistry, Multidisciplinary
Uzma Saher, Muhammad Ovais Omer, Aqeel Javeed, Aftab Ahmad Anjum, Kanwal Rehman, Tanzeela Awan, Gulbeena Saleem, Ameena Mobeen
Summary: Calotropis procera extract contains therapeutically active proteins but also exhibits toxic effects at high doses. The extract shows dose-dependent antiviral activity against Newcastle disease virus in chicken embryos, but also shows toxicity and mutagenicity at higher doses. The study suggests that caution should be exercised when using Calotropis procera extract for therapeutic purposes.
Article
Biochemistry & Molecular Biology
Wenshuai Wang, Xiaoxu Li, Yaohan Zhang, Jianjun Zhang, Le Jia
Summary: Exposure to Nonylphenol is a crucial factor in male reproductive disorders, but the use of Macrolepiota procera mycelium polysaccharides can protect the reproductive system from Nonylphenol-induced harm. The study found that MMP can reverse reproductive impairments caused by Nonylphenol, improve oxidative stress, apoptosis, and inflammatory responses, and suppress the Akt/mTOR signaling pathway.
Article
Biochemistry & Molecular Biology
Lethicia Souza Tavares, Maria Taciana Ralph, Jacqueline Ellen Camelo Batista, Ana Clarissa Sales, Laisla Carolina Andrade Ferreira, Usman Abdulhadi Usman, Valdemiro Amaro da Silva Junior, Marcio Viana Ramos, Jose Vitor Lima-Filho
Summary: The study suggests that LPp2 contains peptidases with strong anti-inflammatory properties that may attenuate inflammatory responses in mice infected with Salmonella. LPp2 enhances intracellular bacterial killing and inhibits mRNA expression of pro-inflammatory cytokines. Mice treated with LPp2 show decreased leukocyte numbers and increased bacterial burden and histological damage in target organs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Multidisciplinary
Barkha Darra Wadhwani, Deepak Mali, Pooja Vyas, Rashmy Nair, Poonam Khandelwal
Summary: Calotropis procera, known as Aak or Madar in Hindi and milk weed in English, is a wasteland plant used in traditional medicine for treating various diseases and also has sacred significance in Hindu rituals. It contains phytoconstituents such as flavonoids, terpenoids, cardenolides, steroids oxypregnanes, but recent research papers on its therapeutic potential and toxicity are lacking, highlighting the need for further study in this area.
Article
Plant Sciences
Vijay L. Kumar, Sneh Verma, Prasenjit Das
Summary: The methanol extract of air-dried latex of Calotropis procera demonstrated protective effects in a rat model of colorectal cancer, reducing tumor occurrence and promoting apoptosis. This suggests the potential therapeutic application of MeDL in CRC.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Johnson Adejoh, Bassey A. Inyang, Maxwell O. Egua, Kenneth C. Nwachukwu, Lukman A. Alli, Michael P. Okoh
Summary: The study evaluated the anti-plasmodial activity of the ethanol extract of the strain against Plasmodium berghei-infected mice, demonstrating its potential as an anti-malarial agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Lethicia Souza Tavares, Betty Dorvigny Mancebo, Lucas Nunes Santana, Alluanan Adelson do Nascimento Silva, Roberta Lane de Oliveira Silva, Ana Maria Benko-Iseppon, Marcio Viana Ramos, Camila Tauane Monteiro do Nascimento, Thalles Barbosa Grangeiro, Jeanlex Soares Sousa, Rinaldo Aparecido Mota, Valdemiro Amaro da Silva Junior, Jose Vitor Lima-Filho
Summary: This study demonstrates that recombinant osmotin inclusion bodies from Calotropis procera can prevent infection-induced inflammation, providing a new approach for the treatment of infections.
Article
Plant Sciences
Vijay L. Kumar, Sneh Verma, Prasenjit Das
Summary: This study evaluated the efficacy of Calotropis procera dried latex extract (MeDL) in treating inflammation and oxidative stress in an experimental model of colorectal carcinoma (CRC). The results showed that MeDL effectively suppressed oxidative stress and inflammation caused by colon cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Environmental Studies
Mojtaba Dolatkordestani, Mansour Taghvaei, Andrea Mastinu
Summary: The application of superabsorbents and seed coatings can enhance the growth and physiological responses of Calotropisprocera L. (milkweed) under water deficit conditions. Superabsorbent polymers in growth media improve growth indices and chlorophyll content, while reducing the activity of antioxidant enzymes and proline. Seed coatings improve growth indices, antioxidant enzyme activity, and chlorophyll content. Vermicompost-coated seeds show the most adaptive responses to water stress.
Article
Chemistry, Physical
Pooja V. Nagime, Sudarshan Singh, Nishat M. Shaikh, Komal S. Gomare, Havagiray Chitme, Basel A. Abdel-Wahab, Yahya S. Alqahtany, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb, Marwa B. Bakir
Summary: This study comprehensively demonstrates the sustainable synthesis of biogenic C. procera flower extract capped and stabilized silver nanoparticles (CP-AgNPs) and thoroughly characterizes their phytochemical properties and potential biological applications. The synthesis of CP-AgNPs was rapid and resulted in cubic nanoparticles with a plasmonic peak at around 400 nm. The CP-AgNPs exhibited stable dispersion, high anionic zeta potential, and crystalline structure, and showed hydrogen peroxide scavenging efficacy, antibacterial and antifungal activity, as well as significant in vitro antidiabetic and anti-inflammatory activity. This efficient approach for synthesizing CP-AgNPs has potential applications in water treatment, biosensors, biomedicine, and allied science.
Article
Environmental Sciences
Fatemeh Adabavazeh, Nazi Nadernejad, Shahram Pourseyedi, Roya Razavizadeh, Hossein Mozafari
Summary: This study investigated the effects of synthesized magnetic nanoparticles (MNPs) on the morphology, physiology, and essential oil components of Calotropis procera seedlings. The results showed that MNPs significantly increased growth parameters, chlorophyll pigments, soluble sugars, and total proteins in the leaf. MNPs also affected antioxidant enzyme activities, H2O2, and malondialdehyde contents. Additionally, MNPs enhanced the concentration of major essential oil components. These findings suggest that MNPs could be a promising method for improving plant growth and essential oil production in agriculture.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Plant Sciences
Brenda Martins Cotta Salome, Ariadna Freitas Santos, Leonardo Monteiro Ribeiro, Islaine Franciely Pinheiro de Azevedo, Maria Olivia Mercadante-Simoes
Summary: An in-depth understanding of the development and distribution of laticifer is important for the production of rubber and medicines, as well as for studying plant adaptations. This study characterized and described the ontogenesis of the laticifer system in Calotropis procera, an invasive subshrub species in arid landscapes. The results showed that laticifer differentiates early in the primary structure and originates from precursor cells. The ability of C. procera to grow and produce laticifer throughout the year contributes to its wide distribution in arid environments.
Article
Multidisciplinary Sciences
Lara J. Bou Malhab, Khuloud Bajbouj, Naglaa G. Shehab, Salma M. Elayoty, Jithna Sinoj, Saryia Adra, Jalal Taneera, Mohamed A. Saleh, Wael M. Abdel-Rahman, Mohammad H. Semreen, Karem H. Alzoubi, Yasser Bustanji, Waseem El-Huneidi, Eman Abu-Gharbieh
Summary: Calotropis procera is a perennial flowering plant used in traditional medicine with potential therapeutic activities. The plant extract showed high antioxidant activity and inhibited the growth of cancer cells in a dose-dependent manner. It induced apoptosis and caused cell cycle arrest in different phases for different cell lines. The extract contained various phenolic acids and flavonoids, and their concentrations were quantitatively analyzed. Overall, Calotropis procera has great potential for medicinal use.
Article
Energy & Fuels
M. Suba Sri, M. Subhashini, M. Kalpana Devi, R. Jayakala Devi, R. Usha
Summary: Medical textiles play a crucial role in the healthcare industry, with their strong protection and antibacterial properties. This study aimed to enhance conventional cotton gauze by incorporating hydroxyapatite nanoparticles (HAp NP) derived from Calotropis procera and Wrightia tinctoria plant latex serum extract. The synthesized nanoparticles exhibited excellent antibacterial activity against Candida albicans, Aspergillus niger, Staphylococcus aureus, and Escherichia coli. This work highlights the potential of plant extract-mediated HAp NP for medical applications.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Review
Chemistry, Multidisciplinary
Mohammad Humayoon Amini, Kamran Ashraf, Fatimah Salim, Siong Meng Lim, Kalavathy Ramasamy, Nurhuda Manshoor, Sadia Sultan, Wasim Ahmad
Summary: Calotropis procera is a valuable medicinal plant with various phytochemicals, showing multiple biological activities such as anti-inflammatory, antioxidant, anticancer, and wound healing properties. Studies on the antimicrobial activities of C. procera identified existing knowledge gaps and pointed towards future research opportunities.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Biology
Kento Nagata, Keita Ohashi, Chika Hashimoto, Alaa El-Din Hamid Sayed, Takako Yasuda, Bibek Dutta, Takayuki Kajihara, Hiroshi Mitani, Michiyo Suzuki, Tomoo Funayama, Shoji Oda, Tomomi Watanabe-Asaka
Summary: This study investigated the radiation responses in the kidney, the main hematopoietic organ in Japanese medaka, and found that radiation caused cell death and cell cycle arrest in hematopoietic cells in the kidney, leading to a decrease in peripheral blood cells. The recovery of peripheral blood cell density was observed after gamma-ray and proton beam irradiation, but not after carbon ion beam irradiation. The study also showed that anemic medaka had delayed recovery of peripheral blood cell density when irradiated after phenylhydrazine administration. The findings suggest that hematopoietic stem cells in medaka kidney prioritize proliferation to increase peripheral blood cells, even in the presence of high-dose irradiation.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lamya H. Al-Wahaibi, Md Tabish Rehman, Muneera S. M. Al-Saleem, Omer A. Basudan, Ali A. El-Gamal, Mohamed S. A. Abdelkader, Mohamed F. AlAjmi, Wael M. Abdel-Mageed
Summary: The study reveals that certain abyssomicins have strong binding and inhibitory abilities against key proteins of the novel coronavirus, and they possess stable drug-like properties. These abyssomicins are considered potential candidates for further in vitro and in vivo evaluation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Soil Science
Zeinab Bakr, Mohammed Abdel-Wahab, Ali A. Thabet, Mohamed Hamed, Mohamed Abd El-Aal, Eman Saad, Mehwish Faheem, Alaa El -Din H. Sayed
Summary: Earthworms were used as biomarkers for soil contamination and exposed to different types of nanoparticles. The results showed that nanoparticle exposure significantly affected the antioxidant and immune activities, lipid peroxidation, and DNA fragmentation in the earthworms, and caused damage to the intestinal wall. During the recovery period, only some indicators returned to normal levels for earthworms exposed to polyethylene nanoparticles.
APPLIED SOIL ECOLOGY
(2023)
Article
Environmental Sciences
Alaa El-Din H. Sayed, Mohamed Hamed, Abdelaziz A. A. El-Sayed, Bruno Nunes, Hamdy A. M. Soliman
Summary: The use of plant growth regulators has led to environmental contamination in water bodies adjacent to agricultural areas. This study investigates the toxic effects of gibberellic acid (GA(3)), a commonly used plant growth regulator, on Nile tilapia (Oreochromis niloticus). Results show that GA(3) exposure negatively affects hematological indices, erythrocyte morphology, nuclear abnormalities, and genotoxicity in the fish. Dietary supplementation of Spirulina (Arthrospira platensis) can mitigate the hemotoxic effects induced by GA(3).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Alaa El-Din H. Sayed, Mervat N. Hana, Mohamed Hamed, Hany M. R. Abdel-Latif, Jae-Seong Lee, Hamdy A. M. Soliman
Summary: This study evaluated the protective effects of antioxidants, such as lycopene, citric acid, and chlorella, against the toxic effects of ingested microplastics in Clarias gariepinus. The results showed that these antioxidants partially or completely reversed the histopathological changes in the kidney, liver, and intestine of the fish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Ecology
Deok-Seo Yoon, Hyuntae Choi, Alaa El -Din H. Sayed, Kyung-Hoon Shin, Joung Han Yim, Sanghee Kim, Min-Chul Lee, Jae-Seong Lee
Summary: Changes in temperature and starvation affect metabolism and fatty acid composition in zooplankton. However, little is known about fatty acid modulation in Antarctic zooplankton. This study investigated the changes in life history parameters and fatty acid profiles in the Antarctic copepod Tigriopus kingsejongensis under starvation at four different temperatures. The results showed that higher temperatures accelerated the development of T. kingsejongensis and increased overall offspring production. Starvation and higher temperatures led to a decrease in polyunsaturated fatty acids (PUFAs) and an increase in saturated fatty acids in T. kingsejongensis. However, specific PUFAs, such as docosahexaenoic acid and docosapentaenoic acid, increased under starvation and higher temperatures. This study provides valuable insights into fatty acid regulation in Antarctic copepods under environmental stressors.
REGIONAL STUDIES IN MARINE SCIENCE
(2023)
Article
Environmental Sciences
Eman Saad, Mohamed Hamed, Abdelnaby M. Elshahawy, Mohamed Abd El-Aal, Alaa El-Din H. Sayed
Summary: This study provides an intensive investigation on the influence of alkaline rocks on Nile Tilapia. The results show that exposure to bulk alkaline rocks leads to decreased blood profiles, liver and kidney dysfunction, increased antioxidant enzyme activities, DNA mutation, and erythrocyte distortion. This highlights the importance of climate changes, rock erosion, and their impact on water quality.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wafaa H. B. Hassan, Zeinab I. El Sayed, Lamya H. Al-Wahaibi, Mahmoud M. Abdel-Aal, Wael M. Abdel-Mageed, Eman Abdelsalam, Sahar Abdelaziz
Summary: This study investigated the chemical components of Cliona sp. marine sponge collected from the Red Sea and evaluated their biological activities. A total of 63 compounds were identified from the n-hexane, dichloromethane, and ethyl acetate fractions, including three sterols and one amino acid. The ethyl acetate fraction exhibited potent cytotoxic activity against colon and larynx carcinoma cell lines, while the dichloromethane fraction showed strong antioxidant activity. The total ethanolic extract showed the strongest antibacterial activity. These findings highlight the potential of Cliona sp. extract and its fractions as a source of novel natural drugs with medicinal and pharmaceutical applications.
Article
Environmental Sciences
Alaa El-Din H. Sayed, Hamdy A. M. Soliman, Shaimaa K. Idriss, Sary Kh. Abdel-Ghaffar, Asmaa A. A. Hussein
Summary: This study aimed to evaluate the catfish's response to exposure to monoaromatic petroleum hydrocarbons (benzene, toluene, and xylene) and its recovery after exposure. Oxidative stress, histopathological changes, and immunological changes were used as biomarkers. The results showed that benzene and xylene exposure significantly increased cortisol, lipid peroxidation, and cytokines (IL-1 beta, IL-6) levels compared to control. Fishes exposed to benzene exhibited a significant decrease in superoxide dismutase (SOD), total antioxidant capacity (TAC), and acetylcholinstease (Ach) levels. Histopathological signs in the liver, kidney, and spleen were observed after exposure, but most of these lesions improved or disappeared after the recovery period. Monocyclic aromatic hydrocarbons (BTX) are hazardous to fish, and their toxicity levels were benzene > xylene > toluene even after the recovery period.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Mahmoud Abd-Elkareem, Alaa El-Din H. Sayed, Nasser S. Abou Khalil, Mohamed H. Kotob
Summary: This study aimed to examine the potential protective effects of Nigella sativa seed against 4-nonylphenol-induced hepatotoxicity in African catfish. The results showed that 2.5% Nigella sativa seed significantly reduced the liver damage caused by 4-nonylphenol.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Afaf E. Abdel Ghani, Muneera S. M. Al-Saleem, Wael M. Abdel-Mageed, Ehsan M. AbouZeid, Marwa Y. Mahmoud, Rehab H. Abdallah
Summary: This study investigated the phytochemical constituents and biological activities of the non-polar fractions of Chia, revealing its potential as a source of antioxidants, antidiabetic agents, anti-inflammatory agents, and anticancer agents. The findings provide a valuable basis for future in vivo and clinical studies, as well as for the pharmaceutical industry.
Article
Environmental Sciences
Mohamed Hamed, Christopher J. Martyniuk, Rashad E. M. Said, Hamdy A. M. Soliman, Ahmed E. A. Badrey, Elhagag A. Hassan, Hani N. Abdelhamid, Alaa G. M. Osman, Alaa El -Din H. Sayed
Summary: This study reports the presence of pyrogallol in wastewater in Egypt for the first time. Acute and sub-acute toxicity experiments were conducted to evaluate the toxic effects of pyrogallol on catfish. The results showed that pyrogallol exposure caused morphological changes, hematological and biochemical alterations, indicating potential risks to aquatic species.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Rehab H. Abdallah, Muneera S. M. Al-Saleem, Wael M. Abdel-Mageed, Al-Sayed R. Al-Attar, Youssef M. Shehata, Doaa M. Abdel-Fattah, Rahnaa M. Atta
Summary: Annona muricate is a tropical plant with edible fruits that have therapeutic properties. The plant extracts were analyzed using LCMS/MS, resulting in the identification of 388 components, including new compounds. The extracts showed potential anticancer properties against Ehrlich ascites carcinoma in mice.
Article
Multidisciplinary Sciences
Esraa Ammar, Mohamed Hamed, Mahmoud S. S. Mohamed, Alaa El-Din H. Sayed
Summary: The combination of polyethylene microplastics (PE-MPs) and 4-nonylphenol (4-NP) has hazardous effects on blood biomarkers in Cyprinus carpio juveniles. After 15 days of exposure and 15 days of recovery, biochemical analyses showed significant increases in creatine kinase, lactate dehydrogenase, glucose, liver enzymes, total protein, and A/G ratios. Hematological parameters indicated significant decreases in red blood cells, hemoglobin, hematocrit, neutrophil percentage, and white blood cells, while mean corpuscular volume and lymphocyte percentages showed significant increases. These findings highlight the potential risk of PE-MP and 4-NP combinations on human health.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Alaa El-Din H. Sayed, Shaimaa K. Idriss, Sary Kh. Abdel-Ghaffar, Asmaa A. A. Hussein
Summary: The study examined the DNA damage response in erythrocytes of fish exposed to volatile organic compounds (VOCs), finding evidence of genotoxic effects and potential biomarkers for environmental pollution. Despite the dangers of VOCs, little is known about their hemotoxic, cytotoxic, and genotoxic effects on fish. The research optimized an assay method to measure apoptosis and DNA damage in erythrocytes of tilapia fish exposed to benzene, toluene, and xylene and identified the highest levels of apoptosis, DNA damage, and histopathological alterations in fish exposed to benzene.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
