Elaphuri Davidiani Cornu Improves Depressive-Like Behavior in Mice and Increases Neurotrophic Factor Expression in Mouse Primary Astrocytes via cAMP and ERK-Dependent Pathways

Active components, derived from Kai-xin-san, a herbal formula, increase the expressions of neurotrophic factor NGF and BDNF on mouse astrocyte primary cultures via cAMP-dependent signaling pathway

(2018) Cheng Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

(2018) Andrea Cipriani et al.   LANCET

Herbal medicines in the treatment of psychiatric disorders: 10-year updated review

(2018) Jerome Sarris   PHYTOTHERAPY RESEARCH

Direct and indirect evidences of BDNF and NGF as key modulators in depression: Role of antidepressants treatment

(2018) Amal Chandra Mondal et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Characterization of Collagen Peptides in Elaphuri Davidiani Cornu Aqueous Extract with Proliferative Activity on Osteoblasts Using Nano-Liquid Chromatography in Tandem with Orbitrap Mass Spectrometry

(2017) Yanjuan Zhai et al.   MOLECULES

Kai-Xin-San series formulae alleviate depressive-like behaviors on chronic mild stressed mice via regulating neurotrophic factor system on hippocampus

(2017) Yue Zhu et al.   Scientific Reports

Kai-Xin-San, a standardized traditional Chinese medicine formula, up-regulates the expressions of synaptic proteins on hippocampus of chronic mild stress induced depressive rats and primary cultured rat hippocampal neuron

(2016) Yue Zhu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Kai-Xin-San, a traditional Chinese medicine formula, induces neuronal differentiation of cultured PC12 cells: Modulating neurotransmitter regulation enzymes and potentiating NGF inducing neurite outgrowth

(2016) Yue Zhu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phytochemical constituents as future antidepressants: a comprehensive review

(2015) Roodabeh Bahramsoltani et al.   REVIEWS IN THE NEUROSCIENCES

Kai-Xin-San, a Chinese Herbal Decoction Containing Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma, and Poria, Stimulates the Expression and Secretion of Neurotrophic Factors in Cultured Astrocytes

(2013) Kevin Yue Zhu et al.   Evidence-based Complementary and Alternative Medicine

Comparative analysis of nucleosides and nucleobases from different sections of Elaphuri Davidiani Cornu and Cervi Cornu by UHPLC–MS/MS

(2013) Fengtao Li et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484)

(2013) M L Molendijk et al.   MOLECULAR PSYCHIATRY