Olanzapine-Induced Activation of Hypothalamic Astrocytes and Toll-Like Receptor-4 Signaling via Endoplasmic Reticulum Stress Were Related to Olanzapine-Induced Weight Gain

Increased Appetite Plays a Key Role in Olanzapine-Induced Weight Gain in

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Brown adipose tissue activity is modulated in olanzapine-treated young rats by simvastatin

(2020) Xuemei Liu et al.   BMC Pharmacology & Toxicology

Olanzapine induced autophagy through suppression of NF‐κB activation in human glioma cells

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Toll-like receptors control p38 and JNK MAPK signaling pathways in rat astrocytes differently, when cultured in normal or high glucose concentrations

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Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate

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High-fat diet suppresses the astrocytic process arborization and downregulates the glial glutamate transporters in the hippocampus of mice

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The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced Weight Gain and Insulin Resistance

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Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

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Metabolic side effects induced by olanzapine treatment are neutralized by CB1 receptor antagonist compounds co-administration in female rats

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The atypical antipsychotic olanzapine causes weight gain by targeting serotonin receptor 2C

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PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a

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Prevention of the adverse effects of olanzapine on lipid metabolism with the antiepileptic zonisamide

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Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation

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Astrocytes and endoplasmic reticulum stress: A bridge between obesity and neurodegenerative diseases

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Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

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Astrocyte IKKβ/NF-κB signaling is required for diet-induced obesity and hypothalamic inflammation

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Cocaine induces astrocytosis through ER stress-mediated activation of autophagy

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Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

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Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats

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The atypical antipsychotic, olanzapine, potentiates ghrelin-induced receptor signaling: An in vitro study with cells expressing cloned human growth hormone secretagogue receptor

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Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes

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Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

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Clozapine and olanzapine inhibit proton currents in BV2 microglial cells

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Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses

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Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker

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Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

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Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice

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Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine

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Toll-Like Receptor 4 Promotes Autonomic Dysfunction, Inflammation and Microglia Activation in the Hypothalamic Paraventricular Nucleus: Role of Endoplasmic Reticulum Stress

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Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes

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Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats

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Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female rats

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Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats

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Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats

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Betahistine ameliorates olanzapine-induced weight gain through modulation of histaminergic, NPY and AMPK pathways

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Regulation of S100B in white adipose tissue by obesity in mice

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Effects of Antipsychotic Medications on Appetite, Weight, and Insulin Resistance

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Hormones and diet, but not body weight, control hypothalamic microglial activity

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LPS or ethanol triggers clathrin- and rafts/caveolae-dependent endocytosis of TLR4 in cortical astrocytes

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Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia

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Expression of adiponectin receptors 1 (AdipoR1) and 2 (AdipoR2) in the porcine pituitary during the oestrous cycle

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Hypothalamic Astrocytes in Obesity

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Regional astrogliosis in the mouse hypothalamus in response to obesity

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 -Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas

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Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

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The acute effects of olanzapine on ghrelin secretion, CCK sensitivity, meal size, locomotor activity and body temperature

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Obesity is associated with hypothalamic injury in rodents and humans

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Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation

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Olanzapine treatment and metabolic dysfunction: a dose response study in female Sprague Dawley rats

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FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

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Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

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S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase

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Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

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Energy-restricted pair-feeding normalizes low levels of brain-derived neurotrophic factor/tyrosine kinase B mRNA expression in the hippocampus, but not ventromedial hypothalamic nucleus, in diet-induced obese mice

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Oestrogen Modulates Hypothalamic Control of Energy Homeostasis Through Multiple Mechanisms

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The Role of Thermogenesis in Antipsychotic Drug-induced Weight Gain

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Dose translation from animal to human studies revisited

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Neocortical glial cell numbers in human brains

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Protective effects of olanzapine and haloperidol on serum withdrawal-induced apoptosis in SH-SY5Y cells

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