Article
Engineering, Biomedical
Yan Cai, Jichao Pan, Zhiyong Li
Summary: The study presents a mathematical model to evaluate the influences of intraplaque neovascularization and hemorrhage on vulnerable plaque development. The simulation results showed that high microvessel density region and extravascular flow across the leaky wall of the neovasculature contribute to intraplaque hemorrhage in vulnerable plaques. The sensitivity analysis of model parameters indicated that reducing microvessel density and wall permeability of the neovasculature can significantly decrease the IPH area and extent.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Clinical Neurology
Shi-Yao Gu, Lu-Ni Zhang, Jing Chen, Fang Li, Ming-Hua Yao, Cai-Xia Jia, Rong Wu
Summary: This study investigated the associations of carotid plaque morphology and location with intraplaque neovascularization (IPN). The results showed that IPN grade was significantly associated with plaque morphology and location, with higher grades observed among Type III morphology and common carotid artery plaques. There was also a significant negative association between IPN grade and serum high-density lipoprotein cholesterol (HDL-C) level. After adjusting for confounding factors, plaque morphology and location, as well as HDL-C, remained significantly associated with IPN grade. Therefore, carotid plaque location and morphology could serve as biomarkers for plaque vulnerability, and HDL-C may play a role in the management of carotid atherosclerosis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhe Huang, Xue-Qing Cheng, Ya-Ni Liu, Xiao-Jun Bi, You-Bin Deng
Summary: This study aimed to investigate the relationship between carotid plaque enhancement on perfluorobutane microbubble contrast-enhanced ultrasonography (CEUS) and future recurrent stroke, and to determine whether plaque enhancement can contribute to risk assessment for recurrent stroke compared with the Essen Stroke Risk Score (ESRS). The results showed that carotid plaque enhancement was an independent predictor of recurrent stroke and adding plaque enhancement to the ESRS improved risk stratification capability.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Runqing Huang, J. Kevin DeMarco, Hideki Ota, Thanila A. Macedo, Sahar S. Abdelmoneim, John I. I. I. I. I. I. Huston, Patricia A. Pellikka, Sharon L. Mulvagh
Summary: Combining stress echocardiography (SE) with carotid contrast-enhanced ultrasound (CEUS) in patients with known or suspected coronary artery disease (CAD) may provide incremental prognostic value for predicting the occurrence of cardiovascular events beyond clinical risk factors or either test alone. Carotid CEUS detected intraplaque neovascularization (IPN) and localized to plaque shoulder was found to be an independent predictor of cardiovascular events in patients referred for SE.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Cardiac & Cardiovascular Systems
Christie A. Boswell-Patterson, Marie-France Hetu, Abigail Kearney, Stephen C. Pang, M. Yat Tse, Julia E. Herr, Michaela Spence, Jianhua Zhou, Amer M. Johri
Summary: A novel phantom platform of neovascularized atherosclerotic plaque in the carotid artery was developed in this study, utilizing synthetic plaque models and commercially available technology for quantitative measurement of IPN. The analysis distinguished between neovascularized and calcified plaques, providing objective measures of IPN for improved clinical identification of vulnerable plaques.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Geriatrics & Gerontology
Yan Song, Ying Dang, Jichang Wang, Hui Cai, Jun Feng, Hongmei Zhang, Litao Ruan
Summary: The study found that intraplaque neovascularization (IPN) detected through CEUS can independently predict the risk of ischemic stroke recurrence in patients with recent strokes and carotid atherosclerosis. IPN may be an earlier indicator than carotid stenosis in predicting stroke recurrence, helping in risk stratification.
Article
Acoustics
Yuto Uchihara, Kozue Saito, Rie Motoyama, Hatsue Ishibashi-Ueda, Eriko Yamaguchi, Kinta Hatakeyama, Akito Tanaka, Hiroharu Kataoka, Koji Iihara, Kazuma Sugie, Masatoshi Koga, Kazunori Toyoda, Kazuyuki Nagatsuka, Masafumi Ihara
Summary: This study aimed to assess intraplaque neovessels using contrast-enhanced ultrasound and determine their connection to the vessel lumen histopathologically. Additionally, the study investigated whether plaque vulnerability could be more accurately assessed. The results showed that symptomatic plaques had stronger contrast effects from the luminal side and higher neovessel density compared to asymptomatic plaques.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shuai Zhang, Lin Gao, Bing Kang, Xinxin Yu, Ran Zhang, Ximing Wang
Summary: A CT-based radiomics nomogram was developed and validated for the detection of intraplaque hemorrhage in carotid arteries. The results showed that the radiomics nomogram had satisfactory performance in distinguishing carotid plaques with and without intraplaque hemorrhage.
INSIGHTS INTO IMAGING
(2022)
Article
Acoustics
Yi Song, Hang Xing, Zhiqi Zhang, Lewis Oscar Felix
Summary: The study found that superb microvascular imaging (SMI) and contrast-enhanced carotid ultrasonography (CEUS) have strong agreement in detecting carotid intraplaque neovascularization (IPN), with SMI showing high consistency with pathologic evaluations of IPN. Individuals with carotid IPN are more likely to develop stroke or transient ischemic attack (TIA).
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Clinical Neurology
Penghui Zeng, Qing Zhang, Xiaowen Liang, Min Zhang, Dan Luo, Zhiyi Chen
Summary: This review summarizes the application and semi-quantitative/quantitative diagnostic standards of ultrasound techniques in evaluating intraplaque neovascularization (IPN), and looks forward to future research prospects. With the development of novel techniques like artificial intelligence, ultrasound will offer appropriate selections for achieving more accurate diagnosis.
CEREBROVASCULAR DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Raiyan Tripti Zaman, Hisanori Kosuge, Sanjiv Sam Gambhir, Lei Xing
Summary: Carotid artery stenosis is a major cause of stroke or mini-stroke in the United States, and carotid endarterectomy is used to treat it. Researchers have developed a sensing interferometer imaging system to noninvasively assess vulnerable carotid plaques.
Review
Acoustics
Hualin Yan, Xian Wu, Ying He, Daniel Staub, Xiaorong Wen, Yan Luo
Summary: This meta-analysis found that carotid intraplaque neovascularization can predict cardiovascular events and is significantly associated with past cardiac events and cerebrovascular accidents. Therefore, carotid CEUS plays an important role in cardiovascular event risk assessment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yanqin Guo, Xinghua Wang, Lu Wang, Xiaoli Wei, Yinling Duan, Xiaohuan Yang, Min Zhang, Bin Zhao
Summary: This study compared the consistency between superb microvascular imaging (SMI) and contrast-enhanced ultrasound (CEUS) for the detection of neovascularization in carotid plaques of different thicknesses and evaluated their diagnostic value. The results showed that SMI was able to detect neovascularization in carotid plaques and had good agreement with CEUS.
ACADEMIC RADIOLOGY
(2023)
Article
Clinical Neurology
Qi Lyu, Xiaojie Tian, Yafang Ding, Yanhong Yan, Yabo Huang, Peng Zhou, Pinjing Hui
Summary: The study found that contrast agent inside-out direction diffusion is an important indicator for detecting vulnerable plaque fibrous cap rupture, with the degree of enhancement correlating with the morphology of intraplaque neovascularization. Increasing plaque enhancement was associated with higher microvessel density, larger microvessel area, and more irregular-shaped microvessels, indicating an increased risk of plaque vulnerability.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Peripheral Vascular Disease
Yuting Tan, Fang Nie, Guode Wu, Fangzhou Guo, Yanqing Wang, Longli Wang
Summary: This study aims to investigate the influence of H-type hypertension on intraplaque neovascularization (IPN). The results showed that H-type hypertension is significantly associated with the degree of plaque enhancement, potentially increasing plaque vulnerability.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)