Article
Nutrition & Dietetics
Alfonso M. Duran, W. Lawrence Beeson, Anthony Firek, Zaida Cordero-MacIntyre, Marino De Leon
Summary: This study aims to identify the cellular pathways stimulated by dietary omega-3 polyunsaturated fatty acid (PUFA) supplementation in patients with type 2 diabetes mellitus (T2DM) affected by painful diabetic neuropathy (pDN). The results show that supplementation leads to a shift towards an anti-inflammatory state and improved membrane fluidity, which may be responsible for the reduction in adverse symptoms associated with neuroinflammatory diseases and painful neuropathy.
Article
Biochemistry & Molecular Biology
Ines Drenjancevic, Jan Pitha
Summary: In addition to proven medications, omega-3 polyunsaturated fatty acids (n-3 PUFAs) are considered to have additive effects on cardiovascular health. They influence the cardiovascular system through various mechanisms, including effects on metabolism, inflammation, thrombosis, and direct effects on cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Review
Nutrition & Dietetics
Andrew Elagizi, Carl J. Lavie, Evan O'Keefe, Keri Marshall, James H. O'Keefe, Richard V. Milani
Summary: Interest in the potential cardiovascular benefits of omega-3 polyunsaturated fatty acids (omega-3) began in the 1940s, but there has been controversy due to conflicting results among studies and meta-analyses. Recent large, randomized trials showed discordant findings, with one using a higher dose of omega-3 showing a significant reduction in cardiovascular events. The conflicting results in clinical trials may be due to inadequate dosing of omega-3 and aggressive treatment with other effective therapies.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Review
Cardiac & Cardiovascular Systems
Zheng Gao, Dewen Zhang, Xiaocan Yan, Hekai Shi, Xiaohui Xian
Summary: This study reviewed multiple randomized controlled trials and observational studies and found that omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have a beneficial effect on coronary atherosclerosis. However, they do not significantly affect the volume of lipid plaque, fiber plaque, and calcified plaque in the coronary arteries.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Nutrition & Dietetics
Daniel Rodriguez, Carl J. Lavie, Andrew Elagizi, Richard V. Milani
Summary: This paper discusses the importance of using omega-3 fatty acids in cardiovascular diseases and summarizes related research and recommendations.
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Toxicology
Hao Chen, Siqi Zhang, Wan Shen, Claudia Salazar, Alexandra Schneider, Lauren H. Wyatt, Ana G. Rappold, David Diaz-Sanchez, Robert B. Devlin, James M. Samet, Haiyan Tong
Summary: This study demonstrates that short-term exposure to low-level ambient air pollution is associated with cardiovascular responses, and that dietary intake of omega-3 polyunsaturated fatty acids may provide protection against these cardiovascular effects in healthy adults.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Environmental Sciences
Hao Chen, Siqi Zhang, Wan Shen, Claudia Salazar, Alexandra Schneider, Lauren Wyatt, Ana G. Rappold, David Diaz-Sanchez, Robert B. Devlin, James M. Samet, Haiyan Tong
Summary: The study revealed that high ω-3 group showed significant improvements in respiratory, cardiovascular, and heart rate variability when exposed to NO2 levels below NAAQS standards. In contrast, the low ω-3 group exhibited elevations in coagulation markers and reductions in heart rate variability, with no observed changes in lung function, blood lipids, and vascular function under the same conditions.
ENVIRONMENTAL HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Olatunji Anthony Akerele, Sarah Jane Manning, Sarah Emily Dixon, Amelia Estelle Lacey, Sukhinder Kaur Cheema
Summary: The study found that a maternal diet high in Ω-3 PUFA can prevent dyslipidemia in non-pregnant mice and maintain the expected lipid profile during pregnancy, while a very low Ω-3 PUFA diet can lead to hyperlipidemia in mice before pregnancy and during pregnancy. Omega (n)-3 polyunsaturated fatty acids are crucial for maintaining maternal metabolic profile and fetal sustainability during pregnancy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Daiji Nagayama, Yasuhiro Watanabe, Takashi Yamaguchi, Kenji Suzuki, Atsuhito Saiki, Kentaro Fujishiro, Kohji Shirai
Summary: This cross-sectional study found that using ABSI to diagnose MetS can better identify individuals at risk of arterial stiffening compared to using waist circumference and body mass index. ABSI can help assess the risk of cardiovascular disease more effectively.
Article
Endocrinology & Metabolism
Masahiro Ohira, Kazuki Abe, Takashi Yamaguchi, Hiroki Onda, Shuhei Yamaoka, Shoko Nakamura, Shou Tanaka, Yasuhiro Watanabe, Taiki Nabekura, Takashi Oshiro, Daiji Nagayama, Atsuhito Saiki, Ichiro Tatsuno
Summary: This study aimed to evaluate the relationship between the improvement in type 2 diabetes and hormones in patients with obesity and type 2 diabetes who underwent bariatric surgery (BS). The results showed that preoperative plasma aldosterone levels were related to complete remission (CR) of type 2 diabetes after BS, and measuring plasma aldosterone levels preoperatively is useful for predicting the CR of type 2 diabetes after BS.
Article
Endocrinology & Metabolism
Yasuhiro Watanabe, Takashi Yamaguchi, Sho Tanaka, Akira Sasaki, Takeshi Naitoh, Hisahiro Matsubara, Koutaro Yokote, Shinichi Okazumi, Satoshi Ugi, Hiroshi Yamamoto, Masayuki Ohta, Yasushi Ishigaki, Kazunori Kasama, Yosuke Seki, Motoyoshi Tsujino, Kohji Shirai, Yasuhiro Miyazaki, Takayuki Masaki, Daiji Nagayama, Atushito Saiki, Ichiro Tatsuno
Summary: This study investigates the psychosocial background and outcomes after bariatric surgery in subjects with childhood onset obesity (CO). The results suggest that CO may be associated with genetic and psychosocial factors, and CO and post-puberty onset obesity (PPO) may differ in pathogenesis and require different treatment strategies.
Article
Endocrinology & Metabolism
Takashi Yamaguchi, Satoshi Morimoto, Chikahito Suda, Atsuhiro Ichihara, Noriko Ishihara, Shoko Nakamura, Sho Tanaka, Yasuhiro Watanabe, Haruki Imamura, Masahiro Ohira, Naomi Shimizu, Atsuhito Saiki, Ichiro Tatsuno
Summary: This study examined the relationship between soluble (pro)renin receptor (s[P]RR) levels and body composition and metabolic factors in severely obese patients who underwent laparoscopic sleeve gastrectomy (LSG). The results showed that blood s(P)RR levels were high in these patients and decreased after weight loss through LSG. The study suggests that blood s(P)RR levels in obese patients may be associated with visceral fat and play a role in insulin resistance and renal damage mechanisms associated with obesity.
Article
Endocrinology & Metabolism
Yasuhiro Watanabe, Takashi Yamaguchi, Daiji Nagayama, Sho Tanaka, Akira Sasaki, Takeshi Naitoh, Hisahiro Matsubara, Koutaro Yokote, Shinichi Okazumi, Satoshi Ugi, Hiroshi Yamamoto, Masayuki Ohta, Yasushi Ishigaki, Kazunori Kasama, Yosuke Seki, Motoyoshi Tsujino, Kohji Shirai, Yasuhiro Miyazaki, Takayuki Masaki, Atsuhito Saiki, Ichiro Tatsuno
Summary: A study on 322 Japanese subjects showed that 83.0% of the patients achieved HbA1c level <7% after LSG surgery, but 26.8% experienced diabetes relapse. Preoperative HbA1c, weight loss after surgery, and weight regain were identified as important factors contributing to diabetes relapse.
Article
Endocrinology & Metabolism
Masahiro Ohira, Yasuhiro Watanabe, Takashi Yamaguchi, Hiroki Onda, Shuhei Yamaoka, Kazuki Abe, Shoko Nakamura, Sho Tanaka, Naoyuki Kawagoe, Taiki Nabekura, Takashi Oshiro, Daiji Nagayama, Ichiro Tatsuno, Atsuhito Saiki
Summary: Following laparoscopic sleeve gastrectomy (LSG), obese patients experienced significant increases in high-density lipoprotein cholesterol (HDL-C) levels and pre-heparin lipoprotein lipase (LPL) levels, while body mass index (BMI) and serum triglyceride (TG) levels decreased significantly. Simple linear regression analysis revealed a significant correlation between changes in HDL-C levels and total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Multiple regression analysis further indicated that the increase in HDL-C levels after LSG was associated with reductions in TG levels and elevations in pre-heparin LPL levels.
Article
Endocrinology & Metabolism
Masahiro Ohira, Yasuhiro Watanabe, Takashi Yamaguchi, Hiroki Onda, Shuhei Yamaoka, Kazuki Abe, Shoko Nakamura, Shou Tanaka, Naoyuki Kawagoe, Taiki Nabekura, Atsuhito Saiki, Takashi Oshiro, Daiji Nagayama, Ichiro Tatsuno
Summary: The preoperative measurement of IGF-1 can help predict successful weight loss, decrease body fat mass, and maintain skeletal muscle mass after LSG.
Article
Endocrinology & Metabolism
Yasuhiro Watanabe, Takashi Yamaguchi, Shuhei Yamaoka, Kazuki Abe, Hiroki Onda, Shoko Nakamura, Sho Tanaka, Takashi Oshiro, Masahiro Ohira, Daiji Nagayama, Naomi Shimizu, Ichiro Tatsuno, Atsuhito Saiki
Summary: This study compared the impact of weight loss achieved through conventional medical therapy or laparoscopic sleeve gastrectomy (LSG) on albuminuria in Japanese subjects with severe obesity. The results showed that the LSG group had greater weight loss, lower glycosylated hemoglobin levels, and more significant improvement in albuminuria compared to the medical therapy group.
