Article
Oncology
Jamie Jae Young Kwon, Alice Q. Liu, Thomas D. Milner, Eitan Prisman
Summary: TORS has similar oncologic control to radiotherapy in treating oropharyngeal squamous cell carcinoma, with the potential for improved quality of life and reduced decisional regret.
Article
Oncology
Anthony C. Nichols, Julie Theurer, Eitan Prisman, Nancy Read, Eric Berthelet, Eric Tran, Kevin Fung, John R. de Almeida, Andrew Bayley, David P. Goldstein, Michael Hier, Khalil Sultanem, Keith Richardson, Alex Mlynarek, Suren Krishnan, Hien Le, John Yoo, S. Danielle MacNeil, Eric Winquist, J. Alex Hammond, Varagur Venkatesan, Sara Kuruvilla, Andrew Warner, Sylvia Mitchell, Jeff Chen, Martin Corsten, Stephanie Johnson-Obaseki, Michael Odell, Christina Parker, Bret Wehrli, Keith Kwan, David A. Palma
Summary: The study found that for early-stage OPSCC, radiotherapy performed better in terms of long-term swallowing quality of life compared to transoral robotic surgery plus neck dissection, although this difference decreases over time. Some differences in QOL concerns gradually resolved in the long term, but it is worth noting that TORS patients started using more nutritional supplements at 3 years, and dry mouth scores increased over time in RT patients.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Otorhinolaryngology
Carly E. A. Barbon, Christopher M. K. L. Yao, Clare P. Alvarez, Ryan P. Goepfert, Clifton D. Fuller, Stephen Y. Lai, Neil D. Gross, Katherine A. Hutcheson
Summary: The study describes physiologic swallowing impairments post-TORS and RT, with TORS showing focal injury associated with DIGEST(safety)/DIGEST(efficiency) while RT showing diffuse physiologic impairment associated with dysphagia.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Otorhinolaryngology
Mitesh P. Mehta, Rebecca Prince, Zeeshan Butt, Bryce E. Maxwell, Brittni N. Carnes, Urjeet A. Patel, Katelyn O. Stepan, Bharat B. Mittal, Sandeep Samant
Summary: The study found that patients with oropharyngeal cancer who underwent TORS-A surgery had better long-term outcomes in terms of self-reported dysphagia and xerostomia compared to those who underwent TORS+RT or TORS+CT/RT treatment.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Otorhinolaryngology
Sarah E. Stephen, Jennifer M. Murphy, Fiona R. Beyer, Diane Sellstrom, Vinidh Paleri, Joanne M. Patterson
Summary: This systematic review examined the functional outcomes following transoral surgery for oropharyngeal cancer in the early postoperative period. The study found oropharyngeal dysfunction across all categories of outcome measures reported, with factors such as pretreatment function, T-classification, and tumor volume influencing the outcomes. Further research is needed to determine optimal outcome measures for postoperative comparisons.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Robert M. McKenzie, Harman S. Parhar, Tony L. Ng, Eitan Prisman
Summary: Pathologic muscle invasion (pMI) in oropharyngeal squamous cell carcinoma (OPSCC) is correlated with higher pathologic tumor staging, poor pathologic factors, and higher rates of positive margin on main specimen.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Jamie R. Oliver, Michael J. Persky, Binhuan Wang, Umamaheswar Duvvuri, Neil D. Gross, Alec E. Vaezi, Luc G. T. Morris, Babak Givi
Summary: The study showed that the utilization of transoral robotic surgery (TORS) in oropharyngeal cancer patients has been increasing annually, with significant differences in positive margin rates between surgical centers. The rates of 30-day unplanned readmission and early postoperative mortality after TORS were low, and high-volume centers had better outcomes with lower positive margin rates and early postoperative mortality.
Article
Otorhinolaryngology
Esther Lee, Daniel Gorelik, Hannah R. Crowder, Christopher Badger, Jennifer Schottler, Ning-Wei Li, Robert Siegel, Nader Sadeghi, Joseph F. Goodman, Punam G. Thakkar, Arjun S. Joshi
Summary: The study evaluated the 2-year follow-up swallowing function in patients with HPV+ OPSCC who completed NAC+S treatment, showing satisfactory long-term swallowing outcomes. Patients who underwent unilateral neck dissection were significantly associated with higher MDADI scores in this study cohort.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Otorhinolaryngology
Harman S. Parhar, Gregory S. Weinstein, Bert W. O'Malley, David Shimunov, Christopher H. Rassekh, Ara A. Chalian, Jason G. Newman, Devraj Basu, Steven B. Cannady, Karthik Rajasekaran, Alexander Lin, John N. Lukens, Samuel Swisher-McClure, Roger B. Cohen, Joshua M. Bauml, Charu Aggrawal, Robert M. Brody
Summary: The TORS approach for surgically resectable HPV-negative OPSCC resulted in encouraging oncologic outcomes with low perioperative morbidity rates.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Otorhinolaryngology
Ryan S. Jackson, Katelyn Stepan, Craig Bollig, Rahul K. Sharma, Mihir Patel, Sean Massa, Sidharth Puram, Jose P. Zevallos, Patrik Pipkorn, Joseph Zenga
Summary: This study analyzed the outcomes of patients with oropharyngeal squamous cell carcinoma who underwent transoral robotic surgery (TORS) using the National Cancer Database, finding that patients with early stage disease had significantly improved overall survival rates. These findings suggest that TORS may be considered in the treatment of HPV-negative OPSCC.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Armando De Virgilio, Raul Pellini, Giovanni Cammaroto, Rossella Sgarzani, Andrea De Vito, Manlio Gessaroli, Andrea Costantino, Gerardo Petruzzi, Bianca Maria Festa, Flaminia Campo, Claudio Moretti, Barbara Pichi, Giuseppe Mercante, Giuseppe Spriano, Claudio Vicini, Giuseppe Meccariello
Summary: This study retrospectively evaluated the clinical and pathological characteristics, treatment details, and oncological outcomes of 139 patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with Trans Oral Robotic Surgery (TORS). The results showed that TORS is a safe and effective treatment option with good oncological outcomes.
Article
Otorhinolaryngology
Craig A. Bollig, Kevin Wang, Pablo Llerena, Sidharth Puram, Patrik J. Pipkorn, Ryan S. Jackson, Vanessa C. Stubbs
Summary: This study analyzed 785 patients with OPSGMs and found that non-soft palate primary site and treatment at an academic facility were independently associated with TORS. There were no significant differences in positive margin rate, 30-day mortality, or overall survival between TORS and nonrobotic resections, but the 30-day unplanned readmission rate was higher in the TORS group.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Otorhinolaryngology
Yeshwant Chillakuru, Daniel A. Benito, David Strum, Varun Mehta, Prashant Saini, Timothy Shim, Christina Darwish, Arjun S. Joshi, Punam Thakkar, Joseph F. Goodman
Summary: The study found that in patients with oropharyngeal squamous cell carcinoma, those undergoing transoral robotic surgery (TORS) had better overall survival compared to those undergoing nonrobotic surgery (NRS). Specifically, TORS was associated with significantly improved survival rates in patients with base of tongue primaries.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Otorhinolaryngology
Allen L. Feng, Andrew J. Holcomb, Nicholas B. Abt, Tara E. Mokhtari, Krish Suresh, Christopher McHugh, Anuraag S. Parikh, Allison Holman, Rachael E. Kammer, Tessa A. Goldsmith, Daniel L. Faden, Daniel G. Deschler, Mark A. Varvares, Derrick T. Lin, Jeremy D. Richmon
Summary: The study found that feeding tubes are rarely required after transoral robotic surgery for early-stage oropharyngeal squamous cell carcinoma. With appropriate multidisciplinary planning and care, patients can reliably avoid the need for feeding tube placement in the perioperative setting.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Otorhinolaryngology
Francesca Gaino, Philippe Gorphe, Vincent Vander Poorten, F. Christopher Holsinger, Renan B. Lira, Umamaheswar Duvvuri, Renaud Garrel, Sebastien Van Der Vorst, Giovanni Cristalli, Fabio Ferreli, Armando De Virgilio, Caterina Giannitto, Emanuela Morenghi, Giovanni Colombo, Luca Malvezzi, Giuseppe Spriano, Giuseppe Mercante
Summary: This study developed a Pharyngoscore to quantify the risk of difficult oropharyngeal exposure (DOE) before TORS. Male gender, modified Mallampati Class (MMC) >= III, smaller interincisor gap, and larger neck circumference were found to be associated with DOE.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Ophthalmology
Marina Knudsen Kirkegaard, Marthe Minderman, Lene Dissing Sjo, Steven T. Pals, Patrick R. G. Eriksen, Steffen Heegaard
Summary: This study aimed to reclassify ocular adnexal large B-cell lymphomas (OA-LBCLs) and investigate the prevalence and association of MYD88 and CD79B mutations with clinical parameters. The results revealed that OA-LBCL mainly consists of two subtypes, and MYD88 mutations, as well as cMYC/BCL2 double-expressor DLBCL, are associated with poor prognosis.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, Research & Experimental
Susanne Irene Scott, Anne Kathrine O. Madsen, Niclas Rubek, Birgitte Wittenborg Charabi, Irene Wessel, Claus Jensen, Jeppe Friborg, Christian von Buchwald
Summary: This study investigated the outcomes of dysphagia and quality of life in patients treated for oropharyngeal cancer with primary trans oral robotic surgery (TORS) or radiotherapy (RT). The results showed significant improvements in swallowing function after 1 to 3 years of treatment, particularly in patients treated with TORS. However, these improvements did not translate into clinically meaningful improvements in quality of life.
Article
Anesthesiology
Anders H. Springborg, Claus Varnum, Niklas I. Nielsen, Lasse E. Rasmussen, Per Kjaersgaard-Andersen, Lina Pleckaitiene, Kirill Gromov, Anders Troelsen, Henrik Kehlet, Nicolai B. Foss
Summary: Pain after total knee arthroplasty is a common problem, and perioperative glucocorticoids have been shown to reduce pain and facilitate recovery. However, the optimal timing and dose of glucocorticoids are still unknown. This study aims to evaluate the effect of a repeat moderate dose of glucocorticoids in high pain catastrophizers who experience moderate to severe pain 24 hours after surgery.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Physiology
Adrian W. Midgley, Andrew R. Levy, Felipe A. Cunha, Angela Key, Joanne M. Patterson, Simon N. Rogers
Summary: The purpose of this study was to assess the safety and feasibility of using the cardiopulmonary exercise test (CPET) for evaluating head and neck cancer (HaNC) survivors. The study also aimed to compare their cardiorespiratory fitness to age and sex-matched norms and establish their current physical activity levels. The results showed that most HaNC survivors had lower levels of cardiorespiratory fitness, which should be taken into account when determining an appropriate ramp rate.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Article
Anesthesiology
M. Cihoric, H. Kehlet, J. Hojlund, M. L. Lauritsen, K. Kanstrup, N. B. Foss
Summary: The feasibility of assessing hydration status and fluid distribution using Bioimpedance spectroscopy Analysis (BIA) in surgical patients was evaluated. BIA measurements correlated with fluid balance, weight changes, and postoperative clinical complications.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Review
Otorhinolaryngology
Elizabeth A. Rowe, Jane Dunton, Samuel Cooke, Despina Laparidou, J. M. Patterson
Summary: This review highlights the lack of knowledge regarding patient adherence to swallowing recommendations in head and neck cancer survivors during (chemo)radiotherapy. Seven studies were identified, revealing six facilitators (e.g., pain relief, behavioural intervention) and barriers (e.g., pain, depression) to adherence. Adherence to swallowing recommendations positively impacted swallowing outcomes in one study. Further research is needed to understand survivors' barriers and facilitators, in order to improve adherence and treatment outcomes.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2023)
Article
Oncology
Emmanouil Terzidis, Jeppe Friborg, Ivan R. Vogelius, Giedrius Lelkaitis, Christian von Buchwald, Anders B. Olin, Helle H. Johannesen, Barbara M. Fischer, Irene Wessel, Jacob H. Rasmussen
Summary: This study aimed to evaluate the mismatch between tumor volumes defined from PET/MRI hybrid imaging and pathology, and its potential clinical impact. The results showed a mismatch between imaging and pathological defined tumor volumes in all patients. However, after the addition of a clinical 5 mm margin, the entire pathological volume was fully encompassed in the imaging-defined tumor volume in most patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Respiratory System
Tobias Todsen, Martin G. Tolsgaard, Thomas Benfield, Fredrik Folke, Kathrine K. Jakobsen, Niels Tobias Gredal, Annette K. Ersboll, Christian von Buchwald, Nikolai Kirkby
Summary: This study compared the detection rate of SARS-CoV-2 using nasopharyngeal swab (NPS), oropharyngeal swab (OPS), and saliva specimen collection. The results showed that OPS had the highest detection rate, while saliva sampling had the lowest. OPS sampling had higher detection rate and lower discomfort compared to NPS. Although saliva sampling had the lowest detection rate, it was the least costly.
Editorial Material
Virology
Tina Dalianis, Christian von Buchwald, Anders Nasman, Stina Syrjanen
Article
Clinical Neurology
Elisabeth Kjaer Jensen, Thomas K. Ringsted, Joakim M. Bischoff, Morten A. Petersen, Kirsten Moller, Henrik Kehlet, Mads U. Werner
Summary: This study aimed to investigate and describe the underlying pathophysiological changes in the groin areas and examine the effects of re-surgery on pain and function using quantitative somatosensory testing (QST). The results showed that re-surgery can improve pain and function, and QST analyses are useful for mechanism-based somatosensory research.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Otorhinolaryngology
Kristine Grubbe Gregersen, Jeppe Friborg, Claus Andrup Kristensen, Kristian Hveysel Bork
Summary: Recurrent respiratory papillomatosis (RRP) is a neoplasm caused by human papilloma virus (HPV) 6/11, which affects the upper and lower airway in both younger and older patients. Despite the potential decline due to HPV vaccination, RRP remains challenging to manage and significantly impacts quality of life. Systemic bevacizumab has shown efficacy in treating aggressive RRP in both juvenile and adult patients. In this study, five consecutive adult patients with aggressive laryngeal and tracheal papillomatosis were treated with systemic bevacizumab, demonstrating positive effects without pulmonary spread and manageable side effects.
ACTA OTO-LARYNGOLOGICA CASE REPORTS
(2023)
Article
Oncology
Katrin Hakansson, Anne Marie Lindegaard, Mogens Bernsdorf, Anita Gothelf, Claus Andrup Kristensen, Lena Specht, Jeppe Friborg, Ivan Vogelius
Summary: A previous study showed that most relapses in head and neck squamous cell carcinoma patients occur in the pretreatment FDG-PET avid volume. This study aimed to investigate if this finding is true for oropharynx squamous cell carcinoma patients and compare the relapse patterns between HPV positive and HPV negative patients.
Article
Oncology
K. Hakansson, E. Giannoulis, A. Lindegaard, J. Friborg, I. Vogelius
Editorial Material
Otorhinolaryngology
Jacob P. S. Nielsen, Christian von Buchwald, Christian Gronhoj
ACTA OTO-LARYNGOLOGICA
(2023)
Article
Multidisciplinary Sciences
Adrian W. Midgley, Andrew R. Levy, Simon N. Rogers, Rachel C. Brooker, Valerie Bryant, Mary Gemma Cherry, Steven Lane, Michael M. Nugent, Ruth Price, Andrew G. Schache, Bridget Young, Joanne M. Patterson
Summary: The aim of this study is to investigate the feasibility and acceptability of introducing a remotely delivered, fully personalised, collaborative, and flexible exercise programme into the usual care pathway for head and neck cancer patients. The study will recruit 70 patients and assess the retention, uptake, and adherence to the exercise programme, as well as the impact on fatigue, quality of life, physical activity levels, and physical fitness. The results of this feasibility study will inform the design of a future randomised controlled trial.