Journal
ALLERGOLOGY INTERNATIONAL
Volume 70, Issue 1, Pages 30-38Publisher
JAPANESE SOCIETY ALLERGOLOGY
DOI: 10.1016/j.alit.2020.11.003
Keywords
Cytotoxicity; Eosinophil; Granule protein; Innate immunity; Neutrophil
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This article discusses the importance of granule proteins in neutrophils and eosinophils in antimicrobial action, as well as the potential tissue damage and organ dysfunction caused by excessive release.
Neutrophils and eosinophils are granulocytes which are characterized by the presence of granules in the cytoplasm. Granules provide a safe storage site for granule proteins that play important roles in the immune function of granulocytes. Upon granulocytes activation, diverse proteins are released from the granules into the extracellular space and contribute to the fight against infections. In this article, we describe granule proteins of both neutrophils and eosinophils able to kill pathogens and review their anticipated mechanism of antimicrobial toxicity. It should be noted that an excess of granules protein release can lead to tissue damage of the host resulting in chronic inflammation and organ dysfunction. Copyright (C) 2020, Japanese Society of Allergology. Production and hosting by Elsevier B.V.
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