Mesenchymal Stem Cells Enhance Therapeutic Effect and Prevent Adverse Gastrointestinal Reaction of Methotrexate Treatment in Collagen-Induced Arthritis

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update

(2020) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

Dietary restriction increases protective gut bacteria to rescue lethal methotrexate-induced intestinal toxicity

(2020) Duozhuang Tang et al.   Gut Microbes

Bone marrow mesenchymal stem cells improve bone erosion in collagen-induced arthritis by inhibiting osteoclasia-related factors and differentiating into chondrocytes

(2020) Jinfang Gao et al.   Stem Cell Research & Therapy

Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis

(2020) Xuezhi Yang et al.   CELL PROLIFERATION

Methotrexate Pulmonary Toxicity: Deep Inspiration

(2020) Joel M Kremer   Arthritis & Rheumatology

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: Challenges, opportunities, and future perspectives

(2019) Shobha Regmi et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Comparison of therapeutic effects of different mesenchymal stem cells on rheumatoid arthritis in mice

(2019) Qing Zhang et al.   PeerJ

Macrophage M1/M2 polarization and rheumatoid arthritis: A systematic review

(2019) Samuele Tardito et al.   AUTOIMMUNITY REVIEWS

Mesenchymal stem cells for the treatment of ulcerative colitis: a systematic review and meta-analysis of experimental and clinical studies

(2019) Xiao Shi et al.   Stem Cell Research & Therapy

Estrogen receptor β activation ameliorates DSS-induced chronic colitis by inhibiting inflammation and promoting Treg differentiation

(2019) Di Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulatory T-cell dynamics with abatacept treatment in rheumatoid arthritis

(2018) Kane Langdon et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Treatment of experimental necrotizing enterocolitis with stem cell-derived exosomes

(2018) Christopher J. McCulloh et al.   JOURNAL OF PEDIATRIC SURGERY

Mesenchymal stem cells and extracellular matrix scaffold promote muscle regeneration by synergistically regulating macrophage polarization toward the M2 phenotype

(2018) Xinyu Qiu et al.   Stem Cell Research & Therapy

Apremilast Ameliorates Experimental Arthritis via Suppression of Th1 and Th17 Cells and Enhancement of CD4+Foxp3+ Regulatory T Cells Differentiation

(2018) Weiqian Chen et al.   Frontiers in Immunology

Induction and Amelioration of Methotrexate-Induced Gastrointestinal Toxicity are Related to Immune Response and Gut Microbiota

(2018) Bailing Zhou et al.   EBioMedicine

Inadequate response to treat-to-target methotrexate therapy in patients with new-onset rheumatoid arthritis: development and validation of clinical predictors

(2018) Xavier M Teitsma et al.   ANNALS OF THE RHEUMATIC DISEASES

Methotrexate mechanism in treatment of rheumatoid arthritis

(2018) Benjamin Friedman et al.   JOINT BONE SPINE

Intravenous Infusion of Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Rheumatoid Arthritis: A Phase Ia Clinical Trial

(2018) Eun Hye Park et al.   Stem Cells Translational Medicine

Defective T-Cell Apoptosis and T-Regulatory Cell Dysfunction in Rheumatoid Arthritis

(2018) Charles Malemud   Cells

Is macrophage polarization important in rheumatoid arthritis?

(2017) Yang Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/IIa clinical trial

(2016) Jose M Álvaro-Gracia et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased autophagy in CD4+T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance

(2016) Jorg van Loosdregt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Severe apoptotic enteropathy caused by methotrexate treatment for rheumatoid arthritis

(2016) Ségolène Toquet et al.   JOINT BONE SPINE

Mechanism of action of methotrexate in rheumatoid arthritis and the search for biomarkers

(2016) Philip M. Brown et al.   Nature Reviews Rheumatology

Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis

(2016) Tae-Hoon Shin et al.   Cell Death & Disease

Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine

(2015) Emanuela Sala et al.   GASTROENTEROLOGY

Tetramethylpyrazine identified by a network pharmacology approach ameliorates methotrexate-induced oxidative organ injury

(2015) Bo Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The impact of biological therapy on regulatory T cells in rheumatoid arthritis

(2015) R. Byng-Maddick et al.   RHEUMATOLOGY

2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

(2015) Jasvinder A. Singh et al.   ARTHRITIS CARE & RESEARCH

CD8+ T Cell Profiles in Patients With Rheumatoid Arthritis and Their Relationship to Disease Activity

(2015) Helena Carvalheiro et al.   Arthritis & Rheumatology

Rheumatoid arthritis pathophysiology: update on emerging cytokine and cytokine-associated cell targets

(2014) D. E. Furst et al.   RHEUMATOLOGY

The Antifolates

(2012) Michele Visentin et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Combined use of etanercept and MTX restores CD4+/CD8+ ratio and Tregs in spleen and thymus in collagen-induced arthritis

(2012) B. Huang et al.   INFLAMMATION RESEARCH

Healing of intestinal inflammation by IL-22

(2012) Atsushi Mizoguchi   INFLAMMATORY BOWEL DISEASES

Mesenchymal stromal cell-conditioned medium prevents radiation-induced small intestine injury in mice

(2011) Zhimai Gao et al.   CYTOTHERAPY

Methotrexate—how does it really work?

(2010) Edwin S. L. Chan et al.   Nature Reviews Rheumatology

Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis

(2009) E Gonzalez-Rey et al.   GUT

Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature

(2008) K Visser et al.   ANNALS OF THE RHEUMATIC DISEASES