Article
Medicine, General & Internal
Justine Chinn, Shaina Sedighim, Katharine A. Kirby, Samuel Hohmann, Afshan B. Hameed, Jennifer Jolley, Ninh T. Nguyen
Summary: This study compared characteristics and outcomes of women who underwent childbirth with vs without COVID-19 in a large US cohort, and found that women with COVID-19 during childbirth had higher rates of mortality, intubation, ICU admission, and preterm birth.
Article
Medicine, General & Internal
N. Vaid, M. Ardissino, T. A. N. Reed, J. Goodall, P. Utting, M. Miscampbell, D. Condurache, D. L. Cohen
Summary: This study found that in 981 hospitalized COVID-19 patients, the use of immunosuppressants was significantly associated with higher mortality rates. However, no association was found between immunosuppression and composite outcomes such as mortality or intubation.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Infectious Diseases
Marion Ludwig, Josephine Jacob, Frederike Basedow, Frank Andersohn, Jochen Walker
Summary: The study compared the clinical and demographic characteristics of German patients hospitalized for infection with either SARS-CoV-2 or Influenza. Results showed that COVID-19 patients had higher in-hospital mortality and worse clinical outcomes, which were not attributable to demographic characteristics, preexisting comorbidities, or patient triage.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Milena S. Marcolino, Patricia K. Ziegelmann, Maira V. R. Souza-Silva, I. J. B. Nascimento, Luana M. Oliveira, Luanna S. Monteiro, Thais L. S. Sales, Karen B. Ruschel, Karina P. M. P. Martins, Ana Paula B. S. Etges, Israel Molina, Carisi A. Polanczyk
Summary: This study investigated the characteristics and outcomes of COVID-19 patients hospitalized in Brazilian hospitals. It found that certain parameters at hospital admission, such as age, chronic diseases, laboratory indicators, and treatment methods, were independently associated with a higher risk of in-hospital mortality. The study also highlighted the potential overuse of antimicrobials in COVID-19 patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Warren Gavin, Elliott Campbell, Syed-Adeel Zaidi, Neha Gavin, Lana Dbeibo, Cole Beeler, Kari Kuebler, Ahmed Abdel-Rahman, Mark Luetkemeyer, Areeba Kara
Summary: This retrospective study evaluated COVID-19 patients admitted to one site in March 2020 and found that age and gender may impact disease outcomes. Certain biomarkers such as D-dimer, procalcitonin, lactate dehydrogenase, and BNP may serve as early indicators of disease trajectory.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Multidisciplinary Sciences
Ahmed M. Altibi, Bhargava Pallavi, Hassan Liaqat, Alexander A. Slota, Radhika Sheth, Lama Al Jebbawi, Matthew E. George, Allison LeDuc, Enas Abdallah, Luke R. Russell, Saniya Jain, Narine Shirvanian, Ahmad Masri, Vivek Kak
Summary: Incarcerated individuals with COVID-19 experience more severe clinical symptoms, higher rates of ICU admissions, vasopressor requirements, intubation, in-hospital mortality, and 30-day mortality compared to non-prisoners.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Peter A. Minchella, Duncan Chanda, Jonas Z. Hines, Sombo Fwoloshi, Megumi Itoh, Davies Kampamba, Robert Chirwa, Suilanji Sivile, Khozya D. Zyambo, Simon Agolory, Lloyd B. Mulenga
Summary: This study investigated the characteristics and outcomes of patients admitted to COVID-19 treatment centers in Zambia. The findings suggest that the characteristics of admitted patients during the Omicron wave and risk factors for in-hospital mortality were similar to data reported elsewhere. Within-wave analyses revealed a pattern of prioritizing higher-risk patients during surges in demand for health services.
Article
Immunology
Dieu Hien Thi Huynh, Thu Suong Thi Nguyen, Bao An Huynh Nguyen, Quoc Tung Nguyen, Vinh An Thi Duong, Anh Ngoc Thi Lam, Ton Bao Le, Thanh Nhan Nguyen Le, Anh Tuan Tran, Huy Dung Tran, Giau Van Vo, Minh Nam Nguyen
Summary: A cross-sectional study involving 205 pediatric patients, including 150 post-COVID-19 patients and 55 noninfected patients, identified 10 common respiratory symptoms in post-COVID-19 pediatric patients and significant differences in clinical symptoms between the two groups. Post-COVID-19 pediatric patients had lower lymphocyte count and higher rates of pneumonia diagnosis, which can persist for up to 16 weeks after discharge. These findings are important for monitoring and managing the clinical burden of post-COVID-19 symptoms in the pediatric population.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Virology
Mariusz Gujski, Mateusz Jankowski, Daniel Rabczenko, Pawel Gorynski, Grzegorz Juszczyk
Summary: A retrospective analysis of COVID-19 hospitalized patients in Poland from March to December 2020 found that patients over 60 years of age, male gender, and those with cardiovascular diseases or genitourinary system diseases had higher odds of COVID-19-related in-hospital death risk. The presence of at least one comorbidity more than doubled the risk of in-hospital death, emphasizing the importance of managing underlying health conditions during a COVID-19 infection.
Article
Immunology
Mengdie Wang, Nan Jiang, Changjun Li, Jing Wang, Heping Yang, Li Liu, Xiangping Tan, Zhenyuan Chen, Yanhong Gong, Xiaoxv Yin, Qiao Zong, Nian Xiong, Guopeng Zhang
Summary: Male patients with COVID-19 are more likely to have poor outcomes compared to females, with higher rates of complications such as lymphopenia and thrombocytopenia. However, there was no significant difference in disease outcomes between postmenopausal and premenopausal females after age-matching. Further studies are needed to explore the underlying causes of these sex-specific differences in disease outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Shiv Patel, Gia Thinh Truong, Ajay Rajan, Zachary Creech, Ryan Walters, Ian Ng, Christopher Destache, Renuga Vivekanandan, Maureen Tierney, Manasa Velagapudi
Summary: By investigating the long-term effects of COVID-19 and analyzing the discharge placement of patients, this study aimed to identify predictors of rehabilitation needs in individuals with COVID-19 sequelae. A retrospective chart review was conducted on adult patients from multiple hospitals, examining discharge disposition, length of hospital stay, and all-cause mortality and readmission rates within 30 and 90 days. The study found that younger age and shorter hospitalization stays were significant predictors of home discharge, which was associated with lower all-cause mortality rates at 30 and 90 days.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Piotr Rzymski, Monika Pazgan-Simon, Krzysztof Simon, Tadeusz Lapinski, Dorota Zarebska-Michaluk, Barbara Szczepanska, Michal Chojnicki, Iwona Mozer-Lisewska, Robert Flisiak
Summary: A study analyzing COVID-19 vaccine recipients who were hospitalized with severe cases in Poland found that while deaths and severe cases were rare, they still occurred, especially among individuals with diminished immune responses or non-responders to the vaccine. Close monitoring of high-risk individuals for vaccine failure is recommended.
Article
Respiratory System
Onur Turan, Burcu Arpinar Yigitbas, Pakize Ayse Turan, Arzu Mirici
Summary: This study investigated the characteristics and prognosis of COPD patients among COVID-19 population in Turkey. It found that although COPD patients had some poor prognostic features, there was no statistical difference in overall survival rates between COPD and non-COPD COVID-19 patients. Age, oxygenation status, serum D-dimer level, lymphocyte count, and pneumonia were significantly associated with mortality in COVID-19 patients.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hannah R. Volkman, Janice Perez-Padilla, Joshua M. Wong, Liliana Sanchez-Gonzalez, Lauren Acevedo-Molina, Martin Lugo-Menendez, Carene A. Oliveras Garcia, Laura E. Adams, Veronica M. Frasqueri-Quintana, Robert Rodriguez-Gonzalez, Javier A. Gonzalez-Cosme, Andres E. Calvo Diaz, Luisa Alvarado, Vanessa Rivera-Amill, Jessica Brown, Karen K. Wong, Jorge Bertran-Pasarell, Gabriela Paz-Bailey
Summary: Hispanics are the majority ethnic population in Puerto Rico. A study on 109 hospitalized COVID-19 patients showed that patients had a median of 3 underlying conditions, with obesity and diabetes as the most common. 28% of patients were admitted to the ICU and 18% died during hospitalization.
Article
Multidisciplinary Sciences
Niels Pouw, Josephine van de Maat, Karin Veerman, Jaap ten Oever, Nico Janssen, Evertine Abbink, Monique Reijers, Quirijn de Mast, Wouter Hoefsloot, Reinout van Crevel, Kitty Slieker, Marjan van Apeldoorn, Marc Blaauw, Anton Dofferhoff, Jacobien Hoogerwerf
Summary: This retrospective cohort study in the Netherlands describes the clinical characteristics, disease course, and outcomes of a large cohort of hospitalized COVID-19 patients. It found that patients aged 70 years and older had a higher mortality rate and longer ICU stay compared to younger patients. These findings suggest a need for further investigation into the benefits of ICU admission for elderly and fragile COVID-19 patients.
Editorial Material
Cardiac & Cardiovascular Systems
Jonathan W. Cunningham, Mandeep R. Mehra
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Surgery
Karola S. Jering, Martina M. McGrath, Finnian R. Mc Causland, Brian Claggett, Jonathan W. Cunningham, Scott D. Solomon
Summary: Solid-organ transplant recipients hospitalized with COVID-19 have higher odds of complications and in-hospital mortality compared to admissions for other causes, including non-COVID-19 pneumonia. The odds of in-hospital death are 2.5 times higher for SOT recipients with COVID-19 compared to those with non-COVID-19 pneumonia, regardless of the time of hospitalization.
CLINICAL TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Senthil Selvaraj, Brian Claggett, Michelle C. Johansen, Jonathan W. Cunningham, Rebecca F. Gottesman, Bing Yu, Eric Boerwinkle, Thomas H. Mosley, Amil M. Shah, Scott D. Solomon
Summary: The genetic predisposition to Alzheimer's disease through APOEε4 is not associated with an increased prevalence of HF, HF hospitalization, myocardial remodeling, or biochemical evidence of HF.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Marc P. Bonaca, Elliott M. Antman, Jonathan W. Cunningham, Stephen D. Wiviott, Sabina A. Murphy, Jonathan L. Halperin, Jeffrey Weitz, Michael A. Grosso, Hans J. Lanz, Eugene Braunwald, Robert P. Giugliano, Christian T. Ruff
Summary: In patients with atrial fibrillation and peripheral artery disease, those with PAD have higher risk of stroke and cardiovascular events. While both higher dose edoxaban and warfarin have similar efficacy and safety in stroke and bleeding prevention in AF patients, lower dose edoxaban is inferior in stroke prevention for patients with PAD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Health Care Sciences & Services
Shaan Khurshid, Christopher Reeder, Lia X. Harrington, Pulkit Singh, Gopal Sarma, Samuel F. Friedman, Paolo Di Achille, Nathaniel Diamant, Jonathan W. Cunningham, Ashby C. Turner, Emily S. Lau, Julian S. Haimovich, Mostafa A. Al-Alusi, Xin Wang, Marcus D. R. Klarqvist, Jeffrey M. Ashburner, Christian Diedrich, Mercedeh Ghadessi, Johanna Mielke, Hanna M. Eilken, Alice McElhinney, Andrea Derix, Steven J. Atlas, Patrick T. Ellinor, Anthony A. Philippakis, Christopher D. Anderson, Jennifer E. Ho, Puneet Batra, Steven A. Lubitz
Summary: This study used electronic health record datasets and employed sampling and natural language processing to recover missing data, resulting in a community-based research cohort. The results indicated that NLP can reduce missing vital signs, and the recovered vital signs were highly correlated with values derived from structured fields. Compared to convenience samples, C3PO showed lower incidence of atrial fibrillation and myocardial infarction/stroke, and the risk models were better calibrated.
NPJ DIGITAL MEDICINE
(2022)
Article
Genetics & Heredity
James P. Pirruccello, Paolo Di Achille, Victor Nauffal, Mahan Nekoui, Samuel F. Friedman, Marcus D. R. Klarqvist, Mark D. Chaffin, Lu-Chen Weng, Jonathan W. Cunningham, Shaan Khurshid, Carolina Roselli, Honghuang Lin, Satoshi Koyama, Kaoru Ito, Yoichiro Kamatani, Issei Komuro, Sean J. Jurgens, Emelia J. Benjamin, Puneet Batra, Pradeep Natarajan, Kenney Ng, Udo Hoffmann, Steven A. Lubitz, Jennifer E. Ho, Mark E. Lindsay, Anthony A. Philippakiss, Patrick T. Ellinor
Summary: This study utilized deep learning models to recognize and measure right heart structures and function. Genome-wide association studies identified several loci associated with right heart measurements, some of which were previously linked with congenital heart disease. Additionally, a polygenic predictor was associated with right ventricular ejection fraction and risk of dilated cardiomyopathy.
Letter
Cardiac & Cardiovascular Systems
Luqing Zhang, Jonathan W. Cunningham, Brian L. Claggett, Jaison Jacob, Michael M. Mendelson, Pablo Serrano-Fernandez, Sergio Kaiser, Denise P. Yates, Margaret Healey, Chien-Wei Chen, Gordon M. Turner, Natasha L. Patel-Murray, Faye Zhao, Michael T. Beste, Jason M. Laramie, William T. Abraham, Pardeep S. Jhund, Lars Kober, Milton Packer, Jean Rouleau, Michael R. Zile, Margaret F. Prescott, Martin Lefkowitz, John J. V. McMurray, Scott D. Solomon, William Chutkow
Article
Cardiac & Cardiovascular Systems
Jenine E. John, Brian Claggett, Hicham Skali, Scott D. Solomon, Jonathan W. Cunningham, Kunihiro Matsushita, Suma H. Konety, Dalane W. Kitzman, Thomas H. Mosley, Donald Clark, Patricia P. Chang, Amil M. Shah
Summary: Coronary artery disease (CAD) is a significant risk factor for heart failure with preserved ejection fraction (HFpEF). The risk of developing HFpEF and heart failure with reduced ejection fraction (HFrEF) is highest within the first year after CAD develops. After one year post-CAD, the risk of developing HFrEF and HFpEF is similar. Echocardiographic measurements, particularly left ventricular diastolic function, partially account for the relationship between CAD and incident HFpEF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medical Informatics
Pulkit Singh, Julian Haimovich, Christopher Reeder, Shaan Khurshid, Emily S. Lau, Jonathan W. Cunningham, Anthony Philippakis, Christopher D. Anderson, Jennifer E. Ho, Steven A. Lubitz, Puneet Batra
Summary: This study demonstrates that pretrained transformer models can effectively extract quantitative clinical measurements from diagnostic reports with a relatively small number of annotations. The proposed workflow may serve as a roadmap for other quantitative entity extraction.
JMIR MEDICAL INFORMATICS
(2022)
Article
Cardiac & Cardiovascular Systems
Jonathan W. Cunningham, Paolo Di Achille, Valerie N. Morrill, Lu-Chen Weng, Seung Hoan Choi, Shaan Khurshid, Victor Nauffal, James P. Pirruccello, Scott D. Solomon, Puneet Batra, Jennifer E. Ho, Anthony A. Philippakis, Patrick T. Ellinor, Steven A. Lubitz
Summary: The absence of a dicrotic notch on finger photoplethysmography is a trait associated with age and cardiovascular disease. Little is known about its genetic underpinnings or its predictive value for incident cardiovascular disease.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Genetics & Heredity
Victor Nauffal, Paolo Di Achille, Marcus D. R. Klarqvist, Jonathan W. W. Cunningham, Matthew C. C. Hill, James P. P. Pirruccello, Lu-Chen Weng, Valerie N. N. Morrill, Seung Hoan Choi, Shaan Khurshid, Samuel F. F. Friedman, Mahan Nekoui, Carolina Roselli, Kenney Ng, Anthony A. A. Philippakis, Puneet Batra, Patrick T. T. Ellinor, Steven A. A. Lubitz
Summary: In this study, a machine learning model was developed to measure native myocardial T1 time, a marker of myocardial fibrosis, and identify the biological pathways underlying fibrosis in the human heart. The model was applied to a large sample of UK Biobank participants and revealed associations between greater T1 time and various cardiovascular diseases and conditions. Genome-wide association analysis further identified 11 independent loci associated with T1 time, implicating genes involved in important biological processes such as glucose transport, iron homeostasis, tissue repair, oxidative stress, cardiac hypertrophy, and calcium signaling. This research provides insights into the pathways involved in myocardial fibrosis and myofibroblast cell state acquisition, and highlights the potential of machine learning in large-scale quantification of cardiac fibrosis using imaging techniques.
Letter
Cardiac & Cardiovascular Systems
Jonathan W. Cunningham, Brian L. Claggett, Scott D. Solomon, Muthiah Vaduganathan
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan W. Cunningham, Pulkit Singh, Christopher Reeder, Emily S. Lau, Shaan Khurshid, Xin Wang, Patrick T. Ellinor, Steven A. Lubitz, Puneet Batra, Jennifer E. Ho
JACC-HEART FAILURE
(2023)
Letter
Cardiac & Cardiovascular Systems
Dongchu Xu, Jonathan Cunningham, Pablo-miki Marti-castellote, Luqing Zhang, Natasha l. Patel-murray, Margaret f. Prescott, William chutkow Md, Michael m. Mendelson, Scott d. Solomon, Brian l. Claggett
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Urology & Nephrology
Katherine Scovner Ravi, Caroline Espersen, Katherine A. Curtis, Jonathan W. Cunningham, Karola S. Jering, Narayana G. Prasad, Elke Platz, Finnian R. Mc Causland
Summary: Among hospitalized patients undergoing HD, dynamic changes in laboratory values, QTc duration, and volume status were observed. Further research is needed to evaluate whether HD prescriptions can be adjusted to alter these variations and potentially improve patient outcomes.
