Review
Cardiac & Cardiovascular Systems
Deepak Acharya, Toshinobu Kazui, Dina Al Rameni, Tushar Acharya, Edward Betterton, Elizabeth Juneman, Renzo Loyaga-Rendon, Kapildeo Lotun, Ranjith Shetty, Arka Chatterjee
Summary: Aortic valve disorders, including pre-existing and de novo aortic insufficiency, can lead to worsened LVAD effectiveness and heart failure symptoms. Severe AI is associated with poor outcomes in LVAD patients. Diagnosis of AI requires echocardiographic, device assessment, and/or catheterization studies, as standard echocardiographic criteria are insufficient. Management includes repair or replacement of the aortic valve at the time of LVAD implantation for pre-existing AI, while de novo AI on LVAD support poses challenges and may require repeat surgical intervention or percutaneous techniques.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Manuel Hein, Simon Schoechlin, Undine Schulz, Jan Minners, Philipp Breitbart, Cornelius Lehane, Franz-Josef Neumann, Philipp Ruile
Summary: Early hypoattenuated leaflet thickening (HALT) is a common finding in transcatheter aortic valve replacement (TAVR) patients, but its long-term prognostic impact remains uncertain. This study found that HALT was not associated with patient survival or cardiovascular mortality during a median follow-up of more than 3 years, but it was associated with symptomatic hemodynamic valve deterioration.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Andrew S. Perry, Song Li
Summary: The study found that early aortic valve replacement in asymptomatic patients with high-gradient severe aortic stenosis was associated with a lower mortality rate compared to watchful waiting, and there was no significant correlation between left ventricular ejection fraction and the mortality benefit of aortic valve replacement.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Rebecca T. Hahn, John Webb, Philippe Pibarot, Julien Ternacle, Howard C. Herrmann, Rakesh M. Suri, Danny Dvir, Jonathon Leipsic, Philipp Blanke, Wael A. Jaber, Susheel Kodali, Samir Kapadia, Raj Makkar, Vinod Thourani, Mathew Williams, Erwan Salaun, Flavien Vincent, Ke Xu, Martin B. Leon, Michael Mack
Summary: This study aimed to report the outcomes of valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) at 5 years. ViV-TAVR was found to be an effective treatment option for degenerated surgical bioprostheses, with sustained improvement in clinical and echocardiographic outcomes observed over the long term.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Adil Wani, Daniel R. Harland, Tanvir K. Bajwa, Stacie Kroboth, Khawaja Afzal Ammar, Suhail Q. Allaqaband, Sue Duval, Bijoy K. Khandheria, A. Jamil Tajik, Renuka Jain
Summary: By analyzing patients with different subtypes of severe AS after TAVR, it was found that myocardial mechanics improved post-TAVR and the recovery of GLS was associated with a survival benefit. Patients with low-flow AS showed significant improvement in GLS post-TAVR, but still had impaired function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Lukas Weber, Hans Rickli, Philipp K. Haager, Lucas Joerg, Daniel Weilenmann, Joannis Chronis, Johannes Rigger, Marc Buser, Niklas F. Ehl, Micha T. Maeder
Summary: Patients with post-AVR PH had worse hemodynamic profiles in pre-AVR right heart catheterization compared to those without, characterized by higher mean pulmonary artery pressure, mean pulmonary artery wedge pressure, and pulmonary vascular resistance, and lower pulmonary artery capacitance despite similar aortic stenosis severity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ben Swinkels, Jurrien ten Berg, Johannes Kelder, Freddy Vermeulen, Wim Jan van Boven, Bas de Mol
Summary: Impaired left ventricular function, severe prosthesis-patient mismatch, and increased aortic cross-clamp time were found to be independent predictors of decreased long-term survival after aortic valve replacement. Patients with a mechanical prosthesis had a higher risk of major bleeding events, and younger age did not protect patients with a mechanical prosthesis against major bleeding events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Kyung Oh, Sun Hack Lee, Seung-Ah Lee, Do-Yoon Kang, Sahmin Lee, Ho Jin Kim, Jung-Min Ahn, Joon Bum Kim, Duk-Woo Park, Jong-Min Song, Suk Jung Choo, Duk-Hyun Kang, Jae-Kwan Song, Seung-Jung Park, Dae-Hee Kim
Summary: The degree of LVMi regression is an independent predictor of postoperative outcomes after TAVR in patients with severe AS who received successful TAVR without significant PVR.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Christian Mogilansky, Parwis Massoudy, Markus Czesla, Robert Balan
Summary: The incidence of postoperative conduction disorders, particularly LBBB, has significantly increased after the implantation of a rapid deployment Intuity Elite aortic valve prosthesis. However, the occurrence of conduction disorders has decreased but remains high at medium-term follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
David Frumkin, Malte Pietron, Andreas Kind, Anna Brand, Fabian Knebel, Michael Laule, David M. M. Leistner, Ulf Landmesser, Florian Krackhardt, Mohammad Sherif, Simon H. H. Suendermann, Herko Grubitzsch, Alexander Lembcke, Stefan M. M. Niehues, Karl Stangl, Henryk Dreger
Summary: This study analyzed the incidence of transcatheter valve embolization and migration (TVEM) in a large cohort of patients undergoing transcatheter aortic valve implantation (TAVI) and examined the embolized valves using computed tomography (CT). The study found that there were no pathological findings requiring intervention in the CT scans.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Wunan Zhou, Yee-Ping Sun, Sanjay Divakaran, Navkaranbir S. Bajaj, Ankur Gupta, Alvin Chandra, Victoria Morgan, Leanne Barrett, Laurel Martell, Courtney F. Bibbo, Jon Hainer, Eldrin F. Lewis, Viviany R. Taqueti, Sharmila Dorbala, Ron Blankstein, Piotr Slomka, Pinak B. Shah, Tsuyoshi Kaneko, Dale S. Adler, Patrick O'Gara, Marcelo F. Di Carli
Summary: In patients with aortic stenosis, impaired myocardial flow reserve (MFR) and stress myocardial blood flow (MBF) are associated with adverse myocardial characteristics, including markers of myocardial injury and wall stress. MFR may serve as an early sensitive marker for myocardial decompensation.
Article
Medicine, General & Internal
Dan Loberman, Daniel E. Rinewalt, Hari Reddy Mallidi, Ashraf A. Sabe, Rephael Mohr, Sa'ar Minha, Tomer Ziv-Baran
Summary: This study aimed to identify predictors for long-term all-cause readmissions in patients who underwent transcatheter aortic valve replacement (TAVR). The results revealed that elevated procedural risk, anemia, renal dysfunction, and procedural complication were important predictors for readmission.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Maina P. Jalava, Mikko Savontaus, Tuomas Ahvenvaara, Teemu Laakso, Marko Virtanen, Matti Niemela, Tuomas Tauriainen, Pasi Maaranen, Annastiina Husso, Eve Kinnunen, Sebastian Dahlbacka, Jussi Jaakkola, Stefano Rosato, Paola D'Errigo, Mika Laine, Timo Makikallio, Peter Raivio, Markku Eskola, Antti Valtola, Tatu Juvonen, Fausto Biancari, Juhani Airaksinen, Vesa Anttila
Summary: This study investigated the outcomes of transcatheter and surgical aortic valve replacement in patients with severe aortic stenosis and left ventricular systolic dysfunction. It found that reduced left ventricular ejection fraction was associated with increased morbidity and mortality after both procedures. Although the 30-day mortality rate was higher after surgery, the intermediate-term survival was comparable to transcatheter intervention.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Philippe Pibarot, Howard C. Herrmann, Changfu Wu, Rebecca T. Hahn, Catherine M. Otto, Amr E. Abbas, John Chambers, Marc R. Dweck, Jonathon A. Leipsic, Matheus Simonato, Toby Rogers, Janarthanan Sathananthan, Mayra Guerrero, Julien Ternacle, Harindra C. Wijeysundera, Lars Sondergaard, Marco Barbanti, Erwan Salaun, Philippe Genereux, Tsuyoshi Kaneko, Uri Landes, David A. Wood, G. Michael Deeb, Stephanie L. Sellers, John Lewis, Mahesh Madhavan, Linda Gillam, Michael Reardon, Sabine Bleiziffer, Patrick T. O'Gara, Josep Rodes-Cabau, Paul A. Grayburn, Patrizio Lancellotti, Vinod H. Thourani, Jeroen J. Bax, Michael J. Mack, Martin B. Leon
Summary: This article aims to provide standardized definitions for nonstructural and structural BVD and BVF following aortic or mitral biological valve replacement, in order to facilitate research reporting and implementation in clinical practice.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yujin Yang, Jung-Min Ahn, Do-Yoon Kang, Euihong Ko, Seonok Kim, Tae Oh Kim, Ju Hyeon Kim, Junghoon Lee, Seung-Ah Lee, Dae-Hee Kim, Ho Jin Kim, Joon Bum Kim, Suk Jung Choo, Seung-Jung Park, Duk-Woo Park
Summary: In patients with severe aortic stenosis undergoing transcatheter aortic valve replacement, electrocardiographic left ventricular hypertrophy (LVH) assessed by Cornell criteria was significantly associated with lower risks of major adverse cardiac or cerebrovascular events (MACCE), all-cause mortality, and cardiovascular mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Hyo-Hyun Kim, Sak Lee, Seung Hyun Lee, Young-Nam Youn, Kyung-Jong Yoo, Hyun-Chel Joo
Summary: This study aimed to examine the long-term fate of aortic diameter expansion at 4 cardiac regions after wrapping or replacement during aortic valve surgery. The results showed that aortic wrapping and replacement may be long-term durable treatment options for patients with a moderately enlarged ascending aorta. However, careful evaluation of redilation in the proximal arch after an aorta wrapping procedure is recommended.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Chi Young Shim, Jiwon Seo, Young Jin Kim, Seung Hyun Lee, Raffaele De Caterina, Sak Lee, Geu-Ru Hong
Summary: This study compared the efficacy and safety of edoxaban with warfarin in patients early after surgical bioprosthetic valve implantation or valve repair. The results showed that edoxaban is noninferior to warfarin for preventing thromboembolism and is potentially comparable for risk of major bleeding.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Jong Wook Song, Sarah Soh, Jae-Kwang Shim, Sak Lee, Seung Hyun Lee, Hye Bin Kim, Min-Yu Kim, Young Lan Kwak
Summary: Intravenous iron supplementation during index hospitalization for complex cardiac surgery did not minimize packed erythrocytes transfusion, despite higher hemoglobin concentration and reticulocyte count in the iron group.
Article
Radiology, Nuclear Medicine & Medical Imaging
Young Joo Suh, Sak Lee, Geu-Ru Hong, Young-Guk Ko, Myeong-Ki Hong, Young Jin Kim
Summary: Noncontrast-enhanced cardiac CT examination is feasible for aortic annular measurements before TAVR and provides measurement values comparable to contrast-enhanced examination.
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
(2022)
Article
Cardiac & Cardiovascular Systems
Yu Rim Shin, Seung Up Kim, Sak Lee, Jae Young Choi, Han Ki Park, Jeong Eun Yoo, Young Nyun Park
Summary: Patients with Fontan circulation have a high incidence of liver fibrosis and cirrhosis. This study found that transient elastography (TE) and the enhanced liver fibrosis (ELF) test were unable to predict the degree of liver fibrosis in Fontan patients. Elevated N-terminal pro-brain natriuretic peptide levels and ventricular end-diastolic pressure may be associated with advanced liver fibrosis.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Jung-Hwan Kim, Joon-Young Song, Hyo-Sup Shim, Sak Lee, Young-Nam Youn, Hyun-Chel Joo, Kyung-Jong Yoo, Seung-Hyun Lee
Summary: Cardiac adipose tissue is associated with the recurrence of atrial fibrillation, but its correlation with maze surgery is unclear. This study found a positive correlation between the adipose component of the left atrium and AF recurrence in patients who underwent a modified Cox maze III procedure. Therefore, it may be necessary to use statins in a randomized study to reduce perioperative adipose tissue.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jung-Hwan Kim, Seung Hyun Lee, Sak Lee, Young-Nam Youn, Kyung-Jong Yoo, Hyun-Chel Joo
Summary: The study aimed to investigate whether distal aortic maximum false lumen area (MFLA) ratio predicts late aortic dilation and reintervention after open repair of acute type I aortic dissection. The results showed that a high MFLA ratio on the descending thoracic aorta after acute type I aortic dissection repair is associated with increased risk of late aortic reintervention and distal aortic dilation.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Hyo-Hyun Kim, Jung-Hwan Kim, Seung Hyun Lee, Kyung-Jong Yoo, Young-Nam Youn
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Hee Jung Kim, Kyung-Do Han, Wan Kee Kim, Yang Hyun Cho, Seung-Hyun Lee, Hyung Gon Je
Summary: This study evaluated the clinical benefits of the maze procedure during mitral valve surgery, and the results showed that the maze procedure can reduce the risk of death, ischemic or hemorrhagic stroke, bleeding events, and the composite outcome of interest.
Article
Infectious Diseases
Jinnam Kim, Jung Ho Kim, Hi Jae Lee, Se Ju Lee, Changhyup Kim, Jung Ah Lee, Ki Hyun Lee, Won Kyung Pyo, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Seung Hyun Lee, Jun Yong Choi, Joon-Sup Yeom
Summary: Appropriate postoperative antibiotic treatment does not have a significant effect on the recurrence, mortality, or postoperative complications in patients with infective endocarditis (IE).
Article
Biochemistry & Molecular Biology
Jung-Hwan Kim, Eui Hwa Jang, Ji-Yeon Ryu, Jiyong Lee, Jae Ho Kim, Wonhyoung Ryu, Young-Nam Youn
Summary: We investigated the effectiveness of a sirolimus-embedded silk microneedle wrap as an external vascular device for drug delivery, inhibition of neointimal hyperplasia, and vascular remodeling. In a vein graft model using dogs, the sirolimus-embedded silk MN wrap successfully delivered the drug to the intimal layer and prevented vein graft dilatation. It also inhibited neointimal hyperplasia, resulting in decreased collagen density in the intima layer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Hyo-Hyun Kim, Eun Hye Park, Seung Hyun Lee, Kyung-Jong Yoo, Young-Nam Youn
Summary: Patients with iron deficiency anemia (IDA) who were scheduled for off-pump coronary artery bypass grafting (OPCAB) were randomly assigned to receive either intravenous ferric carboxymaltose (IVFC) or placebo treatment. The IVFC treatment significantly reduced the need for red blood cell and platelet transfusions, and patients in the IVFC group had higher levels of hematologic parameters and iron concentrations after surgery. Preoperative IVFC treatment improved the values of hematologic parameters and iron bioavailability in patients with IDA undergoing OPCAB.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Jae-Kwang Shim, Kwang-Sub Kim, Pierre Couture, Andre Denault, Young-Lan Kwak, Kyung-Jong Yoo, Young-Nam Youn
Summary: Off-pump coronary surgery requires careful management of cardiac displacement and hemodynamics to avoid complications and poor outcomes. Objective hemodynamic targets, such as maintaining mean arterial pressure and venous oxygen saturation within specific ranges, must be considered before the surgery. Transesophageal echocardiography should be used to assess for any potential complications and ensure that the patient can tolerate the procedure. Careful inspection of the ascending aorta is also necessary to prevent embolism.
KOREAN JOURNAL OF ANESTHESIOLOGY
(2023)