Artemisinin-based combination therapy (ACT) and drug resistance molecular markers: A systematic review of clinical studies from two malaria endemic regions – India and sub-Saharan Africa

In vivo/ex vivo efficacy of artemether–lumefantrine and artesunate–amodiaquine as first-line treatment for uncomplicated falciparum malaria in children: an open label randomized controlled trial in Burkina Faso

(2020) Moussa Lingani et al.   MALARIA JOURNAL

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Efficacy and safety of artemisinin-based combination therapy and the implications of Pfkelch13 and Pfcoronin molecular markers in treatment failure in Senegal

(2020) Mamadou Alpha Diallo et al.   Scientific Reports

Piperaquine resistant Cambodian Plasmodium falciparum clinical isolates: in vitro genotypic and phenotypic characterization

(2020) Nonlawat Boonyalai et al.   MALARIA JOURNAL

Efficacy and safety of artesunate–amodiaquine and artemether–lumefantrine and prevalence of molecular markers associated with resistance, Guinea: an open-label two-arm randomised controlled trial

(2020) Abdoul Habib Beavogui et al.   MALARIA JOURNAL

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

(2020) Aline Uwimana et al.   NATURE MEDICINE

No evidence of amplified Plasmodium falciparum plasmepsin II gene copy number in an area with artemisinin-resistant malaria along the China–Myanmar border

(2020) Fang Huang et al.   MALARIA JOURNAL

Monitoring the Efficacy and Safety of Artemisinin-Based Combination Therapies: A Review and Network Meta-analysis of Antimalarial Therapeutic Efficacy Trials in Cameroon

(2019) Solange Whegang Youdom et al.   Drugs in research & development

Lack of convincing evidence of artemisinin resistance in India

(2019) Charlotte Rasmussen et al.   CLINICAL INFECTIOUS DISEASES

Effects and Mechanism of Action of Artemisinin on Mitochondria of Plasmodium berghei

(2019) Hong-ping Hou et al.   Chinese Journal of Integrative Medicine

Antimalarial drug resistance in Africa: the calm before the storm?

(2019) Melissa D Conrad et al.   LANCET INFECTIOUS DISEASES

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

(2019) Rob W van der Pluijm et al.   LANCET INFECTIOUS DISEASES

Triple artemisinin-containing combination anti-malarial treatments should be implemented now to delay the emergence of resistance: the case against

(2019) Sanjeev Krishna   MALARIA JOURNAL

Triple artemisinin-containing combination anti-malarial treatments should be implemented now to delay the emergence of resistance

(2019) Nicholas J. White   MALARIA JOURNAL

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Efficacy of artemisinin-based combination therapies and prevalence of molecular markers associated with artemisinin, piperaquine and sulfadoxine-pyrimethamine resistance in Sierra Leone

(2018) Samuel J. Smith et al.   ACTA TROPICA

Inactivation of Plasmepsins 2 and 3 Sensitizes Plasmodium falciparum to the Antimalarial Drug Piperaquine

(2018) Angana Mukherjee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Malaria

(2018) Elizabeth A Ashley et al.   LANCET

Efficacy and safety of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2017

(2018) Elizabeth Davlantes et al.   MALARIA JOURNAL

Efficacy and safety of artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Sudan: a systematic review and meta-analysis

(2018) Ishag Adam et al.   MALARIA JOURNAL

Drug resistance in Plasmodium

(2018) Kasturi Haldar et al.   NATURE REVIEWS MICROBIOLOGY

Impact of treatment and re-treatment with artemether-lumefantrine and artesunate-amodiaquine on selection of Plasmodium falciparum multidrug resistance gene-1 polymorphisms in the Democratic Republic of Congo and Uganda

(2018) Vito Baraka et al.   PLoS One

Evolutionary ARMS Race: Antimalarial Resistance Molecular Surveillance

(2018) Christiane Prosser et al.   TRENDS IN PARASITOLOGY

Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

(2018) Selina Bopp et al.   Nature Communications

How to combat emerging artemisinin resistance: Lessons from “The Three Little Pigs”

(2018) Thanat Chookajorn   PLoS Pathogens

Plasmodium falciparum drug resistance gene status in the Horn of Africa: A systematic review

(2018) Abdullahi Jalei Abdifatah et al.   African Journal of Pharmacy and Pharmacology

Efficacy, Safety, and Selection of Molecular Markers of Drug Resistance by Two ACTs in Mali

(2018) Abdoulaye A. Djimdé et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Absence of High Level of Duplication of the plasmepsin 2 Gene in Africa

(2018) Marie Gladys Robert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating Plasmodium falciparum malaria patients using mathematical modelling

(2018) Saber Dini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

(2018) Leila S. Ross et al.   Nature Communications

Novel pfkelch13 gene polymorphism associates with artemisinin resistance in eastern India

(2018) Sabyasachi Das et al.   CLINICAL INFECTIOUS DISEASES

Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania

(2018) Mwaka A. Kakolwa et al.   MALARIA JOURNAL

Evidence of Artemisinin-Resistant Plasmodium falciparum Malaria in Eastern India

(2018) Sabyasachi Das et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current scenario and future strategies to fight artemisinin resistance

(2018) Rahul Pasupureddy et al.   PARASITOLOGY RESEARCH

Oxidative stress in malaria and artemisinin combination therapy: Pros and Cons

(2017) Reginald A. Kavishe et al.   FEBS Journal

Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study

(2017) Roberto Amato et al.   LANCET INFECTIOUS DISEASES

A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study

(2017) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

Efficacy of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015

(2017) Mateusz M. Plucinski et al.   MALARIA JOURNAL

What happened to anti-malarial markets after the Affordable Medicines Facility-malaria pilot? Trends in ACT availability, price and market share from five African countries under continuation of the private sector co-payment mechanism

(2017) Sarah Tougher et al.   MALARIA JOURNAL

Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination

(2017) Judith Recht et al.   MALARIA JOURNAL

Profile of molecular mutations in pfdhfr, pfdhps, pfmdr1, and pfcrt genes of Plasmodium falciparum related to resistance to different anti-malarial drugs in the Bata District (Equatorial Guinea)

(2017) Pedro Berzosa et al.   MALARIA JOURNAL

Presence of quintuple dhfr N51, C59, S108 – dhps A437, K540 mutations in Plasmodium falciparum isolates from pregnant women and the general population in Nanoro, Burkina Faso

(2017) Esmée Ruizendaal et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

(2017) Benjamin Blasco et al.   NATURE MEDICINE

Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa

(2017) Feng Lu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of artesunate + sulphadoxine/pyrimethamine and artemether + lumefantrine anddhfranddhpsmutations in Somalia: evidence for updating the malaria treatment policy

(2017) Marian Warsame et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Antimalarial Drug Resistance: A Threat to Malaria Elimination

(2017) Didier Menard et al.   Cold Spring Harbor Perspectives in Medicine

Clinical and molecular monitoring of Plasmodium falciparum resistance to antimalarial drug (artesunate+sulphadoxine-pyrimethamine) in two highly malarious district of Madhya Pradesh, Central India from 2012–2014

(2017) Sweta Mishra et al.   Pathogens and Global Health

Population coverage of artemisinin-based combination treatment in children younger than 5 years with fever and Plasmodium falciparum infection in Africa, 2003–2015: a modelling study using data from national surveys

(2017) Adam Bennett et al.   Lancet Global Health

Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in Africa

(2017) Lucy C. Okell et al.   Scientific Reports

Prevalence of mutations linked to antimalarial resistance in Plasmodium falciparum from Chhattisgarh, Central India: A malaria elimination point of view

(2017) Priyanka Patel et al.   Scientific Reports

Mutational prevalence of chloroquine resistance transporter gene among Plasmodium falciparum field isolates in Assam and Arunachal Pradesh, India

(2016) J Sharma et al.   Indian Journal of Medical Microbiology

Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate–amodiaquine fixed dose combination or artemether–lumefantrine in Liberia

(2016) Sabina Dahlström Otienoburu et al.   MALARIA JOURNAL

Plasmodium falciparum: multifaceted resistance to artemisinins

(2016) Lucie Paloque et al.   MALARIA JOURNAL

A Worldwide Map ofPlasmodium falciparumK13-Propeller Polymorphisms

(2016) Didier Ménard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk of drug resistance in Plasmodium falciparum malaria therapy—a systematic review and meta-analysis

(2016) Li-Juan Zhou et al.   PARASITOLOGY RESEARCH

Monitoring antimalarial drug resistance in India via sentinel sites: outcomes and risk factors for treatment failure, 2009–2010

(2016) Neelima Mishra et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Artesunate-Amodiaquine and Artemether-Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso

(2016) Paul Sondo et al.   PLoS One

Surveillance of Artemisinin Resistance in Plasmodium falciparum in India Using the kelch13 Molecular Marker

(2015) Neelima Mishra et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Emergence of sulfadoxine–pyrimethamine resistance in Indian isolates of Plasmodium falciparum in the last two decades

(2015) Amit Kumar et al.   INFECTION GENETICS AND EVOLUTION

Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial

(2015) Adoke Yeka et al.   JOURNAL OF INFECTIOUS DISEASES

Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola

(2015) Kinanga Kiaco et al.   MALARIA JOURNAL

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Treatment of uncomplicated malaria with artesunate plus sulfadoxine-pyrimethamine is failing in Somalia: evidence from therapeutic efficacy studies andPfdhfrandPfdhpsmutant alleles

(2015) Marian Warsame et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Double Mutation in thepfmdr1Gene Is Associated with Emergence of Chloroquine-Resistant Plasmodium falciparum Malaria in Eastern India

(2014) Sabyasachi Das et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role ofPfmdr1inIn VitroPlasmodium falciparum Susceptibility to Chloroquine, Quinine, Monodesethylamodiaquine, Mefloquine, Lumefantrine, and Dihydroartemisinin

(2014) Nathalie Wurtz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis

(2014) Ric N Price et al.   LANCET INFECTIOUS DISEASES

Declining efficacy of artesunate plus sulphadoxine-pyrimethamine in northeastern India

(2014) Neelima Mishra et al.   MALARIA JOURNAL

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

High Prevalence of Asymptomatic Malaria in a Tribal Population in Eastern India

(2013) S. Ganguly et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A clinical and molecular study of artesunate + sulphadoxine-pyrimethamine in three districts of central and eastern India

(2013) Prakriti Srivastava et al.   MALARIA JOURNAL

Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan

(2013) Nahla B Gadalla et al.   MALARIA JOURNAL

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

(2013) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping ‘partially resistant’, ‘fully resistant’, and ‘super resistant’ malaria

(2013) Inbarani Naidoo et al.   TRENDS IN PARASITOLOGY

Antidogmatic approaches to artemisinin resistance: reappraisal as treatment failure with artemisinin combination therapy

(2013) Sanjeev Krishna et al.   TRENDS IN PARASITOLOGY

Comparative Efficacies of Artemisinin Combination Therapies in Plasmodium falciparum Malaria and Polymorphism ofpfATPase6,pfcrt,pfdhfr, andpfdhpsGenes in Tea Gardens of Jalpaiguri District, India

(2012) Pabitra Saha et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lack of Association of the S769N Mutation in Plasmodium falciparum SERCA (PfATP6) with Resistance to Artemisinins

(2012) Long Cui et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia

(2012) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Endoplasmic Reticulum PI(3)P Lipid Binding Targets Malaria Proteins to the Host Cell

(2012) Souvik Bhattacharjee et al.   CELL

Plasmodium falciparum Drug Resistance Phenotype as Assessed by Patient Antimalarial Drug Levels and Its Association With pfmdr1 Polymorphisms

(2012) Maja Malmberg et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy of artemether-lumefantrine in treatment of malaria among under-fives and prevalence of drug resistance markers in Igombe-Mwanza, north-western Tanzania

(2012) Erasmus Kamugisha et al.   MALARIA JOURNAL

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Increasedpfmdr1Copy Number and Sequence Polymorphisms in Plasmodium falciparum Isolates from Sudanese Malaria Patients Treated with Artemether-Lumefantrine

(2011) Nahla B. Gadalla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy and Effectiveness of Artemether-Lumefantrine after Initial and Repeated Treatment in Children < 5 Years of Age with Acute Uncomplicated Plasmodium falciparum Malaria in Rural Tanzania: A Randomized Trial

(2011) B. E. Ngasala et al.   CLINICAL INFECTIOUS DISEASES

Prolonged Selection of pfmdr1 Polymorphisms After Treatment of Falciparum Malaria With Artemether-Lumefantrine in Uganda

(2011) Frederick N. Baliraine et al.   JOURNAL OF INFECTIOUS DISEASES

Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study

(2011) Billy E Ngasala et al.   MALARIA JOURNAL

High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

(2011) Ghyslain Mombo-Ngoma et al.   MALARIA JOURNAL

Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

(2010) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selection of Known Plasmodium falciparum Resistance-Mediating Polymorphisms by Artemether-Lumefantrine and Amodiaquine- Sulfadoxine-Pyrimethamine but Not Dihydroartemisinin- Piperaquine in Burkina Faso

(2010) A. F. Some et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phosphatidylinositol 3-Phosphate, an Essential Lipid in Plasmodium, Localizes to the Food Vacuole Membrane and the Apicoplast

(2010) Lina Tawk et al.   EUKARYOTIC CELL

Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations

(2010) Sankar Sridaran et al.   MALARIA JOURNAL

Molecular Correlates of High-Level Antifolate Resistance in Rwandan Children with Plasmodium falciparum Malaria

(2009) C. Karema et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

(2009) P. A. Moura et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery, mechanisms of action and combination therapy of artemisinin

(2009) Liwang Cui et al.   Expert Review of Anti-Infective Therapy

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE

Selection of Plasmodium falciparum Multidrug Resistance Gene 1 Alleles in Asexual Stages and Gametocytes by Artemether-Lumefantrine in Nigerian Children with Uncomplicated Falciparum Malaria

(2008) C. T. Happi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE