Review
Biochemistry & Molecular Biology
Senhua Chen, Runlin Cai, Zhaoming Liu, Hui Cui, Zhigang She
Summary: This review summarizes the discoveries of new metabolites isolated from mangrove-associated fungi over the past thirty years, focusing on the bioactivity and unique chemical diversity of these natural products.
NATURAL PRODUCT REPORTS
(2022)
Article
Microbiology
Martin Muthee Gakuubi, Kuan Chieh Ching, Madhaiyan Munusamy, Mario Wibowo, Zhao-Xun Liang, Yoganathan Kanagasundaram, Siew Bee Ng
Summary: This study investigated the diversity, antimicrobial, and cytotoxic activities of fungal endophytes obtained from different habitats in Singapore. The majority of the identified strains belonged to the phylum Ascomycota, and the most dominant genus was Colletotrichum. Chemical elicitation and variation of fermentation media led to the discovery of more bioactive strains. Active constituents were isolated and characterized, including a known compound and five novel compounds. These compounds showed strong antifungal and antiproliferative activities.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Infectious Diseases
Rafael Conrado, Tainah Colombo Gomes, Gabriella Sales Calaco Roque, Ana Olivia De Souza
Summary: This review discusses the importance of microorganisms as sources of natural compounds, particularly in pharmaceutical applications, and presents examples of bioactive secondary metabolites produced by fungi with pharmacological effects.
Article
Chemistry, Medicinal
Bo Peng, Jian Cai, Zimin Xiao, Manli Liu, Xinlong Li, Bin Yang, Wei Fang, Yi-You Huang, Chunmei Chen, Xuefeng Zhou, Huaming Tao
Summary: A chemical investigation of two fungi strains derived from the Beibu Gulf led to the discovery of 23 natural products, including two polyketide derivatives and three hydroxyphenylacetic acid derivatives. The structures were determined through NMR and MS analyses, and the absolute configurations were established through ECD calculation. The compounds exhibited various bioactivities, including antifungal and cytotoxic effects, as well as inhibition of PDE4 and AChE.
Review
Biochemistry & Molecular Biology
Yuanwei Liu, Kishneth Palaniveloo, Siti Aisyah Alias, Jaya Seelan Sathiya Seelan
Summary: Soft corals host a variety of marine fungi that produce chemically diverse, bioactive secondary metabolites, with terpenoids and indole alkaloids being the most common. Research has shown that these symbiotic relationships hold significant potential for future studies.
Article
Plant Sciences
Kathawut Sopalun, Wanpen Laosripaiboon, Anyalak Wachirachaikarn, Siriluck Iamtham
Summary: The study isolated and identified endophytic fungi from mangrove plants, showing their potential bioactivity including antifungal, antioxidant, and antimutagenic activities. The results indicated that mangrove plants harbor a rich source of fungal endophytes with diverse bioactivity.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Review
Food Science & Technology
Dan Xu, Mengyao Xue, Zhen Shen, Xiaowei Jia, Xuwen Hou, Daowan Lai, Ligang Zhou
Summary: Fungal phytotoxic secondary metabolites are toxic substances produced by fungi through biochemical reactions, with a high level of diversity in their properties. These metabolites are mainly isolated from phytopathogenic fungal species, with aromatic polyketides and sesquiterpenoids being the main phytotoxic compounds.
Article
Chemistry, Applied
Zhiyong Xu, Bingxue Xiong, Jing Xu
Summary: Chemical investigation of the endophytic fungus Phyllosticta capitalensis isolated from the hypocotyls of the Chinese mangrove Bruguiera sexangula led to the isolation of eight known secondary metabolites, whose structures were elucidated and subjected to antimicrobial and cytotoxic activities evaluation. This is the first report of these compounds being isolated from this fungal species.
NATURAL PRODUCT RESEARCH
(2021)
Article
Agronomy
Muhammad Musa, Farzana Gul Jan, Muhammad Hamayun, Gul Jan, Sumera Afzal Khan, Gauhar Rehman, Sajid Ali, In-Jung Lee
Summary: Heavy metal contamination in soil and accumulation in plants pose a serious threat to crops and human health. Endophytic fungi can enhance the plant's ability to tolerate stressful conditions. The present study found that the endophytic fungus Paecilomyces lilacinus (MRF) isolated from the roots of Justicia adathoda has the capability to alleviate heavy metal stress and improve the growth and physiological characteristics of tomatoes.
Review
Biochemistry & Molecular Biology
Xiaolin Li, Huayan Xu, Yuyue Li, Shengrong Liao, Yonghong Liu
Summary: The increasing number of unique secondary metabolites from marine microorganisms has attracted the interest of natural product chemists. Cultivating microorganisms in co-culture is a promising strategy for enhancing chemical diversity and discovering novel metabolites. This review focuses on marine-derived co-culture microorganisms, selection and fermentation methods, screening approaches, and the challenges and prospects of co-culture.
Review
Microbiology
Tang-Chang Xu, Yi-Han Lu, Jun-Fei Wang, Zhi-Qiang Song, Ya-Ge Hou, Si-Si Liu, Chuan-Sheng Liu, Shao-Hua Wu
Summary: The genus Diaporthe and its anamorph Phomopsis are widely distributed worldwide and are considered potential sources for diverse bioactive metabolites. Most species are plant pathogens or endophytes, and studies have found a large number of bioactive secondary metabolites from these genera, with activities such as cytotoxic, antibacterial, and antioxidant properties. Polyketides are the most common chemical group, comprising 64% of the compounds.
Article
Microbiology
Kumaravel Kaliaperumal, Limbadri Salendra, Yonghong Liu, Zhiran Ju, Sunil Kumar Sahu, Sanniyasi Elumalai, Kumaran Subramanian, Nahaa M. Alotaibi, Nawaf Alshammari, Mohd Saeed, Rohini Karunakaran
Summary: Fungus-derived secondary metabolites have biomedical potential and chemical diversity. Mining endophytic fungi for drug candidates is an ongoing process. In this study, seven secondary metabolites were extracted from endophytic fungi derived from a sponge and subjected to characterization and bioactivity screening. One of the compounds, averufin (1), displayed strong anticancer activity.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Yuyou Luo, Xiongming Luo, Tong Zhang, Siyuan Li, Shuping Liu, Yuxin Ma, Zongming Wang, Xiaobao Jin, Jing Liu, Xin Wang
Summary: Mangroves are unique ecosystems with abundant resources, and fungi in these ecosystems play an important role. Many secondary metabolites derived from mangrove fungi have potential anti-tumor effects, making them promising sources for the search of novel anti-cancer drugs. This review summarizes 110 anti-tumor secondary metabolites from 39 mangrove fungal strains collected from the South China Sea between 2016 and 2022. Information on their sources, unique structures, and cytotoxicity qualities is provided, making this review a valuable resource for further development.
BIOENGINEERING-BASEL
(2022)
Review
Plant Sciences
Neveen Atta Elhamouly, Omar A. Hewedy, Amr Zaitoon, Angelica Miraples, Omnia T. Elshorbagy, Suzan Hussien, Amira El-Tahan, Deliang Peng
Summary: The global environment is influenced by various secondary metabolites, produced by plants and microorganisms, which have diverse chemical properties and play significant roles in plant disease control and growth promotion. Fungal secondary metabolites are particularly important in this regard.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biodiversity Conservation
Muhamad Naim Abd Malek, Fabrizio Frontalini, Khairun Yahya, Anita Talib, Latiffah Zakaria
Summary: This study integrates information on benthic foraminifera from Malaysian mangroves, revealing a total of 223 species, which is relatively high compared to global mangrove records but comparatively low compared to other shallow and deep-water environments. The results provide new insight into benthic foraminiferal diversity in mangroves and can be used as baseline data for monitoring and implementing conservation and restoration plans.
BIODIVERSITY AND CONSERVATION
(2021)