The Dynamic Roles of the Inner Membrane Complex in the Multiple Stages of the Malaria Parasite

A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium

(2020) Xu Wang et al.   EMBO JOURNAL

Molecular Characterization and Immuno-Reactivity Patterns of a Novel Plasmodium falciparum Armadillo-Type Repeat Protein, PfATRP

(2020) Emmanuel Amlabu et al.   Frontiers in Cellular and Infection Microbiology

Critical Steps of Plasmodium falciparum Ookinete Maturation

(2020) Giulia Siciliano et al.   Frontiers in Microbiology

Identifying and combating the impacts of COVID-19 on malaria

(2020) Stephen J. Rogerson et al.   BMC Medicine

The potential public health consequences of COVID-19 on malaria in Africa

(2020) Ellie Sherrard-Smith et al.   NATURE MEDICINE

Three-dimensional ultrastructure of Plasmodium falciparum throughout cytokinesis

(2020) Rachel M. Rudlaff et al.   PLoS Pathogens

Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum

(2020) Thomas C. A. Blake et al.   PLoS Pathogens

Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

(2020) Dihia Moussaoui et al.   eLife

Structural role of essential light chains in the apicomplexan glideosome

(2020) Samuel Pazicky et al.   Communications Biology

An essential contractile ring protein controls cell division in Plasmodium falciparum

(2019) Rachel M. Rudlaff et al.   Nature Communications

Plasmodium myosin A drives parasite invasion by an atypical force generating mechanism

(2019) Julien Robert-Paganin et al.   Nature Communications

Toxoplasma F-box protein 1 is required for daughter cell scaffold function during parasite replication

(2019) Carlos Gustavo Baptista et al.   PLoS Pathogens

Distinct Functional Contributions by the Conserved Domains of the Malaria Parasite Alveolin IMC1h

(2019) Michael P. Coghlan et al.   Frontiers in Cellular and Infection Microbiology

The apical annuli of Toxoplasma gondii are composed of coiled‐coil and signalling proteins embedded in the inner membrane complex sutures

(2019) Klemens Engelberg et al.   CELLULAR MICROBIOLOGY

The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress

(2018) Abigail J. Perrin et al.   mBio

Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection

(2018) Nicanor Obaldia et al.   mBio

A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy

(2018) Rebecca S. Lee et al.   Nature Communications

A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection

(2018) Gigliola Zanghì et al.   Cell Reports

Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow

(2018) Mariana De Niz et al.   Science Advances

ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility

(2018) Han Gao et al.   CURRENT BIOLOGY

Inner membrane complex 1l protein of Plasmodium falciparum links membrane lipids with cytoskeletal element ‘actin’ and its associated motor ‘myosin’

(2018) Vikash Kumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Compositional and expression analyses of the glideosome during thePlasmodiumlife cycle reveal an additional myosin light chain required for maximum motility

(2017) Judith L. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study

(2017) Mallika Imwong et al.   LANCET INFECTIOUS DISEASES

The Plasmodium alveolin IMC1a is stabilised by its terminal cysteine motifs and facilitates sporozoite morphogenesis and infectivity in a dose-dependent manner

(2017) Fatimah S. Al-Khattaf et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Palmitoylation of Plasmodium alveolins promotes cytoskeletal function

(2017) Annie Z. Tremp et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A genetic system to study Plasmodium falciparum protein function

(2017) Jakob Birnbaum et al.   NATURE METHODS

Myosin-dependent cell-cell communication controls synchronicity of division in acute and chronic stages of Toxoplasma gondii

(2017) Karine Frénal et al.   Nature Communications

Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development

(2017) Ekta Saini et al.   Scientific Reports

Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae

(2017) Elena Gómez-Díaz et al.   Scientific Reports

Plasmodium Sporozoite Biology

(2017) Friedrich Frischknecht et al.   Cold Spring Harbor Perspectives in Medicine

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development

(2017) Molly Parkyn Schneider et al.   PLoS Pathogens

A MORN1-associated HAD phosphatase in the basal complex is essential forToxoplasma gondiidaughter budding

(2016) Klemens Engelberg et al.   CELLULAR MICROBIOLOGY

The development of malaria parasites in the mosquito midgut

(2016) Sandra Bennink et al.   CELLULAR MICROBIOLOGY

Study ofPlasmodium falciparumDHHC palmitoyl transferases identifies a role for PfDHHC9 in gametocytogenesis

(2016) Chwen L. Tay et al.   CELLULAR MICROBIOLOGY

Palmitoyl transferases have critical roles in the development of mosquito and liver stages ofPlasmodium

(2016) Christine S. Hopp et al.   CELLULAR MICROBIOLOGY

Pellicle formation in the malaria parasite

(2016) Maya Kono et al.   JOURNAL OF CELL SCIENCE

The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites

(2016) Kartik S. Bane et al.   PLoS Pathogens

Commit and Transmit: Molecular Players in Plasmodium Sexual Development and Zygote Differentiation

(2015) David S. Guttery et al.   TRENDS IN PARASITOLOGY

Novel Components of the Toxoplasma Inner Membrane Complex Revealed by BioID

(2015) Allan L. Chen et al.   mBio

The Plasmodium palmitoyl-S-acyl-transferase DHHC2 is essential for ookinete morphogenesis and malaria transmission

(2015) Jorge M. Santos et al.   Scientific Reports

A Novel Bipartite Centrosome Coordinates the Apicomplexan Cell Cycle

(2015) Elena S. Suvorova et al.   PLOS BIOLOGY

Genome-Wide Identification of the Target Genes of AP2-O, a Plasmodium AP2-Family Transcription Factor

(2015) Izumi Kaneko et al.   PLoS Pathogens

Characterization ofPlasmodiumdevelopmental transcriptomes inAnopheles gambiaemidgut reveals novel regulators of malaria transmission

(2014) Karolina A. Akinosoglou et al.   CELLULAR MICROBIOLOGY

Calcium dynamics ofPlasmodium bergheisporozoite motility

(2014) Allison F. Carey et al.   CELLULAR MICROBIOLOGY

Identification and characterization ofToxoplasma SIP, a conserved apicomplexan cytoskeleton protein involved in maintaining the shape, motility and virulence of the parasite

(2014) Gaelle Lentini et al.   CELLULAR MICROBIOLOGY

The inner membrane complex through development ofToxoplasma gondiiandPlasmodium

(2014) Clare R. Harding et al.   CELLULAR MICROBIOLOGY

The Role of Palmitoylation for Protein Recruitment to the Inner Membrane Complex of the Malaria Parasite

(2014) Johanna Wetzel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of the Toxoplasma gondii inner membrane complex

(2014) Dinkorma T. Ouologuem et al.   JOURNAL OF CELL SCIENCE

Plasmodium alveolins possess distinct but structurally and functionally related multi-repeat domains

(2014) Fatimah S. Al-Khattaf et al.   PARASITOLOGY RESEARCH

Distinct temporal recruitment of Plasmodium alveolins to the subpellicular network

(2014) Annie Z. Tremp et al.   PARASITOLOGY RESEARCH

Plasmodium falciparum transmission stages accumulate in the human bone marrow

(2014) R. Joice et al.   Science Translational Medicine

Structure ofToxoplasma gondiifructose-1,6-bisphosphate aldolase

(2014) Lauren E. Boucher et al.   Acta Crystallographica Section F-Structural Biology Communications

Electron tomography ofPlasmodium falciparummerozoites reveals core cellular events that underpin erythrocyte invasion

(2013) Eric Hanssen et al.   CELLULAR MICROBIOLOGY

Characterization of Tt ALV2, an Essential Charged Repeat Motif Protein of the Tetrahymena thermophila Membrane Skeleton

(2013) Houda El-Haddad et al.   EUKARYOTIC CELL

Morphogenesis ofPlasmodiumzoites is uncoupled from tensile strength

(2013) Annie Z. Tremp et al.   MOLECULAR MICROBIOLOGY

Global Analysis of Apicomplexan Protein S-Acyl Transferases Reveals an Enzyme Essential for Invasion

(2013) Karine Frénal et al.   TRAFFIC

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes

(2013) David T. Riglar et al.   Nature Communications

The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays

(2013) Will J. R. Stone et al.   Scientific Reports

A Toxoplasma Palmitoyl Acyl Transferase and the Palmitoylated Armadillo Repeat Protein TgARO Govern Apical Rhoptry Tethering and Reveal a Critical Role for the Rhoptries in Host Cell Invasion but Not Egress

(2013) Josh R. Beck et al.   PLoS Pathogens

Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite

(2013) B. Poulin et al.   Biology Open

Structural basis for chirality and directional motility ofPlasmodiumsporozoites

(2012) Mikhail Kudryashev et al.   CELLULAR MICROBIOLOGY

Targeted proteomic dissection ofToxoplasmacytoskeleton sub-compartments using MORN1

(2012) Alexander Lorestani et al.   Cytoskeleton

Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes

(2012) M. K. Dearnley et al.   JOURNAL OF CELL SCIENCE

Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

(2012) Ashley M. Vaughan et al.   JOURNAL OF CLINICAL INVESTIGATION

Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum

(2012) Jürgen Bosch et al.   JOURNAL OF STRUCTURAL BIOLOGY

Toxoplasma ISP4 is a central IMC Sub-compartment Protein whose localization depends on palmitoylation but not myristoylation

(2012) Connie Fung et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Evolution and Architecture of the Inner Membrane Complex in Asexual and Sexual Stages of the Malaria Parasite

(2012) M. Kono et al.   MOLECULAR BIOLOGY AND EVOLUTION

Subcellular Location, Phosphorylation and Assembly into the Motor Complex of GAP45 during Plasmodium falciparum Schizont Development

(2012) Mohd A. Mohd Ridzuan et al.   PLoS One

The Alveolin IMC1h Is Required for Normal Ookinete and Sporozoite Motility Behaviour and Host Colonisation in Plasmodium berghei

(2012) Katrin Volkmann et al.   PLoS One

Shape-shifting gametocytes: how and why does P. falciparum go banana-shaped?

(2012) Matthew W.A. Dixon et al.   TRENDS IN PARASITOLOGY

Shedding of TRAP by a Rhomboid Protease from the Malaria Sporozoite Surface Is Essential for Gliding Motility and Sporozoite Infectivity

(2012) Ijeoma Ejigiri et al.   PLoS Pathogens

Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum

(2011) María J López-Barragán et al.   BMC GENOMICS

Stage-specific depletion of myosin A supports an essential role in motility of malarial ookinetes

(2011) Inga Siden-Kiamos et al.   CELLULAR MICROBIOLOGY

Organelle segregation into Plasmodium liver stage merozoites

(2011) Rebecca R. Stanway et al.   CELLULAR MICROBIOLOGY

Malaria proteases mediate inside-out egress of gametocytes from red blood cells following parasite transmission to the mosquito

(2011) Ludmilla Sologub et al.   CELLULAR MICROBIOLOGY

Tracking Glideosome-Associated Protein 50 Reveals the Development and Organization of the Inner Membrane Complex of Plasmodium falciparum

(2011) Jeffrey A. Yeoman et al.   EUKARYOTIC CELL

Functional Dissection of the Apicomplexan Glideosome Molecular Architecture

(2010) Karine Frénal et al.   Cell Host & Microbe

Metamorphosis of the malaria parasite in the liver is associated with organelle clearance

(2010) Bamini Jayabalasingham et al.   CELL RESEARCH

Malaria parasites form filamentous cell-to-cell connections during reproduction in the mosquito midgut

(2010) Ingrid Rupp et al.   CELL RESEARCH

A Toxoplasma MORN1 Null Mutant Undergoes Repeated Divisions but Is Defective in Basal Assembly, Apicoplast Division and Cytokinesis

(2010) Alexander Lorestani et al.   PLoS One

A Novel Family of Toxoplasma IMC Proteins Displays a Hierarchical Organization and Functions in Coordinating Parasite Division

(2010) Josh R. Beck et al.   PLoS Pathogens

Plasmodium Sporozoite Motility Is Modulated by the Turnover of Discrete Adhesion Sites

(2009) Sylvia Münter et al.   Cell Host & Microbe

Positioning of large organelles by a membrane- associated cytoskeleton inPlasmodiumsporozoites

(2009) Mikhail Kudryashev et al.   CELLULAR MICROBIOLOGY

A Novel Family of Apicomplexan Glideosome-associated Proteins with an Inner Membrane-anchoring Role

(2009) Hayley E. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Types of Ca2+ Release Channels Participate in the Secretory Cycle of Paramecium Cells

(2009) E.-M. Ladenburger et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum

(2009) Guangan Hu et al.   NATURE BIOTECHNOLOGY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

MORN1 Has a Conserved Role in Asexual and Sexual Development across the Apicomplexa

(2008) David J. P. Ferguson et al.   EUKARYOTIC CELL

IMC1b Is a Putative Membrane Skeleton Protein Involved in Cell Shape, Mechanical Strength, Motility, and Infectivity of Malaria Ookinetes

(2008) Annie Z. Tremp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alveolins, a New Family of Cortical Proteins that Define the Protist Infrakingdom Alveolata

(2008) S. B. Gould et al.   MOLECULAR BIOLOGY AND EVOLUTION

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH

Organizational Changes of the Daughter Basal Complex during the Parasite Replication of Toxoplasma gondii

(2008) Ke Hu   PLoS Pathogens