Article
Dentistry, Oral Surgery & Medicine
Ying Wu, Hao Xu, Yufeng Wang, Chunlei Li, Guoyao Tang, Hong Hua, Xiaoying Li, Xin Jin, Xin Zeng, Yu Zhou, Qianming Chen
Summary: An improved scoring system for oral lichen planus (OLP), called RHU scoring system, was designed to accurately and sensitively reflect the severity of the disease. It has the potential to be widely used.
Review
Dentistry, Oral Surgery & Medicine
Sreedevi P. Unnikrishnan, Edward Rampersaud, Alice Mcgee, Maggie E. Cruickshank, Rasha Abu-Eid, Karolin Hijazi
Summary: This systematic review identified 11 clinical severity scoring systems for oral lichen planus that have undergone validity or reliability testing, with the most reported being the Thongprasom score, the ODSS, and the REU scoring systems. However, clinical scoring systems for extraoral mucosal lichen planus have not been validated or reliability tested extensively.
Review
Biochemistry & Molecular Biology
Marijana Vicic, Nika Hlaca, Marija Kastelan, Ines Brajac, Vlatka Sotosek, Larisa Prpic Massari
Summary: Lichen planus is a chronic disease that affects the skin, appendages, and mucous membranes. The etiology of the disease is not fully understood, but immune-mediated mechanisms are recognized, with genetic susceptibility and environmental factors playing a role. The immunopathogenesis involves cell-mediated cytotoxicity, particularly cytotoxic T lymphocytes, along with the involvement of other immune cells and inflammatory pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Alberto Deganello, Alberto Paderno, Riccardo Morello, Milena Fior, Giulia Berretti, Francesca Del Bon, Marco Alparone, Elena Bardellini, Alessandra Majorana, Piero Nicolai
Summary: Oral lichen planus (OLP) is a chronic mucocutaneous immune-mediated disease that affects 1% to 4% of the worldwide population. A study aimed to assess the diagnostic potential of narrow band imaging (NBI) in OLP patients, specifically focusing on identifying high-grade dysplasia/carcinoma in newly developed lesions. The findings showed that HD-NBI had optimal overall diagnostic potential with high sensitivity and specificity for detecting high-grade dysplasia/carcinoma in OLP patients.
Article
Dentistry, Oral Surgery & Medicine
Honglin Liao, Yuxue Luo, Li Long, Jiakuan Peng, Xuemei Qiu, Peiyang Yuan, Hao Xu, Lu Jiang
Summary: The study found that anxiety levels were higher in OLP patients compared to healthy individuals, with female patients showing higher levels of anxiety. Gender had an impact on anxiety levels among OLP patients. The research suggests that OLP patients can be classified into weakly anxiety-related or highly anxiety-related types.
Review
Dentistry, Oral Surgery & Medicine
Asma El-Howati, Martin H. Thornhill, Helen E. Colley, Craig Murdoch
Summary: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa. The mechanisms of pathogenesis are still not fully understood, but evidence suggests a chronic, dysregulated immune response leading to increased expression of cytokines, chemokines, and adhesion molecules. CD8+ cytotoxic and CD4+ Th1 polarised T cells are the main lymphocytes involved, but recent evidence indicates the involvement of other T cell subsets.
Review
Dermatology
Raul E. Ruiz-Lozano, Julio C. Hernandez-Camarena, Jorge E. Valdez-Garcia, Mariana Roman-Zamudio, Monica Herrera-Rodriguez, Daniela Andrade-Carrillo, Lucas A. Garza-Garza, Jesus A. Cardenas-de la Garza
Summary: Ocular involvement of lichenoid dermatoses, although rare, can lead to serious complications if left untreated. Dermatologists should be vigilant in recognizing eye symptoms and refer patients to ophthalmologists promptly to prevent blinding complications.
DERMATOLOGIC THERAPY
(2021)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Heyu Zhang, Tiejun Li
Summary: This study investigated the association between oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in a retrospective cohort of 3568 patients. The findings suggest that not all cases of OSCC are transformed from OLP, indicating that the previous understanding of OLP transformation may have been overestimated. Strict diagnostic criteria for OLP and close surveillance are important in correctly identifying the origin of OSCC and avoiding overestimation of the risk of OLP transformation.
Article
Oncology
Katharina Theresa Obermeier, Sabina Noreen Wuersching, Paris Liokatis, Wenko Smolka, Philipp Poxleitner, Christin Kleye, Michael Ehrenfeld, Maximilian Kollmuss, Sven Otto
Summary: Oral lichen ruber planus (OLP) is a chronic inflammatory disease of the oral mucosa that can progress to oral squamous cell carcinoma (OSCC) in a small percentage of cases. Surgical treatment, including tumor resection and neck dissection, is recommended. This study examined 103 OLP patients and compared their lymph node metastasis and survival rates with a group of OSCC patients without OLP. The analysis showed that patients with OLP had a significantly lower risk of lymph node metastasis compared to those without OLP.
Article
Dentistry, Oral Surgery & Medicine
Rakefet Czerninski, Zinat Awadieh, Svetlana Feldman, Naama Keshet, Abraham Zlotogorski, Yuval Ramot
Summary: This study describes familial OLP in 20 families, predominantly Jewish. The high prevalence of hypothyroidism and oral squamous cell carcinoma in familial OLP patients suggests a potential predisposition to malignant transformation in this high-risk group.
Article
Immunology
Qionghua Li, Fei Wang, Yujie Shi, Liang Zhong, Shumin Duan, Wenjing Kuang, Na Liu, En Luo, Yu Zhou, Lu Jiang, Hongxia Dan, Xiaobo Luo, Dunfang Zhang, Qianming Chen, Xin Zeng, Taiwen Li
Summary: This study characterized the mucosal immune microenvironment of oral lichen planus (OLP) using single-cell RNA sequencing and immune repertoire sequencing. Activated tissue-resident memory CD8+ T cells were found in OLP tissues, along with clonal expansion of T cell receptor repertoires and BCR clonal expansion. Fibroblasts were identified as potential promoters of immune cell recruitment into connective tissue in OLP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yunshan Li, Yaodong He, Junwei Xiang, Linfei Feng, Yuanyin Wang, Ran Chen
Summary: Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), play important regulatory roles in eukaryotes by post-transcriptionally inhibiting gene expression. The role and mechanisms of miRNAs in oral lichen planus (OLP) are still unclear, but they show potential as biomarkers for OLP diagnosis and therapeutic targets.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Cristovao Antunes de lanna, Beatriz Nascimento Monteiro da Silva, Andreia Cristina de Melo, Martin H. Bonamino, Lisia Daltro Borges Alves, Luis Felipe Ribeiro Pinto, Abel Silveira Cardoso, Heliton Spindola Antunes, Mariana Boroni, Daniel Cohen Goldemberg
Summary: By comparing the gene expression profiles of Oral Lichen Planus and Oral Squamous Cell Carcinoma, similarities were found in processes such as keratinization, cell proliferation, and immune response. Key tumor suppressors and oncogenes were dysregulated in both diseases.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
M. Contaldo, R. Grassi, F. Fiori, G. M. Nardi, R. Borgia, A. Romano, R. Serpico, M. Petruzzi
Summary: Oral Lichen planus is an immune-mediated disease with unknown causes that affects the oral mucous. Human papillomavirus infection may be correlated with Oral Lichen Planus.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Lara Marie DeAngelis, Nicola Cirillo, Alexis Perez-Gonzalez, Michael McCullough
Summary: This study used multiplex immunohistochemistry (mIHC) to investigate the presence and abundance of mucosal-associated invariant T (MAIT) cells in oral lichen planus (OLP) tissue samples, as well as their relationship with Candida infection and symptoms. The results showed the presence of MAIT cell phenotypes in OLP tissue, with significant differences in the percentage of positive cells between different OLP groups. The relative abundance of triple-stained cells also varied significantly. Reduced percentage of certain cells was observed in symptomatic OLP with and without Candida, suggesting a potential role of these cells in OLP pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mahmoud Ahmed Elhadad, Yasmine Gaweesh
Article
Dentistry, Oral Surgery & Medicine
Hossam H. Elsabagh, Eglal Moussa, Sabah A. Mahmoud, Rasha O. Elsaka, Hams Abdelrahman
Article
Dentistry, Oral Surgery & Medicine
Abdelsalam Th Elaskary, Yasmine Y. Gaweesh, Moataz Maebed, Sang-Choon Cho, Maha El Tantawi
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Shaimaa A. Muhamed, Eglal M. Moussa, Noha K. Aboasy, Yasmin Y. Gaweesh
Summary: This study evaluated the effectiveness of a topical sialogogue spray containing 1% malic acid in treating xerostomia in patients with type 2 diabetes mellitus. The results showed that the spray significantly increased the unstimulated salivary flow rate and alleviated the symptoms of xerostomia in these patients.
Article
Dentistry, Oral Surgery & Medicine
Mohamed El Khalifa, M. Abu el Sadat, Youssria S. Gaweesh, Yasmine Y. Gaweesh
Summary: The purpose of this study was to assess the accuracy and repeatability of CBCT for measuring gingival thickness and its correlation with labial bone defects. The results showed that CBCT demonstrated high diagnostic accuracy and minimal discrepancies compared to transgingival probing. Additionally, the presence of dehiscence and fenestration defects was positively correlated with thin gingival phenotype.
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Abdelsalam Th Elaskary, Yasmine Y. Gaweesh, Maha El Tantawi, Moataz A. Maebed
Summary: The study showed that vestibular socket therapy in compromised fresh extraction sockets in the esthetic zone led to successful implant placement with improved bone height and thickness, as well as favorable esthetic and periodontal outcomes. The 6-day protocol effectively eliminated infection and prepared sockets for implant placement, reducing treatment time and surgical interventions.
INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
(2021)