Journal
CELL REPORTS
Volume 34, Issue 1, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2020.108601
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Funding
- National Institutes of Health (NIH) [R01 CA225680, R01 AG047156, R01 AI112844, R01 AI147394]
- Center for Biomedical Discovery at Mayo Clinic [93059065]
- NIH [U24DK100469]
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The study revealed that proliferating B cells require monounsaturated fatty acids to maintain metabolism and activity, supporting immune responses. Stearoyl-CoA desaturase-mediated production of monounsaturated fatty acids is crucial for humoral immunity.
Immune cells can metabolize glucose, amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain mitochondrial metabolism and mTOR activity and to prevent excessive autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.
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