Article
Clinical Neurology
Ingrid Jullian-Desayes, Wojciech Trzepizur, Jerome Boursier, Marie Joyeux-Faure, Sebastien Bailly, Meriem Benmerad, Marc Le Vaillant, Sandrine Jaffre, Thierry Pigeanne, Acya Bizieux-Thaminy, Marie-Pierre Humeau, Claire Alizon, Francois Goupil, Charlotte Costentin, Jonathan Gaucher, Renaud Tamisier, Frederic Gagnadoux, Jean-Louis Pepin
Summary: This study investigated the association between liver damage and the severity of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) using individual participant data meta-analysis. The results confirmed a strong association between OSA severity and liver steatosis, with the relationship between OSA and fibrosis mainly attributed to BMI as shown by causal mediation analysis.
Review
Clinical Neurology
Yet H. Khor, Christopher J. Ryerson, Shane A. Landry, Mark E. Howard, Thomas J. Churchward, Bradley A. Edwards, Garun S. Hamilton, Simon A. Joosten
Summary: Obstructive sleep apnea is a common comorbidity in patients with interstitial lung disease, and its significance in health outcomes is increasingly recognized. The relationship between ILD and OSA is complex and bidirectional, with multiple mechanisms potentially contributing to their pathogenic and physiologic links. This review synthesizes current evidence and hypotheses on the interactions between ILD and OSA, emphasizing the epidemiological, pathogenic, and pathophysiological aspects of their relationship.
SLEEP MEDICINE REVIEWS
(2021)
Review
Microbiology
Andras Bikov, Silvano Dragonieri, Balazs Csoma, Carmen Mazzuca, Panaiotis Finamore, Giulia Rocchi, Lorenza Putignani, Michele Guarino, Simone Scarlata
Summary: The bacteria in the human body, especially the gut microbiome, play an important role in respiratory diseases such as bronchial asthma, chronic obstructive pulmonary disease, and obstructive sleep apnea. This article summarizes the evidence and discusses the impact of altered gut microbiome on these diseases and their comorbidities, as well as the potential of manipulating the gut microbiome for therapeutic purposes.
Article
Clinical Neurology
Eunhye Bae, Nakwon Kwak, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Jaeyoung Cho
Summary: This study assessed mortality in patients with chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), and overlap syndrome, and found that patients with overlap syndrome had increased mortality, although not higher than those with COPD alone. In predicting mortality, measurement of hypoxemic load was found to be more accurate than the apnea-hypopnea index.
Article
Pharmacology & Pharmacy
Manyun Tang, Yidan Wang, Mengjie Wang, Rui Tong, Tao Shi
Summary: Patients with overlap syndrome are at higher risk for cardiovascular diseases and have increased 1-year mortality compared to those with COPD or OSAS alone. Factors such as Charlson comorbidity index score, hypertension, pulmonary thromboembolism, and heart failure were identified as independent risk factors for 1-year all-cause mortality. More research is needed to understand the relationship between OS and cardiovascular diseases to better manage these patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Czerwaty, Karolina Dzaman, Krystyna Maria Sobczyk, Katarzyna Irmina Sikorska
Summary: This systematic review aims to define the significance of the coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), known as overlap syndrome (OS), based on the current state of knowledge. After searching multiple databases, 38 eligible studies were included in this review, covering a total population of 27,064 participants. The paper summarizes the most important and up-to-date information regarding OS, including its prevalence, impact of age/gender/body mass index, polysomnography findings, pulmonary function, comorbidities, prediction of OSA in COPD patients, and treatment options for this syndrome.
Article
Respiratory System
John S. Kim, Ali Azarbarzin, Anna J. Podolanczuk, Michaela R. Anderson, Brian E. Cade, Steven M. Kawut, Artur Wysoczanski, Andrew F. Laine, Eric A. Hoffman, Daniel J. Gottlieb, Christine Kim Garcia, R. Graham Barr, Susan Redline
Summary: This study aimed to investigate the association between obstructive sleep apnea (OSA) and interstitial lung disease (ILD) as well as its impact on lung function. The results showed that OSA severity was associated with an increase in high-attenuation areas (HAAs) and a decline in lung volumes over time, indicating OSA may be a contributing factor in the early stages of ILD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Neurosciences
Tianfeng Peng, Shan Yuan, Wenjing Wang, Zhuanyun Li, Ayshat Mussa Jumbe, Yaling Yu, Zhenghao Hu, Ruijie Niu, Xiaorong Wang, Jinnong Zhang
Summary: This study aimed to analyze the clinical characteristics of patients with COPD and OSA overlap syndrome (OS) and develop a nomogram for predicting OSA. The results identified several valuable predictors for predicting OSA, including age, type 2 diabetes, neck circumference, dyspnea scale, sleep apnea clinical score, and C-reactive protein. The nomogram showed good discrimination and calibration.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Immunology
Jose A. Canas, Jose M. Rodrigo-Munoz, Beatriz Sastre, Marta Gil-Martinez, Natalia Redondo, Victoria del Pozo
Summary: Chronic respiratory diseases (CRDs) such as asthma and chronic obstructive pulmonary disease (COPD) are important factors in global mortality and morbidity, accounting for approximately 6% of total deaths worldwide. MicroRNAs (miRNAs) have emerged as promising diagnostic and therapeutic biomarkers for CRDs, playing crucial roles in inflammation-related pathways in asthma and COPD. Their deregulation in various biofluids and cells of patients, as well as their involvement in histopathological changes and treatment response, highlight the potential of miRNAs as prognostic tools and therapeutic targets in these respiratory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Clinical Neurology
Shi Qi Li, Xian Wen Sun, Liu Zhang, Yong Jie Ding, Hong Peng Li, Ya Ru Yan, Ying Ni Lin, Jian Ping Zhou, Qing Yun Li
Summary: COPD is a significant global health burden, with AECOPD exacerbation accelerating disease progression and increasing hospitalization and mortality risk. Insomnia and OSA are common in COPD patients, increasing susceptibility to AECOPD, highlighting the importance of considering sleep disorders in clinical management.
SLEEP MEDICINE REVIEWS
(2021)
Review
Critical Care Medicine
Lei Wang, Yang Cai, Johan Garssen, Paul A. J. Henricks, Gert Folkerts, Saskia Braber
Summary: Epidemiological studies show that COPD is linked to changes in intestinal health. Cigarette smoking, a major cause of COPD, affects the gastrointestinal system and promotes intestinal diseases. Gut-lung interactions occur through circulating inflammatory cells and mediators. Gut microbiota dysbiosis, systemic hypoxia, and oxidative stress play a role in the gut-lung axis. This review summarizes the possible mechanisms of gut-lung interactions in COPD and highlights potential therapies for intestinal dysfunction.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Pan Zhang, Bi Chen, Heqing Lou, Yanan Zhu, Peipei Chen, Zongmei Dong, Xuan Zhu, Ting Li, Peian Lou
Summary: This study evaluates the prevalence and predictors of overlap syndrome in patients with chronic obstructive pulmonary disease (COPD) and its association with clinical outcomes. It found that BMI, neck circumference, ESS, CAT, CCI, HADS, hypertension, and diabetes were independent risk factors for obstructive sleep apnea (OSA) in patients with COPD. The risk of OSA was lower in patients with severe COPD compared to those with mild or moderate COPD.
BMC PULMONARY MEDICINE
(2022)
Article
Clinical Neurology
Sofia F. Furlan, Viktor Sinkunas, Lucas P. Damiani, Ronaldo B. Santos, Matheus Peres, Pedro A. Lemos, Chi-Hang Lee, Geraldo Lorenzi-Filho, Luciano F. Drager
Summary: This study aimed to explore the associations of obstructive sleep apnea (OSA) and sleep duration (SD) with renal function in subjects with coronary artery disease (CAD). The results showed that OSA severity and SD were not independently associated with chronic kidney disease (CKD) in CAD patients.
Review
Medicine, General & Internal
Xiaoyan Gai, Brian Allwood, Yongchang Sun
Summary: The burden of chronic airway diseases, including chronic obstructive pulmonary disease (COPD), continues to increase, especially in low- and middle-income countries. Post-tuberculosis lung disease (PTLD), characterized by chronic lung changes after the cure of pulmonary tuberculosis (TB), may be associated with the pathogenesis of COPD. However, data on PTLD's prevalence, clinical manifestations, computed tomography features, lung function impairment patterns, and influencing factors are limited. More research is needed to elucidate the pathogenesis of PTLD.
CHINESE MEDICAL JOURNAL
(2023)
Review
Medicine, General & Internal
Damini Saxena, Ikuyo Imayama, Muhammad Adrish
Summary: Asthma and obstructive sleep apnea are common conditions with high costs. They have a bidirectional relationship, and asthma may lower the arousal threshold in obstructive sleep apnea. Additionally, obstructive sleep apnea is associated with worse asthma severity, increased exacerbation frequency, and poor quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
