Article
Biophysics
Yu Zhou, Qilong Zhao, Min Wang
Summary: Biomanufacturing of functional tissue analogues is challenging due to difficulties in recreating complex anatomies and bioactive nanofibrous extracellular matrix. In this study, a biomanufacturing approach was developed using concurrent emulsion electrospinning and coaxial cell electrospraying, producing 3D nanofibrous multi-cellular constructs resembling body tissues. Endothelial cells and smooth muscle cells were successfully integrated into the constructs, showing high cell densities and viabilities. The cells exhibited distinct morphologies and enhanced proliferative activities, indicating the potential of this approach in regenerating body tissues.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Polymer Science
Wan-Ying Huang, Norichika Hashimoto, Ryuhei Kitai, Shin-ichiro Suye, Satoshi Fujita
Summary: A novel hollow nanofiber sphere model was designed for investigating the development of intracranial epidermoid cysts, allowing observation of oriented cell migration and collagen fibril secretion in the structure.
Article
Engineering, Multidisciplinary
Kun Li, Yingnan Zhang, Junwei Xu, Jingxi Wang, Xuenan Gu, Ping Li, Yubo Fan
Summary: The magnetic PCL/Fe3O4/ICA 3D scaffold, manufactured through electrospinning, exhibited enhanced cell proliferation and infiltration, especially when combined with the static magnetic field, providing a new idea for the design and application of magnetic scaffolds in bone tissue engineering.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Zihao Jia, Yang Liu, Yingying Wang, Shiyuan Peng, Peng Jia, Wei Zhang, Xiaoyan Tan
Summary: Gas-foaming technique can transform two-dimensional scaffolds into three-dimensional scaffolds, which have shown better cartilage regeneration effects with larger pore size, higher porosity, and higher biocompatibility.
MATERIALS RESEARCH EXPRESS
(2021)
Article
Engineering, Biomedical
Ziqi Gan, Yifan Zhao, Yeke Wu, Wei Yang, Zhihe Zhao, Lixing Zhao
Summary: Temporomandibular disorder (TMD) is a clinical challenge with limited therapeutic methods. We developed a biomimetic scaffold with optimal reinforcement, demonstrating its superior properties and potential for complex tissue regeneration in animal models.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Xiangyi Yin, Yuanping Hao, Yun Lu, Dongjie Zhang, Yaodong Zhao, Li Mei, Kunyan Sui, Qihui Zhou, Jilin Hu
Summary: The study developed a novel bio-multifunctional hydrogel patch for accelerating full-thickness abdominal wall defect repair, showing excellent self-healing and mechanical properties, antibacterial ability, and promotion of cell proliferation.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Biomedical
Qilong Zhao, Yu Zhou, Min Wang
Summary: This study demonstrates a new method for directly placing living endothelial cells within bioactive nanofibrous scaffolds in 3D, using concurrent emulsion electrospinning and coaxial cell electrospraying. The technique allows for deep cell distribution and preservation of cell viability, leading to promising bioactive nanofibrous scaffolds with 3D cell incorporation. By combining structural and biochemical cues, the 3D cell-incorporated scaffolds offer an innovative approach to tissue engineering for creating vascularized structures.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Qimanguli Saiding, Yiyao Chen, Juan Wang, Catarina Leite Pereira, Bruno Sarmento, Wenguo Cui, Xinliang Chen
Summary: Hernia reconstruction is a frequently performed surgical procedure that has been greatly improved by plastic surgery techniques. Surgical meshes are commonly used for abdominal wall hernia repair, but there are still challenges in mesh design and complications. This review provides a comprehensive summary of hernia surgical mesh development, including commercial meshes, prosthetic materials, and engineered prosthetics. The review also outlines future research directions for successful hernia repair solutions.
MATERIALS TODAY BIO
(2023)
Article
Materials Science, Multidisciplinary
Irene Chiesa, Carmelo De Maria, Giovanni Vozzi, Riccardo Gottardi
Summary: Each year, thousands of patients face life-threatening ear, nose, and throat disorders, such as tracheal stenosis, or conditions that affect their psychosocial well-being, such as microtia. Tissue engineering offers an exciting alternative by creating bioartificial constructs using three-dimensional scaffolds and human cells that can grow and develop. Bioprinting technologies, which utilize additive manufacturing, are particularly useful in addressing the complex geometries of ear, nose, and throat, allowing for the creation of patient-specific scaffolds with high design flexibility and repeatability.
Article
Chemistry, Multidisciplinary
Yongjie Jiao, Chaojing Li, Shaojie Li, Xingxing Liu, Shuang Yu, Xiaofeng Liu, Yan Li, Fujun Wang, Jianxiong Tang, Lu Wang
Summary: A fabric hydrogel composite hernia mesh with biomechanical and mesh-tissue interface dual compliance is designed for scarless abdominal wall reconstruction. The mesh is composed of a polyester knitted fabric and chitosan-polyacrylamide hydrogel complex. The adhesive fabric hydrogel composite hernia mesh offers significant clinical values for repairing abdominal wall defects and provides design ideas for repairing other load-bearing soft tissues.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Medicine, Research & Experimental
Zhiwei Li, Ye Qi, Lei Sun, Zheng Li, Shaojuan Chen, Yuqi Zhang, Yuan Ma, Jinming Han, Zide Wang, Yulin Zhang, Huimin Geng, Bin Huang, Jian Wang, Gang Li, Xingang Li, Shaohua Wu, Shilei Ni
Summary: The 3D nanofibrous sponges developed in this study show promise for the treatment of spinal cord injury by promoting neuronal regeneration and fiber regrowth. In a rat SCI model, these scaffolds not only restored neural function but also facilitated axon reinnervation and remyelination.
Article
Engineering, Biomedical
Andreia Leal Pereira, Angela Semitela, Andre F. Girao, Antonio Completo, Paula A. A. P. Marques, Samuel Guieu, Maria Helena V. Fernandes
Summary: One tissue engineering strategy involves creating scaffolds that resemble the extracellular matrix (ECM) to aid tissue regeneration. In this study, a technique called thermally-induced self-agglomeration (TISA) was used to convert two-dimensional electrospun membranes into highly functional three-dimensional porous-fibrous systems, overcoming the limitations of cell infiltration and proliferation. By electrospinning polycaprolactone/chitosan blends and adjusting the amount of chitosan, the researchers were able to modulate the properties of the resulting 3D nanofibrous scaffolds, leading to porous constructs with distinct morphologic and mechanical features. Viability and proliferation studies with adult human chondrocytes confirmed the biocompatibility of the scaffolds, making them promising for musculoskeletal tissue engineering applications, particularly cartilage repair.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Polymer Science
Anna A. Dokuchaeva, Aleksandra B. Mochalova, Tatyana P. Timchenko, Kseniya S. Podolskaya, Oxana A. Pashkovskaya, Elena V. Karpova, Ilya A. Ivanov, Natalya A. Filatova, Irina Yu Zhuravleva
Summary: This study observed the hemodynamic and structural properties of electrospun, monolayered poly-epsilon-caprolactone (PCL) grafts in an in vivo experiment using a rat aorta replacement model. The results showed that PCL grafts maintained patency without stenosis or thrombosis throughout the follow-up period. The advantages of PCL scaffolds include excellent endothelialization and good surgical outcome, while the disadvantages include slow biodegradation, ineffective cellularization, and risks for mineralization and intimal hyperplasia.
Article
Chemistry, Multidisciplinary
Jie Hu, Guopu Chen, Gefei Wang
Summary: Due to the limitations of existing biomaterials, researchers have developed a novel trilayer wound dressing that facilitates abdominal wall repair through directional biofluid transport. In vitro and in vivo experiments have shown that this dressing is biocompatible, prevents reverse penetration, and improves wound microenvironment, thus accelerating the repair process.
Article
Materials Science, Multidisciplinary
Alperen Abaci, Gulden Camci-Unal, Murat Guvendiren
Summary: Three-dimensional (3D) bioprinting is an emerging technology that can fabricate functional tissues and organs, replicating native tissue function. With its precise positioning of cellular materials and utilization of medical images, 3D bioprinting has enormous potential in biomedical applications, such as tissue engineering and regenerative medicine. It is a rapidly progressing field that has shown clinically relevant uses.