LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH

Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice

(2020) Akihiro Kikuchi et al.   Scientific Reports

LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

(2019) Meng Xu et al.   CELL

Increased liver localization of lipopolysaccharides in human and experimental non‐alcoholic fatty liver disease

(2019) Guido Carpino et al.   HEPATOLOGY

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice

(2016) Keita Chikamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A dipeptidyl peptidase-IV inhibitor improves hepatic steatosis and insulin resistance by AMPK-dependent and JNK-dependent inhibition of LECT2 expression

(2015) Hwan-Jin Hwang et al.   BIOCHEMICAL PHARMACOLOGY

Leukocyte cell-derived chemotaxin 2 (LECT2)-associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States

(2014) O. M. Mereuta et al.   BLOOD

LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance

(2014) Fei Lan et al.   DIABETES

Hepatic Crown-Like Structure: A Unique Histological Feature in Non-Alcoholic Steatohepatitis in Mice and Humans

(2013) Michiko Itoh et al.   PLoS One

Hyperresponsivity to Low-Dose Endotoxin during Progression to Nonalcoholic Steatohepatitis Is Regulated by Leptin-Mediated Signaling

(2012) Kento Imajo et al.   Cell Metabolism

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

(2012) T. Otoda et al.   DIABETES

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LECT2 protects mice against bacterial sepsis by activating macrophages via the CD209a receptor

(2012) Xin-Jiang Lu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

The tumor suppressor function of LECT2 in human hepatocellular carcinoma makes it a potential therapeutic target

(2011) H T Ong et al.   CANCER GENE THERAPY

JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease

(2011) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

(2010) Hirofumi Misu et al.   Cell Metabolism

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients

(2008) Toshinari Takamura et al.   Obesity