Article
Public, Environmental & Occupational Health
James W. White, Mark Hamer, G. David Batty
Summary: The study found that exposure to homelessness in early adulthood was essentially unrelated to biomarkers in middle age, with inconsistent links found for specific types of experience.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Endocrinology & Metabolism
Chunyan Hu, Yi Zhang, Jie Zhang, Yanan Huo, Qin Wan, Mian Li, Hongyan Qi, Rui Du, Yuanyue Zhu, Yingfen Qin, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Guijun Qin, Xulei Tang, Gang Chen, Min Xu, Tiange Wang, Zhiyun Zhao, Yuhong Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Li Chen, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Lulu Chen, Jiajun Zhao, Yiming Mu, Weiqing Wang, Yu Xu, Yufang Bi, Jieli Lu, Guang Ning
Summary: Age at menarche was inversely associated with the risk of diabetes in Chinese women, and this association appeared to be modified by the presence of ideal cardiovascular health metrics. The increased risk associated with age at menarche <14 years was observed in participants with three or fewer health metrics, but not in women with four or more health metrics. Further studies are needed to clarify the precise interrelationship and generalizability of these results.
JOURNAL OF DIABETES
(2021)
Article
Public, Environmental & Occupational Health
Donghao Lu, Yongfu Yu, Jonas F. Ludvigsson, Anna Sara Oberg, Henrik Toft Sorensen, Krisztina D. Laszlo, Jiong Li, Sven Cnattingius
Summary: This binational cohort study investigated the association between intrauterine growth restriction, represented by birth weight for gestational age (GA), and cardiovascular disease (CVD) risk in early adulthood. The study included over 3 million births from Sweden and Denmark. The results showed that individuals born severely small for GA or preterm had an increased risk of CVD. However, the association was attenuated when comparing individuals born SGA with their AGA siblings.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Louise R. Jones, Pauline M. Emmett, Nicholas P. Hays, Yassaman Shahkhalili, Caroline M. Taylor
Summary: The study aimed to replicate a previous finding that low fat intake in early childhood was linked to increased adiposity in adulthood, but the results did not support this. Instead, a positive association was found between high fat intake at 18 months and fat mass in boys at 9 years, with no association in girls. Additionally, fat intake was positively correlated with serum leptin concentration in boys, but not in girls.
Review
Endocrinology & Metabolism
Jiahong Sun, Bo Xi, Lili Yang, Min Zhao, Markus Juonala, Costan G. Magnussen
Summary: The study found that individuals who were obese in childhood but had normal weight in adulthood did not have a tendency to develop cardiovascular disease risk factors in adulthood, while those who were obese in adulthood or both periods had a higher likelihood of developing cardiovascular disease risk factors.
Article
Health Care Sciences & Services
Hunha Cho, Jeong-Won Han
Summary: The average age of menarche is decreasing in South Korean women, and early menarche is associated with a higher incidence of obesity. This study aimed to analyze the factors associated with obesity in adult women who experienced early menarche and provide basic data for obesity management.
Article
Endocrinology & Metabolism
Zijun Liao, Xianghui Xie, Jing Wang, Yiren Chen, Ting Zhang, Gongshu Liu, Fangfang Chen
Summary: This study investigates the impact of factors in the first 1,000 days of life on metabolic phenotypes of obesity in preschool children. The results show that maternal obesity and accelerated BMI growth rate between 6 and 24 months are related to both metabolically healthy and metabolically unhealthy overweight or obesity. Children with these early life factors should receive weight control interventions to prevent metabolic abnormalities.
Article
Public, Environmental & Occupational Health
Kehan Li, Jianzhong Yin, Zixiu Qin, Bangjing Ma, Ruifeng He, Duoji Zhuoma, Zihao Wang, Qiaolan Liu, Xing Zhao
Summary: This study found a linear inverse association between age at menarche and metabolic dysfunction-associated fatty liver disease (MAFLD) in Chinese women. Early adulthood adiposity partially mediated this association. Obesity prevention strategies should be implemented from young adulthood in women who experience early menarche to reduce the risk of MAFLD.
PREVENTIVE MEDICINE
(2023)
Article
Obstetrics & Gynecology
An-Shun Tai, Ro-Ting Lin, Yi-Chun Lin, Chung-Hsing Wang, Sheng-Hsuan Lin, Seiya Imoto
Summary: The age at menarche plays a mediation role in the genetic influence on uterine fibroids, and the study has identified four causal genetic mechanisms underlying the age at menarche-mediated effects of common genetic loci on uterine fibroid development.
HUMAN REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Ahmad Majzoub, Haitham Elbardisi, Sarah Madani, Kristian Leisegang, Mohamed Mahdi, Ashok Agarwal, Ralf Henkel, Kareim Khalafalla, Sami ElSaid, Mohamed Arafa
Summary: The study aims to assess the impact of MetAge and body composition on male sexual and gonadal status, especially in men younger than 40 years old. The results showed that age and body composition parameters significantly affected the androgenic state. Erectile dysfunction in men younger than 40 years was associated with lower testosterone levels, older MetAge, and higher BMI and degree of obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Prabha H. Andraweera, Michelle D. Plummer, Amy Garrett, Shalem Leemaqz, Melanie R. Wittwer, Emily Aldridge, Maleesa M. Pathirana, Gus A. Dekker, Claire T. Roberts, Margaret A. Arstall
Summary: This study aimed to compare the risk factors for cardiovascular disease (CVD) 10 years after childbirth between women with >= 1 cardio metabolic risk factor in early first pregnancy and those with no risk factors. The results showed that women with >= 1 risk factor during the first pregnancy were 5.5 times more likely to have metabolic syndrome 10 years postpartum and had higher risks of obesity, elevated total cholesterol levels, and increased insulin resistance. Therefore, identifying cardio metabolic risk factors in early pregnancy may help identify young women at risk of future CVD.
Review
Obstetrics & Gynecology
S. R. Mishra, H-F Chung, M. Waller, G. D. Mishra
Summary: This study evaluated estrogen exposure measurement and the mutual effect of age at menarche and age at menopause on the risk of cardiovascular disease events. Reproductive lifespan was the most commonly used method for estrogen exposure measurement. The findings suggest that a shorter reproductive lifespan is associated with a higher risk of cardiovascular disease events, particularly stroke.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Nutrition & Dietetics
Jordana Carolina Marques Godinho-Mota, Joao Felipe Mota, Larissa Vaz Goncalves, Leonardo Ribeiro Soares, Raquel Machado Schincaglia, Carla M. Prado, Karine Anuska Martins, Ruffo Freitas-Junior
Summary: The study showed that chemotherapy for breast cancer negatively affected body composition and metabolic profile, with premenopausal women experiencing greater unfavorable impacts on adiposity markers and bone mineral density. However, no changes were observed in dietary intake and physical activity after chemotherapy.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Izzuddin M. Aris, Wei Perng, Dana Dabelea, Jody M. Ganiban, Chang Liu, Kristine Marceau, Olivia C. Robertson, Christine W. Hockett, Nicole L. Mihalopoulos, Xiangrong Kong, Megan M. Herting, T. Michael O'Shea, Elizabeth T. Jensen, Marie-France Hivert, Emily Oken
Summary: This study showed that faster gains in weight, height, or BMI in early life were associated with earlier pubertal onset, indicating that children who experience rapid early growth should be closely monitored for early puberty and provided with appropriate support services.
Article
Endocrinology & Metabolism
Wei-De Lin, Chi-Fung Cheng, Chung-Hsing Wang, Wen-Miin Liang, Chien-Hsiun Chen, Ai-Ru Hsieh, Mu-Lin Chiu, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Chang-Hai Tsai, Cherry Yin-Yi Chang, Ying-Ju Lin, Fuu-Jen Tsai
Summary: In this study on Taiwanese Han Chinese girls, 105 SNPs related to ICPP risk were identified, with 22 showing risk for early puberty in the validation group. Replication study found 33 SNPs associated with ICPP risk, contributing to understanding the genetic characteristics and biological pathways underlying pubertal timing and ICPP pathogenesis.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Francine Silva dos Santos, Gicele Costa Mintem, Isabel Oliveira de Oliveira, Bernardo Lessa Horta, Elisabete Ramos, Carla Lopes, Denise Petrucci Gigante
Summary: This study evaluated the association between ultra-processed foods (UPF) and serum IL-6 concentration, finding that it is not explained by adiposity.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Mariana Lima Correa, Bruna Goncalves Cordeiro da Silva, Fernando C. Wehrmeister, Bernardo L. Horta, Helen Goncalves, Luciana Anselmi, Fernando Barros, Ana Maria Baptista Menezes
Summary: Maternal smoking during pregnancy is associated with a decrease in offspring's IQ, and this association is partly mediated by breastfeeding and birth weight.
PREVENTIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Michel S. Naslavsky, Marilia O. Scliar, Guilherme L. Yamamoto, Jaqueline Yu Ting Wang, Stepanka Zverinova, Tatiana Karp, Kelly Nunes, Jose Ricardo Magliocco Ceroni, Diego Lima de Carvalho, Carlos Eduardo da Silva Simoes, Daniel Bozoklian, Ricardo Nonaka, Nayane dos Santos Brito Silva, Andreia da Silva Souza, Heloisa de Souza Andrade, Marilia Rodrigues Silva Passos, Camila Ferreira Bannwart Castro, Celso T. Mendes-Junior, Rafael L. Mercuri, Thiago L. A. Miller, Jose Leonel Buzzo, Fernanda O. Rego, Nathalia M. Araujo, Wagner C. S. Magalhaes, Regina Celia Mingroni-Netto, Victor Borda, Heinner Guio, Carlos P. Rojas, Cesar Sanchez, Omar Caceres, Michael Dean, Mauricio L. Barreto, Maria Fernanda Lima-Costa, Bernardo L. Horta, Eduardo Tarazona-Santos, Diogo Meyer, Pedro A. F. Galante, Victor Guryev, Erick C. Castelli, Yeda A. O. Duarte, Maria Rita Passos-Bueno, Mayana Zatz
Summary: This study presents a high-coverage WGS dataset of elderly Brazilians from a mixed population, providing valuable data on non-European and mixed populations. The results demonstrate that WGS can identify previously undescribed variants and genomic segments, as well as alleles from HLA genes. The study also shows the clinical usefulness of reclassifying and validating variants associated with dominantly-inherited Mendelian disorders. Furthermore, the findings highlight the improved potential of whole-genome and HLA imputation using WGS data.
NATURE COMMUNICATIONS
(2022)
Review
Pediatrics
Bernardo Lessa Horta, Nigel Rollins, Mariane S. Dias, Valquiria Garcez, Rafael Perez-Escamilla
Summary: Breastfeeding reduces the odds of overweight or obesity in children. Even after considering the effects of publication bias and residual confounding, breastfeeding remains beneficial. The benefits of breastfeeding are also observed in studies that are susceptible to positive confounding by socioeconomic status.
Article
Public, Environmental & Occupational Health
Jesem Douglas Yamall Orellana, Joseph Murray, Natalia Peixoto Lima, Ricardo Tavares Pinheiro, Bernardo Lessa Horta
Summary: This study examines the relationship between robbery victimization and mental disorders in young adults, specifically Major Depressive Disorder and Generalized Anxiety Disorder. The findings suggest that being a victim of robbery increases the likelihood of experiencing these mental disorders, particularly when the robbery occurred within the previous 12 months.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Dentistry, Oral Surgery & Medicine
L. A. Chisini, F. D. S. Costa, B. L. Horta, L. Tovo-Rodrigues, F. F. Demarco, M. B. Correa
Summary: This research investigates the association between dental caries trajectory and rs307355 (TAS1R3) and rs35874116 (TAS1R2), as well as the epistatic association between rs307355 (TAS1R3) and rs35874116 (TAS1R2). A representative sample of 5,914 individuals from the 1982 Pelotas birth cohort was prospectively studied. Group-based trajectory modeling identified different groups with similar dental caries trajectories throughout life. Genetic material was collected for genotyping rs307355 (TAS1R3) and rs35874116 (TAS1R2). The study found that the genotype and allele of rs307355 (TAS1R3) were positively associated with the trajectory of decayed and missing dental components. Epistatic interaction between rs307355 and rs35874116 may increase the decayed caries trajectory.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Tatiana Pereira Cenci, Mariana Gonzalez Cademartori, Laylla Galdino dos Santos, Marcos Britto Correa, Bas Loomans, Bernardo Lessa Horta, Flavio Fernando Demarco
Summary: This study investigated the prevalence of tooth wear and its associated factors in adults from the 1982 Pelotas Birth Cohort. The results showed that 61.6% of the individuals had tooth wear, with females having a lower prevalence compared to males. Additionally, the consumption of acid and alcoholic beverages was positively associated with tooth wear.
JOURNAL OF DENTISTRY
(2023)
Article
Public, Environmental & Occupational Health
Franciney Anselmo Ferreira, Fernando Jose Herkrath, Bernardo Lessa Horta, Luiza Garnelo
Summary: This study analyzed the work processes of institutional supporters in delivering care services through a mobile river clinic. The findings highlight the lack of institutionalization in the work of supporters, the importance of immersion in rural mobile activities, and the centrality of daily living work. The study also reveals that the lack of administrative support and underfunding for infrastructure and logistics weaken the interventions of supporters and multiprofessional teams.
INTERFACE-COMUNICACAO SAUDE EDUCACAO
(2023)
Article
Dentistry, Oral Surgery & Medicine
Luiz Alexandre Chisini, Francine da costa Santos, Rodrigo Varella de Carvalho, Bernardo Lessa Horta, Luciana Tovo-Rodrigues, Flavio Fernando Demarco, Marcos Britto Correa
Summary: This study aimed to investigate the influence of Single Nucleotide Polymorphisms (SNPs) in tooth mineral tissue genes on dental caries trajectory and the potential gene-gene interaction. A representative sample of 5,914 births from the 1982 Pelotas birth cohort study was prospectively investigated. The findings suggest that certain SNPs in tooth mineral tissue genes are associated with dental caries trajectory and epistatic interactions, expanding the understanding of individual caries experience. The results highlight the clinical significance of SNPs in the pathway of tooth mineral tissue genes in the development of dental caries throughout the lifespan.
JOURNAL OF DENTISTRY
(2023)
Article
Medicine, General & Internal
Natalia E. Poveda, Linda S. Adair, Reynaldo Martorell, Shivani A. Patel, Manuel Ramirez-Zea, Santosh K. Bhargava, Sonny A. Bechayda, Delia B. Carba, Maria F. Kroker-Lobos, Bernardo Lessa Horta, Natalia Peixoto Lima, Monica Mazariegos, Ana Maria Baptista Menezes, Shane A. Norris, Lukhanyo H. Nyati, Linda M. Richter, Harshpal Sachdev, Fernando C. Wehrmeister, Aryeh D. Stein
Summary: This study found that higher birth weight and relative weight gains in infancy, childhood, and adolescence were positively associated with adult body composition. Relative weight gains in childhood and adolescence were the strongest predictors of adult body composition, while a faster linear growth in infancy weakly predicted higher adult adiposity.
Article
Public, Environmental & Occupational Health
Charles Phillipe de Lucena Alves, Inacio Crochemore-Silva, Natalia P. Lima, Pieter Coenen, Bernardo Lessa Horta
Summary: This study found that there was no association or limited clinical relevance between occupational and leisure-time physical activity and cardiovascular risk factors in early adulthood.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Vania Pereira Oliveira, Mariane da Silva Dias, Natalia Peixoto Lima, Bernardo Lessa Horta
Summary: This study aimed to investigate the association between birth conditions, nutritional status, childhood growth, and cardiometabolic risk factors at 30 years of age. The researchers also examined whether body mass index (BMI) at 30 years old mediated the relationship between childhood weight gain and cardiometabolic risk factors. The findings suggest that rapid relative weight gain after 2 years of age may have long-term consequences on the risk of metabolic and cardiovascular disorders.
CADERNOS DE SAUDE PUBLICA
(2023)
Meeting Abstract
Obstetrics & Gynecology
Michael Ross, Manasa Kavasery, MacKenzie Cervantes, Kelly Coca, Bernardo Horta, Mina Desai
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Pediatrics
Elma Izze da Silva Magalhaes, Natalia Peixoto Lima, Ana Maria Baptista Menezes, Helen Goncalves, Fernando C. Wehrmeister, Maria Cecilia Formoso Assuncao, Bernardo Lessa Horta
Summary: The purpose of this study was to investigate the impact of grandmother's smoking during pregnancy on the birthweight of grandchildren, as well as whether maternal smoking during pregnancy modified this association. The study found that although grandmother's smoking was not associated with grandchild's birthweight, it had an effect when the mother also smoked during pregnancy.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Psychiatry
Dominique P. Behague, Helen Goncalves, Suelen Henriques da Cruz, Larissa de Cruz, Bernardo L. Horta, Natalia P. Lima
Summary: This paper explores how Brazilian socially sensitive therapy can respond to care-users' desire to change the social and political forces shaping their lives. The study shows that the use of socially sensitive therapy is associated with increased political participation and reporting of discrimination, with greater empowering effects observed in individuals with lower education and family income.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
