Article
Biochemistry & Molecular Biology
Sumera Zaib, Fatima Akram, Wania Waris, Syed Talha Liaqat, Zainab Zaib, Imtiaz Khan, Ayed A. Dera, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk
Summary: This study explores potential inhibitors for the replication of dengue virus, using molecular docking, ADMET properties, and molecular dynamic simulation. By observing and validating interactions of various complexes, and conducting preclinical testing, a flavonoid called ladanein from Orthosiphon aristatus was identified as a lead compound with inhibitory potential against major replication protein of dengue virus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Plant Sciences
Chunsheng Zhu, Hongjuan Niu, Meng Bian, Xiaochuan Zhang, Xiaomeng Zhang, Zheng Zhou
Summary: In this study, the anti-hyperuricemia effect of Orthosiphon aristatus was investigated. It was found that O. aristatus intervention decreased serum uric acid levels and increased uric acid levels in cecal contents of hyperuricemic rats. Additionally, O. aristatus improved intestinal morphology and altered gut microbiota composition and metabolites.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Multidisciplinary Sciences
Syafiqah mhd Jamal, Hasnah Bahari, Daryl jesus Arapoc, Muhammad akif Adnan, Imran jazary mad Diah, Azmiza syawani Jasni
Summary: This study evaluated the effects of gamma irradiation on microbial contaminants and phytochemical constituents of Orthosiphon aristatus. The results showed that gamma irradiation significantly reduced and eliminated microbial contaminants while preserving the phytochemical constituents. A low dose of 6 kGy was found to be effective in reducing and eliminating microbial contamination in O. aristatus.
Article
Chemistry, Applied
Lee Suan Chua, Farah Izana Abdullah, Teck Kwang Lim, Qingsong Lin
Summary: This study aimed to extract bioactive peptides from the white and purple flower varieties of Orthosiphon aristatus leaves. The results showed that trypsin hydrolysates had higher antioxidant and antibacterial activities. The white flower hydrolysates exhibited higher radical scavenging activity, while the purple flower hydrolysates showed higher ferric reducing power and bacterial growth inhibition.
Article
Chemistry, Medicinal
Salah Abdalrazak Alshehade, Raghdaa Hamdan Al Zarzour, Michael Mathai, Nelli Giribabu, Atefehalsadat Seyedan, Gurjeet Kaur, Fouad Saleih Resq Al-Suede, Amin Malik Shah Abdul Majid, Vikneswaran Murugaiyah, Hassan Almoustafa, Mohammed Abdullah Alshawsh
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, and Orthosiphon aristatus has been shown to inhibit its progression. Feeding C57BL/6 mice with O. aristatus extract for 8 weeks reduced liver enzyme levels and decreased serum glucose, insulin, cholesterol, triglycerides, low-density lipoprotein, and atherogenic risk index. Histological analysis also revealed a reversal of hepatic fat accumulation and reduced NAFLD severity. Furthermore, O. aristatus demonstrated antioxidant and anti-inflammatory activities. Overall, the primary mechanism of action of O. aristatus in treating NAFLD appears to be its antioxidant activity.
Article
Biotechnology & Applied Microbiology
Fahrauk Faramayuda, Totik Sri Mariani, Elfahmi, Sukrasno
Summary: The study successfully produced rosmarinic acid and sinensetin by adding cinnamic acid precursor to callus cultures of a purple variety of Orthosiphon aristatus. Callus grown on SH media with 2,4-D 0.4 ppm showed good characteristics in producing callus faster than other concentrations.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Yu-Xin Yan, Li-Jun Yan, Yong-Chao Wang, Yu-Xiang Bei
Summary: Investigation of the methanol extract of Orthosiphon aristatus leaves resulted in the isolation of four compounds, including a new lignan and three compounds isolated from this plant for the first time. Their structures were determined based on spectroscopic evidence and comparison with existing literature.
CHEMISTRY OF NATURAL COMPOUNDS
(2021)
Review
Food Science & Technology
Shivraj Hariram Nile, Jiajia Su, Die Wu, Leran Wang, Jiangning Hu, Elwira Sieniawska, Guoyin Kai
Summary: Fritillaria thunbergii, known as Zhe beimu in China, is considered the oldest traditional folk medicine and is used for treating various ailments. Research on its traditional uses, phytochemistry, and pharmacology can potentially lead to the development of plant-based drugs and therapeutic applications.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Lee Suan Chua
Summary: This study compared the phytochemical profiles of Orthosiphon aristatus extracts prepared using water and ethanol in a reflux system. The results showed higher precipitate formation in ethanol extract, and LC-MS/MS analysis revealed the presence of not only saponins but also other phytochemicals such as phenolic acids and flavonoids. Acetone precipitation was found to significantly increase the content of specific compounds in the water extract.
NATURAL PRODUCTS JOURNAL
(2021)
Article
Biology
Tayyiba Afzal, Yamin Bibi, Muhammad Ishaque, Saadia Masood, Abdul Qayyum, Sobia Nisa, Zahid Hussain Shah, Hameed Alsamadany, Gyuhwa Chung
Summary: This research found that the leaves of Pseudocaryopteris foetida are rich in phenolic and flavonoid compounds, showing certain antioxidant activity but weak cytotoxicity. Further research should be focused on isolating bioactive compounds from this plant for potential clinical applications.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Plant Sciences
Oleh Koshovyi, Inna Vlasova, Valdas Jakstas, Gabriele Vilkickyte, Vaidotas Zvikas, Roman Hrytsyk, Lyubov Grytsyk, Ain Raal
Summary: Through studying the chemical composition of American cranberry leaves and its amino-acids preparations, a safe and effective hepatoprotective agent was discovered.
Article
Biology
May Poh Yik Goh, Ajmal Faiz Kamaluddin, Terence Jit Loong Tan, Hartini Yasin, Hussein Taha, Abdalla Jama, Norhayati Ahmad
Summary: Litsea elliptica leaf extracts exhibit significant antioxidant activity, particularly the methanolic extract from young leaves, and demonstrate high cytotoxicity against the A549 cancer cell line. The compounds present in these extracts show potential for further therapeutic applications against carcinoma cells.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Faizal Maulana, Alfari Andiqa Muhammad, Ali Umar, Fachrur Rizal Mahendra, Muhammad Musthofa, Waras Nurcholis
Summary: This study used LC-MS/MS and PCA analyses to investigate the metabolite profile of Orthosiphon aristatus extracts and evaluate their inhibitory activity against α-glucosidase. In addition, in silico analysis revealed that rosmarinic acid may have potential anti-diabetic activity.
INDONESIAN JOURNAL OF CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Vairakkannu Sivasakthi, Kuppusamy Selvam, Settu Loganathan, Palanisamy Prakash
Summary: This study aimed to investigate the phytochemical constituents of ethanol leaf extract of Ixora brachiata and evaluate their antioxidant, anticancer, and larvicidal properties. The extract showed promising cytotoxicity against cancer cells and larvicidal action against mosquito larvae, suggesting its potential therapeutic use in combating life-threatening diseases and emerging infectious threats.
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2021)
Article
Plant Sciences
Waras Nurcholis, Rahma Alfadzrin, Nurul Izzati, Rini Arianti, Boglarka Agnes Vinnai, Fadillah Sabri, Endre Kristof, I. Made Artika
Summary: This study aimed to compare the effects of different extraction methods and durations on the total flavonoid and phenolic compound contents and antioxidant activities of Java cardamom fruit extracts. The results showed that the microwave-assisted extraction method for 3 minutes produced extracts with the highest antioxidant activity.
Article
Food Science & Technology
Ariyanti S. Dewi, Mei Arumia, Dohan A. Samodro, Nurrahmi D. Fajarningsih, Gintung Patantis, Muhammad Nursid, Irmanida Batubara, Yusro N. Fawzya
Summary: Sequentially prepared sea cucumber ethanol extracts (SCEEs) and protein hydrolysates (SCPHs) of Holothuria atra (HA), H. leucospilota (HL), and Bohadschia marmorata (BM) using 60% ethanol and Neutrase. The SCEEs of HL contained phenolic acids and exhibited the strongest radical scavenging activity, while its SCPHs contained hydrophobic amino acids and showed significant antiglycation effects. Additionally, the SCEEs of HA exhibited tyrosinase inhibition, associated with sulfated saponins. This study highlights the antityrosinase and antiglycation properties of SCEEs and SCPHs.
JOURNAL OF AQUATIC FOOD PRODUCT TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rudi Heryanto, Cecep Abdurohman Putra, Munawar Khalil, Mohamad Rafi, Sastia Prama Putri, Alfi Hudatul Karomah, Irmanida Batubara
Summary: This study used GC-MS to analyze extracts of Xylocarpus granatum, a mangrove species, to determine its antioxidant activity and metabolite composition, and to predict the metabolites with antioxidant properties. Results showed that the stem extracts of X. granatum were rich in catechins and catechin glycosides, which had high antioxidant potential. Principal component analysis successfully grouped the different parts of X. granatum into three categories, which can contribute to further research on its antioxidant effects.
Article
Biology
Sony Hartono Wijaya, Ahmad Kamal Nasution, Irmanida Batubara, Pei Gao, Ming Huang, Naoaki Ono, Shigehiko Kanaya, Md. Altaf-Ul-Amin
Summary: The use of herbal medicines has increased due to their lower side effects compared to conventional medicine. Unani herbal medicines are commonly used in Southern Asia and are composed of multiple medicinal plants to treat various diseases. This study aimed to develop a predictive model of Unani therapeutic usage based on its constituent metabolites using deep learning and data-intensive science approaches. The deep neural network approach provided a better prediction model than other algorithms, and 118 important metabolites for nine therapeutic usages of Unani were identified.
Article
Chemistry, Medicinal
Saat Egra, Harlinda Kuspradini, Irawan Wijaya Kusuma, Irmanida Batubara, Kosei Yamauchi, Tohru Mitsunaga
Summary: This study investigated the antibacterial activity of oral medicines used by indigenous peoples in East and North Kalimantan. Ten commonly used medicinal plants were selected and tested using antimicrobial assays and GTase inhibition activity. The most effective sample, Garcinia parvifolia, showed antimicrobial activity against Streptococcus sobrinus and Porphyromonas gingivalis. Garcidepsidone A and garcidepsidone B were identified as active compounds. These findings suggest that the leaf extract of Garcinia parvifolia used by indigenous peoples can inhibit oral pathogens and reduce dental caries.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Forestry
Dodi Nandika, Arinana Arinana, Lina Karlinasari, Irmanida Batubara, Djoko Santoso, Lucia Dhiantika Witasari, Yanti Rachmayanti, Dikhi Firmansyah, I. Ketut Sudiana, Decsa Medika Hertanto, Yusuf Sudo Hadi, Mohamad Miftah Rahman
Summary: The chemical components and bioactivity of fungus comb from Macrotermes gilvus Hagen mounds were investigated. The extracts from the fungus comb showed inhibition against Aspergillus foeti-dus and Schizophyllum commune, economically important wood-staining fungi. The ethyl acetate extract and methanol extract exhibited high bioactivity against S. commune, and azelaic acid and erucamide were identified as the dominant components in ethyl acetate extracts.
Article
Biology
Endang Kintamani, Irmanida Batubara, Cecep Kusmana, Tatang Tiryana, Edi Mirmanto, Shadila F. F. Asoka
Summary: Exposure to UV/infrared radiation is a major extrinsic factor in skin aging. This study focuses on ten varieties of andaliman fruit and their essential oils, aiming to identify potential skin anti-aging agents. The chemical components of the essential oils were analyzed, and two main compounds, geranyl acetate and D-limonene, were identified as prospective candidates. These findings have implications for the development of anti-aging products in the pharmaceutical industry.
Article
Horticulture
Muhamad Syukur, Awang Maharijaya, Waras Nurcholis, Arya Widura Ritonga, Muhammad Ridha Alfarabi Istiqlal, Abdul Hakim, Sulassih Sulassih, Ambar Yuswi Perdani, Arya Yuda Pangestu, Andi Nadia Nurul Lathifa Hatta, Zulfikar Damaralam Sahid
Summary: This study evaluated a chili hybrid for its yield components, total phenolic and flavonoid content, antioxidants, and alpha-glucosidase inhibitory activities. It was found that one of the hybrid varieties had high yield, antioxidant activity, and alpha-glucosidase inhibitory activity, which may contribute to the prevention of diabetes and its complications.
Article
Multidisciplinary Sciences
Indah Fajarwati, Dedy Duryadi Solihin, Tutik Wresdiyati, Irmanida Batubara
Summary: Alloxan and streptozotocin can induce self-recovery in diabetic animal models, leading to unstable hyperglycemia conditions and affecting the accuracy of examination.
Article
Plant Sciences
Nurlela Nurlela, Setyanto Tri Wahyudi, Auliya Ilmiawati, Waras Nurcholis, Hiroshi Takemori, Irmanida Batubara
Summary: This study analyzed the chemical profiles and antibacterial properties of different Adenostemma species using metabolomics and in silico methods. The results revealed significant chemical differences between species and identified potential antibacterial compounds.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Food Science & Technology
Erwin Afrendi, Muhammad Eka Prastya, Rika Indri Astuti, Wulan Tri Wahyuni, Irmanida Batubara
Summary: This study aimed to investigate the effect of ethanolic clove extract as an antitoxin agent, and the results showed that clove leaf extract has potential antitoxin activity. Further research should be done to analyze the antitoxin mechanism of this extract in a yeast model for a comprehensive understanding.
INTERNATIONAL JOURNAL OF FOOD SCIENCE
(2023)
Article
Agronomy
Zulfikar Damaralam Sahid, Muhamad Syukur, Awang Maharijaya, Waras Nurcholis
Summary: Big chili has the largest fruit size among different types of chili peppers. Besides its spicy taste, big chilies also contain beneficial biochemical compounds. This study identified and analyzed the biochemical compounds in several genotypes of big chili peppers using the microplate reader method. The results showed variations in compound content and antioxidant properties among different genotypes of big chili.
Article
Chemistry, Applied
Rini Anggi Arista, Bambang Pontjo Priosoeryanto, Waras Nurcholis
Summary: This study identified bioactive compounds in different parts of Java cardamom and found 1,8-Cineol to be the dominant secondary metabolite with strong antioxidant activity, particularly in the fruit essential oil. Antioxidant activity was highest in the fruit essential oil compared to other parts, indicating its potential for use as a source of antioxidants in the pharmaceutical industry.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Food Science & Technology
Anita Maya Sutedja, Ayumi Ito, Emiko Yanase, Irmanida Batubara, Dedi Fardiaz, Hanifah Nuryani Lioe
Summary: This study investigated the processing of jack bean milk and the changes in phenolic compounds during the processing. The boiling of the beans led to an increase in total phenolic content (TPC) and total flavonoid content (TFC), possibly due to the release of phenolics caused by the destruction of chemical bonds. The soaking step resulted in a decrease in TFC, likely due to the migration of compounds into the soaking water. Kaempferol glucosides were identified as important components in jack bean milk, indicating their potential for the development of functional drinks.
FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Computer Science, Theory & Methods
Heru C. Rustamaji, Yustina S. Suharini, Angga A. Permana, Wisnu A. Kusuma, Sri Nurdiati, Irmanida Batubara, Taufik Djatna
Summary: This study uses network analysis and community detection algorithms to determine comorbid diseases related to cancer. Five best algorithms were identified, providing valuable insights for disease management and understanding in the healthcare context.
APPLIED NETWORK SCIENCE
(2022)
