Article
Materials Science, Textiles
Mohadeseh Rezaie, Nahid Hassanzadeh Nemati, Davood Mehrabani, Ali Komeili
Summary: This study investigated the elasticity, degradation, and mechanical strength of SCMC and CA-based scaffolds, as well as their effects on fibroblasts. The results showed that the SCMC/CA nanofiber scaffolds had favorable properties for skin tissue engineering applications, with high porosity, elasticity, and biological compatibility.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Medicine, Research & Experimental
Kairi Lorenz, Liis Preem, Kadi Sagor, Marta Putrins, Tanel Tenson, Karin Kogermann
Summary: Increasing evidence suggests that chronic wounds are associated with bacterial biofilms. New wound care products are being developed to inhibit biofilm formation and treat existing ones. In order to analyze these new antibacterial drug delivery systems, standardized assays and appropriate tools and models are needed. This study demonstrates that optimized in vitro and ex vivo wound infection and biofilm models provide a convenient approach for testing the antibacterial and antibiofilm properties of novel wound dressings. The results can be used to design more effective wound care products and screen different formulations and active substances.
MOLECULAR PHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Xiaohan Fu, Juan Wang, Dejian Qian, Zhaowen Chen, Liang Chen, Wenguo Cui, Yan Wang
Summary: In this study, a novel living electrospun short fibrous sponge was constructed by incorporating nanofat (NF) to release living cells and active growth factors for enhanced angiogenesis and wound healing. The modified living sponges exhibited stable mechanical properties, reversible water absorption, and excellent adhesion even after compression and long-term immersion. The NF-modified sponges promoted tube formation of human umbilical vein endothelial cells (HUVECs) due to the presence of living cells and vascular endothelial growth factor (VEGF). In vivo, the living sponges acted as a bionic living skin to create a favorable microenvironment for tissue regeneration and promote healing of diabetic wounds.
ADVANCED FIBER MATERIALS
(2023)
Article
Engineering, Biomedical
Wei Chen, Yongsheng Li, Yuting Huang, Yao Dai, Tingfei Xi, Zheng Zhou, Hairong Liu
Summary: The study indicates that quercetin-modified PHBV fibrous scaffold has the potential to promote cartilage regeneration in tissue engineering. By regulating related genes, it can inhibit chondrocyte apoptosis and reduce oxidative stress.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Review
Chemistry, Medicinal
Ganesan Padmini Tamilarasi, Govindaraj Sabarees, Manikandan Krishnan, Siddan Gouthaman, Veerachamy Alagarsamy, Viswas Raja Solomon
Summary: Treating a wound infection caused by a multidrug-resistant bacterium is difficult, so there is a need to develop wound dressings resistant to these bacteria. Many diabetic and burn wounds show signs of infection. Diabetes can lead to chronic sores, vascular damage, and neuropathy.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shutong Qian, Juan Wang, Zhimo Liu, Jiayi Mao, Binfan Zhao, Xiyuan Mao, Liucheng Zhang, Liying Cheng, Yuguang Zhang, Xiaoming Sun, Wenguo Cui
Summary: A Janus electrospun short fiber scaffold has been fabricated, which can aggregate wound exudate and trigger the cascade release of curcumin, thus promoting the healing process of chronic wounds.
Review
Materials Science, Multidisciplinary
Biruk Fentahun Adamu, Jing Gao, Abdul Khalique Jhatial, Degu Melaku Kumelachew
Summary: Modern wound dressings are now incorporating functional materials like electrospun nanofibers to assist in wound healing and tissue regeneration. These dressings also provide breathability for cellular growth and have potential applications in drug delivery systems.
MATERIALS & DESIGN
(2021)
Article
Biotechnology & Applied Microbiology
Jiah Shin Chin, Leigh E. Madden, Anthony R. J. Phillips, Sing Yian Chew, David L. Becker
Summary: This study evaluated the effects of 3D fibrous scaffolds fabricated using wet electrospinning on wound healing. The results showed that the poly(epsilon-caprolactone) (PCL) scaffold promoted fibroblast migration and angiogenesis, facilitating re-epithelialization. On the other hand, the addition of rat tail type 1 collagen to the scaffold hindered re-epithelialization and induced an inflammatory response.
BIOENGINEERING-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Hengjie Zhang, Jianhua Zhang, Xu Peng, Zhan Li, Wanjie Bai, Tianyou Wang, Zhipeng Gu, Yiwen Li
Summary: In this study, a series of smart internal bio-glues were developed by integrating o-nitrobenzene modified biopolymers with up-conversion nanoparticles (UCNPs). The prepared smart bio-glues can undergo gelation and induce strong tissue adhesion under both dry and wet conditions upon irradiation by near-infrared (NIR) light. These NIR light-responsive bio-glues with deeper tissue penetration ability exhibit good biocompatibility, excellent hemostatic performance, and the potent ability to accelerate wound healing for both external and internal wounds.
Article
Chemistry, Multidisciplinary
Xiaotong Wu, Jianmei Chen, Anwei Zhou, Yinfeng Zhao, Zihan Tian, Yiping Zhang, Kerong Chen, Xinghai Ning, Yurui Xu
Summary: A light-activated chemically reactive fibrous patch called ChemPatch was developed to prevent postoperative peritoneal adhesion. The ChemPatch, constructed using electrospinning, exhibited good adhesion to tissues and possessed antioxidant and radical scavenging activity. It also promoted tissue regeneration and prevented postoperative peritoneal adhesion, making it a dual-active bioadhesive barrier.
Article
Biochemistry & Molecular Biology
Sepideh Yoosefi, Amir Rakhshani, Vahideh Montazeri, Mohamadreza Tavakoli, Amin Aliabadi, Yousef Fatahi, Helia Behrouzfar, Shadi Keihankhadiv, Behzad Darbasizadeh, Hamidreza Motasadizadeh, Hassan Farhadnejad
Summary: The present study aimed to improve wound healing rate using LDH-VAN/IBU/CMC-PEO bionanocomposite fibrous mats. The fabricated mats showed sustained drug release and no cytotoxicity, and could accelerate the wound healing process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Ziyu Song, Jiajun Wang, Shaojie Tan, Jing Gao, Lu Wang
Summary: This study combines PCL/gelatin nanofiber membranes with rGO-loaded chitosan non-woven fabrics to prepare biomimetic bilayer skin scaffolds for the treatment of severely damaged wounds. The scaffolds showed good cell proliferation and adhesion, fast re-epithelialization, high conductivity, and improved cell viability. They also enhanced structural stability and moisture absorption, promoting skin tissue regeneration.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Review
Materials Science, Multidisciplinary
Zijian Wang, Weikang Hu, Wang Wang, Yu Xiao, Yun Chen, Xinghuan Wang
Summary: This review summarizes the impact of bacterial infection on wound healing and presents the latest advances in antibacterial nanofibrous materials for accelerating the healing process. By incorporating substances such as antibiotics, antimicrobial peptides, metals, and antibacterial polymers into ENMs, the antibacterial activity of ENMs is enhanced.
ADVANCED FIBER MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Walaa S. Aburayan, Areej M. Alajmi, Ahmed J. Alfahad, Wijdan K. Alsharif, Abdullah A. Alshehri, Rayan Y. Booq, Samar A. Alsudir, Fatemah M. Alsulaihem, Haitham A. Bukhary, Moutaz Y. Badr, Essam J. Alyamani, Essam A. Tawfik
Summary: A fibrous material system composed of a biocompatible polymer loaded with melittin, the active ingredient of bee venom, was proposed for the treatment of skin infections caused by antimicrobial-resistant bacteria. The system exhibited effective antibacterial properties and could be used as a wound dressing patch.
Article
Engineering, Biomedical
Ritopa Das, Thinh T. Le, Benjamin Schiff, Meysam T. Chorsi, Jinyoung Park, Priscilla Lam, Andrew Kemerley, Ajayan Mannoor Supran, Amit Eshed, Ngoc Luu, Nikhil G. Menon, Tannin A. Schmidt, Hanzhang Wang, Qian Wu, Mahesh Thirunavukkarasu, Nilanjana Maulik, Thanh D. Nguyen
Summary: Electrical stimulation combined with tissue engineering techniques using a biodegradable self-charged piezoelectric PLLA nanofiber matrix can effectively promote wound healing and prevent bacterial growth. This novel approach utilizes an external ultrasound to activate the piezoelectric scaffold, generating controlled surface charges with different polarities that suppress bacterial growth and promote skin regeneration simultaneously. In vitro and in vivo experiments demonstrate the efficacy of this multi-tasking, battery-free electrical stimulator in facilitating cell proliferation, gene expression related to wound healing, and bacterial infection prevention.
Article
Engineering, Biomedical
Dan-Kai Wu, Wen-Chuan Chen, Kun-Jhih Lin, Cheng-Lun Tsai, Kang-Ping Lin, Hung-Wen Wei
Summary: This study analyzed the multi-directional biomechanical performance of spiral clavicle plates, showing that they enhanced structural stability under different mechanical loads. The improvement in multi-directional biomechanical stability provided by spiral clavicle plates is worth considering in clinical applications, with further investigation needed on implant safety based on mechanical tests and clinical observations.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Yutao Cui, Zhonghan Wang, Zuhao Li, Xuan Ji, Baoming Yuan, Yu Sun, Chuangang Peng, Yi Leng, Minghan Dou, Jincheng Wang, He Liu, Dankai Wu
Summary: This study developed a drug-releasing inorganic-organic bioactive interface to enhance osseointegration in joint replacement for osteoporotic patients, effectively preventing complications such as prosthesis loosening and periprosthetic fractures. The interface improved osteogenic differentiation, inhibited osteoclast-related gene expression, and regulated osteoclastic activity, showing promising results in ameliorating osteoporosis and promoting stable bone integration around the interface.
MATERIALS & DESIGN
(2021)
Review
Biotechnology & Applied Microbiology
Yuhang Tian, Danhua Wu, Dankai Wu, Yutao Cui, Guangkai Ren, Yanbing Wang, Jincheng Wang, Chuangang Peng
Summary: This review discusses the role and application of chitosan in the treatment of infected bone defects. Chitosan, as an antibacterial natural polymer, has been widely studied in bone tissue engineering. By promoting the adhesion and proliferation of osteoblast-related cells, chitosan can provide an ideal carrier for bone repair. In addition, the properties of functionalized chitosan are analyzed and compared. The latest research on the combination of chitosan with other materials and biomolecules for the treatment of infected bone defects is summarized in this review.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Baoming Yuan, Guangkai Ren, Yutao Cui, Feng Gao, Weiwei Miao, Zhengwei Li, Shicheng Zhou, Qingyu Wang, Yanbing Wang, Jin Dai, Chuangang Peng, Dankai Wu
Summary: The covert-inferior pelvic approach combined with a subpubic plate effectively fixed Nakatani type-I, II, and III fractures. It offers rapid recovery post-surgery, safety, simplicity, short learning curve, no abdominal soft tissue damage, no effect on pubic symphysis micromotion, and esthetic benefits. This method may serve as an alternative option for anterior pelvic ring fractures and complement other approaches.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Review
Biotechnology & Applied Microbiology
Jingwei Wang, Yutao Cui, He Liu, Shaorong Li, Shouye Sun, Hang Xu, Chuangang Peng, Yanbing Wang, Dankai Wu
Summary: This review presents advanced strategies using miRNA as bone tissue engineering materials. miRNA promotes osteogenic differentiation of stem cells by regulating intracellular signaling pathways. Various functional bone tissue engineering materials have been developed using miRNA and have shown significant efficacy in promoting bone repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Surgery
Le Qi, Yikun Jiang, Yanbing Wang, Chuangang Peng, Dankai Wu
Summary: This study introduces a novel surgical approach, pediatric physeal slide-traction plate fixation (PPSP), for Neer-Horwitz grade IV PHFs in children. A 9-year-old boy underwent this surgery and achieved satisfactory recovery after 22 months of follow-up.
FRONTIERS IN SURGERY
(2022)
Review
Pediatrics
Yikun Jiang, Le Qi, Chuangang Peng, Qiwei Li, Peng Zhang, Yanbing Wang, Dankai Wu
Summary: The coronoid process of the ulna is important for maintaining elbow joint stability. Reconstruction of the coronoid process with the olecranon tip can restore stability and kinematics. This technique is safe and effective for treating chronic elbow instability caused by coronoid process defects of the ulna.
FRONTIERS IN PEDIATRICS
(2022)
Review
Biotechnology & Applied Microbiology
Shouye Sun, Yutao Cui, Baoming Yuan, Minghan Dou, Gan Wang, Hang Xu, Jingwei Wang, Wen Yin, Dankai Wu, Chuangang Peng
Summary: This paper reviews the application of polyethylene glycol (PEG)-based hydrogels in the treatment of bone defects. The advantages and disadvantages of PEG as a carrier are analyzed, and various modification methods of PEG hydrogels are summarized. On this basis, the application of PEG-based hydrogel drug delivery systems in promoting bone regeneration in recent years is summarized. Finally, the shortcomings and future developments of PEG-based hydrogel drug delivery systems are discussed. This review provides a theoretical basis and fabrication strategy for the application of PEG-based composite drug delivery systems in local bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Yutao Cui, He Liu, Yuhang Tian, Yi Fan, Shaorong Li, Gan Wang, Yanbing Wang, Chuangang Peng, Dankai Wu
Summary: The treatment of infected bone defects is a challenging problem in orthopedics. This review analyzes the impaired bone repair ability and mechanisms in the microenvironment of pathogen infection and excessive inflammation, and discusses the composite dual-functional scaffold and drug delivery systems with antibacterial and bone-promoting capabilities. It provides a theoretical basis and clinically significant treatment methods for infectious bone defects.
MATERIALS TODAY BIO
(2022)
Article
Biophysics
Gan Wang, Yutao Cui, He Liu, Yuhang Tian, Shaorong Li, Yi Fan, Shouye Sun, Dankai Wu, Chuangang Peng
Summary: This review examines the application of antimicrobial peptides (AMPs) in treating bacterial bone infection in open fractures, discussing their mechanisms, loading strategies, and future development. AMPs have good biocompatibility and can serve as a reliable alternative to traditional antibiotics.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Yi Fan, Guangkai Ren, Yutao Cui, He Liu, Shaorong Li, Yuhang Tian, Gan Wang, Chuangang Peng, Yanbing Wang, Dankai Wu
Summary: Peptide-based hydrogels are widely studied and applied in bone repair due to their biocompatibility, biodegradability, and designability. By introducing biologically functional groups and adjusting the composition, peptide-based hydrogels can have different properties. They can be used alone to fill bone defects or as sustained-release carriers to enhance bone regeneration. Additionally, peptide-based hydrogels can provide solutions for repairing large bone defects by incorporating other scaffold materials.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Biomaterials
Yutao Cui, Jingwei Wang, Yuhang Tian, Yi Fan, Shaorong Li, Gan Wang, Chuangang Peng, He Liu, Dankai Wu
Summary: In this study, a functionalized decellularized bone scaffold was developed by incorporating peptides derived from bone morphogenetic protein-2, which enhanced osteogenesis and showed great potential for the treatment of large bone defects.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Dermatology
Yutao Cui, Baoming Yuan, Yan Zhang, Guangkai Ren, Minghan Dou, Chuangang Peng, Dankai Wu
Summary: This study designed a reverse-traction skin-stretching device (RT-SSD) to relieve skin tension and promote wound healing. The application of RT-SSD effectively reduced skin tension and protected subcutaneous microcirculation, leading to improved healing of large skin defects.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Materials Science, Biomaterials
Shaorong Li, Yutao Cui, He Liu, Yuhang Tian, Gan Wang, Yi Fan, Jingwei Wang, Dankai Wu, Yanbing Wang
Summary: The use of metal ions in the treatment of bone defects has significant effects on promoting bone tissue growth, inhibiting osteoclast activity, and exerting antibacterial effects. Metal ions-modified composite scaffolds are effective in promoting bone defect healing.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Medicine, Research & Experimental
Chuangang Peng, Guangkai Ren, Minghan Dou, Baoming Yuan, Dankai Wu
Summary: The purpose of this study was to demonstrate that minimally invasive plate osteosynthesis (MIPO) technology can simplify the treatment of complex fractures and improve patient prognosis. Through a case presentation of a 38-year-old man, who suffered from multiple fractures, the application and effectiveness of MIPO technique in managing complex fractures were showcased.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
