Article
Dentistry, Oral Surgery & Medicine
Xue Yuan, Vedanshi Amin, Tianli Zhu, Mizuho Kittaka, Yasuyoshi Ueki, Teresita M. Bellido, Hakan Turkkahraman
Summary: The aim of this study was to investigate the early effects of Type 1 diabetes mellitus (T1DM) on the periodontium. By examining diabetic mice using histology, molecular and cellular assays, it was found that gingival inflammation and soft tissue degeneration increased in the diabetic condition, but the alveolar bone was preserved through the recruitment of more osteoprogenitor cells and increased bone formation rates.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Endocrinology & Metabolism
Wenjin Li, Jing Zheng, Yao Xu, Weiran Niu, Dong Guo, Jianing Cui, Wenjin Bian, Xiaohui Wang, Jinliang Niu
Summary: This study observed the elongation of unopposed rodent molars in a type 1 diabetes mellitus model and explored the pathological changes of periodontal ligament and alveolar bone, as well as their correlation with tooth axial movement. The results showed that tooth elongation was inhibited in type 1 diabetic mice, with increased osteoclasts and lower bone mineral density. There were also changes in the expression of osteogenesis-related genes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Carlos Poblete Jara, Guilherme Nogueira, Joseane Morari, Thais Paulino do Prado, Renan de Medeiros Bezerra, Licio A. Velloso, William Velander, Eliana Pereira de Araujo
Summary: This study establishes a mouse model that mimics the healing defects in chronic wounds associated with type two diabetic skin ulcers in the elderly. The model exhibits similarities in metabolic phenotype and skin changes to elderly patients with diabetic foot ulcers, providing a valuable tool for advancing wound treatment research.
Article
Endocrinology & Metabolism
Ning-Ning Hou, Cheng-Xia Kan, Na Huang, Yong-Ping Liu, En-Wen Mao, Yu-Ting Ma, Fang Han, Hong-Xi Sun, Xiao-Dong Sun
Summary: The study found a negative association between serum Dickkopf-1 levels and albuminuria, suggesting that lower serum Dickkopf-1 levels could be a critical risk factor for the development of albuminuria in individuals with diabetes.
WORLD JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Pei Hu, Jennifer A. McKenzie, Evan G. Buettmann, Nicole Migotsky, Michael J. Gardner, Matthew J. Silva
Summary: Type 1 diabetes impairs bone formation and fracture healing in humans. Akita mice, with a mutation in the insulin-2 gene, showed reduced bone mass and weaker bones, as well as impaired fracture healing. Akita mice exhibited osteopenia and decreased bone mechanical properties, mimicking some skeletal features of T1DM in humans.
Article
Endocrinology & Metabolism
Fei Gao, Cheng Li, Jiahui Peng, Wei Lu, Wei Zhu, Jian Zhou, Jingyi Lu, Xiaojing Ma
Summary: This study found that serum DKK-1 levels significantly decreased after 12 weeks of hypoglycemic treatment, and Delta DKK-1 levels were negatively correlated with baseline DKK-1 levels. Baseline DKK-1 levels were positively related to total cholesterol and LDL-C, with patients in the lower baseline DKK-1 group showing more favorable cardiometabolic factors in some aspects.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Tyler N. Kambis, Hamid R. Shahshahan, Paras K. Mishra
Summary: Metabolic remodeling is a key factor in diabetic cardiomyopathy, and high glycemic fluctuations can increase metabolic stress. However, the influence of metabolites and genes on metabolic remodeling in the T1DM heart is not well understood. Our study found that differential expression of metabolic genes and metabolites can synergistically influence metabolic remodeling in T1DM hearts. Through high throughput analysis of Akita mouse hearts, we identified disrupted metabolic pathways that contribute to T1DM cardiac metabolic derangement. These findings provide a foundation for understanding and developing novel therapies to prevent/improve metabolic remodeling in T1DM hearts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Dibya Sundar Panda, Hussein M. Eid, Mohammed H. Elkomy, Ahmed Khames, Randa M. Hassan, Fatma I. Abo El-Ela, Heba A. Yassin
Summary: The study aims to develop lecithin-chitosan based nanoparticles loaded with berberine for wound healing in diabetic animals. The optimized nanoparticulate system showed sustained release profile and synergistic effect in wound healing by reducing inflammation, inducing blood vessels and fibroblast proliferation, and promoting collagen fibers deposition. Further clinical investigation is needed to explore the potential benefits of this system in diabetic patients.
Article
Dentistry, Oral Surgery & Medicine
Ema Paljevic, Ivana Brekalo Prso, Jelena Vidas Hrstic, Elvis Bozac, Sonja Pezelj-Ribaric, Romana Persic Bukmir
Summary: This study aimed to compare the healing of periapical bone between type II diabetes patients and healthy patients after root canal treatment.
Article
Multidisciplinary Sciences
Nuria Martinez, Lorissa J. Smulan, Michael L. Jameson, Clare M. Smith, Kelly Cavallo, Michelle Bellerose, John Williams, Kim West, Christopher M. Sassetti, Amit Singhal, Hardy Kornfeld
Summary: Diabetes mellitus, especially type 2 diabetes, increases the risk of developing tuberculosis. In a mouse model, it was found that mice with type 2 diabetes, induced by a high-fat diet and streptozotocin, had higher mortality, more severe lung pathology, and higher bacterial burden following Mycobacterium tuberculosis infection compared to mice treated with streptozotocin or high-fat diet alone. The elevated plasma glycerol level in the type 2 diabetes model mice was found to contribute to their susceptibility to infection, as glycerol is a preferred carbon source for M. tuberculosis.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and with lower BV/TV. A new BMA parameter, Ad.N/BS, is positively correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while that of metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and lower BV/TV. The new BMA parameter Ad.N/BS is correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Mathematics
Jordan Kralev, Tsonyo Slavov
Summary: The study aims to design a robust μ-controller for glucose-insulin metabolism to address the blood glucose control issue in type I diabetes.
Review
Medicine, General & Internal
Jose Ignacio Martinez-Montoro, Beatriz Garcia-Fontana, Cristina Garcia-Fontana, Manuel Munoz-Torres
Summary: Bone fragility is a common complication in subjects with type 2 diabetes mellitus. Traditional techniques for evaluating bone fragility do not perform well in this population, but new technologies and biomarkers are emerging as potential solutions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Hematology
Franziska Hettler, Christina Schreck, Sandra Romero Marquez, Thomas Engleitner, Baiba Vilne, Theresa Landspersky, Heike Weidner, Renate Hausinger, Ritu Mishra, Rupert Oellinger, Martina Rauner, Ronald Naumann, Christian Peschel, Florian Bassermann, Roland Rad, Rouzanna Istvanffy, Robert A. J. Oostendorp
Summary: Chronic inflammation and aging remodel the bone marrow microenvironment, leading to reduced hematopoietic stem cell (HSC) function. In this study, a mouse model with Sfrp1 gene deletion in osteolineage cells was established to investigate the mechanisms of HSC decline and potential strategies to counteract it. The results showed that HSC from these mice had diminished repopulating activity, DNA damage, increased expression of reactive oxygen species pathway, and reduced proliferation. Treatment with IQ-1, which inhibited the phosphorylation of p300, restored HSC function by reducing the association of beta-catenin/phosphop300 and decreasing nuclear p300 in OS1(Delta/Delta) mice. These findings highlight the essential role of osteoprogenitor Sfrp1 in maintaining HSC function and provide a new strategy to restore poor HSC function by downregulating the nuclear beta-catenin/phospho-p300 association.
Article
Endocrinology & Metabolism
Aliya A. Khan, Mishaela R. Rubin, Peter Schwarz, Tamara Vokes, Dolores M. Shoback, Claudia Gagnon, Andrea Palermo, Claudio Marcocci, Bart L. Clarke, Lisa G. Abbott, Lorenz C. Hofbauer, Lynn Kohlmeier, Susanne Pihl, Xuebei An, Walter Frank Eng, Alden R. Smith, Jenny Ukena, Christopher T. Sibley, Aimee D. Shu, Lars Rejnmark
Summary: TransCon PTH demonstrated efficacy in maintaining normocalcemia and allowing independence from conventional therapy in individuals with hypoparathyroidism. The treatment also showed significant improvements in health-related quality of life and hypoparathyroidism-related symptoms.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Eva Maria Woelfel, Franziska Lademann, Haniyeh Hemmatian, Stephane Blouin, Phaedra Messmer, Lorenz C. Hofbauer, Bjoern Busse, Martina Rauner, Katharina Jaehn-Rickert, Elena Tsourdi
Summary: Hyperthyroidism causes secondary osteoporosis by promoting bone resorption. Osteocytic osteolysis and elevated tartrate-resistant acid phosphatase (TRAP) activity were observed in hyperthyroid mice. The bone microarchitecture and turnover recovered after treatment, but the osteocytic osteolysis effects were not reversed.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Engineering, Biomedical
Sofie Dragoun Kolibova, Eva Maria Woelfel, Haniyeh Hemmatian, Petar Milovanovic, Herbert Mushumba, Birgit Wulff, Maximilian Neidhardt, Klaus Pueschel, Antonio Virgilio Failla, Annegreet Vlug, Alexander Schlaefer, Benjamin Ondruschka, Michael Amling, Lorenz C. Hofbauer, Martina Rauner, Bjoern Busse, Katharina Jaehn-Rickert
Summary: Type 1 diabetes mellitus (T1DM) is associated with increased bone fragility. Our study found accelerated osteocyte apoptosis and local mineralization in T1DM patients, suggesting that T1DM speeds up bone aging and impairs its biomechanical competence. Dysfunction of the osteocyte network hampers bone remodeling and repair, contributing to the increased fracture risk in T1DM individuals.
ACTA BIOMATERIALIA
(2023)
Article
Endocrinology & Metabolism
Manuel Gado, Annett Heinrich, Denise Wiedersich, Katrin Sameith, Andreas Dahl, Vasileia I. Alexaki, Michael M. Swarbrick, Ulrike Baschant, Ingo Grafe, Nikolaos Perakakis, Stefan R. Bornstein, Martina Rauner, Lorenz C. Hofbauer, Holger Henneicke
Summary: This study demonstrates that activation of the sympathetic nervous system through cold exposure or selective I33-adrenergic receptor agonist can alleviate the adverse metabolic effects caused by chronic glucocorticoid exposure. Cold exposure preserves the function of brown adipose tissue and reverses white adipose tissue lipid accumulation, correcting obesity, hyperinsulinemia, and hyperglycemia caused by glucocorticoids.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Engineering, Biomedical
Gloria Ruiz-Gomez, Juliane Salbach-Hirsch, Jan-Niklas Duerig, Linda Koehler, Kanagasabai Balamurugan, Sandra Rother, Sophie-Luise Heidig, Stephanie Moeller, Matthias Schnabelrauch, Giulia Furesi, Sophie Paehlig, Pedro M. Guillem-Gloria, Christine Hofbauer, Vera Hintze, M. Teresa Pisabarro, Joerg Rademann, Lorenz C. Hofbauer
Summary: The WNT signaling pathway is important for bone development and regeneration, and abnormalities in WNT ligands and inhibitors are associated with various bone diseases. This study focused on glycosaminoglycan (GAG) recognition by DKK1, a WNT inhibitor, and aimed to develop WNT signaling regulators. Through a multidisciplinary approach, researchers designed and synthesized GAG derivatives with improved neutralizing properties for DKK1. These derivatives showed increased WNT pathway activity and improved bone regeneration in experimental models. The findings suggest that rationally engineered GAG variants could be used as novel therapeutic approaches.
Article
Biochemistry & Molecular Biology
Maria G. Ledesma-Colunga, Ulrike Baschant, Heike Weidner, Tiago C. Alves, Peter Mirtschink, Lorenz C. Hofbauer, Martina Rauner
Summary: In this study, the authors investigated the role of transferrin receptor 2 (Tfr2) in the pathogenesis of inflammatory arthritis. They found that Tfr2-deficient mice developed more severe joint inflammation and bone erosion compared to control mice. Further experiments suggested that Tfr2 deficiency promoted macrophage polarization towards a pro-inflammatory state, contributing to the progression of arthritis.
Article
Endocrinology & Metabolism
Souad Daamouch, Sylvia Thiele, Lorenz Hofbauer, Martina Rauner
Summary: The link between obesity and low bone strength is a significant medical concern. Previous research has shown that Dkk1, a Wnt inhibitor, is upregulated in bone tissue in obesity and drives obesity-induced bone loss. This study investigated the role of adipogenic Dkk1 in bone homeostasis and obesity-induced bone loss in mice. The results suggest that adipogenic Dkk1 plays a transient role in bone mass regulation during adolescence, but does not contribute to bone homeostasis or obesity-induced bone loss later in life.
ENDOCRINE CONNECTIONS
(2023)
Article
Medicine, General & Internal
Athanasios D. Anastasilakis, Stergios A. Polyzos, Panagiotis A. Vorkas, Athina Gkiomisi, Maria P. Yavropoulou, Martina Rauner, Panagiotis Nikolakopoulos, Stergios Papachatzopoulos, Polyzois Makras, Spyridon Gerou, Lorenz C. Hofbauer, Andrea Palermo, Elena Tsourdi
Summary: Menstrual cessation affects lipid metabolism. This study evaluated the effects of goserelin-induced menstrual cessation and subsequent menstrual restoration on lipid metabolism. The results showed that levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoprotein A1 increased during menstrual cessation, but remained unchanged during menstrual restoration.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Lorenz C. Hofbauer, Franziska Lademann, Martina Rauner
Summary: Osteocytes, senescent cells implicated in bone loss disorders, have been shown to be effectively cleared through systemic senolysis, preventing age-related bone loss and mitigating bone marrow adiposity. Cell-specific senolysis in osteocytes alone had only a partial effect. Surprisingly, transplantation of senescent fibroblasts into young mice led to osteocyte senescence and bone loss. These findings on osteocyte senescence and the effects of remote senolysis suggest potential strategies against multisystem aging.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Lejla Emini, Juliane Salbach-Hirsch, Johannes Krug, Katharina Jaehn-Rickert, Bjoern Busse, Martina Rauner, Lorenz C. Hofbauer
Summary: This study assessed the suitability of TH mice as a model for studying diabetic bone disease by comparing the characteristics of diabetic and non-diabetic TH mice. The study found that although TH mice with T2DM had higher blood glucose levels and weight, there were no differences in bone strength and bone cell parameters compared to non-diabetic TH mice.