Article
Chemistry, Analytical
Hongli Ni, Peng Lin, Yifan Zhu, Meng Zhang, Yuying Tan, Yuewei Zhan, Zian Wang, Ji-Xin Cheng
Summary: This study introduces a compact fiber laser-based multiwindow SRS imaging system that addresses issues with bulky and environmentally sensitive solid-state OPO, and slow wavelength tuning speed, demonstrating high-quality SRS metabolic imaging across various Raman windows.
ANALYTICAL CHEMISTRY
(2021)
Article
Optics
Thomas Wurthwein, Maximilian Brinkmann, Tim Hellwig, Kristin Wallmeier, Carsten Fallnich
Summary: The technology utilizes a compact and fast tunable fiber-based light source for frequency modulation coherent anti-Stokes Raman scattering (CARS). With wavelength tuning, Raman resonances between 700 cm(-1) and 3200 cm(-1) can be addressed within 5 ms, allowing for frame-to-frame wavelength switching for FMCARS measurements. Integration of high-sensitivity functionality via fiber optics enables a 40 times enhanced sensitivity at a lock-in amplifier bandwidth.
Article
Nanoscience & Nanotechnology
Katarzyna Fidecka, Nicola Rotiroti, Jessica Giacoboni, Fernando Camara, Matthieu Refregiers, Riccardo Vago, Emanuela Licandro, Frederic Jamme
Summary: This study reports the characterization of nonfluorescent halloysite nanotubes (HNTs) using multiphoton microscopy and reveals the discovery of the SH signal generated by HNTs at the nanoscale level. The study sheds light on the understanding of the signal's generation from the nanoparticle's aluminosilicate skeleton and suggests potential technological applications of HNTs in various domains.
ACS APPLIED NANO MATERIALS
(2021)
Article
Physics, Applied
Dana Jashaner, Yuxia Zhou, Taximaiti Yusufu
Summary: We present a widely-tunable mid-infrared picosecond optical vortex laser source, utilizing a synchronized-pumped optical parametric oscillator optimized for emission up to 5 μm in the mid-infrared range. The vortex output with a continuously-tunable wavelength range of 2.6-5 μm can be achieved by translating the MgO:PPLN crystal. At the maximum pump power of 15 W, the measured maximum idler output powers were 3.7 W, 1.7 W, and 0.165 W at wavelengths of 2.6 μm, 3.8 μm, and 5 μm, respectively. The corresponding photon conversion efficiencies were estimated to be 60% at 2.6 μm, 40% at 3.8 μm, and 5.2% at 5 μm.
APPLIED PHYSICS EXPRESS
(2022)
Article
Optics
Lijiong Shen, Jianwei Lee, Antony Winata Hartanto, Pengkian Tan, Christian Kurtsiefer
Summary: An alternative approach using time-correlated photon pairs generated in SPDC is proposed to measure the temporal response of single-photon detectors. By changing the critical phase-matching conditions of the SPDC process, a wavelength-tunable source of photon pairs is achieved. The experimental results demonstrate the characterization of single-photon avalanche detectors sensitive to different wavelength bands.
Article
Engineering, Electrical & Electronic
Xiushan Du, Yuke Zhai, Leonardo Midolo, Lin Zhang, Xiaoyan Zhou
Summary: This paper proposes a method for efficient frequency conversion using a nanomechanical silicon-rich nitride waveguide device, to address the frequency conversion challenge in on-demand single-photon sources. Numerical results show that optimal conversion efficiency over 99% and high signal-to-noise ratio can be achieved when the waveguide loss is negligible.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Optics
Jinsheng Liu, Yufang Ding, Xingbin Gu, Peng Yuan, Dongfang Zhang, Jing Wang, Guoqiang Xie, Heng Tu, Jiyong Yao, Liejia Qian, Jingui Ma
Summary: In this study, a sub-picosecond mid-infrared light source was developed to enhance the efficiency of optical rectification (OR). Numerical simulations were conducted to determine the optimal parameters, and experimental results demonstrated the superior output performance of the light source for high-efficiency OR in various materials.
Article
Optics
Jinsheng Liu, Yufang Ding, Xingbin Gu, Peng Yuan, Dongfang Zhang, Jing Wang, Guoqiang Xie, Heng Tu, Jiyong Yao, Liejia Qian, Jingui Ma
Summary: In this study, a sub-picosecond mid-infrared light source was developed to enhance the efficiency of optical rectification. Optimal pump parameters were determined through numerical simulations, and an optical system was built accordingly. The experimental results demonstrated that this light source is capable of generating efficient coherent terahertz radiation in a wide range of wavelengths.
Article
Engineering, Electrical & Electronic
Robinson Guzman, Luis Gonzalez, Alberto Zarzuelo, Jessica Cuello, Muhsin Ali, Ilka Visscher, Robert Grootjans, Joern Epping, Chris Roeloffzen, Guillermo Carpintero
Summary: Photonics-based techniques are crucial in generating high-frequency signals in millimeter and Terahertz wave ranges. Photonic integration provides added advantages of energy-efficiency, flexibility, and scalability, in addition to signal quality. The optical heterodyne system presented in this study achieves continuous-wave generation of RF frequencies over a wide tuning range from C-band to W-band with record low RF electrical linewidth.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lapo Turrini, Michele Sorelli, Giuseppe de Vito, Caterina Credi, Natascia Tiso, Francesco Vanzi, Francesco Saverio Pavone
Summary: In this study, transgenic zebrafish larvae were used to investigate functional alterations during seizure and the involvement of different brain regions. The study found that the epileptic larval brain undergoes transitions between different neural activity states and different brain regions are progressively recruited into seizures of diverse severity.
Article
Chemistry, Analytical
Ifat Jahangir, M. Ahsan Uddin, Alina Franken, Amol K. Singh, Goutam Koley
Summary: In this work, a mixed dimensional heterojunction of graphene and planar InN nanowires has been studied for highly sensitive gas sensing applications. The high surface carrier concentration of InN has been effectively suppressed through controlled partial surface oxidation. The resulting surface modified InN nanowires form excellent Schottky junctions with graphene and show highly tunable barrier heights by the gate voltage, serving as a mixed dimensional barristor device.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Violaine Hubert, Ines Hristovska, Szilvia Karpati, Sarah Benkeder, Arindam Dey, Chloe Dumot, Camille Amaz, Naura Chounlamountri, Chantal Watrin, Jean-Christophe Comte, Fabien Chauveau, Emmanuel Brun, Patrice Marche, Frederic Lerouge, Stephane Parola, Yves Berthezene, Thomas Vorup-Jensen, Olivier Pascual, Marlene Wiart
Summary: This study proposes and validates a preclinical in vivo MRI tool to monitor neuroinflammation following ischemic stroke, based on injection of a novel multimodal nanoprobe designed for internalization by phagocytic cells. The study confirms efficient internalization of NanoGd by microglia and shows hypointense signals in the ischemic lesion using in vivo MRI with NanoGd injection in a mouse model. Additionally, the study demonstrates NanoGd internalization by activated phagocytic cells through both intravital microscopy and ex vivo analysis.
Article
Optics
J. Connor Skehan, Oskar B. Helgason, Jochen Schroeder, Victor Torres-Company, Peter A. Andrekson
Summary: This article demonstrates a method to generate a widely and arbitrarily tunable laser source with a very narrow linewidth, achieving a high power, high side mode suppression ratio output wave. The method is implemented across 1530 -1585 nm range and the prospects of extending its performance are discussed.
Article
Optics
Juehyung Kang, Ungyo Kang, Hyeong Soo Nam, Wooseop Kim, Hyun Jung Kim, Ryeong Hyeon Kim, Jin Won Kim, Hongki Yoo
Summary: This letter presents a novel method for nonlinear multimodal imaging of biological samples using a single light source and detector. The developed system successfully acquired multimodal images of swine coronary arteries, indicating its potential value for various biomedical applications.
Article
Chemistry, Physical
Denis V. Lebedev, Vitaly A. Shkoldin, Alexey M. Mozharov, Artem O. Larin, V. Dmitry Permyakov, Anton K. Samusev, Anatoly E. Petukhov, Alexander O. Golubok, V. Alexander Arkhipov, Ivan S. Mukhin
Summary: This work presents a simple approach to fabricate nanoscale electrically driven light sources based on the phenomenon of light emission via inelastic tunneling of electrons. By using STM lithography, hybrid nanoantennas with a minimum diameter of 60 nm were formed, which can efficiently emit photons in the visible range.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Rheumatology
Jiazhen Zheng, Xihao Huang, Jinghan Huang, Bingyao Meng, Furong Li, Huamin Liu, Liren Chen, Rui Zhou, Mengchen Zou, Xianbo Wu
Summary: This study evaluated the association between glycemic control and the risk of symptomatic knee osteoarthritis in a community-based cohort of older adults. The findings suggest that diabetes, poor glycemic management, and long-term diabetes are potential risk factors for knee osteoarthritis. The study also highlights the importance of targeting blood glucose in addition to bodyweight as a preventive measure for knee osteoarthritis.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Oncology
Haiyan Zhang, Zhiping Fan, Fen Huang, Lijie Han, Yajing Xu, Na Xu, Lan Deng, Shunqing Wang, Dongjun Lin, Xiaodan Luo, Qing Zhang, Xiaodan Liu, Xudong Li, Xinquan Liang, Shuangfeng Xie, Hong Qu, Sijian Yu, Hongsheng Zhou, Pengcheng Shi, Li Xuan, Ren Lin, Hui Liu, Hua Jin, Jing Sun, Qifa Liu
Summary: A randomized phase III trial in China compared busulfan plus cyclophosphamide (BuCy) regimen with total body irradiation plus cyclophosphamide (TBI-Cy) regimen as conditioning for allo-HSCT in adult standard-risk B-cell-ALL patients. The study found that BuCy regimen had noninferior efficacy and safety compared to TBI-Cy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Engineering, Environmental
Wei Peng, Zhaoyang Wang, Ruihu Lu, Qi Li, Ziyun Wang, Yan Zhao, Lin Xu, Liqiang Mai
Summary: In this study, a novel metallic heterostructure composed of defect-rich nickel and amorphous/crystalline molybdenum nitride anchored on a carbon matrix (MoN/Ni@C) was fabricated and demonstrated as a superior electrocatalyst for the hydrogen evolution reaction (HER). The MoN/Ni@C electrocatalyst exhibited low HER overpotential and small Tafel slope, along with excellent stability in alkaline solution. Density functional theory calculations revealed that the interfacial electron transfer contributed to the distortion of Ni surface and the optimal thermoneutral hydrogen adsorption free energies on Mo and Ni active sites. The amorphous/crystalline structure in the MoN phase provided more active sites and promoted structural stability. This work provides new insights into designing non-noble-metal-based electrocatalysts with superior HER activities.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Optics
Zitong Feng, Hesham Sakr, John R. Hayes, Eric Numkam Fokoua, Meng Ding, Francesco Poletti, David J. Richardson, Radan Slavik
Summary: Optical fibers with a low thermal coefficient have been developed for frequency and timing transmission. A new hollow core fiber with a thin acrylate coating has been shown to have a stable thermal coefficient over a wide temperature range and can be insensitive to temperature around -134 degrees C.
Article
Biochemical Research Methods
Feng Liu, Weicheng Ren, Hailong Liu, Hao Liu, Shuyue Wang, Di Zhang, Dandan Sun, Feifei Zhang, Zhengkang Shao, Jia Feng, Menghan Yan, Lan Yang, Zhiwei Wang, Jinliang Zhang, Yingwu Wang
Summary: Liquid chromatography coupled to mass spectrometry (LC-MS) is utilized for host cell proteins (HCP) identification in antibody drug development, but its application in prokaryotic-derived growth hormone (GH) samples is rare. In this study, a universal workflow combining optimized sample preparation and one-dimensional ultra-high performance LC-MS-based shotgun proteomics was developed to profile HCP in GH samples, providing guidance for purification process development and biosimilar development. A standard-spiking strategy was also developed to enhance HCP identification, enabling trace-level HCP analysis. These protocols open avenues for HCP profiling in biotherapeutics derived from prokaryotic host cells.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Engineering, Environmental
Zixuan Cai, Xin Zhou, Yushi Yang, Jie Li, Weihua Liu, Qianqian Wang, Lin Hao, Zhi Wang, Yusuke Yamauchi, Jungmok You, Shuaihua Zhang, Qiuhua Wu, Chun Wang
Summary: A series of cyano-functionalized ionic porous organic polymers (CN-iPOPs) were prepared and used for the sensitive analysis of estrogens in environmental and food samples. The optimized CN-iPOP3 showed exceptional sorption capacity for estrogens, making it an advanced adsorbent for solid phase extraction (SPE) of estrogens.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Haoran Wang, Qing Cheng, Ziqi Zhai, Xiangyun Cui, Mingxuan Li, Ruiquan Ye, Liang Sun, Huolin Shen
Summary: Transcriptomic and proteomic analyses were performed to identify genes and proteins associated with celery cytoplasmic male sterility. The results provide a foundation for further investigation into the mechanisms of pollen development and the causes of cytoplasmic male sterility in celery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Rui Yang, Lijun Yang, Tingmei Wang, Qihua Wang
Summary: This study introduces a powder metallurgy route to enhance the mechanical properties of equiatomic CoCrNi medium-entropy alloys using multiple strengthening mechanisms. The yield strength of the alloy produced by mechanical alloying is significantly higher than that of alloys prepared from commercial powders or casting. The coordination of ultra-fine grains, twins, and high-density stacking faults contributes to the enhanced strength. Molecular dynamic simulations further demonstrate the influence of twins and stacking faults on the grain refinement effect. These findings highlight the effectiveness of mechanical alloying in producing MEAs with superior strength.
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2023)
Article
Engineering, Electrical & Electronic
Peiye Liu, Gert Frolund Pedersen, Wonbin Hong, Shuai Zhang
Summary: A dual-polarized wideband low-sidelobe slot array antenna for wireless communication systems in the V-band is proposed. The design utilizes Taylor distribution and compact wideband unequal power dividers to achieve stable amplitude and phase distribution among elements. Orthogonally polarized feeding networks with unequal power dividers are used to connect the subarrays to the input ports. The fabricated prototype demonstrates high gain, wide impedance bandwidth, and low sidelobe levels.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2023)
Article
Biochemistry & Molecular Biology
Yu-Xiong Ju, Peng Song, Ping-Yue Wang, Xin-Xin Chen, Tao Chen, Xiao-Hui Yao, Wei-Guo Zhao, Dong-Yang Zhang
Summary: In this study, a hydrogel electrode with excellent mechanical strength was created by simulating the collagen fiber network and proteoglycan in cartilage. The hydrogel electrode showed enhanced mechanical properties and fracture energy due to the bionic structure. The hydrogel electrode also achieved a high capacitance and energy density, maintaining a high capacitance after multiple charge-discharge cycles and stretching.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Thermodynamics
Lan Li, Xiwei Li, Shengbing Wan, Zheng Liu, Yafen Zhang, Qinghong Kong, Junhao Zhang
Summary: An efficient flame retardant (ADM) with phosphophenanthrene and thiazole groups was synthesized to alleviate the fire hazard of epoxy resin (EP). EP/4% ADM composites containing only 0.25% phosphorus reached UL-94 V-0 rating and had a high limiting oxygen index of 35.8%. The improved flame retardancy was attributed to the decomposition of DOPO, which captured reactive radicals, and the dilution effect of the thiazole group.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Biochemical Research Methods
Duanyang Xu, Konstantinos N. Bourdakos, Anna Crisford, Peter Johnson, Ibrahim Abughazaleh, Panuwat Srisamran, Richard O. C. Oreffo, Sumeet Mahajan, David J. Richardson, Lin Xu
Summary: We present an all-fiber ized 1840-nm thulium-fiber-laser source for label-free biological imaging through nonlinear microscopy. The source consists of a dissipative-soliton mode-locked seed laser and a chirped-pulse-amplification system. It utilizes short pulses generated by the mode-locked laser and pulse compression techniques to achieve high-quality imaging of biological samples.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Geochemistry & Geophysics
Yuan Fang, Yuxian Wang, Linlin Xu, Yujia Chen, Alexander Wong, David A. Clausi
Summary: This article proposes a Bayesian neural network for unsupervised subpixel mapping, which integrates different prior information and model constraints to achieve more accurate and visual results compared to other state-of-the-art methods.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2023)
Article
Biochemistry & Molecular Biology
Yen-Ting Liu, Celeste Romero, Xue Xiao, Lei Guo, Xiaoyun Zhou, Mark A. Applebaum, Lin Xu, Stephen X. Skapek
Summary: CDKN2A/B deletion or silencing is common in human cancer, highlighting the importance of bypassing its tumor suppression. In childhood cancers like RMS and neuroblastoma, CDKN2A/B transcripts are expressed independently, but one, ARF, is always silenced. TGF beta can induce CDKN2A/B transcripts, but only when cells are pretreated with methyltransferase inhibitors or EZH2 inhibitors, suggesting a crosstalk between methyltransferase inhibition and TGF beta-dependent activation.
MOLECULAR AND CELLULAR BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoxuan Jia, Lijuan Wan, Xiaoshan Chen, Wanying Ji, Shaoqing Huang, Yuangang Qi, Jingjing Cui, Shengcai Wei, Jin Cheng, Fan Chai, Caizhen Feng, Yulu Liu, Hongmei Zhang, Yingshi Sun, Nan Hong, Shengxiang Rao, Xinhua Zhang, Youping Xiao, Yingjiang Ye, Lei Tang, Yi Wang
Summary: This study aimed to investigate the ability of CT and endoscopic sonography (EUS) in predicting the malignant risk of 1-2-cm gastric gastrointestinal stromal tumors (gGISTs) and to determine whether radiomics could be used for risk stratification. The results showed that the CT radiomics model performed well in discriminating malignant 1-2-cm gGISTs and had potential clinical applicability.
EUROPEAN RADIOLOGY
(2023)
