Article
Infectious Diseases
C. Merla, A. Kuka, G. Petazzoni, U. Postiglione, M. Zatelli, S. Gaiarsa, B. Mariani, M. Corbella, P. Marone, D. Sassera, P. Cambieri
Summary: This study characterized livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) strains in patients from the Policlinico San Matteo in Pavia, Italy. The study found a low but relatively constant frequency of LA-MRSA in these patients, which is comparable to previous studies.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Mubashar Idrees, Khadija Saeed, Muhammad Akbar Shahid, Muhammad Akhtar, Khadija Qammar, Javariya Hassan, Tayyaba Khaliq, Ali Saeed
Summary: This cross-sectional study aimed to determine the prevalence of mecA and mecC genes among phenotypically identified MRSA and evaluate their effectiveness against different antibiotics. The results showed a high prevalence of mecA and mecC in MRSA samples, and penicillin and amoxicillin/clavulanic acid were ineffective against MRSA, while vancomycin, teicoplanin, and linezolid were the most effective drugs.
Article
Microbiology
Mohamed Shohayeb, Tarek El-Banna, Lamis E. Elsawy, Maisra M. El-Bouseary
Summary: This study evaluated the prevalence of PVL genes as a marker for CA-MRSA at tertiary hospitals in Mansoura, Dakahlia, Egypt. The results showed that PVL genes were generally highly prevalent among mecA-positive MRSA isolates, whether they are CA-MRSA, HA-MRSA, or HCW isolates. Therefore, PVL is not a valid marker for CA-MRSA in this region.
Article
Public, Environmental & Occupational Health
F. Hong, S. Salmon, X. Y. Ong, K. Liew, Y. Koh, A. Young, B. Ang, M. L. Foo, L. C. Lee, M. L. Ling, K. Marimuthu, S. Pada, B. F. Poh, K. C. Thoon, D. Fisher
Summary: In Singaporean acute healthcare facilities, while universal MRSA entry swabbing is practiced in accordance with national policy, there are significant variations in the response to positive and negative surveillance swabs, including the role of routine antiseptic bathing and MRSA decolonization. Most facilities view decolonization as 'bioburden reduction' rather than long-term clearance.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Astronomy & Astrophysics
Manish N. Sanghani, Luc Lajaunie, Kuljeet Kaur Marhas, William D. A. Rickard, Silver Sung-Yun Hsiao, Zan Peeters, Hsien Shang, Der-Chuen Lee, Jose J. Calvino, Martin Bizzarro
Summary: This study reports the structural and chemical investigation of nine presolar silicate grains from different chondrites. The grains have diverse origins and compositions, and formed through various condensation processes in stellar outflows.
ASTROPHYSICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Eike Steinig, Izzard Aglua, Sebastian Duchene, Michael T. Meehan, Mition Yoannes, Cadhla Firth, Jan Jaworski, Jimmy Drekore, Bohu Urakoko, Harry Poka, Clive Wurr, Eri Ebos, David Nangen, Elke Mueller, Peter Mulvey, Charlene Jackson, Anita Blomfeldt, Hege Vangstein Aamot, Moses Laman, Laurens Manning, Megan Earls, David C. Coleman, Andrew Greenhill, Rebecca Ford, Marc Stegger, Muhammad Ali Syed, Bushra Jamil, Stefan Monecke, Ralf Ehricht, Simon Smith, William Pomat, Paul Horwood, Steven Y. C. Tong, Emma McBryde
Summary: Community-associated, methicillin-resistant Staphylococcus aureus (MRSA) lineages have emerged and disseminated in various geographically distinct regions around the world. The spread of these MRSA lineages is associated with increases in effective reproduction number (R-e) and sustained transmission. The emergence and epidemiological trajectory of community-associated MRSA lineages from different regions show common signatures of epidemic growth, particularly at the divergence of antibiotic-resistant strains.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Ravi Mural, Guangchao Sun, Marcin Grzybowski, Michael C. Tross, Hongyu Jin, Christine Smith, Linsey Newton, Carson M. Andorf, Margaret R. Woodhouse, Addie M. Thompson, Brandi Sigmon, James C. Schnable
Summary: Classical genetic studies have found that mutations in individual genes can affect multiple phenotypes. However, current quantitative genetic studies of natural genetic variants often only examine a few traits, limiting the potential to identify pleiotropic effects. This study used high-density genetic marker data and a genome-wide association strategy to identify marker-trait associations in the maize genome. Many associations were found between genetic loci and diverse traits, as well as the same or similar traits across different environments. Additionally, significant signals were located near genes with previously unknown functions.
Article
Plant Sciences
Michaela Jung, Beat Keller, Morgane Roth, Maria Jose Aranzana, Annemarie Auwerkerken, Walter Guerra, Mehdi Al-Rifai, Mariusz Lewandowski, Nadia Sanin, Marijn Rymenants, Frederique Didelot, Christian Dujak, Carolina Font i Forcada, Andrea Knauf, Francois Laurens, Bruno Studer, Helene Muranty, Andrea Patocchi
Summary: The study using the multi-environment apple reference population demonstrated genetic architecture and genomic predictive abilities for 30 quantitative traits in apple; GWAS revealed 59 stable and 277 location-specific associations, 69.2% of which were novel; genotype by environment interactions accounted for up to 24% of the phenotypic variability.
HORTICULTURE RESEARCH
(2022)
Article
Genetics & Heredity
Brooke R. Tomlinson, Morgan E. Malof, Lindsey N. Shaw
Summary: One key characteristic of Staphylococcus aureus infections is biofilm formation, which varies phenotypically among different clones. Through transcriptomic analysis, it was discovered that S. aureus undergoes molecular changes and metabolic shifts during biofilm formation, which may affect antibiotic tolerance and bacterial persistence.
MICROBIAL GENOMICS
(2021)
Article
Microbiology
Christen L. Grettenberger
Summary: Photosynthetic Cyanobacteria and their order Gloeobacterales play a crucial role in oxygenic photosynthesis and hold clues to the evolutionary history of this process. However, the limited number of genomes and taxa available from Gloeobacterales poses challenges for studying their evolution. New methods are needed to search for these evolutionarily important taxa for a better understanding of the origin and evolution of oxygenic photosynthesis.
Review
Microbiology
Elena Mitevska, Britney Wong, Bas G. J. Surewaard, Craig N. Jenne
Summary: The prevalence of MRSA in Canada has been increasing since the early 1980s, with a steady rise in the 1990s and 2000s, especially among vulnerable populations. Studies have shown high susceptibility of MRSA to trimethoprim-sulfamethoxazole, but potentially variable resistance to other drugs.
Article
Agronomy
Jared Zystro, Tessa E. Peters, Kathleen M. Miller, William F. Tracy
Summary: The translation highlights the importance of identifying stable genotypes in organic systems due to the difficulty in controlling environment factors. The study on sweet corn genotypes showed significant performance differences between hybrid and inbred varieties, with the need for additional consideration of spatial factors in the experiment.
Editorial Material
Biochemistry & Molecular Biology
Carmen M. Escudero Martinez
Summary: A new study explores the genetic factors that govern the interaction between plant hosts and root-associated microbiota, which can pave the way for developing climate-smart crops.
Article
Electrochemistry
Ulysse Rocabert, Falk Muench, Maximilian Fries, Benedikt Beckmann, Konrad Loewe, Hugo A. Vieyra, Matthias Katter, Alexander Barcza, Wolfgang Ensinger, Oliver Gutfleisch
Summary: This study focuses on the corrosion properties of La-Fe-Si alloys in aqueous heat exchange media, utilizing linear sweep voltammetry to assess materials like α-Fe and hydrogenated La(FeMnSi)13, while also considering specific chemical compounds and commercial corrosion inhibitors as influencing factors.
ELECTROCHIMICA ACTA
(2022)
Article
Agronomy
Keren Brooks, Spyridon Mourtzinis, Shawn P. Conley, Mark S. Reiter, John Gaska, David Lee Holshouser, Trent Irby, Jonathan Kleinjan, Carrie Knott, Chad Lee, Laura Lindsey, Seth Naeve, Jeremy Ross, Maninder Pal Singh, Rachel Vann, Emma Matcham
Summary: This study evaluated the effect of S and N on soybean yield in diverse environments across the United States, and found that soil and environmental factors are poor indicators of yield response to S and N additions. S did not limit yield in most environments, and the use of N and S fertilizers are rarely justified across diverse growing environments.
Article
Public, Environmental & Occupational Health
Hagai Levine, Raid Kayouf, Vladislav Rozhavski, Tamar Sela, Inbal Rajuan-Galor, Anat Tzurel Ferber, Shiraz Yona, Olga Gorochovski, Tami Halperin, Michael Hartal
Article
Oncology
Jianxuan Zou, Dan Chen, Yunhui Zong, Sisi Ye, Jinle Tang, Huimin Meng, Gangli An, Xingding Zhang, Lin Yang
Article
Oncology
Isere Kuiatse, Veerabhadran Baladandayuthapani, Heather Y. Lin, Sheeba K. Thomas, Chad C. Bjorklund, Donna M. Weber, Michael Wang, Jatin J. Shah, Xing-Ding Zhang, Richard J. Jones, Stephen M. Ansell, Guang Yang, Steven P. Treon, Robert Z. Orlowski
CLINICAL CANCER RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Bingzong Li, Jinxiang Fu, Ping Chen, Xueping Ge, Yali Li, Isere Kuiatse, Hua Wang, Huihan Wang, Xingding Zhang, Robert Z. Orlowski
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Multidisciplinary Sciences
Lin Qi, Xue Sun, Feng-E Li, Bao-Song Zhu, Frank K. Braun, Zhi-Qiang Liu, Jin-Le Tang, Chao Wu, Fei Xu, Hui-Han Wang, Luis A. Velasquez, Kui Zhao, Feng-Rui Lei, Ji-Gang Zhang, Yun-Tian Shen, Jian-Xuan Zou, Hui-Min Meng, Gang-Li An, Lin Yang, Xing-Ding Zhang
Article
Oncology
Xing-Ding Zhang, Veerabhadran Baladandayuthapani, Heather Lin, George Mulligan, Bin Li, Dixie-Lee W. Esseltine, Lin Qi, Jianliang Xu, Walter Hunziker, Bart Barlogie, Saad Z. Usmani, Qing Zhang, John Crowley, Antje Hoering, Jatin J. Shah, Donna M. Weber, Elisabet E. Manasanch, Sheeba K. Thomas, Bing-Zong Li, Hui-Han Wang, Jiexin Zhang, Isere Kuiatse, Jin-Le Tang, Hua Wang, Jin He, Jing Yang, Enrico Milan, Simone Cenci, Wen-Cai Ma, Zhi-Qiang Wang, Richard Eric Davis, Lin Yang, Robert Z. Orlowski
Article
Medicine, General & Internal
F. Li, Z. Guo, Y. Zhang, H. Wang, X. Zhang, T. Si, H. Yu, L. Qi
IRISH JOURNAL OF MEDICAL SCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Sivan Kaminski Strauss, Dvir Schirman, Ghil Jona, Aaron N. Brooks, Aditya M. Kunjapur, Alex N. Nguyen Ba, Alice Flint, Andras Solt, Andreas Mershin, Atray Dixit, Avihu H. Yona, Balint Csorgo, Bede Phillip Busby, Bianca P. Hennig, Csaba Pal, Daniel Schraivogel, Daniel Schultz, David G. Wernick, Deepa Agashe, Dikla Levi, Dmitry Zabezhinsky, Dor Russ, Ehud Sass, Einat Tamar, Elad Herz, Emmanuel D. Levy, George M. Church, Idan Yelin, Iftach Nachman, Jeffrey E. Gerst, Joseph M. Georgeson, Katarzyna P. Adamala, Lars M. Steinmetz, Marc Ruebsam, Markus Ralser, Michael Klutstein, Michael M. Desai, Nilima Walunjkar, Ning Yin, Noa Aharon Hefetz, Noah Jakimo, Olga Snitser, Omri Adini, Prashant Kumar, Rachel Soo Hoo Smith, Razi Zeidan, Ronen Hazan, Roni Rak, Roy Kishony, Shannon Johnson, Shira Nouriel, Sibylle C. Vonesch, Simmie Foster, Tal Dagan, Tanita Wein, Thrasyvoulos Karydis, Timothy M. Wannier, Timothy Stiles, Viridiana Olin-Sandoval, William F. Mueller, Yinon M. Bar-On, Orna Dahan, Yitzhak Pilpel
Article
Biochemistry & Molecular Biology
Idan Yelin, Olga Snitser, Gal Novich, Rachel Katz, Ofir Tal, Miriam Parizade, Gabriel Chodick, Gideon Koren, Varda Shalev, Roy Kishony
Article
Infectious Diseases
N. Hassoun-Kheir, O. Snitser, K. Hussein, G. Rabino, O. Eluk, S. Warman, W. Aboalhega, Y. Geffen, S. Mendelson, R. Kishony, M. Paul
Summary: Significant concordance was found between epidemiological and genomic transmission patterns, with genetic linkage analysis serving as an important aid to epidemiological transmission assessment. However, epidemiological investigations are limited by the potential for unidentified transmissions and over-estimation of associations.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Tamar Lachish, Tami Halperin, Olga Snitser, Livnat Kashat, Ofer Merin, Tarif Bader, Assaf Rokney, Eli Schwartz, Marc Victor Assous
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2020)
Article
Cell Biology
Fan Yang, Xue-Qi Liu, Jian-Zhong He, Shi-Ping Xian, Peng-Fei Yang, Zhi-Ying Mai, Miao Li, Ye Liu, Xing-Ding Zhang
Summary: According to recent studies, the tight junction protein occludin (OCLN) is highly expressed in bladder cancer tissues and is associated with a poor prognosis. Downregulation of OCLN inhibits tumor angiogenesis, while overexpression of OCLN has the opposite effect. Mechanistically, OCLN increases levels of interleukin-8 (IL8) and phosphorylated Signal Transducer and Activator of Transcription 3 (p-STAT3) to promote bladder cancer angiogenesis. OCLN regulates IL8 transcriptional activity through the transcription factor STAT4.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mathew Stracy, Olga Snitser, Idan Yelin, Yara Amer, Miriam Parizade, Rachel Katz, Galit Rimler, Tamar Wolf, Esma Herzel, Gideon Koren, Jacob Kuint, Betsy Foxman, Gabriel Chodick, Varda Shalev, Roy Kishony
Summary: Currently, the treatment of bacterial infections focuses on choosing antibiotics based on the susceptibility of the pathogen, but there is less attention given to the risk of treatment-induced resistance. By using genomic sequencing and machine learning analysis, it is possible to predict and minimize the emergence of resistance at the individual-patient level.