Synthetic biology 2020–2030: six commercially-available products that are changing our world

Genome editing approaches to augment livestock breeding programs

(2020) Thomas Frederick Bishop et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The Emerging Landscape of Immune Cell Therapies

(2020) Evan W. Weber et al.   CELL

Superior field performance of waxy corn engineered using CRISPR–Cas9

(2020) Huirong Gao et al.   NATURE BIOTECHNOLOGY

Engineering CAR-T Cells for Next-Generation Cancer Therapy

(2020) Mihe Hong et al.   CANCER CELL

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

(2020) Andrew V. Anzalone et al.   NATURE BIOTECHNOLOGY

Microbiome Engineering: Synthetic Biology of Plant-Associated Microbiomes in Sustainable Agriculture

(2020) Jing Ke et al.   TRENDS IN BIOTECHNOLOGY

Clinical development of CAR T cell therapy in China: 2020 update

(2020) Jianshu Wei et al.   Cellular & Molecular Immunology

Synthetic biology for protein-based materials

(2020) Zhi-Gang Qian et al.   CURRENT OPINION IN BIOTECHNOLOGY

Cell-free systems for accelerating glycoprotein expression and biomanufacturing

(2020) Jasmine Hershewe et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Computational planning of the synthesis of complex natural products

(2020) Barbara Mikulak-Klucznik et al.   NATURE

The second decade of synthetic biology: 2010–2020

(2020) Fankang Meng et al.   Nature Communications

Nature’s Machinery, Repurposed: Expanding the Repertoire of Iron-Dependent Oxygenases

(2020) Noah P. Dunham et al.   ACS Catalysis

Genome Edited Crops Touch the Market: A View on the Global Development and Regulatory Environment

(2020) Jochen Menz et al.   Frontiers in Plant Science

Escherichia coli is engineered to grow on CO2 and formic acid

(2020) Junho Bang et al.   Nature Microbiology

Biosynthesis of inorganic nanomaterials using microbial cells and bacteriophages

(2020) Yoojin Choi et al.   Nature Reviews Chemistry

Applications of CRISPR Technologies Across the Food Supply Chain

(2019) Katelyn Brandt et al.   Annual Review of Food Science and Technology

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0

(2019) Laurent Heirendt et al.   Nature Protocols

Synthetic biology for fibers, adhesives, and active camouflage materials in protection and aerospace

(2019) Aled D. Roberts et al.   MRS Communications

Building a global alliance of biofoundries

(2019) Nathan Hillson et al.   Nature Communications

Synthetic biology strategies for microbial biosynthesis of plant natural products

(2019) Aaron Cravens et al.   Nature Communications

Synthetic biology for bio-derived structural materials

(2019) Kevin W Keating et al.   Current Opinion in Chemical Engineering

Hierarchical structure of bacterial-derived cellulose and its impact on biomedical applications

(2019) Elizabeth M van Zyl et al.   Current Opinion in Chemical Engineering

Bacterial Candidates for Colonization and Degradation of Marine Plastic Debris

(2019) Line Roager et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Common principles and best practices for engineering microbiomes

(2019) Christopher E. Lawson et al.   NATURE REVIEWS MICROBIOLOGY

A robotic platform for flow synthesis of organic compounds informed by AI planning

(2019) Connor W. Coley et al.   SCIENCE

Technology Feature | Beyond CRISPR: What’s current and upcoming in genome editing

(2019) Chris Tachibana   SCIENCE

Artificial Photosynthesis at Efficiencies Greatly Exceeding That of Natural Photosynthesis

(2019) Dilek K. Dogutan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Conversion of Escherichia coli to Generate All Biomass Carbon from CO2

(2019) Shmuel Gleizer et al.   CELL

Cell-free gene expression: an expanded repertoire of applications

(2019) Adam D. Silverman et al.   NATURE REVIEWS GENETICS

Eyeing organs for human transplants, companies unveil the most extensively gene-edited pigs yet

(2019) Kelly Servick   SCIENCE

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Machine Learning in Enzyme Engineering

(2019) Stanislav Mazurenko et al.   ACS Catalysis

Engineered Living Materials: Prospects and Challenges for Using Biological Systems to Direct the Assembly of Smart Materials

(2018) Peter Q. Nguyen et al.   ADVANCED MATERIALS

Accessing Bioactive Natural Products from the Human Microbiome

(2018) Aleksandr Milshteyn et al.   Cell Host & Microbe

Toward an orthogonal central dogma

(2018) Chang C Liu et al.   Nature Chemical Biology

Programming gene and engineered-cell therapies with synthetic biology

(2018) Tasuku Kitada et al.   SCIENCE

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

(2018) Vincent M Isabella et al.   NATURE BIOTECHNOLOGY

Fabrication and Characterization of Recombinant Silk‐Elastin‐Like‐Protein (SELP) Fiber

(2018) Erin G. Roberts et al.   MACROMOLECULAR BIOSCIENCE

Biological Engineered Living Materials: Growing Functional Materials with Genetically Programmable Properties

(2018) Charlie Gilbert et al.   ACS Synthetic Biology

Remote detection of buried landmines using a bacterial sensor

(2017) Shimshon Belkin et al.   NATURE BIOTECHNOLOGY

plantiSMASH: automated identification, annotation and expression analysis of plant biosynthetic gene clusters

(2017) Satria A. Kautsar et al.   NUCLEIC ACIDS RESEARCH

Microbiome engineering: Current applications and its future

(2017) Jee Loon Foo et al.   Biotechnology Journal

DNA nanotechnology

(2017) Nadrian C. Seeman et al.   Nature Reviews Materials

Microbiome therapeutics — Advances and challenges

(2016) Mark Mimee et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineered phages for electronics

(2016) Yue Cui   BIOSENSORS & BIOELECTRONICS

Manipulating Bacterial Communities by in situ Microbiome Engineering

(2016) Ravi U. Sheth et al.   TRENDS IN GENETICS

Use of plant colonizing bacteria as chassis for transfer of N 2 -fixation to cereals

(2015) Barney A Geddes et al.   CURRENT OPINION IN BIOTECHNOLOGY

Grand challenges in space synthetic biology

(2015) Amor A. Menezes et al.   Journal of the Royal Society Interface

Engineering Microbiomes to Improve Plant and Animal Health

(2015) U.G. Mueller et al.   TRENDS IN MICROBIOLOGY

A Highly Characterized Yeast Toolkit for Modular, Multipart Assembly

(2015) Michael E. Lee et al.   ACS Synthetic Biology

Accurate design of co-assembling multi-component protein nanomaterials

(2014) Neil P. King et al.   NATURE

Improved soybean oil quality by targeted mutagenesis of the fatty acid desaturase 2 gene family

(2014) William Haun et al.   PLANT BIOTECHNOLOGY JOURNAL

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol

(2011) Harry Yim et al.   Nature Chemical Biology

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Five hard truths for synthetic biology

(2010) Roberta Kwok   NATURE

Solar energy harvesting in the epicuticle of the oriental hornet (Vespa orientalis)

(2010) Marian Plotkin et al.   NATURWISSENSCHAFTEN

Dramatic colour changes in a bird of paradise caused by uniquely structured breast feather barbules

(2010) D. G. Stavenga et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Synthesis of Methyl Halides from Biomass Using Engineered Microbes

(2009) Travis S. Bayer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY