Article
Chemistry, Physical
Puguang Peng, Feiyao Yang, Zhonglin Wang, Di Wei
Summary: This study presents an ultra-thin paper-based iontronic power source enabled by translational Li+ transport within 2D nanofluidic channels of graphene oxide and fine-tuned interfacial redox reactions. The paper-based source exhibits high energy and power densities, maintains a working state when bent or cut, and can be easily recycled through incineration.
ADVANCED ENERGY MATERIALS
(2023)
Article
Multidisciplinary Sciences
Fridus Van der Weijden, Mirella Rijnen, Cees Valkenburg
Summary: In this study, three commercially available qPCR kits for detecting and quantifying selected periodontal bacterial species were compared using 100 clinical samples. Kit A detected target species more frequently and had higher bacterial cell numbers compared to kit B. There was a high degree of similarity between the outcomes of kits A and C, indicating satisfactory performance with small but significant differences between the three kits.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Younseong Song, Yong Tae Kim, Yunho Choi, Hogi Kim, Min Hee Yeom, Yesol Kim, Tae Jae Lee, Kyoung G. Lee, Sung Gap Im
Summary: The all-in-one tube platform developed allows genetic analysis involving DNA extraction, amplification, and detection to be performed in a single tube with high efficiency and compatibility with existing real-time PCR instruments. It provides high sensitivity, selectivity, and reliability for accurate detection of various pathogens and can be used in food safety, forensic, and clinical diagnostic applications.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Electrical & Electronic
Zuoqin Ding, Jialve Sun, Changhui Li, Yaocheng Shi
Summary: This paper presents a method to build micro-ring resonators as ultrasound sensors on the Silicon-On-Insulator platform. By utilizing the transverse magnetic mode and introducing the elastomer as cladding, the sensitivity and bandwidth of the sensors are improved. The fabricated micro-ring resonator shows high Q value and steep slope, achieving high sensing bandwidth and sensitivity.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Biophysics
Joan Aymerich, Amparo Ferrer-Vilanova, Jose Cisneros-Fernandez, Roger Escude-Pujol, Gonzalo Guirado, Lluis Teres, Michele Dei, Xavier Munoz-Berbel, Francisco Serra- Graells
Summary: Early detection of low bacterial concentrations is crucial for minimizing healthcare and safety issues. In this study, a potentiostatic-amperometric Delta-Sigma modulator with the ability to cancel flicker noise and improve the limit of detection was developed. The integrated circuit, with an area of 2.3 mm2, was attached to an inkjet-printed electrochemical sensor. The disposable device was capable of detecting live bacterial concentrations as low as 102 CFU/mL within an hour.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Xin Ye, Yang Li, Lijuan Wang, Xueen Fang, Jilie Kong
Summary: A novel all-in-one microfluidic nucleic acid diagnosis system was established for the simultaneous detection of multiple sexually transmitted pathogens with minimal manual manipulations, showing good detection limits, stability, and specificity. The automated system reduced the turnaround time to 50 minutes and could significantly improve disease prevention and control.
Review
Biodiversity Conservation
Kailash Bohara, Amit K. Yadav, Pabitra Joshi
Summary: Organisms release their nucleic acid into the environment, and eDNA/eRNA techniques are used to detect them. These techniques are being extensively employed in aquaculture and fisheries settings to identify different organisms and pathogens. However, the reliability of results can be challenging due to nucleic acid degradation. This review discusses the detection of aquaculture diseases and parasites using eDNA/eRNA methods and the fate of nucleic acids in different water quality and environmental parameters.
Article
Plant Sciences
Kandeeparoopan Prasannath, Victor J. Galea, Olufemi A. Akinsanmi
Summary: A multiplex quantitative PCR (qPCR) assay was developed to detect and quantify the inoculum sources of various flower blight pathogens in the macadamia canopy. The assay revealed that remnant racemes served as the main inoculum source for all the pathogens, while yellow halo leaf spot contributed only specific species. Pathogenicity tests on developing racemes confirmed the findings and suggested the removal of remnant racemes as a control measure for flower blights in macadamia orchards.
Article
Chemistry, Analytical
Qiaoqiao Zhou, Jiangfei Pan, Laiming Mo, Zhaofan Luo, Zhifeng Qin, Zong Dai, Changqing Yi
Summary: This study developed a cost-effective, portable, and easy-to-use on-site genetic diagnostics sensing system for pathogen screening. The system consists of a paper-based biochip and a smartphone-based portable device, which together enable simultaneous detection of multiple pathogens and have demonstrated practicality in foodborne pathogen detection.
Article
Chemistry, Multidisciplinary
Haichao Huang, Xiang Chu, Yanting Xie, Binbin Zhang, Zixing Wang, Zhongyi Duan, Ningjun Chen, Zhong Xu, Haitao Zhang, Weiqing Yang
Summary: MXene-based microsupercapacitors (MSCs) have been developed for on-chip energy storage in miniaturized and portable electronics. However, limited energy density and operating voltage have hindered their practical application. In this study, a symmetric MXene-based on-chip MSC with ultrahigh energy density and high operating voltage was achieved through the adjustment of acetone on MXene ink and natural sedimentation strategy. Laser-etching technology was used to develop an all-in-one Si-electronics with high integration capacity and processing compatibility.
Article
Ophthalmology
Paulo J. M. Bispo, Nicole Belanger, Ashley Li, Renee Liu, Gayatri Susarla, Weilin Chan, James Chodosh, Michael S. Gilmore, Lucia Sobrin
Summary: A newly developed ocular panel was designed to improve the diagnostic yield of intraocular infections by rapidly and sensitively detecting a wide range of pathogens.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Fisheries
P. M. Arbon, K. Condon, M. Andrade Martinez, D. R. Jerry
Summary: This study utilized qPCR to investigate the presence of pathogenic agents in wild-sourced black tiger shrimp broodstock collected for the Australian aquaculture industry, revealing that 44.9% of samples were positive for at least one pathogen target. Infectious hypodermal haematopoietic necrosis virus and gill-associated virus were the most prevalent pathogens detected.
Article
Engineering, Environmental
Yonghui Yan, Jing Yan, Xin Gong, Xiaowan Tang, Xueya Xu, Ting Meng, Fan Bu, Dongming Cai, Zhenyuan Zhang, Guangdi Nie, Haifeng Zhang
Summary: In this study, a self-supporting electrode with a Negative Poisson's Ratio (NPR) structure was fabricated using electrospinning and laser direct writing technology, overcoming the limitations of traditional carbon-based materials and the integration problem of rigid electrodes and soft substrates. Furthermore, a quasi solid-state asymmetric micro-supercapacitor with a NPR structure was assembled, achieving a higher area energy density.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Hyuna Park, Wonjong Jung, Hyeongseok Jang, Kak Namkoong, Kwon-Young Choi
Summary: This study developed a simple and rapid thermolysis method that can bypass the need for viral RNA extraction and purification. The method integrates thermolysis, RT, and digital PCR into a single chip for large-scale viral analysis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Rajendran Vinoth, Pakkiyam Sangavi, Tatsuo Nakagawa, Mathiyarasu Jayaraman, A. M. Vinu Mohan
Summary: A hand-held microfluidic device with integrated filtration membrane is developed for electrochemical monitoring of multiple salivary biomarkers. The device uses a "channel-inside-channel" configuration to enable pump-less passive flow of saliva. It also integrates a flexible porous filtration membrane at the inlet to prevent biofouling. Enzyme-based electrochemical sensors are used to monitor glucose, lactate, cholesterol, and uric acid levels in saliva samples. The device shows good correlation with blood glucose measurements, demonstrating its efficacy in saliva-based point-of-care analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Yasin Cotur, Michael Kasimatis, Matti Kaisti, Selin Olenik, Charis Georgiou, Firat Guder
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Biophysics
Tuukka Panula, Tero Koivisto, Mikko Pankaala, Teemu Niiranen, Ilkka Kantola, Matti Kaisti
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Engineering, Electrical & Electronic
Saeed Mehrang, Olli Lahdenoja, Matti Kaisti, Mojtaba Jafari Tadi, Tero Hurnanen, Antti Airola, Timo Knuutila, Jussi Jaakkola, Samuli Jaakkola, Tuija Vasankari, Tuomas Kiviniemi, Juhani Airaksinen, Tero Koivisto, Mikko Pankaala
IEEE SENSORS JOURNAL
(2020)
Article
Clinical Neurology
Nea Kalleinen, Jenni Aittokallio, Laura Lampio, Matti Kaisti, Paivi Polo-Kantola, Olli Polo, Olli J. Heinonen, Tarja Saaresranta
Summary: This 10-year observational study found that changes in sleep architecture in middle-aged women were more age-dependent rather than menopause-dependent. With aging, shorter sleep latency, decreased stage 2 sleep, and increased slow-wave sleep were observed.
Correction
Clinical Neurology
Nea Kalleinen, Jenni Aittokallio, Laura Lampio, Matti Kaisti, Paeivi Polo-Kantola, Olli Polo, Olli J. Heinonen, Tarja Saaresranta
Review
Engineering, Biomedical
Tuukka Panula, Jukka-Pekka Sirkia, David Wong, Matti Kaisti
Summary: Hypertension is a marker for cardiovascular diseases and can be life threatening. Non-invasive blood pressure monitoring techniques have been proposed and investigated. Telemonitoring solutions for home management of hypertension have accelerated the development of new monitoring techniques. This review highlights clinical validation, trade-offs, current measurement techniques, promising studies, modeling and machine learning approaches, and unresolved challenges.
IEEE REVIEWS IN BIOMEDICAL ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yasin Cotur, Selin Olenik, Tarek Asfour, Michael Bruyns-Haylett, Michael Kasimatis, Ugur Tanriverdi, Laura Gonzalez-Macia, Hong Seok Lee, Andrei S. Kozlov, Firat Guder
Summary: This article introduces a continuous wearable respiration sensor inspired by the lateral line system of fish, capable of detecting mechanical disturbances in water. The sensor continuously measures respiratory activity by sensing the force applied to an air channel embedded in silicone-based elastomeric material, potentially enabling early detection of disorders resulting in altered respiratory patterns.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Tuukka Panula, Jukka-Pekka Sirkia, Tero Koivisto, Mikko Paenkaala, Teemu Niiranen, Ilkka Kantola, Matti Kaisti
Summary: The aim of this study was to develop a blood pressure measurement technology that can be integrated into a finger-worn pulse oximeter, eliminating the need for a brachial cuff. The researchers proposed a miniature cuffless tonometric finger probe system that uses the oscillometric method to measure blood pressure. They successfully verified the functionality of the device and demonstrated its ability to assess arterial stiffness and detect atrial fibrillation.
Article
Engineering, Electrical & Electronic
Tuukka Panula, Jukka-Pekka Sirkia, Matti Kaisti
Summary: Continuous blood pressure monitoring is crucial for understanding cardiovascular health, and we propose a simple and effective technique that utilizes a wearable device to measure blood pressure based on the nonpulsatile component of the photoplethysmograph. Our method shows a high correlation and minimal error when compared to a reference device, making it a promising solution for remote continuous blood pressure monitoring.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Computer Science, Artificial Intelligence
Jukka-Pekka Sirkia, Tuukka Panula, Matti Kaisti
Summary: Strict privacy regulations pose challenges to the development of machine learning in health technology. This article presents a system that utilizes synthetic data and wearable edge devices to protect privacy and achieve accurate data analysis.
EXPERT SYSTEMS WITH APPLICATIONS
(2024)
Proceedings Paper
Engineering, Biomedical
Tuukka Panula, Jukka-Pekka Sirkia, Matti Kaisti
Summary: The study introduces a miniature cuffless tonometric finger probe system for blood pressure measurement using the oscillometric method. It is also capable of collecting arterial pulse wave data for deriving other cardiovascular parameters. The device is convenient and can be used in daily life, offering a new option for cardiovascular health monitoring.
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
(2021)
Article
Food Science & Technology
Max Grell, Giandrin Barandun, Tarek Asfour, Michael Kasimatis, Alex Silva Pinto Collins, Jieni Wang, Firat Guder
Summary: Our study demonstrates that point-of-use measurements of NH4+ combined with soil conductivity, pH, weather, and timing data can predict levels of NO3- in soil. Additionally, a long short-term memory recurrent neural network model can forecast NH4+ and NO3- levels up to 12 days into the future. This approach eliminates the need for dedicated instruments to determine the levels of NO3- in soil, allowing for accurate forecasting of the impact of climate on fertilization planning and crop requirements.
Proceedings Paper
Cardiac & Cardiovascular Systems
Jukka-Pekka Sirkia, Tuukka Panula, Matti Kaisti
2020 COMPUTING IN CARDIOLOGY
(2020)
