Review
Immunology
Martin Kolev, Madhumita Das, Monica Gerber, Scott Baver, Pascal Deschatelets, Maciej M. Markiewski
Summary: Recent studies have shown that complement plays a role in accelerating cancer progression by suppressing antitumor immunity in the tumor microenvironment. Activation of intracellular complement is crucial for the survival of immune cells, making it important for tumor cell survival and growth. Additionally, intracellular complement activation is essential for priming antitumor T cell responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Vanessa Trijoulet, Casper W. Berg, David C. M. Miller, Anders Nielsen, Anna Rindorf, Christoffer Moesgaard Albertsen
Summary: Reference points play a crucial role in fisheries management for inferring stock status and guiding future fishing opportunities. Internal estimation yields more accurate and reliable results compared to external estimation.
ICES JOURNAL OF MARINE SCIENCE
(2022)
Article
Clinical Neurology
Christian W. Keller, Johanna Oechtering, Heinz Wiendl, Ludwig Kappos, Jens Kuhle, Jan D. Luenemann
Summary: The study showed that activation profiles of complement pathways in early relapse-onset MS patients were not correlated with disease activity, suggesting that complement activation products are not suitable biomarkers for assessing disease activity in early MS.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Review
Immunology
Nil Saez-Calveras, Olaf Stuve
Summary: The complement system plays a role in the development and treatment of multiple sclerosis (MS). Evidence from various studies suggests that complement activation is involved in the formation of white matter plaques and gray matter lesions in MS. This system may have a dual effect, promoting the clearance of debris but also leading to demyelination and synapse loss. Complement interactions with risk factors and self-reactive B cells may contribute to MS pathogenesis. Developing complement-modulating therapies for MS is promising but requires a better understanding of the different complement effectors and improved drug delivery to the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Maximilian F. Konig, Vasanth Sathiyakumar, Casey M. Phan, Steven P. Schulman, Allan C. Gelber
Summary: A 38-year-old female mail carrier experienced sudden chest pain and shortness of breath on her way home from work, with examination revealing abnormalities in her heart.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Clinical Neurology
Antonio Carotenuto, Laura Cacciaguerra, Elisabetta Pagani, Paolo Preziosa, Massimo Filippi, Maria A. Rocca
Summary: Carotenuto et al. reveal dysfunction of the glymphatic system in multiple sclerosis, especially in progressive stages, and show that the abnormalities are associated with the accumulation of demyelinating lesions and grey matter atrophy. Glymphatic system dysfunction may contribute to disability in multiple sclerosis.
Article
Biochemistry & Molecular Biology
Wei-Chieh Huang, Kao-Chang Lin, Chih-Wei Hsia, Chih-Hsuan Hsia, Ting-Yu Chen, Periyakali Saravana Bhavan, Joen-Rong Sheu, Shaw-Min Hou
Summary: Pterostilbene shows strong inhibitory effects on platelet activation and thrombotic formation in both human platelets and mice, suggesting its potential as a therapeutic agent for thromboembolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Julien Bourel, Vincent Planche, Nadege Dubourdieu, Aymeric Oliveira, Alexandra Sere, Eva-Gunnel Ducourneau, Marion Tible, Marlene Maitre, Thierry Leste-Lasserre, Agnes Nadjar, Aline Desmedt, Philippe Ciofi, Stephane H. Oliet, Aude Panatier, Thomas Tourdias
Summary: Memory impairment in multiple sclerosis (MS) may be caused by hippocampal synaptic dysfunction and dendritic loss associated with microglial activation, possibly driven by overexpression of C3 protein. In early-stage experimental autoimmune encephalomyelitis (EAE), inhibition of C3 activity prevented dendritic loss and memory impairment, highlighting the potential of complement inhibitors as neuroprotective strategies in MS.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Medicine, General & Internal
Athina-Maria Aloizou, Vasileios Siokas, Georgia Pateraki, Ioannis Liampas, Christos Bakirtzis, Zisis Tsouris, George Lazopoulos, Daniela Calina, Anca Oana Docea, Aristidis Tsatsakis, Dimitrios P. Bogdanos, Efthimios Dardiotis
Summary: Numerous studies have explored the potential of using multiple sclerosis disease-modifying drugs in the setting of ischemic stroke, yielding mostly positive results in animal studies. However, concerns on safety and other issues need to be addressed before implementing these drugs in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Diogo A. Galico, Muralee Murugesu
Summary: Modulating the optical properties of materials through structural modification allows for greater control towards applications. By tuning the inner core and outer shell of lanthanide-based nanosized molecular cluster aggregates, fine-tuning of optical properties is achieved. Controlling the composition and spacing of emitter ions results in enhanced ratiometric luminescence thermometry performance.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Immunology
Michael Linzey, Krista DiSano, Nora Welsh, Andrew Pachner, Francesca Gilli
Summary: The study found significantly increased expression of complement factors in two clinically distinct mouse models of MS, with the classical complement pathway associated with pathogenesis in the progressive disease and the alternative pathway related to a worse outcome in the relapsing form. Understanding the roles of the complement system in MS is critical for the development of targeted therapies in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Shiyin Zhang, Shikui Wei, Jun Hao Liew, Kunyang Han, Yao Zhao, Yunchao Wei
Summary: This article presents a simple yet effective interaction scheme named Inside-Outside Guidance (IOG) for precise object segmentation. By leveraging an inside point and two outside points, IOG achieves one foreground click and four background clicks for accurate segmentation. IOG not only outperforms state-of-the-art methods on popular benchmarks, but also demonstrates strong generalization capability across various domains including street scenes, aerial imagery, and medical images.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2023)
Article
Clinical Neurology
Bert A. 't Hart, Antonio Luchicchi, Geert J. Schenk, Peter K. Stys, Jeroen J. G. Geurts
Summary: Recent studies support the pathogenic concept of an endogenous trigger for multiple sclerosis, where autoimmunity is a natural response of the immune system to excess antigen turnover in diseased tissue and individuals genetically predisposed are high responders to critical antigens. In the pathogenesis of multiple sclerosis, T cells hyper-react to post-translationally modified myelin-oligodendrocyte glycoprotein, playing a core pathogenic role.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Review
Clinical Neurology
Jiwon Oh, Laura Airas, Daniel Harrison, Elina Jaervinen, Terrie Livingston, Stefan Lanker, Rayaz A. Malik, Darin T. Okuda, Pablo Villoslada, Helga E. de Vries
Summary: Key unmet needs in multiple sclerosis include early detection of pathology, disability worsening independent of relapses, and accurate monitoring of treatment response. Recent advances in neuroimaging technology have shown potential in addressing these needs, but further clinical research is necessary for translation into practice.
FRONTIERS IN NEUROLOGY
(2023)
Article
Business
Jinxin Liu, Shibin Sheng, Chengli Shu, Mengli Zhao
Summary: Based on data collected from multiple companies operating in China, this study found that the influence of outside-in networking on firm performance is not weaker than that of inside-out R&D. Additionally, the effects of both inside-out R&D and outside-in networking expenses are strengthened in regions with stronger consumer protection, while inside-out R&D expenses become less effective in a corrupt environment.
INDUSTRIAL MARKETING MANAGEMENT
(2021)