Article
Health Care Sciences & Services
Mais Iflaifel, Charlotte L. Hall, Heidi R. Green, Andrew Willis, Stefan Rennick-Egglestone, Edmund Juszczak, Mark Townsend, Jennifer Martin, Kirsty Sprange
Summary: This study explores the perspectives of key partners on the use of online and offline recruitment to improve diversity in mental health research. It finds that online methods are more accessible to individuals who may feel stigmatized, and can reach a wider population. However, online methods require closer data monitoring and face practical challenges. Integrating online and offline methods is crucial.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Health Care Sciences & Services
Trefor Aspden, Megan Armstrong, Marc Serfaty
Summary: This study explored the views of healthcare professionals on recruiting to psychosocial research studies and factors that may hinder or facilitate recruitment. Healthcare professionals generally have positive attitudes towards psychosocial research, but identified lack of time and narrow screening criteria as barriers to recruitment, and expressed anxieties about approaching patients for trial recruitment in the palliative phase of their illness.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Medicine, Research & Experimental
Nicola Farrar, Daisy Elliott, Catherine Houghton, Marcus Jepson, Nicola Mills, Sangeetha Paramasivan, Lucy Plumb, Julia Wade, Bridget Young, Jenny L. Donovan, Leila Rooshenas
Summary: This study provides a comprehensive analysis of recruiters' potential challenges and their experiences and perspectives in the clinical environment. The study identifies complex situations that recruiters face when recruiting patients for RCTs, including recruitment in a clinical environment, enthusiasm for RCTs, making judgement about approaching patients, communication challenges, and the interplay between recruiters and professional roles.
Article
Critical Care Medicine
Evelijn S. Lourijsen, Sietze Reitsma, Marleen Vleming, Gerjon Hannink, Gwijde F. J. P. M. Adriaensen, Marjolein E. Cornet, D. Rienk Hoven, Ward J. M. Videler, Jochen H. Bretschneider, Susanne M. Reinartz, Maroeska M. Rovers, Wytske J. Fokkens
Summary: This study aimed to assess the efficacy of endoscopic sinus surgery (ESS) plus medical therapy versus medical therapy alone in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). The results indicated that ESS plus medical therapy was more efficacious than medical therapy alone in improving disease-specific health-related quality of life (HRQoL) in these patients.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Nicola Harrison, Caroline Brundle, Anne Heaven, Andrew Clegg
Summary: A study found that it takes approximately 148 minutes of researcher time to recruit community-dwelling older people for a primary care cluster randomized controlled trial. It is recommended that trials recruiting older people in the community allocate two and a half hours of researcher time per person, on average, for consent, baseline data collection, travel and administration. Variability in researcher activity time may exist due to factors such as location, capacity and cognition of individuals, hearing and visual impairment, and desire for social contact.
Article
Respiratory System
Narelle S. Cox, Christine F. McDonald, Ajay Mahal, Jennifer A. Alison, Richard Wootton, Catherine J. Hill, Paolo Zanaboni, Paul O'Halloran, Janet Bondarenko, Heather Macdonald, Kathryn Barker, Hayley Crute, Christie Mellerick, Bruna Wageck, Helen Boursinos, Aroub Lahham, Amanda Nichols, Pawel Czupryn, Monique Corbett, Emma Handley, Angela T. Burge, Anne E. Holland
Summary: The study found no significant differences between center-based pulmonary rehabilitation and telerehabilitation for both primary and secondary outcomes at the end of rehabilitation and at the 12-month follow-up. Although equivalence of telerehabilitation for CRQ-D was not confirmed, it showed equivalence in 6-minute walk distance at the end of rehabilitation and possibly had superiority at 12 months.
Article
Medicine, Research & Experimental
Arabella Scantlebury, Catriona McDaid, Stephen Brealey, Elizabeth Cook, Hemant Sharma, Arun Ranganathan, Joy Adamson
Summary: This study explored key issues to consider when recruiting to orthopaedic surgical trials from the perspective of staff and patients, using a qualitative process evaluation of UK-wide orthopaedic surgical RCT and mixed methods randomised feasibility study. The findings highlighted the importance of factors such as equipoise, randomisation, communication, patient's circumstances, altruism, and trust in clinical and research teams in recruitment to surgical trials. It emphasized the need for a methodological shift to ensure that existing evidence on factors affecting recruitment to randomised controlled trials is used to optimize recruitment in future trials.
Article
Public, Environmental & Occupational Health
Ralf Buckley
Summary: This article discusses the critical role of saturation in the reliability of qualitative social sciences and highlights the need for more detailed method descriptions. By following a ten-step methodological protocol, rigor can be improved in research.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Oncology
Mathijs R. de Veer, Merel Hermus, Charlene J. Van der Zijden, Berend J. Van der Wilk, Bas P. L. Wijnhoven, Anne M. Stiggelbout, Jan Willem T. Dekker, Peter Paul L. O. Coene, Jan J. Busschbach, Jan J. B. Van Lanschot, Sjoerd M. Lagarde, Leonieke W. Kranenburg
Summary: This study examines how surgeons use steering behavior to influence patients' choice of treatment and participation in a randomized trial. The results suggest that surgeons employ various techniques, such as framing and suggestive language, to steer patients towards a particular treatment option.
Editorial Material
Medicine, Research & Experimental
Caroline Brundle, Anne Heaven, Andrew Clegg
Summary: During the COVID-19 pandemic, researchers had to adapt their study procedures, including conducting remote recruitment and data collection. This article reflects on the experience of using the MoCA Blind/Telephone assessment during the initial telephone eligibility check for a randomized controlled trial with older people. The authors found that telephone administration of the MoCA posed challenges, such as uncertainty about the participants' difficulties in answering questions and practical difficulties in completing the assessment. They also discuss the potential impact on trial recruitment and participant engagement, as well as the feasibility of using videoconferencing for cognitive assessments.
Article
Medicine, General & Internal
Fang-Ting Yu, Cun-Zhi Liu, Guang-Xia Ni, Guo-Wei Cai, Zhi-Shun Liu, Xiao-Qing Zhou, Chao-Yang Ma, Xiu-Li Meng, Jian-Feng Tu, He-Wen Li, Jing-Wen Yang, Shi-Yan Yan, Hai-Yang Fu, Wen-Tao Xu, Jing Li, Hong-Chun Xiang, Tian-Heng Sun, Beng Zhang, Mei-Hua Li, Wen-Jun Wan, Cheng He, Xiao-Lan Ji, Wei Zhu, Guang-Xia Shi, Li-Qiong Wang
Summary: This is a multicenter randomized sham-controlled trial aiming to evaluate the efficacy and safety of acupuncture for chronic sciatica. A total of 216 patients will be enrolled and followed up for 52 weeks. The primary outcomes are changes in leg pain intensity and disability.
Article
Allergy
Claus Bachert, Joseph K. Han, Martin Y. Desrosiers, Philippe Gevaert, Enrico Heffler, Claire Hopkins, Jody R. Tversky, Peter Barker, David Cohen, Claire Emson, Ubaldo J. Martin, Vivian H. Shih, Sofia Necander, James L. Kreindler, Maria Jison, Viktoria Werkstrom
Summary: This study assessed the efficacy and safety of benralizumab in treating CRSwNP. The results showed that benralizumab significantly improved NPS and nasal blockage score, and had significant improvement on difficulty with sense of smell score. Subgroup analyses suggested influences of comorbid asthma, number of NP surgeries, sex, body mass index, and baseline blood eosinophil count on treatment effects.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Psychiatry
Julia Bornemann, James B. Close, Meg J. Spriggs, Robin Carhart-Harris, Leor Roseman
Summary: By interviewing 11 individuals who self-medicate with psychedelic drugs for chronic pain, it was found that pain scores significantly improved during and after psychedelic experiences. Processes like Positive Reframing and Somatic Presence played a role in improving mental wellbeing and relationship with pain. Other strategies such as mindfulness, breathwork, and movement were also reported as helpful.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Cherish Boxall, Susanne Renz, Zina Eminton, Jacqueline Nuttall, Alan Saji, Charlotte Cluff, Christopher Wilcox, Ingrid Muller, Alison M. Layton, Irene Soulsby, Miriam Santer
Summary: Decentralised clinical trials can effectively address recruitment and retention barriers, and the use of decentralised methods in dermatology trials can enhance recruitment and retention capabilities.
Article
Medicine, General & Internal
Yuan Zhang, Bing Yan, Shen Shen, Xicheng Song, Yan Jiang, Li Shi, Changqing Zhao, Yi Yang, Luyun Jiang, Jiping Li, Jing Ye, Jinfeng Liu, Lijia Wan, Yucheng Yang, Jianjun Chen, Feng Liu, Lizhong Su, Yu Xu, Guolin Tan, Shaoqing Yu, Yu Zhang, Lin Wang, Shengyang Liu, Hongyue Yan, Wei Liu, Bo Chen, Chengshuo Wang, Luo Zhang
Summary: This study evaluates the efficacy and safety of CM310 in patients with severe eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). The findings suggest that CM310 can reduce nasal polyp size, alleviate nasal congestion, improve sinus CT scores, and significantly relieve daily symptoms and improve quality of life. CM310 also reduces type 2-related biomarkers. Overall, CM310 is an effective additional treatment option for severe ECRSwNP.
Article
Allergy
Wytske J. Fokkens, Joaquim Mullol, David Kennedy, Carl Philpott, Veronica Seccia, Robert C. Kern, Andre Coste, Ana R. Sousa, Peter H. Howarth, Victoria S. Benson, Bhabita Mayer, Steve W. Yancey, Robert Chan, Simon B. Gane
Summary: This study found that Mepolizumab can reduce the risk of further surgery in patients with severe CRSwNP, regardless of their baseline characteristics.
Article
Otorhinolaryngology
Carl M. Philpott, Andreas Espehana, Mairenn Garden, Ngan Ta, Nishita Gadi, Kala Kumaresan, Devina Maru, Lorenzo D. Stafford, Nina Bleasdale, Duncan Boak
Summary: This study aimed to identify the top 10 research priorities in Smell and Taste Disorders (SAID). Through an electronic survey and workshop, key questions related to understanding disease mechanisms, improving healthcare services, and managing long-term effects were identified. The results of this study will serve as the basis for research funding applications and the development of the FifthSense research hub.
CLINICAL OTOLARYNGOLOGY
(2023)
Letter
Otorhinolaryngology
Matt Lechner, Jacklyn Liu, Nicholas Counsell, David Gillespie, Deepak Chandrasekharan, Ngan Hong Ta, Kiran Jumani, Raj Gupta, John Rocke, Claire Williams, Abigail Tetteh, Rajesh Amnolsingh, Sadie Khwaja, Rachel L. Batterham, Carol H. Yan, Thomas A. Treibel, James C. Moon, Jane Woods, Ria Brunton, Jim Boardman, Matthew Hatter, Mohamed Abdelwahab, F. Christopher Holsinger, Robson Capasso, Jayakar V. Nayak, Peter H. Hwang, Zara M. Patel, Santdeep Paun, Nicholas Eynon-Lewis, B. Nirmal Kumar, Samuel Jayaraj, Claire Hopkins, Carl Philpott, Valerie J. Lund
Editorial Material
Otorhinolaryngology
Shyam Ajay Gokani, Ngan Hong Ta, Andreas Espehana, Elizabeth Mairenn Garden, Gabija Klyvyte, Louis Luke, Tharsika Myuran, Vinushy Uththerakunaseelan, Duncan Cameron Boak, Carl Martin Philpott
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Letter
Otorhinolaryngology
Matt Lechner, Jacklyn Liu, Nicholas Counsell, Carol. H. H. Yan, Santdeep Paun, Nicholas Eynon-Lewis, Liam Sutton, Samuel Jayaraj, Rachel L. Batterham, Claire Hopkins, Carl Philpott, Valerie J. Lund, Matthew Hatter, Mohamed Abdelwahab, F. Christopher Holsinger, Robson Capasso, Jayakar. V. V. Nayak, Peter. H. H. Hwang, Zara. M. M. Patel
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Allergy
Jorge F. Maspero, Asif H. Khan, Carl Philpott, Peter W. Hellings, Claire Hopkins, Martin Wagenmann, Shahid Siddiqui, Jerome Msihid, Scott Nash, Chien-Chia Chuang, Siddhesh Kamat, Paul J. Rowe, Yamo Deniz, Juby A. Jacob-Nara
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease with severe symptoms. This study compared the physical and mental health-related quality of life (HRQoL) and overall health status of severe CRSwNP patients with the general population and other chronic diseases. The results showed that the HRQoL of CRSwNP patients was lower than the general population and similar to diseases such as diabetes and asthma.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Editorial Material
Otorhinolaryngology
E. M. Garden, A. Espehana, D. Boak, N. Gadi, C. M. Philpott
Summary: This paper discusses the challenges of people with smell and taste disorders and emphasizes the importance of patient advocacy in addressing these challenges. Recent findings have identified the top 10 research priorities in SATDs and established six Research Hubs to carry out research in different aspects of smell and taste disorders.
CURRENT OTORHINOLARYNGOLOGY REPORTS
(2023)
Review
Otorhinolaryngology
Shyam A. Gokani, Andreas Espehana, Ana C. Pratas, Louis Luke, Ekta Sharma, Jennifer Mattock, Jelena Gavrilovic, Allan Clark, Tom Wileman, Carl M. Philpott
Summary: This study aimed to identify and summarize clinical studies of biomarkers in adults with chronic rhinosinusitis (CRS) to guide future research into CRS endotypes. The study identified numerous potential biomarkers for differentiating CRS phenotypes. Future studies should focus on the prognostic role of nasal tissue biomarkers or expand on the more limited studies of nasal secretions and nasal lavage fluid.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2023)
Article
Public, Environmental & Occupational Health
Jane Vennik, Stephanie Hughes, Emily Lyness, Clare McDermott, Kirsten A. Smith, Mary Steele, Jennifer Bostock, Jeremy Howick, Paul Little, Geraldine Leydon, Christian Mallen, Leanne Morrison, Beth Stuart, Hazel Everitt, Felicity L. Bishop
Summary: This study examined patients' perception of empathy in primary care consultations delivered by telephone. The findings showed that patients generally perceive good levels of clinical empathy in telephone consultations, although slightly lower compared to face-to-face consultations. Additionally, the study identified specific features of telephone consultations that can shape clinical empathy, including the setting for an empathic encounter, feeling connected, and being acknowledged.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Multidisciplinary Sciences
Jane Vennik, Adam W. A. Geraghty, Kate Martinson, Lucy Yardley, Beth Stuart, Michael Moore, Nick Francis, Alastair Hay, Theo Verheij, Katherine Bradbury, Kate Greenwell, Laura Dennison, Sian Williamson, James Denison-Day, Ben Ainsworth, James Raftery, Shihua Zhu, Christopher Butler, Samantha Richards-Hall, Paul Little
Summary: Most adults in the UK experience viral respiratory tract infections (RTIs) annually, and certain individuals are at higher risk. Common nasal sprays and digital interventions promoting physical activity and stress management are being tested to reduce the incidence and severity of RTIs. This randomized controlled trial aims to compare the effectiveness and economic impact of these interventions. Recruitment started in December 2020 and is expected to be completed by April 2024.
Article
Medicine, General & Internal
Shyam Ajay Gokani, Allan Clark, Amin Javer, Carl Philpott
Summary: This study aimed to evaluate factors associated with non-adherence to prescribed medication after endoscopic sinus surgery (ESS) and compare SNOT-22 scores post-operation between adherent and non-adherent patients. Of the 94 participants included in this retrospective cohort study, 66% did not adhere to their post-operative medication regimen. The most common reasons for non-adherence were symptom improvement, symptom deterioration, and side effects. Non-intentionally non-adherent (NINA) participants had lower post-operative SNOT-22 scores compared to intentionally non-adherent (INA) and adherent patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Louis Luke, Liam Lee, Shyam Ajay Gokani, Duncan Boak, Jim Boardman, Carl Philpott
Summary: This study aims to understand the patient experience, clinician interactions, and management of symptoms, smell, and taste disturbance in individuals with chronic rhinosinusitis with nasal polyposis (CRSwNP). An online survey collected qualitative and quantitative data from 124 participants, including patients, otolaryngology clinics, and online support groups. The majority of participants were female and from the UK. Rhinologists and otolaryngology clinicians scored the highest in patient satisfaction, while general practitioners scored the lowest. Satisfaction with the management of smell and taste disturbance was lower compared to overall satisfaction. Hyposmia/anosmia was reported as the most debilitating symptom, and there is a need for better treatment options, education, and patient support.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Kala Kumaresan, Sara Bengtsson, Saber Sami, Allan Clark, Thomas Hummel, James Boardman, Juliet High, Rashed Sobhan, Carl Philpott
Summary: Smell loss is a common problem, and viral infections are the second most common cause. Smell loss can have negative impacts on quality of life, and effective therapeutic treatment options are lacking. Previous studies suggest the regenerative potential of vitamin A in olfactory receptor neurons. This study aims to compare intranasally delivered vitamin A with no intervention to determine its efficacy.
PILOT AND FEASIBILITY STUDIES
(2023)
Review
Medicine, General & Internal
Andreas Espehana, Liam Lee, Elizabeth Mairenn Garden, Gabija Klyvyte, Shyam Gokani, Lavandan Jegatheeswaran, Jeremy Jonathan Wong, Carl Philpott
Summary: Olfactory dysfunction affects around 20% of the global population, with a higher incidence in individuals over the age of 60. The current literature on olfaction is limited due to methodological heterogeneity, resulting in a lack of effective treatments. Local and systemic drug delivery methods are used to treat olfactory dysfunction, with various options available for local drug delivery. Further research is needed to establish effective methods of drug delivery to the olfactory epithelium for treating smell disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nursing
Federica Riva-Rovedda, Elena Viottini, Marco Calzamiglia, Fulvio Manghera, Giorgia Manchovas, Alberto Dal Molin, Sara Campagna, Erica Busca, Paola Di Giulio
Summary: Patient and public involvement (PPI) in research refers to conducting research together with the public, rather than conducting research on, about, or for them. PPI can occur at any stage of the research process, and individuals with lived experience can contribute value and influence research questions.
ASSISTENZA INFERMIERISTICA E RICERCA
(2023)