Article
Oncology
Md Zahirul Islam Khan, Helen Ka Wai Law
Summary: RAMS11 is significantly upregulated in CRC cell lines compared to normal cells and is associated with increased CRC proliferation, migration, and metastasis development. The molecular mechanisms of RAMS11 show that it significantly inhibits CRC carcinogenesis through mTOR-dependent autophagy induction. Targeting RAMS11 could be a potential therapeutic strategy for CRC management.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Yiren Yang, Yue Jin, Linzhou Yin, Pengyu Liu, Lingjuan Zhu, Huiyuan Gao
Summary: Colorectal cancer is the third most common malignant tumor globally. Blocking the tryptophan-metabolizing enzyme IDO1 with the antifungal drug sertaconazole nitrate (STZ) showed potential as a novel treatment for colorectal cancer. STZ exhibited anti-proliferative activity and induced apoptosis and autophagy in CRC cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaocong Xiang, Yunhong Tian, Jiani Hu, Rong Xiong, Matthew Bautista, Li Deng, Qiuju Yue, Yuqi Li, Wei Kuang, Junfeng Li, Kang Liu, Chunlei Yu, Gang Feng
Summary: Fangchinoline (Fan) induces apoptosis and autophagy in colorectal cancer cells by activating the AMPK/mTOR/ULK1 signaling pathway, inhibiting tumor growth both in vitro and in vivo, and showing potential as a promising anticancer agent.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinyu Shi, Li Zhou, Hui-Si Huang, Liyuan Peng, Na Xie, Edouard Nice, Li Fu, Cen Jiang, Canhua Huang
Summary: This study reveals that oxiconazole exhibits anti-tumor effect against colorectal cancer (CRC) by inducing autophagy arrest and subsequent apoptosis. Mechanistically, oxiconazole downregulates the antioxidant enzyme peroxiredoxin-2 (PRDX2) to initiate autophagy, leading to growth suppression of CRC cells. The combination of oxiconazole and oxaliplatin achieves an improved anti-tumor effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Ling Qiao, Siyuan Qin, Ningna Weng, Bowen Li, Maochao Luo, Zhe Zhang, Li Zhou, Dong Wang, Canhua Huang
Summary: Toceranib phosphate exhibits potent antitumor activity against human hepatocellular carcinoma (HCC) by stimulating apoptosis and inducing autophagy. The protective role of TOC-induced autophagy in HCC cell death is associated with the inactivation of the Akt/mTOR pathway. Additionally, the combination therapy of sorafenib and TOC shows pronounced synergistic effects on HCC cells.
LIVER INTERNATIONAL
(2023)
Article
Environmental Sciences
Marthandam Asokan Shibu, Yi-Ju Chen, Hong-Siang Yang, Yen-Hua He, Yun-Hsin Lo, Wan-Teng Lin
Summary: This study found that ethanol extract from pine needles has anti-tumor activity against liver cancer cells. A fraction containing pinocembrin, chrysin, and tiliroside can reduce autophagy and increase apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Junli Zhang, Ling Shang, Wendi Jiang, Wenjuan Wu
Summary: This study investigates the effects of Shikonin (SK) and Pyrroline-5-carboxylate reductase 1 (PYCR1) on apoptosis and autophagy in hepatocellular carcinoma. The results demonstrate that SK and siPYCR1 can inhibit the malignant phenotype of HCC cells and induce apoptosis and autophagy in a dose-dependent manner. Additionally, the study shows that SK and siPYCR1 together can downregulate the expression of PI3K/Akt/mTOR signal pathway proteins in HCC cells.
Article
Biotechnology & Applied Microbiology
Xuelian Gong, Ling Jiang, Wei Li, Qingbin Liang, Zhen Li
Summary: The study showed that curcumin effectively inhibited cell viability of renal cell carcinoma, induced apoptosis and autophagy by suppressing the AKT/mTOR pathway. Using curcumin to target the AKT/mTOR pathway could be a promising alternative treatment for RCC.
Article
Biochemistry & Molecular Biology
Qinglian Hu, Liwang Xu, Xiaoyu Huang, Yuxuan Duan, Dongchang Sun, Zhengwei Fu, Yunfen Ge
Summary: In this study, a collaborative MOF system with dual-response properties was constructed for intelligent drug release. The system demonstrated excellent biocompatibility and synergistic efficacy, showing promising potential for biomedical applications.
Article
Oncology
Giuseppa Augello, Maria Rita Emma, Antonina Azzolina, Roberto Puleio, Lucia Condorelli, Antonella Cusimano, Lydia Giannitrapani, James A. McCubrey, Juan Lucio Iovanna, Melchiorre Cervello
Summary: The study revealed that NUPR1 knock-down impaired autophagic flux, increasing cell sensitivity to sorafenib, and activated the p73 signaling pathway, enhancing the anti-tumor effects of the drug. Combined therapy with the p73 activator NSC59984 and sorafenib showed synergistic suppression of tumor growth, suggesting a novel approach for HCC treatment.
Article
Food Science & Technology
Xiaoming Zhao, Tianzhuo Sui, Zhendong Fu, Leichao Zhang, Yiyao Gao, Liping Wang, Hui Zhang
Summary: Taisui, a functional food with rich medicinal value in ancient Chinese books, has shown potential as an anticancer agent for colorectal cancer. It inhibits cancer cell proliferation by inducing S-phase arrest, apoptosis, and autophagy, while regulating related proteins. Taisui fermentation broth induces apoptosis and autophagy in HCT116 cells by regulating reactive oxygen species-mediated JNK/p38 signaling. In addition, it inhibits tumor growth in a mouse xenograft model.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Biochemistry & Molecular Biology
Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki
Summary: The pathogenesis of hepatocellular carcinoma (HCC) is a complex and multifactorial process that remains incompletely understood. Autophagy and apoptosis are two important cellular pathways that play critical roles in cell survival or death. Dysregulation of the balance between apoptosis and autophagy is commonly observed in HCC and other cancers. Autophagy can either inhibit or promote apoptosis, thereby influencing the fate of liver cancer cells. This review provides a concise overview of the pathogenesis of HCC, highlighting recent developments such as endoplasmic reticulum stress, microRNAs, and gut microbiota. The characteristics of HCC associated with specific liver diseases are discussed, and a brief introduction to autophagy and apoptosis is provided. The role of autophagy and apoptosis in HCC initiation, progression, and metastasis is reviewed, with extensive analysis of experimental evidence pointing to an interplay between these two processes. The role of ferroptosis, a recently described form of regulated cell death, is also presented. Finally, the potential therapeutic implications of autophagy and apoptosis in drug resistance are examined.
Article
Biochemistry & Molecular Biology
Yuji Nitta, Tomomi Fujii, Tomoko Uchiyama, Aya Sugimoto, Takeshi Nishikawa, Maiko Takeda, Makito Miyake, Keiji Shimada, Kiyohide Fujimoto
Summary: The study reveals the significant role of miR-138-SOX9 signaling in urothelial carcinoma. Targeting SOX9, miR-138 can reduce the proliferation and invasion of urothelial carcinoma cells by promoting autophagy and apoptosis and inducing cell cycle arrest.
Article
Biochemistry & Molecular Biology
Gi-Hwan Jung, Jae-Han Lee, So-Hee Han, Joong-Seok Woo, Eun-Young Choi, Su-Ji Jeon, Eun-Ji Han, Soo-Hyun Jung, Young-Seok Park, Byung-Kwon Park, Byeong-Soo Kim, Sang-Ki Kim, Ji-Youn Jung
Summary: This study investigated the anticancer effect and mechanism of Chrysin against oral cancer. The results showed that Chrysin induced apoptosis and autophagy in oral cancer cells via the MAPK pathway, with autophagy exerting a cytoprotective effect. This study highlights the therapeutic potential of Chrysin for oral cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fangnan Wu, Chaoyong Tu, Kun Zhang, Hanyang Che, Qiaomei Lin, Zhuokai Li, Qingyun Zhou, Bufu Tang, Yang Yang, Minjiang Chen, Chuxiao Shao
Summary: This study found that PKMYT1 is overexpressed in HCC patients and is associated with poor prognosis. Knockdown of PKMYT1 inhibited proliferation and migration of HCC cell lines, inhibited autophagy, and induced apoptosis. These findings suggest that PKMYT1 may function as an oncogene and could be a new target for HCC treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)