4.4 Article

A new highly selective fluorescence probe for the imaging of endogenous formaldehyde in living cells

Journal

TETRAHEDRON
Volume 78, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2020.131808

Keywords

Fluorescent probe; Formaldehyde; Cell imaging; Naphthalimide

Funding

  1. NSFC [21672083, 21877048]
  2. Guangxi University [A3040051003]
  3. Guangxi Natural Science Foundation [2019GXNSFBA245068]

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NaFP, a new turn-on fluorescent probe designed with a hydrazine recognition site for formaldehyde, shows large turn-on signal and high selectivity for FA in living cells. The probe is capable of imaging exogenous/endogenous FA in living cells based on cell imaging experiments.
A new turn-on fluorescent probe, named as NaFP was structured with hydrazine group as a recognition site for detecting formaldehyde (FA) in living cells. The probe NaFP has large turn-on signal and high selectivity for FA. In addition, the results of cell imaging experiments indicate that NaFP could image exogenous/endogenous FA in living cells. (C) 2020 Elsevier Ltd. All rights reserved.

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