A Conformational Change in the N Terminus of SLC38A9 Signals mTORC1 Activation

Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9

(2020) Simon A. Fromm et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

(2018) Hsiang-Ting Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state

(2018) Hsiang-Ting Lei et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

(2017) Ming-Yuan Su et al.   MOLECULAR CELL

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling

(2017) Mariana E. G. de Araujo et al.   SCIENCE

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

Structural basis for the assembly of the Ragulator-Rag GTPase complex

(2017) Ryo Yonehara et al.   Nature Communications

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

(2016) Deborah C.I. Goberdhan et al.   Cell Metabolism

Structural basis for Mep2 ammonium transceptor activation by phosphorylation

(2016) Bert van den Berg et al.   Nature Communications

Multiple amino acid sensing inputs to mTORC1

(2015) Mitsugu Shimobayashi et al.   CELL RESEARCH

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

(2015) Jennifer Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Improved PEP-FOLD Approach for Peptide and Miniprotein Structure Prediction

(2014) Yimin Shen et al.   Journal of Chemical Theory and Computation

Making new contacts: the mTOR network in metabolism and signalling crosstalk

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Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

PEP-FOLD: an updated de novo structure prediction server for both linear and disulfide bonded cyclic peptides

(2012) P. Thevenet et al.   NUCLEIC ACIDS RESEARCH

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

High-Efficiency Screening of Monoclonal Antibodies for Membrane Protein Crystallography

(2011) Hyun-Ho Lim et al.   PLoS One

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Features and development ofCoot

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transport and signaling through the phosphate-binding site of the yeast Pho84 phosphate transceptor

(2010) Y. Popova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

(2009) Harinder S. Hundal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor

(2008) Griet Van Zeebroeck et al.   Nature Chemical Biology

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE