Journal
STEM CELL RESEARCH
Volume 49, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scr.2020.102081
Keywords
-
Funding
- Swedish Research Council [2015-02424]
- AstraZeneca
- Hjarnfonden [FO2019-0210, FO2020-0171]
- Science for Life Laboratory
- Savstaholm Society
Ask authors/readers for more resources
Down syndrome (DS) is caused by trisomy for chromosome 21 (T21). We generated two induced pluripotent stem cell (iPSC) lines from skin fibroblasts of two males with DS using Sendai virus delivery of OCT4, SOX2, KLF4, and c-MYC. Characterization of the two iPSC lines, UUIGPi013-A and UUIPGi014-A, showed that they are genetically stable with a 47,XY,+21 karyotype. Both lines displayed expression of pluripotency markers and trilineage differentiation capacity. These two iPSC lines provide a useful resource for DS modeling and pharmacological interventions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available