4.3 Article

Pregnant women's cognitive appraisal of a natural disaster affects their children's BMI and central adiposity via DNA methylation: Project Ice Storm

Journal

EARLY HUMAN DEVELOPMENT
Volume 103, Issue -, Pages 189-192

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2016.09.013

Keywords

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Funding

  1. Canadian Institute of Health Research (CIHR) [MOP-1150067]

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We determined the extent to which DNA methylation mediates the effects of maternal cognitive appraisal of a natural disaster during pregnancy on offspring growth at age 13. Negative maternal cognitive appraisal predicted both lower BMI and central adiposity via DNA methylation of diabetes-related genes, suggesting a protective role of epigenetics. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

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