Journal
DYES AND PIGMENTS
Volume 128, Issue -, Pages 165-169Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2016.01.029
Keywords
Borondipyrromethene; Benzimidazole; Lysosome labeling; pH probe
Funding
- National Natural Science Foundation of China [91227118]
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A new optical and fluorometric pH sensor has been obtained by attaching pH sensitive group benzimidazole at the 2-position of borondipyrromethene. Due to the electron-donor effect, benzimidazole group caused obvious bathochromic shift in the absorption and fluorescence spectra. Upon protonation, the solution exhibited drastic blue-shifted absorption and enhanced fluorescence, and the color changed from yellow to green simultaneously. The sensing mechanism was elucidated by quantum chemistry calculation approach. Cell experiments were carried out to verify the compound could selectively locate in the acidic lysosome. These results indicated the Benzimidazole-BODIPY could be used as an optical and off-on fluorescent pH indicator. (C) 2016 Elsevier Ltd. All rights reserved.
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