Article
Cell Biology
Danielle Beckman, Alyssa Bonillas, Giovanne B. Diniz, Sean Ott, Jamin W. Roh, Sonny R. Elizaldi, Brian A. Schmidt, Rebecca L. Sammak, Koen K. A. Van Rompay, Smita S. Iyer, John H. Morrison
Summary: SARS-CoV-2 can directly infect the brain and induce neuroinflammation and neuronal damage, especially in aged, diabetic animals, which is crucial for reducing the short-term and long-term burden of COVID-19.
Article
Multidisciplinary Sciences
Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sa Guimaraes, Monica Beatriz Mathor, Patricia dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira, Durvanei Augusto Maria, Silas Fernandes Eto, Neuza Maria Frazatti Gallina, Giselle Pidde, Carla Cristina Squaiella-Baptistao, Dilza Trevisan Silva, Isadora Maria Villas-Boas, Dayanne Carla Fernandes, Aline Vivian Vatti Auada, Alexandre Campos Banari, Antonio Francisco de Souza Filho, Camila Bianconi, Carla Lilian de Agostini Utescher, Denise Cristina Andre Oliveira, Douglas Oscar Ceolin Mariano, Flavia Ferreira Barbosa, Giuliana Rondon, Josana Kapronezai, Juliana Galvao da Silva, Mauricio Barbugiani Goldfeder, Priscila Comone, Regis Edgar Castilho Junior, Taiana Taina Silva Pereira, Fan Hui Wen, Denise Tambourgi, Ana Marisa Chudzinski-Tavassi
Summary: The new outbreak of COVID-19 has caused millions of deaths worldwide. Efforts are being made to find effective treatments, such as using immunoglobulin from immunized animals or plasma from convalescent patients. Clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with spike protein are underway. Researchers have developed an anti-SARS-CoV-2 equine F(ab ')(2) immunoglobulin that successfully neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster model of SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Nhu Ngoc Nguyen, Linda Houhamdi, Van Thuan Hoang, Jeremy Delerce, Lea Delorme, Philippe Colson, Philippe Brouqui, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
Summary: The reinfection rate of SARS-CoV-2 is low, and the severity of the first and second episodes of infection is similar. The severity of the second episode of COVID-19 is not higher than that of the first infection, even for patients with antibodies.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Microbiology
Christina M. Kackos, Sherri L. Surman, Bart G. Jones, Robert E. Sealy, Trushar Jeevan, Christopher J. H. Davitt, Sergei Pustylnikov, Tamarand L. Darling, Adrianus C. M. Boon, Julia L. Hurwitz, Marcelo M. Samsa, Richard J. Webby
Summary: SARS-CoV-2 continues to disrupt everyday life and cause excess morbidity and mortality worldwide. Vaccination has been key to quelling the impact of this respiratory pathogen, and mRNA vaccines have led the charge on this front. The emergence of SARS-CoV-2 variants has threatened vaccine efficacy, but the mRNA vaccines developed by GreenLight Biosciences have shown robust protective efficacy against the wild-type virus and its variants.
MICROBIOLOGY SPECTRUM
(2023)
Review
Microbiology
Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, Vineet D. Menachery
Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.
CELL HOST & MICROBE
(2021)
Article
Gastroenterology & Hepatology
David Schult, Sandra Reitmeier, Plamena Koyumdzhieva, Tobias Lahmer, Moritz Middelhof, Johanna Erber, Jochen Schneider, Juliane Kager, Marina Frolova, Julia Horstmann, Lisa Fricke, Katja Steiger, Moritz Jesinghaus, Klaus-Peter Janssen, Ulrike Protzer, Klaus Neuhaus, Roland M. Schmid, Dirk Haller, Michael Quante
Summary: There is an ongoing debate about the role of the gut microbiome in COVID-19. This study analyzed fecal and saliva samples from COVID-19 patients and controls to investigate the impact of the microbiome on disease severity. The results showed that the composition of the gut and oral microbiota was associated with COVID-19-related complications and disease progression, and a model was developed to estimate mortality based on microbial profiles.
Article
Multidisciplinary Sciences
Salmaan Sharif, Aamer Ikram, Adnan Khurshid, Muhammad Salman, Nayab Mehmood, Yasir Arshad, Jamal Ahmed, Rana Muhammad Safdar, Lubna Rehman, Ghulam Mujtaba, Jaffar Hussain, Johar Ali, Mehar Angez, Muhammad Masroor Alam, Ribqa Akthar, Muhammad Wasif Malik, Mirza Zeeshan Iqbal Baig, Muhammad Suleman Rana, Muhammad Usman, Muhammad Qaisar Ali, Abdul Ahad, Nazish Badar, Massab Umair, Sana Tamim, Asiya Ashraf, Faheem Tahir, Nida Ali
Summary: The study found 27% of wastewater samples tested positive for SARs-CoV-2, indicating the potential for monitoring viral spread through wastewater surveillance. Additionally, the detection of virus sequence data in wastewater highlights the importance of surveillance for early warning signs.
Article
Clinical Neurology
Zhitao Li, Zhen Zhang, Zhuoya Zhang, Zhiyong Wang, Hao Li
Summary: COVID-19 may lead to cognitive impairment, including memory and attention deficits as well as sleep disturbances, which are associated with brain damage, neuroinflammation, and mitochondrial dysfunction. Large-scale follow-up studies are necessary to understand the impact of COVID-19 on cognitive function and provide evidence for clinical treatment and rehabilitation practices.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Andrea Nachon-Acosta, Gustavo Martinez-Mier, Victor Flores-Gamboa, Octavio Avila-Mercado, Indira Morales Garcia, Carlos Yoldi-Aguirre, Irais Olivares-Garcia, Maritza de la Paz-roman
Summary: The study aimed to determine the characteristics and outcomes of patients undergoing surgery during the COVID-19 pandemic in a third level reference hospital in Mexico. The results showed that patients with COVID-19 infection had higher postoperative morbidity and mortality rates, with significant associations with respiratory, infection, transfusion, renal function, and other complications.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Review
Virology
Noothan J. Satheesh, Salam Salloum-Asfar, Sara A. Abdulla
Summary: COVID-19 caused by SARS-CoV-2 affects the lungs and can enter the central nervous system, potentially leading to neurological complications such as encephalitis and encephalopathy. The virus may also trigger the development of Multiple Sclerosis (MS) as a secondary disease, similar to the increase in Parkinson's disease cases after the Spanish Flu in 1918.
Review
Endocrinology & Metabolism
Salvatore Corrao, Karen Pinelli, Martina Vacca, Massimo Raspanti, Christiano Argano
Summary: This review discusses the prevalence, pathophysiological mechanisms, and outcomes of COVID-19 infection in people with diabetes, proposing a rationale for using drugs prescribed in patients with diabetes and providing pragmatic clinical recommendations for dealing with COVID-19 in this patient population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Heather P. McLaughlin, Brian C. Hiatt, Denny Russell, Christina M. Carlson, Jesica R. Jacobs, Ailyn C. Perez-Osorio, Michelle L. Holshue, Sung W. Choi, Romesh K. Gautom
Summary: The paper discusses the collaboration between the Washington State Public Health Laboratory and the Centers for Disease Control and Prevention in responding to the COVID-19 outbreak, highlighting factors contributing to an effective laboratory response and discussing challenges, successful steps, and lessons learned.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Tapan Behl, Sachin Kumar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sridevi Chirgurupati, Maha Aldubayan, Ahmad Alhowail, Saurabh Bhatia, Simona Bungau
Summary: COVID-19 pandemic may exacerbate the progression of Parkinson's disease, and certain virus infections are also associated with the development of Parkinsonism. Coronavirus primarily infects alveolar cells, potentially leading to acute respiratory distress syndrome. Intake of vitamin D may help reduce the risk and severity of COVID-19 in Parkinsonian patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Microbiology
Maria Karoliny da Silva Torres, Carlos David Araujo Bichara, Maria de Nazare do Socorro de Almeida, Mariana Cayres Vallinoto, Maria Alice Freitas Queiroz, Izaura Maria Vieira Cayres Vallinoto, Eduardo Jose Melo dos Santos, Carlos Alberto Marques de Carvalho, Antonio Carlos R. Vallinoto
Summary: This article conducts an extensive literature review on the impact of SARS-CoV-2 pandemic in terms of biology, sociology, genetics, diagnostics, therapeutics, immunology, and socioeconomics. It aims to provide a comprehensive understanding of the major aspects related to the ongoing pandemic.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaojuan Peng, Qi Liu, Zhaolin Chen, Guiyan Wen, Qing Li, Yanfang Chen, Jie Xiong, Xinzhou Meng, Yuanjin Ding, Ying Shi, Shaohui Tang
Summary: Patients with moderate cases of SARS-CoV-2 have a good prognosis with active treatment, but a small proportion of recovered patients may still be virus carriers, necessitating additional rounds of viral detection.
Article
Biochemistry & Molecular Biology
Priyanka Nagu, Vivek Sharma, Tapan Behl, Amjad Khan A. Pathan, Vineet Mehta
Summary: Wnt signaling is essential for neurogenesis and plays a crucial role in the development and differentiation of neurons in the adult brain. Impaired Wnt signaling pathways are directly associated with the pathogenesis of Alzheimer's disorder (AD). Activation of Wnt signaling improves cognitive functions and restores neurogenesis in animal models. Various natural and synthetic molecules have been identified to modulate Wnt signaling and promote neurogenesis, which could be beneficial in managing AD. However, more research is needed on the role of Wnt signaling in AD patients to further understand the pathogenesis and identify novel therapeutic targets.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Aman Thakur, Bhanu Sharma, Arun Parashar, Vivek Sharma, Ajay Kumar, Vineet Mehta
Summary: This study developed a reliable and efficient 2D-QSAR model and predicted amentoflavone as the most promising herbal molecule for inhibiting human AChE enzyme within the CNS, which could be beneficial for the management of AD.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Pharmacology & Pharmacy
Poonam Negi, Akriti Singh, Swati Pundir, Arun Parashar, Navneet Upadhyay, Shweta Agarwal, Raveen Chauhan, Murtaza M. Tambuwala
Summary: The vagina can be infected by a fungus called Candida albicans, causing a common sickness known as thrush. Over 75% of women will experience this infection at some point, with a high recurrence rate. While there are medicines available, scientists are studying the use of plants to create nanosized carriers for powerful medicine that can effectively treat the infection. This review focuses on nanocarrier-based approaches and essential oil-based formulations for vaginal candidiasis.
THERAPEUTIC DELIVERY
(2023)
Article
Engineering, Multidisciplinary
Priyanka Nagu, Amjad Khan A. Pathan, Vineet Mehta
Summary: Currently, there is a lack of therapeutic interventions for Alzheimer's Disease (AD), and the pathology of AD remains unclear. This research identified 100 herbal molecules with potential therapeutic benefits for inhibiting enzymes and mitigating oxidative and inflammatory stress, as well as neurodegeneration. Quercetin and rutin showed strong potential in modulating AD-related pathways and exhibiting neuroprotective effects. However, further preclinical investigations are needed to validate their potential effects on AD pathogenesis.
JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH
(2023)
Article
Tropical Medicine
Vineet Mehta, Priyanka Nagu, Arun Parashar, Manjusha Chaudhary
Summary: This study investigates the effect of Cassia fistula on collagen-induced arthritis in rats. The results show that the chloroform and hydroalcoholic extracts of Cassia fistula leaf can reduce arthritis index and spleen index, as well as lower the levels of inflammatory factors, thus suppressing the progression of arthritis. Further studies are needed to identify the bioactive molecule responsible for the anti-arthritic potential of Cassia fistula.
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Priyanka Nagu, Amjad Khan A. Pathan, Vineet Mehta
Summary: This study identified quercetin and rutin as promising herbal molecules with antioxidant and anti-inflammatory properties that could be beneficial in managing Alzheimer's disease through targeting oxidative and inflammatory stress pathways.
APPLIED BIOLOGICAL RESEARCH
(2022)
Article
Chemistry, Applied
Akshil Kumar Sharma, Debarshi Ghosh, Nitin Kumar Saluja, Thakur Gurjeet Singh
Summary: Electroporation has applications in selective drug delivery to cells, with the key parameter of induced transmembrane outage (ITMV) determining its success. The FDA recently approved clinical trials for delivering the COVID-19 vaccine through electroporation. Due to time constraints, extensive laboratory experiments are not feasible, leading to increased reliance on simulation-based analysis. This paper presents a closed-form expression of ITMV and validates it through COMSOL Multiphysics simulations, reducing development time for electroporation-assisted COVID-19 vaccine delivery.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Chemistry, Applied
Neelam Sharma, Sandeep Arora, Tapan Behl, Sukhbir Singh, Rajesh Kumar
Summary: This study successfully synthesized freeze-dried inhalable microparticles of herbal extracts using emulsification solvent evaporation technique and optimized the particles' properties using Box-Behnken design. The optimized microparticles demonstrated suitable diameter and bulk density, validating the efficacy of the optimization approach.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Review
Chemistry, Applied
Nikhil Garg, Thakur Gurjeet Singh, Heena Khan, Sandeep Arora, Amarjot Kaur, Ashi Mannan
Summary: Metabolic disorders, caused by elevated body weight, diabetes, and obesity, have reached epidemic levels in some countries. This review explores the use of selected Ocimum species, which are rich in diverse phytoconstituents, for the treatment of metabolic disorders.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Article
Chemistry, Applied
Ikmeet Kaur Grewal, Sukhbir Singh, Sandeep Arora, Neelam Sharma
Summary: This study aims to develop a sustained topical release delivery system for eflornithine hydrochloride using solid lipid microparticles. The optimized formulation showed enhanced permeability and sustained release of the drug, making it a promising strategy for hirsutism treatment.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
Review
Chemistry, Applied
Neha Kanojia, Neelam Sharma, Nidhi Gupta, Sukhbir Singh
Summary: Nanostructured lipid carriers (NLCs) are nano-particulate carrier systems that can effectively deliver drugs and have a wide range of applications in the pharmaceutical and food industries.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)