Article
Radiology, Nuclear Medicine & Medical Imaging
Anna K. Luger, Thomas Sonnweber, Leonhard Gruber, Christoph Schwabl, Katharina Cima, Piotr Tymoszuk, Anna K. Gerstner, Alex Pizzini, Sabina Sahanic, Anna Boehm, Maximilian Coen, Carola J. Strolz, Ewald Woell, Gunter Weiss, Rudolf Kirchmair, Gudrun M. Feuchtner, Helmut Prosch, Ivan Tancevski, Judith Loeffler-Ragg, Gerlig Widmann
Summary: This study aimed to evaluate the improvement of chest CT abnormalities 1 year after COVID-19 pneumonia. The study found that more than half of the participants still had CT abnormalities after 1 year, and age over 60, severe COVID-19 symptoms, and male sex were associated with persistent CT abnormalities at 1-year follow-up. During the follow-up period, about half of the participants had complete resolution of CT abnormalities, but some participants with abnormalities showed no further improvement after 6 months.
Article
Immunology
Dorottya Fesu, Lorinc Polivka, Eniko Barczi, Marcell Foldesi, Gabor Horvath, Edit Hidvegi, Aniko Bohacs, Veronika Muller
Summary: Data about interstitial lung disease (ILD) in patients with persistent symptoms following COVID-19 hospitalization are scarce. This study retrospectively reviewed cases of patients sent for pulmonary post-COVID evaluation due to persistent symptoms, with a focus on those with suspected ILD. The results showed that suspected post-COVID ILD affected 13.8% of symptomatic patients, with new symptoms of cough and sleepiness being more common in this group. Functional impairment and respiratory function abnormalities were detected, indicating the potential long-term effects of COVID-19 on the lungs.
INFLAMMOPHARMACOLOGY
(2023)
Article
Respiratory System
Tori Vigeland Lerum, Trond Mogens Aalokken, Eivind Bronstad, Bernt Aarli, Eirik Ikdahl, Kristine Marie Aarberg Lund, Michael T. Durheim, Jezabel Rivero Rodriguez, Carin Meltzer, Kristian Tonby, Knut Stavem, Ole Henning Skjonsberg, Haseem Ashraf, Gunnar Einvik
Summary: The long-term pulmonary outcomes of COVID-19 after 3 months of hospital admission include chest CT opacities and reduced diffusing capacity in one-fourth of the participants. ICU patients did not show significant differences in dyspnoea scores and lung function, but had a higher prevalence of abnormal chest CT findings.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Oncology
Sungryong Noh, Christopher Bertini, Isabel Mira-Avendano, Maryam Kaous, Bela A. Patel, Saadia A. R. Faiz, Vickie R. D. Shannon, Diwakar D. Balachandran, Lara Bashoura, Roberto E. Adachi, Scott E. Evans, Burton Dickey, Carol S. Wu, Girish S. Shroff, Joanna-Grace Manzano, Bruno Granwehr, Shannon Holloway, Kodwo Dickson, Alyssa Mohammed, Mayoora Muthu, Hui Song, Caroline Chung, Jia Wu, Lyndon Lee, Ying Jiang, Fareed Khawaja, Ajay Sheshadri
Summary: This study found that cancer patients often develop persistent respiratory symptoms and interstitial lung abnormalities (ILAs) within three months after discharge from COVID-19 hospitalization. In addition, age and the severity of illness at admission are associated with persistent ILAs. Fibrotic ILAs are more common at six months post-discharge.
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe Sanchez Tijmes, Constantin A. Marschner, Joao Francisco Ribeiro Gavina de Matos, Camila M. Urzua Fresno, Jose Miguel Gutierrez Chacoff, Paaladinesh Thavendiranathan, Cristina Fuss, Kate Hanneman
Summary: COVID-19 and mRNA-based COVID-19 vaccination can lead to acute and longer-term cardiovascular manifestations, including myocardial injury and myocarditis. Noninvasive imaging such as cardiac MRI plays a key role in identifying cardiovascular diseases, evaluating mechanisms of injury, stratifying risk, and guiding treatment.
Review
Respiratory System
James A. Stockley, Eyas A. Alhuthail, Andrew M. Coney, Dhruv Parekh, Tarekegn Geberhiwot, Nandan Gautum, Shyam C. Madathil, Brendan G. Cooper
Summary: There is limited research on the effects of COVID-19 on respiratory physiology, particularly breathing patterns. This study found evidence of pulmonary restriction in 65.4% of all patients, with abnormal breathing patterns observed in 18.8% of subjects, suggesting an extrapulmonary cause. The effects on lung function appear to be similar in COVID-19 survivors whether or not they received mechanical ventilation.
RESPIRATORY RESEARCH
(2021)
Article
Cell Biology
Giorgio A. Croci, Valentina Vaira, Daria Trabattoni, Mara Biasin, Luca Valenti, Guido Baselli, Massimo Barberis, Elena Guerini Rocco, Giuliana Gregato, Mara Scandroglio, Evgeny Fominskiy, Alessandro Palleschi, Lorenzo Rosso, Mario Nosotti, Mario Clerici, Stefano Ferrero
Summary: This study characterized the immunopathological features of two Italian COVID-19 patients who underwent bilateral lung transplantation, revealing extensive lung damage resembling usual interstitial pneumonia. Gene expression profiling in lung tissues and stimulated blood cells showed overexpression of immune-related genes and a persistent proinflammatory state, indicating sustained immune activation despite immunosuppression.
Review
Cell Biology
Janet Johnston, Delia Dorrian, Dermot Linden, Stefan Cristian Stanel, Pilar Rivera-Ortega, Nazia Chaudhuri
Summary: This review discusses the emerging concern of interstitial lung disease (ILD) as a consequence of SARS-CoV-2 infection. The prevailing radiological pattern observed is organizing pneumonia, with ground-glass opacities and reticulation frequently reported. Longitudinal studies reveal a complex trajectory, with some patients showing improvement in lung function and radiographic abnormalities over time while others display more static fibrotic changes. Age, disease severity, and male sex are emerging as risk factors for residual lung abnormalities. Further research and understanding of the relationship between post-COVID ILD and idiopathic pulmonary fibrosis (IPF) genetics are crucial for guiding clinical decisions and improving outcomes for patients.
Article
Immunology
Sahajal Dhooria, Siddhant Arora, Shivani Chaudhary, Inderpaul Singh Sehgal, Nidhi Prabhakar, Nasim Mohammad, Riya Sharma, Prabir Das, Yashwant Kumar, Mandeep Garg, Goverdhan Dutt Puri, Ashish Bhalla, Valliappan Muthu, Kuruswamy Thurai Prasad, Ritesh Agarwal, Ashutosh Nath Aggarwal
Summary: This study aimed to assess the association between COVID-19 severity and other parameters with clinically significant diffuse parenchymal lung abnormalities (CS-DPLA). The results showed that longer hospital stay was the only independent predictor of CS-DPLA six months after severe COVID-19. Additionally, serum TGF-beta levels may be evaluated further as a biomarker.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sevtap Dogan, Gozde Selvi Guldiken, Burcu Alpaslan, Serap Argun Baris, Nurettin Ozgur Dogan
Summary: This study evaluated the CT scores and fibrotic pattern changes in interstitial lung disease (ILD) patients, with and without previous COVID-19 pneumonia. The results showed that in patients with COVID-19 pneumonia, there was a significant increase in CT scores and worsening of the fibrotic pattern.
EUROPEAN RADIOLOGY
(2023)
Article
Respiratory System
Arianna Sanna, Daniela Pellegrino, Emanuele Messina, Leonardo Maria Siena, Valentina Baccolini, Letizia D'Antoni, Nicholas Landini, Pia Baiocchi, Paolo Villari, Carlo Catalano, Valeria Panebianco, Paolo Palange
Summary: This study evaluated the incidence and risk factors of Post-COVID-19 Interstitial Lung Disease (PC-ILD) in 100 patients with moderate to critical COVID-19. It found that 8% of patients showed residual radiological and functional signs consistent with PC-ILD at the 15-month follow-up. Aging, severity of COVID-19, and degree of pulmonary involvement during acute infection were identified as significant risk factors for developing PC-ILD.
Article
Immunology
Ying Wang, Yuqing Hao, Mengke Hu, Yadong Wang, Haiyan Yang
Summary: This meta-analysis based on adjusted effect estimates demonstrated that pre-existing interstitial lung disease was independently associated with significantly higher risk for COVID-19 severity and mortality.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Respiratory System
Laura Fabbri, Samuel Moss, Fasihul A. Khan, Wenjie Chi, Jun Xia, Karen Robinson, Alan Robert Smyth, Gisli Jenkins, Iain Stewart
Summary: This study assessed the proportion of lung disease in COVID-19 survivors by analyzing chest CT scans and pulmonary function tests. The findings suggest that pulmonary fibrosis and other sequelae are common in COVID-19 patients during follow-up. However, caution should be exercised in interpreting the estimates due to heterogeneity and differences in study populations.
Article
Cell Biology
Hongwei Li, Xue Li, Qian Wu, Xing Wang, Zhonghua Qin, Yaguo Wang, Yanbin He, Qi Wu, Li Li, Huaiyong Chen
Summary: In COVID-19 survivors, about 41% reported at least one clinical symptom and 26.5% exhibited lung imaging abnormalities 6 months after discharge. Plasma proteomics and metabolomics analysis showed that COVID-19 survivors differed from healthy controls in terms of extracellular matrix, immune response, and hemostasis pathways. Moreover, COVID-19 survivors also exhibited abnormal lipid metabolism, disordered immune response, and changes in pulmonary fibrosis-related proteins.
CELL DEATH & DISEASE
(2022)
Article
Medicine, General & Internal
Theodoros Karampitsakos, Vasilina Sotiropoulou, Matthaios Katsaras, Panagiota Tsiri, Vasiliki E. Georgakopoulou, Ilias C. Papanikolaou, Eleni Bibaki, Ioannis Tomos, Irini Lambiri, Ourania Papaioannou, Eirini Zarkadi, Emmanouil Antonakis, Aggeliki Pandi, Elli Malakounidou, Fotios Sampsonas, Sotiria Makrodimitri, Serafeim Chrysikos, Georgios Hillas, Katerina Dimakou, Nikolaos Tzanakis, Nikolaos V. Sipsas, Katerina Antoniou, Argyris Tzouvelekis
Summary: Post-acute sequelae of COVID-19 is a global crisis, and machine learning radiographic models have the potential to evaluate post-COVID-19 interstitial lung disease accurately.
FRONTIERS IN MEDICINE
(2023)