Article
Nutrition & Dietetics
Georgiana-Emmanuela Gilca-Blanariu, Anca Trifan, Manuela Ciocoiu, Iolanda Valentina Popa, Alexandru Burlacu, Gheorghe G. Balan, Andrei Vasile Olteanu, Gabriela Stefanescu
Summary: This study found that hair magnesium concentration in IBD patients is significantly lower compared to healthy controls, and is related to disease activity, psychological status, and sleep quality. The findings suggest that magnesium may play a crucial role in IBD pathophysiology, and supplementation could potentially improve disease progression and sleep quality for patients with magnesium deficiency.
Review
Medicine, General & Internal
M. P. Eugenicos, N. B. Ferreira
Summary: This review examined recent evidence on the impact of depression and anxiety on disease activity, relapse, and healthcare utilization in inflammatory bowel disease (IBD), highlighting the importance of assessing depression and anxiety in routine management of IBD patients. Developing more longitudinal research and randomized controlled trials will provide further insights into the role of mental health in IBD outcomes.
BRITISH MEDICAL BULLETIN
(2021)
Article
Gastroenterology & Hepatology
Laurie Keefer, Alyse Bedell, Christine Norton, Ailsa L. Hart
Summary: Early diagnosis and optimal control of inflammation are best practices for managing inflammatory bowel disease. Patients often experience challenging symptoms, such as abdominal pain, fatigue, depression, and anxiety, that are not properly addressed. This review highlights the burden of these symptoms, suggests assessment methods, and emphasizes the importance of acknowledging and validating patient's symptoms.
Review
Gastroenterology & Hepatology
Lexa K. Murphy, Rocio de la Vega, Sara Ahola Kohut, Joy S. Kawamura, Rona L. Levy, Tonya M. Palermo
Summary: The study found that child depression symptoms and pain catastrophizing were associated with pain and pain impact in pediatric IBD, and pain and impact were also related to child anxiety symptoms, pain worry, and parent pain catastrophizing. Female sex and disease severity were significantly associated with pain and pain impact.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Charles N. N. Bernstein, John D. D. Fisk, Randy Walld, James M. M. Bolton, Jitender Sareen, Scott B. B. Patten, Alexander Singer, Lisa M. Lix, Carol A. A. Hitchon, Renee El-Gabalawy, Lesley A. A. Graff, Alan Katz, Kelcie Witges, James J. J. Marriott, Ruth Ann Marrie
Summary: The use of benzodiazepines and Z-drugs is higher in patients with inflammatory bowel disease (IBD) compared to controls. Strategies are needed to reduce benzodiazepine use in individuals with IBD and provide alternative management options for mood/anxiety disorders, sleep disorders, and other symptoms.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Immunology
Li Ge, Shuman Liu, Sha Li, Jing Yang, Guangran Hu, Changqing Xu, Wengang Song
Summary: This review explores the possible link between psychological stress and inflammatory bowel disease (IBD) from a psychoneuroimmunology perspective. It emphasizes the bidirectionality of the brain-gut axis, suggesting that IBD pathophysiology increases central nervous system inflammation and contributes to anxiety and depression-like behavioral comorbidities.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Georgiana-Emmanuela Gilca-Blanariu, Cristina Gabriela Schiopu, Gabriela Stefanescu, Catalina Mihai, Smaranda Diaconescu, Vlad Adrian Afrasanie, Vasile Valeriu Lupu, Ancuta Lupu, Alexandra Bolos, Cristinel Stefanescu
Summary: Inflammatory bowel disease has a significant impact on the lives of patients and is closely associated with psychiatric symptoms. The modulation of the gut-brain axis and the role of the gut microbiota play crucial roles in this complex relationship.
Article
Psychiatry
Shihao Duan, Yi Yang, Yubin Cao, Pingrun Chen, Chang Liang, Yan Zhang
Summary: This study aimed to investigate the impact of anxiety and depression on the efficacy of medications and IBD-related poor outcomes in patients with inflammatory bowel disease (IBD). The results showed that anxiety and depression symptoms were significantly associated with steroid resistance and IBD-related poor outcomes. Further studies are needed to explore whether interventions for anxiety and depression can improve medication response and prognosis in IBD patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Laura Tasson, Fabiana Zingone, Brigida Barberio, Romina Valentini, Pamela Ballotta, Alexander C. Ford, Marco Scarpa, Imerio Angriman, Matteo Fassan, Edoardo Savarino
Summary: The study found that fatigue is common in IBD patients, and abnormal CRP, sarcopenia, and severe anxiety are factors independently associated with severe fatigue.
SCIENTIFIC REPORTS
(2021)
Review
Psychiatry
Shurong Hu, Yiping Chen, Yan Chen, Caihua Wang
Summary: Mental health is an important aspect of care for IBD patients, with anxiety and depression being common psychological conditions. Screening and treating these mental disorders can lead to improved outcomes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Gastroenterology & Hepatology
Martina Sciberras, Konstantinos Karmiris, Catarina Nascimento, Trevor Tabone, Penelope Nikolaou, Angeliki Theodoropoulou, Abigail Mula, Idan Goren, Henit Yanai, Hadar Amir, Gerassimnos J. Mantzaris, Tereza Georgiadi, Kalliopi Foteinogiannopoulou, Ioannis Koutroubakis, Mariangela Allocca, Gionata Fiorino, Federica Furfaro, Konstantinos Katsanos, Fotios Fousekis, George Michalopoulos, Liberato Camilleri, Joana Torres, Pierre Ellul
Summary: This study assessed the prevalence of depression/anxiety, presenteeism and exercise levels among IBD patients. The results showed that a significant percentage of IBD patients in remission suffer from anxiety and/or depression. Depression/anxiety was associated with a sedentary lifestyle, lower presenteeism at work, and unemployment.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Gastroenterology & Hepatology
Jacqueline Black, Louise Sweeney, Yuhan Yuan, Harinder Singh, Christine Norton, Wladyslawa Czuber-Dochan
Summary: Psychological stress is a possible factor in the disease course and poor psychosocial outcomes in inflammatory bowel disease (IBD). This study aimed to explore the association between stress and disease outcomes, investigate the impact of stress on psychosocial outcomes, and evaluate the efficacy of interventions in reducing stress for people with IBD. The results showed that perceived stress appeared before IBD exacerbation and cognitive behavioral interventions may reduce stress.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Nosheen Umar, Dominic King, Joht Singh Chandan, Neeraj Bhala, Krish Nirantharakumar, Nicola Adderley, Dawit T. Zemedikun, Phil Harvey, Nigel Trudgill
Summary: This population-based retrospective cohort study shows that patients with inflammatory bowel disease (IBD) are at a higher risk of developing mental illnesses, including deliberate self-harm, depression, anxiety, and insomnia. The incidence rate ratios of mental illnesses are particularly high in the first year following IBD diagnosis. IBD is independently associated with an increased risk of deliberate self-harm.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Psychology, Multidisciplinary
Cornelia Rada, Dan Gheonea, Cristian George Tieranu, Denisa Elena Popa
Summary: Inflammatory bowel disease (IBD) is a chronic and incurable disease that significantly affects patients' quality of life. This study found a relationship between early maladaptive schemas and disease activity status, and a high prevalence of early maladaptive schemas in patients. Psychotherapeutic intervention is needed for these patients.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Behavioral Sciences
Chen Wang, Yingyue Sheng, Leilei Yu, Fengwei Tian, Yuzheng Xue, Qixiao Zhai
Summary: This study aims to assess the roles of cognitive behavioral therapy (CBT) in improving quality of life (QoL) and mental health in inflammatory bowel disease (IBD) patients. The analysis of nine randomized controlled trials showed that CBT significantly increased IBDQ scores and decreased anxiety and depression.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Genetics & Heredity
Won Sub Kang, Young Jong Kim, Hae Jeong Park, Su Kang Kim, Jong-Woo Paik, Jong Woo Kim
Article
Psychiatry
Hwayoung Lee, Hyung-Ki Kim, Jun-Tack Kwon, Shohyun Park, Hae Jeong Park, Su Kang Kim, Jin Kyung Park, Won Sub Kang, Young Jong Kim, Joo-Ho Chung, Jong Woo Kim, Hak-Jae Kim
PSYCHIATRY RESEARCH
(2018)
Article
Neurosciences
Soyoen Lee, Sang Min Lee, Won Sub Kang, Geon-Ho Jahng, Chang-Woo Ryu, Jin Kyung Park
NEUROSCIENCE LETTERS
(2019)
Article
Psychiatry
Sun Mi Kim, Young-Hoon Ko, Seoyoung Yoon, Won Sub Kang, Hye-Geum Kim, Hye Youn Park, Cheolmin Shin, Yoo Hyun Um, Soyoung Youn, Jae-Hon Leen, Seung-Ho Jang, Sang Won Jeon, Hong Jun Jeon, Seockhoon Chung, Jae-Won Choi, Kyu-Man Han, Sang-Yeol Lee
PSYCHIATRY INVESTIGATION
(2019)
Article
Psychiatry
Won Sub Kang, Su Kang Kim, Hae Jeong Park
PSYCHIATRY INVESTIGATION
(2020)
Article
Psychiatry
Miae Oh, Jong-Woo Kim, Nan-He Yoon, Seong Ae Lee, Sang Min Lee, Won Sub Kang
PSYCHIATRY INVESTIGATION
(2019)
Article
Biochemistry & Molecular Biology
Hae Jeong Park, Sang A. Kim, Won Sub Kang, Jong Woo Kim
Summary: This study found that early-life stress induced by maternal separation can lead to changes in gut microbiota composition, inflammatory cytokines, and tryptophan-kynurenine metabolism in rats. These alterations were shown to be sex-dependent, with differences in gut microbe abundance and inflammatory cytokine levels observed between male and female rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychology, Clinical
Sang Min Lee, Minha Hong, Saengryeol Park, Won Sub Kang, In-Hwan Oh
Summary: The study investigated the treatment prevalence and economic burden of eating disorders in South Korea between 2010 and 2015, finding an increase in treatment prevalence and medical expenditures over the years. The total economic cost of eating disorders was USD 5455626 in 2015, with the highest economic cost and prevalence observed in the 20-29 age group.
JOURNAL OF EATING DISORDERS
(2021)
Article
Psychiatry
Hae Jeong Park, Won Sub Kang, Jong Woo Kim
Summary: Previous studies have suggested that the TGA haplotype of RTN4 is significantly associated with schizophrenia, potentially increasing the susceptibility to the disorder. The rare TGA haplotype was shown to decrease promoter activity, further supporting its role in the pathogenesis of schizophrenia.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, General & Internal
Sanga Kim, Bup Kyung Choi, Ji Ae Park, Hyung Joong Kim, Tong In Oh, Won Sub Kang, Jong Woo Kim, Hae Jeong Park
Summary: Previous imaging studies have shown morphological malformation and alterations in ionic mobility, water contents, electrical properties, or metabolites in seizure brains. This study examined the potential of MREPT as a technique to detect seizure-induced functional changes in rat brains. The results revealed significantly decreased high-frequency conductivity in the hippocampus of NMDA-treated rats, accompanied by changes in cell structure and neuronal loss.
Article
Medicine, General & Internal
Won Sub Kang, Sang Min Lee, Dongkee Hwang, Hae Jeong Park, Jong Woo Kim
Summary: Accumulating evidence suggests that the autophagy process is involved in the pathogenesis of schizophrenia. This study found that specific ULK2 polymorphisms are associated with susceptibility to schizophrenia in the Korean population.
Article
Medicine, Research & Experimental
Chi Hoon Maeng, Bo-Hyung Kim, Jinmann Chon, Won Sub Kang, Kyounglan Kang, Mihye Woo, Il Ki Hong, Junhee Lee, Kil Yeon Lee
Summary: This study aims to evaluate the effect of a multimodal intervention on preventing or alleviating cancer cachexia in patients undergoing palliative chemotherapy. The results are expected to provide new insights and significantly improve the quality of life for cancer patients.
Letter
Psychiatry
Hae Jeong Park, Won Sub Kang, Miae Oh, Jong Woo Kim
PSYCHIATRY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Young Joo Park, Sang Min Lee, Won Sub Kang
Summary: Schizophrenia patients using clozapine may have an increased risk of pulmonary infection, but they are less likely to report physical symptoms. In this case report, a schizophrenia patient using clozapine did not complain of respiratory symptoms initially, but was later diagnosed with streptococcus intermedius empyema. Thanks to timely admission and proper treatment, the patient fully recovered.
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
(2022)