Article
Endocrinology & Metabolism
Johan Vande Voorde, Rory T. Steven, Arafath K. Najumudeen, Catriona A. Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J. Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn Gilroy, Lucas B. Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A. Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R. M. Lannagan, Nikola Vlahov, Rachel A. Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M. Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian S. W. Li, Oliver D. K. Maddocks, Simon T. Barry, Richard J. A. Goodwin, James Kinross, Joanne Edwards, Mariia O. Yuneva, David Sumpton, Zoltan Takats, Andrew D. Campbell, Josephine Bunch, Owen J. Sansom
Summary: In this study, the potential of untargeted metabolomics as a stratification tool for colorectal cancer (CRC) was investigated. The researchers presented a comprehensive pipeline to uncover metabolic vulnerabilities in CRC based on its genetic origin. Perturbations in methionine metabolism linked to APC deficiency were observed, and adenosylhomocysteinase was identified as an actionable therapeutic target.
Article
Endocrinology & Metabolism
Lin-Lin Cao, Yi Han, Yuanxiao Wang, Lin Pei, Zhihong Yue, Li Qin, Boyu Liu, Jingwen Cui, Mei Jia, Hui Wang
Summary: Metabolic syndrome (MetS) is an independent risk factor for hepatocellular cancer (HCC). Currently, there is a lack of highly sensitive and specific biomarkers for HCC surveillance in MetS population. In this study, metabolomic analysis identified L-glu, PA, and 7-mG as novel biomarkers for MetS(+) HCC. A biomarker panel consisting of L-glu, PA, and AFP showed high diagnostic performance for discriminating MetS(+) HCC from other cancers associated with MetS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Gastroenterology & Hepatology
Tomasz Wilmanski, Noa Rappaport, Christian Diener, Sean M. Gibbons, Nathan D. Price
Summary: This review discusses current approaches for defining and monitoring gut microbiome health, emphasizes the importance of identifying gut microbial ecological features resonant with host molecular phenotypes, and highlights certain gut microbial metabolites as potential biomarkers of gut microbiome health. It further explores how omics measurements and gut microbiome profiles can be integrated into sophisticated host-microbiome mechanistic models for personalized interventions.
Article
Chemistry, Analytical
Krzysztof Ossolinski, Tomasz Ruman, Valerie Copie, Brian P. Tripet, Artur Kolodziej, Aneta Plaza-Altamer, Anna Ossolinska, Tadeusz Ossolinski, Anna Nieczaj, Joanna Niziol
Summary: This study investigated polar metabolite profiles in urine samples from BC patients and normal controls using NMR and LDI-MS and identified potential markers for bladder cancer. The metabolites were able to distinguish urine samples from BC and NCs individuals, and correlate with tumor stages and grades. The findings suggest that these metabolite markers may be useful for non-invasive detection and monitoring of bladder cancer.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemical Research Methods
Ana Rita Lima, Marcia Carvalho, Susana S. Aveiro, Tania Melo, M. Rosario Domingues, Catarina Macedo-Silva, Nuno Coimbra, Carmen Jeronimo, Rui Henrique, Maria de Lourdes Bastos, Paula Guedes de Pinho, Joana Pinto
Summary: Prostate cancer is a global health problem. Metabolomics and lipidomics have the potential to identify new mechanisms underlying PCa development and progress, providing a basis for new and more effective therapies and diagnostics. This study found dysregulations in multiple metabolic pathways associated with PCa development, which may reflect reprogramming of metabolic responses to facilitate rapid proliferation of PCa cells.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Oncology
Lin Yu, Qinhuai Lai, Qian Feng, Yuanmeng Li, Jiafu Feng, Bei Xu
Summary: This study revealed that lipid metabolism may play a crucial role in the progression from chronic gastritis to gastric cancer. Hexadecasphinganine, linoleamide, and N-Hydroxy arachidonoyl amine were identified as candidate diagnostic markers for chronic gastritis and gastric cancer. Additionally, changes in serum lipid levels, including total cholesterol, high-density lipoprotein cholesterol, and apolipoprotein A1, were observed with disease progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Veterinary Sciences
Austin J. J. Bow, Rebecca E. E. Rifkin, Caitlin Priester, Courtney J. J. Christopher, Remigiusz M. M. Grzeskowiak, Silke Hecht, Steve H. H. Adair, Pierre-Yves Mulon, Hector F. F. Castro, Shawn R. R. Campagna, David E. E. Anderson
Summary: Bone tissue engineering is a growing field in regenerative medicine, but comparing treatments objectively is challenging. Metabolomics provides a powerful tool for establishing metabolic signatures. This study used a large bone defect in goats to assess repair capacity, and found distinct temporal patterns in small molecule profiles associated with the bone tissue repair process.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Immunology
Su Han, Xiaoli Zhang, Jian Ding, Xiang Li, Xueli Zhang, Xu Jiang, Shanshan Duan, Beibei Sun, Xinyi Hu, Yannan Gao
Summary: This study used UHPLC-QTOF-MS to analyze the serum metabolites of rats infected with Clonorchis sinensis. It was found that levels of phosphatidylcholines, glycerophosphocholine, and choline in the serum significantly changed, indicating shifts in lipid metabolism. Significant changes were also observed in amino acids and phosphatidylcholines. In conclusion, C. sinensis infection causes significant alterations in rat serum metabolism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Oumaima Zidi, Nessrine Souai, Henda Raies, Farhat Ben Ayed, Amel Mezlini, Sonia Mezrioui, Fabrice Tranchida, Jean-Marc Sabatier, Amor Mosbah, Ameur Cherif, Laetitia Shintu, Soumaya Kouidhi
Summary: Breast cancer is the most common form of cancer among women worldwide, and alterations in gut microbiome-derived metabolites may promote its development. Analysis of fecal metabolites from treated patients revealed significant changes in metabolic profiles influenced by chemotherapy.
Article
Cell Biology
Guo-Bang Li, Hong-Rong Hu, Wen-Feng Pan, Bo Li, Zhi-Ying Ou, Hui-Ying Liang, Cong Li
Summary: The study used metabolomic profiling to identify specific metabolic alterations in pediatric sepsis patients, constructed diagnostic models, and revealed metabolites that can distinguish between case and control subjects. Furthermore, significantly altered metabolites were found in sepsis survivors compared to non-survivors, and fatty acid metabolism may play a crucial role in the pathogenesis of sepsis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Dimitra Diamantidou, Olga Deda, Ioannis Zervos, Ioannis Taitzoglou, Helen Gika, Georgios Theodoridis, Filippos Michopoulos
Summary: Regular physical exercise has significant effects on liver metabolism, accelerating bioenergetic processes and purine catabolism, while providing biosynthetic precursors. The applied methodology can distinguish different training schedules based on the rat liver metabolome.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Environmental Sciences
Fangda Peng, Jing Dai, Qingjun Qian, Xiangfu Cao, Lifang Wang, Min Zhu, Shujin Han, Wubin Liu, Yan Li, Teng Xue, Xianyang Chen, Xiaoli Yang, Jiaolei Wang, Huanqiang Wang, Tao Li, Chunguang Ding
Summary: This study found that coal dust exposure leads to changes in serum metabolites across multiple metabolic pathways. A diagnostic model composed of three differential metabolites showed strong discriminatory ability between coal worker's pneumoconiosis patients and exposed individuals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Qin-Qin Li, Qian-Qian Xiang, Li-Hong Lian, Zhi-Ying Chen, Xia Luo, Cheng-Zhi Ding, Li-Qiang Chen
Summary: The study found that exposure to silver nanoparticles can significantly alter 96 metabolites in fish gills, primarily affecting amino acid metabolism and energy metabolism. Silver nanoparticles specifically induce changes in 72 metabolites, enriching pathways such as aminoacyl-tRNA biosynthesis, ABC transporters, and the citrate cycle. On the other hand, exposure to silver supernatant ions causes specific changes in 14 metabolites, mainly interfering with sphingolipid metabolism in fish gills.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Juntao Zhuang, Xiao Yang, Qi Zheng, Kai Li, Lingkai Cai, Hao Yu, Jiancheng Lv, Kexin Bai, Qiang Cao, Pengchao Li, Haiwei Yang, Junsong Wang, Qiang Lu
Summary: This study explored differential metabolites in serum of bladder cancer patients treated with neoadjuvant chemotherapy (NAC). The results showed significant differences in levels of glutamine, taurine, glutamate, and hypoxanthine between NAC-sensitive and NAC-resistant groups. Amino acid metabolism may be related to the response to chemotherapy.
Review
Biochemistry & Molecular Biology
Raja Ganesan, Sang Jun Yoon, Ki Tae Suk
Summary: Primary liver cancer is a heterogeneous disease characterized by the reprogramming of cellular metabolism to promote cancer cell proliferation and adapt to the tumor microenvironment. Metabolomics and metabolite profiling have emerged as important tools for cancer diagnosis, monitoring, and therapy in liver cirrhosis, liver cancer, and hepatocellular carcinoma (HCC). This review highlights the interaction between liver diseases and metabolic processes at the cellular and systemic levels, with a focus on current metabolomics technologies and their applications in clinical and translational research. The identification of liver cancer biomarkers and the development of novel therapeutic strategies are important drivers of metabolomics science.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan, Pragya Bradu, Aarthi Sukumar, Megha Patil, Kaviyarasi Renu, Abhijit Dey, Balachandar Vellingiri, Alex George, Raja Ganesan
Summary: This review provides a detailed study on pancreatic cancer and its association with different types of cancer related to diabetes. It discusses the combination of anti-diabetic drugs with other anti-cancer drugs and phytochemicals for the prevention and treatment of the disease. The migration and development of pancreatic cancer stem cells (CSCs) are also discussed. Additionally, it explores the mechanisms of diabetes development that enhance the proliferation of pancreatic CSCs, such as increased IGF factor levels, epigenetic modifications, DNA damage, and lifestyle factors like obesity and inflammation.
Article
Biotechnology & Applied Microbiology
Ki-Kwang Oh, Ickwon Choi, Haripriya Gupta, Ganesan Raja, Satya Priya Sharma, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Byeong-Hyun Min, Ji-Ye Hyun, Jung-A Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Dong Joon Kim, Ki-Tae Suk
Summary: We aimed to identify favorable metabolites and pharmacological mechanisms of gut microbiota (GM) for liver regeneration (LR) through network pharmacology. We utilized the gutMGene database to obtain GM metabolites and identified targets associated with the metabolites and LR using public databases. Molecular docking assays were performed to verify the network pharmacological concept. A total of 208 metabolites and 668 targets were identified. AKT1 was found to be a hub target correlated with 12 additional targets. The study provides scientific evidence for the potential microbe (E. coli), chemokine signaling pathway, AKT1, and myricetin in accelerating LR, supporting further clinical trials.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Review
Green & Sustainable Science & Technology
Anirban Goutam Mukherjee, Kaviyarasi Renu, Abilash Valsala Gopalakrishnan, Vishnu Priya Veeraraghavan, Sathishkumar Vinayagam, Soraya Paz-Montelongo, Abhijit Dey, Balachandar Vellingiri, Alex George, Harishkumar Madhyastha, Raja Ganesan
Summary: Heavy metal and metalloid poisoning in the environment and food, such as cadmium, lead, mercury, tin, manganese, aluminium, arsenic, antimony, and selenium, poses a severe threat to human health and ecological system. Accurate detection of even trace quantities of these toxic elements is of utmost importance to understand their risk. Several traditional and advanced technologies, including atomic absorption spectrometry (AAS), spectrofluorimetry, inductively coupled plasma spectrometry, e-tongues, electrochemical aptasensors, Raman spectroscopy, and fluorescence sensors, have proven highly beneficial in quantifying these elements in food and dietary supplements.
Review
Biochemistry & Molecular Biology
Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Sandra Kannampuzha, Reshma Murali, Arunraj Namachivayam, Raja Ganesan, Abhijit Dey, Achsha Babu, Kaviyarasi Renu, Balachandar Vellingiri, Gnanasambandan Ramanathan, C. George Priya Doss, Nehal Elsherbiny, Amira M. Elsherbini, Alsamman M. Alsamman, Hatem Zayed, Abilash Valsala Gopalakrishnan
Summary: Polycystic ovarian syndrome (PCOS) is a complex endocrine and metabolic condition that affects women's reproductive health. The causes of PCOS are still unknown, but alterations in gut microbiota composition and disruptions in secondary bile acid production appear to be involved. PCOS is closely related to both enteric and vaginal bacteria, and patients with PCOS have changed microbiome compositions and decreased microbial diversity. The gut microbiota can interact with the environment to improve metabolic and immunological function, but dysbiosis in the gut microbiome may contribute to inflammation and insulin resistance in PCOS.
Review
Biochemistry & Molecular Biology
Uddesh Ramesh Wanjari, Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, Reshma Murali, Abhijit Dey, Balachandar Vellingiri, Raja Ganesan
Summary: Prostate cancer (PCa) is the leading cause of mortality in men, with unclear pathophysiological factors. PCa cells adopt abnormal lipid signaling and metabolism to gain protection. They modify metabolism in response to excessive nutrient intake, facilitating disease progression. Metabolic syndrome (MetS) is closely linked to carcinogenesis in PCa, exacerbating disease severity. Changes in mitochondrial metabolism are hypothesized to contribute to PCa onset. Examining the metabolome of prostate tissue can help study specific alterations in PCa progression. Additional epidemiological research is needed to determine the relationship between MetS and PCa due to inconsistent initial findings. Multiple risk factors, including MetS, are correlated with PCa progression. This review focuses on analyzing and evaluating metabolic changes in PCa, assessing the impact of metabolic abnormalities on disease aggressiveness and metabolism.
Article
Multidisciplinary Sciences
Narayanaswamy Radhakrishnan, Sengodan Karthi, Pandiyan Raghuraman, Raja Ganesan, Kumaraswamy Srinivasan, Edward-Sam Edwin, Selvaraj Ganesh-Kumar, Norhaizan Mohd Esa, Sengottayan Senthil-Nathan, Prabhakaran Vasantha-Srinivasan, Patcharin Krutmuangh, Mona S. Alwahibi, Mohamed Soliman Elshikh
Summary: The study investigated the chemical characteristics and mosquitocidal activity of essential oil derived from Mikania scandens against Anopheles gambiae. Bio-active compounds were identified through GC-MS analysis, with alpha-bisabolol and stigmasterol being the most abundant. CVO-MS showed strong larvicidal activity against An. gambiae, with a median lethal concentration (LC50) of 488 +/- 2.45 ppm. Additionally, CVO-MS exhibited an inhibitory effect on certain enzymes and caused damage to the gut tissues of the mosquitoes.
Article
Gastroenterology & Hepatology
Raja Ganesan, Haripriya Gupta, Jin-Ju Jeong, Satya Priya Sharma, Sung-Min Won, Ki-Kwang Oh, Sang Jun Yoon, Sang Hak Han, Young Joo Yang, Gwang Ho Baik, Chang Seok Bang, Dong Joon Kim, Ki Tae Suk
Summary: This study aimed to identify novel metabolite mechanisms involved in the development of alcoholic liver disease (ALD) by analyzing stool samples from 247 patients. The results showed that microbial metabolic dysbiosis is associated with ALD-related metabolic dysfunction.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Microbiology
Sung Min Won, Na Young Lee, Ki-Kwang Oh, Haripriya Gupta, Satya Priya Sharma, Kyung Hwan Kim, Byoung Kook Kim, Hyun Chae Joung, Jin Ju Jeong, Raja Ganesan, Sang Hak Han, Sang Jun Yoon, Dong Joon Kim, Ki Tae Suk
Summary: The gut microbiome is closely related to the progression and exacerbation of liver fibrosis. Probiotics such as Lactobacillus lactis and L. rhamnosus have been evaluated for their preventive and therapeutic effects on liver fibrosis using mouse models. The results showed that the effects of Lactobacillus in preventing and treating liver fibrosis varied among different species of microbes.
JOURNAL OF MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Ki-Kwang Oh, Sang-Jun Yoon, Su-Been Lee, Sang Youn Lee, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sung-Min Won, Jin-Ju Jeong, Dong Joon Kim, Ki-Tae Suk
Summary: Non-alcoholic fatty liver disease (NAFLD) is a serious global public health issue. The treatment of NAFLD is still uncertain, but the combination of dietary regulation and beneficial gut microbiota (GM) has been considered as a potential alternative therapy. This study used network pharmacology to analyze the secondary metabolites from GM and Avena sativa (AS) and identified their combined efficacy against NAFLD.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Raja Ganesan, Haripriya Gupta, Jin-Ju Jeong, Satya Priya Sharma, Sung-Min Won, Ki-Kwang Oh, Sang Jun Yoon, Dong Joon Kim, Ki Tae Suk
Summary: This study used metabolomics profiling to identify microbial metabolites that could indicate gut-liver metabolic severity in NAFLD patients. The results showed that NAFLD patients had lower levels of short-chain fatty acids (SCFA) and increased levels of stool cholic acid. The expression of certain metabolites and metabolic pathways was linked to NAFLD.
Review
Biochemistry & Molecular Biology
Sridhar Shanmuga Priya, Prabhakaran Vasantha-Srinivasan, Ammar B. Altemimi, Ramji Keerthana, Narayanaswamy Radhakrishnan, Sengottayan Senthil-Nathan, Kandasamy Kalaivani, Nainarpandian Chandrasekar, Sengodan Karthi, Raja Ganesan, Zina T. Alkanan, Tarun Pal, Om Prakash Verma, Jaroslaw Prockow
Summary: Mosquitoes are potential carriers of various viral diseases and their numbers have significantly increased due to human activities. Control measures such as destroying mosquito breeding grounds, reducing global warming, and using natural and chemical repellents have proven to be effective.
Article
Biotechnology & Applied Microbiology
Ki-Kwang Oh, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Byeong-Hyun Min, Ji-Ye Hyun, Jung-A Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Dong Joon Kim, Ki-Tae Suk
Summary: Through network pharmacology, we discovered that metabolites of gut microbiota and dietary plant-derived natural flavonoids are effective regulators against non-alcoholic fatty liver disease. Protein interaction, bubble chart, and networks of metabolites-targets-key signalling pathway were described using R Package. Molecular docking test verified the affinity between metabolites and targets on a key signalling pathway. Key microbiota, natural resources, metabolites, and targets were identified as promising components to treat NAFLD by suppressing the cAMP signalling pathway. This integrated pharmacological approach sheds light on the relationships between gut microbiota and dietary plant-derived natural flavonoids.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Microbiology
Jin-Ju Jeong, Raja Ganesan, Yoo-Jeong Jin, Hee Jin Park, Byeong Hyun Min, Min Kyo Jeong, Sang Jun Yoon, Mi Ran Choi, Jieun Choi, Ji Hyun Moon, Uigi Min, Jong-Hyun Lim, Do Yup Lee, Sang Hak Han, Young Lim Ham, Byung-Yong Kim, Ki Tae Suk
Summary: This study evaluated the effect of intragastric administration of probiotics on loperamide-induced constipation in rats. The multi-strain probiotics significantly increased the number of fecal pellets and improved gastrointestinal transit rate. The mRNA expression levels of serotonin- and mucin-related genes in the treated colons were significantly increased. Short-chain fatty acids, serotonin, and mucin levels were altered through improvement in intestinal microflora.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chandramohan Govindasamy, Khalid S. Al-Numair, Vasantha-Srinivasan Prabhakaran, Raja Ganesan
Summary: In this study, the effects of DOX, AgNPs, and DOX-AgNPs on metabolome activity in BC cells were investigated. The results showed that these treatments altered energy, amino acid, neurological, and oxidative stress metabolism in BC cells. Several metabolites, including AMP, ADP, ATP, GSH, glutamine, glutamate, trimethylamine, and xanthine, were significantly affected. The findings suggest that these treatments impact important metabolic pathways in BC cells, such as pyrimidine metabolism, sucrose metabolism, and glutathione metabolism.
PROCESS BIOCHEMISTRY
(2023)