Article
Oncology
Pedro Velica, Pedro P. Cunha, Nikola Vojnovic, Iosifina Petrina Foskolou, David Bargiela, Milos Gojkovic, Helene Rundqvist, Randall S. Johnson
Summary: By ectopically expressing the HIF transcription factor in CD8(+) T cells, this study demonstrated an enhanced antitumor efficacy against tumor targets. A specific mutation in HIF2 alpha showed the most effective antitumor T cell response, suggesting a potential strategy to increase therapeutic efficacy of CD8(+) T cells.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Faezzah Baharom, Ramiro A. Ramirez-Valdez, Kennedy K. S. Tobin, Hidehiro Yamane, Charles-Antoine Dutertre, Ahad Khalilnezhad, Glennys Reynoso, Vincent L. Coble, Geoffrey M. Lynn, Matthew P. Mule, Andrew J. Martins, John P. Finnigan, Xiao Meng Zhang, Jessica A. Hamerman, Nina Bhardwaj, John S. Tsang, Heather D. Hickman, Florent Ginhoux, Andrew S. Ishizuka, Robert A. Seder
Summary: The study demonstrates that using a self-assembling nanoparticle vaccine and adjuvant can expand stem-like CD8(+) T cells, optimize anti-tumor immunity, and enhance the strength and effectiveness of the anti-tumor response.
Article
Immunology
Nina Dumauthioz, Benjamin Tschumi, Mathias Wenes, Bastien Marti, Haiping Wang, Fabien Franco, Wenhui Li, Isabel C. Lopez-Mejia, Lluis Fajas, Ping-Chih Ho, Alena Donda, Pedro Romero, Lianjun Zhang
Summary: The overexpression of PGC-1 alpha favors central memory formation of CD8 T cells and enhances antitumor immunity. CD8 T cells with enhanced PGC-1 alpha expression show stronger antitumor immunity in a melanoma model.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Linda Borst, Marjolein Sluijter, Gregor Sturm, Pornpimol Charoentong, Saskia J. Santegoets, Mandy Gulijk, Marit J. van Elsas, Christianne Groeneveldt, Nadine van Montfoort, Francesca Finotello, Zlatko Trajanoski, Szymon M. Kielbasa, Sjoerd H. van der Burg, Thorbald van Hall
Summary: The study found that NKG2A is a late inhibitory receptor, expressed after repeated antigen stimulations, and its expression kinetics is similar to TIM-3 and CD39. NKG2A expression is associated with cell division and promoted by TGF-beta, potentially marking actively dividing tumor-specific TILs.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
BeumJin Park, Seok-Jae Heo, Yong Joon Lee, Mi-Kyoung Seo, Jiyun Hong, Eui-Cheol Shin, Inkyung Jung, Sangwoo Kim
Summary: CD8(+) T cells can recognize and kill early tumor cells, with the efficiency influenced by the coverage of HLA-I tumor antigens. Tumors with HLA-I homozygosity show earlier onset. The association may depend on the tumor type and driver mutation specificity. Testing on an independent dataset confirmed the acceleration of tumor onset in a specific type of tumor with HLA-I heterozygosity.
Review
Immunology
Joseph S. Dolina, Natalija Van Braeckel-Budimir, Graham D. Thomas, Shahram Salek-Ardakani
Summary: Recent research has revealed the heterogeneity within the exhausted CD8(+) T cell lineage, which consists of multiple interconnected subpopulations with distinct characteristics and locations. This understanding calls for a re-focusing of cancer immunotherapies on targeting the driver mechanisms underlying CD8(+) T(ex) development to stabilize functional subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Wei Su, Jordy Saravia, Isabel Risch, Sherri Rankin, Cliff Guy, Nicole M. Chapman, Hao Shi, Yu Sun, K. C. Anil, Wei Li, Hongling Huang, Seon Ah Lim, Haoran Hu, Yan Wang, Danting Liu, Yun Jiao, Ping-Chung Chen, Hadeer Soliman, Koon-Kiu Yan, Jonathan Zhang, Peter Vogel, Xueyan Liu, Geidy E. Serrano, Thomas G. Beach, Jiyang Yu, Junmin Peng, Hongbo Chi
Summary: In this study, brain-resident CD8(+) T cells coexpressing CXCR6 and PD-1 were identified in AD brains and found to restrict AD pathologies. CXCR6 orchestrates the accumulation and tissue residency of brain CD8(+) T cells by regulating their interaction with microglia.
Article
Immunology
Rui Dai, Xiaopei Huang, Yiping Yang
Summary: This study demonstrates the critical role of gamma delta T cells in promoting the CD8(+) T cell response to VV infection. Gamma delta T cells are able to present viral antigens and activate CD8(+) T cells, with MyD88 signaling playing a key role in this process. Understanding the regulation of adaptive T cell response by gamma delta T cells may provide insight for the development of more effective vaccine strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Marzia Rossi, Andrea Vecchi, Camilla Tiezzi, Valeria Barili, Paola Fisicaro, Amalia Penna, Ilaria Montali, Stephane Daffis, Simon P. Fletcher, Anuj Gaggar, Jonathan Medley, Michael Graupe, Latesh Lad, Alessandro Loglio, Roberta Soffredini, Marta Borghi, Teresa Pollicino, Cristina Musolino, Arianna Alfieri, Federica Brillo, Diletta Laccabue, Marco Massari, Chiara Boarini, Gianluca Abbati, Giuseppe Pedrazzi, Gabriele Missale, Pietro Lampertico, Carlo Ferrari, Carolina Boni
Summary: This study characterized the functional impairment of exhausted HBV-specific CD8 T cells in patients with chronic HBV infection. It identified subsets of patients with different capacities to control infection and respond to immune modulation. It also found that functionally more efficient HBV-specific CD8 T cell subsets with lower expression of coinhibitory molecules were present in some chronic viraemic patients. The ability to distinguish patient cohorts with different responses to immune modulation through phenotypic CD8 T cell exhaustion profiling is clinically significant.
Review
Cell Biology
Lovis Kling, Adrian Schreiber, Kai-Uwe Eckardt, Ralph Kettritz
Summary: Hypoxia affects myeloid cells, while HIFs play a crucial role in modulating myeloid cell functions to adapt to low oxygen environments. HIF-1α and HIF-2α are key players in the innate immune response, though with different impact mechanisms.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biology
Risa Ebina-Shibuya, Erin E. West, Rosanne Spolski, Peng Li, Jangsuk Oh, Majid Kazemian, Daniel Gromer, Phillip Swanson, Ning Du, Dorian B. McGavern, Warren J. Leonard
Summary: TSLP plays a crucial role in the development of diseases such as asthma, atopic dermatitis, and allergic inflammation, but its role in CD8(+) T-cell primary responses and memory CD8(+) T cell responses to secondary viral infection is still controversial. Research has shown that TSLP limits the primary CD8(+) T-cell response to influenza, but has little effect on T cell function and the number of memory CD8(+) T cells generated after influenza infection, while inhibiting memory CD8(+) T-cell responses to secondary viral infections.
Article
Multidisciplinary Sciences
Ditte E. Jaehger, Mie L. Hubbe, Martin K. Kraemer, Gael Clergeaud, Andre V. Olsen, Camilla Stavnsbjerg, Mette N. Wiinholt, Andreas Kjaer, Jonas R. Henriksen, Anders E. Hansen, Thomas L. Andresen
Summary: Adoptive T-cell transfer (ACT) is a curative therapeutic option for melanoma and hematological cancer patients, and improving the post-infusion performance of transferred T cells can enhance treatment efficacy. In vivo priming and expansion of previously non-activated T cells can boost the cytotoxicity of activated T cells. Flexible delivery vehicles of tumor-associated antigens (TAAs) and a TLR7/8 agonist can effectively enhance T-cell expansion and anti-tumor reactivity.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Bingjie Zhang, Rabi Upadhyay, Yuhan Hao, Marie I. Samanovic, Ramin S. Herati, John D. Blair, Jordan Axelrad, Mark J. Mulligan, Dan R. Littman, Rahul Satija
Summary: This study analyzed the T cell response after BNT162b2 vaccination using multimodal sequencing technologies. The researchers identified CD8(+) T cell subpopulations and explored their transcriptome, chromatin landscape, and immunophenotype. They also found that the frequency and differentiation outcomes of these CD8(+) T cell subpopulations were predictive of clinical outcomes in COVID-19 patients.
Article
Immunology
Yatong Chen, Jing Xu, Xiaodong Wu, Hui Yao, Zhou Yan, Ting Guo, Wenjing Wang, Peixiao Wang, Yu Li, Xiangmin Yang, Hao Li, Huijie Bian, Zhi-Nan Chen
Summary: Deletion of CD147 in T cells limits tumor growth in mouse melanoma and lung cancer. CD147 is upregulated in CD8(+) TILs and coexpressed with immune-checkpoint molecules, leading to increased antitumor responses and potential as a target for cancer immunotherapy.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Fortunato, Giada Amodio, Silvia Gregori
Summary: Tolerogenic dendritic cells (tolDC) play a central role in immune homeostasis and peripheral tolerance. We developed a protocol to generate genetically engineered tolDC overexpressing IL-10 (DCIL-10) and found that they can modulate cytotoxic CD8(+) T cell responses by reducing proliferation and activation, and inducing anergic CD8(+) T cells without signs of exhaustion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)