The CYP2W1 enzyme: regulation, properties and activation of prodrugs

Membrane topology and search for potential redox partners of colon cancer-specific cytochrome P450 2W1

(2016) Jia Guo et al.   FEBS LETTERS

KRT13, FAIM2 and CYP2W1 mRNA Expression in Oral Squamous Cell Carcinoma Patients with Risk Habits

(2015) Firstine Kelsi Hartanto et al.   Asian Pacific Journal of Cancer Prevention

Cytochrome P450 2W1 (CYP2W1) in Colorectal Cancers

(2015) Felicia Fei-Lei Chung et al.   CURRENT CANCER DRUG TARGETS

Novel single nucleotide polymorphisms (SNPs) of CYP2W1 gene in Chinese Uygur and Han populations

(2015) Guang-Zhao Qi et al.   Drug Metabolism and Pharmacokinetics

Genetic variation in the human cytochrome P450 supergene family

(2015) Kohei Fujikura et al.   Pharmacogenetics and Genomics

Developmental Regulation and Induction of Cytochrome P450 2W1, an Enzyme Expressed in Colon Tumors

(2015) Eva Choong et al.   PLoS One

The expression of CYP2W1 in colorectal primary tumors, corresponding lymph node metastases and liver metastases

(2014) Kristina Stenstedt et al.   ACTA ONCOLOGICA

Differential Expression of Cytochrome P450 Enzymes in Normal and Tumor Tissues from Childhood Rhabdomyosarcoma

(2014) Dora Molina-Ortiz et al.   PLoS One

CYP2W1 Is Highly Expressed in Adrenal Glands and Is Positively Associated with the Response to Mitotane in Adrenocortical Carcinoma

(2014) Cristina L. Ronchi et al.   PLoS One

Prognostic value of CYP2W1 expression in patients with human hepatocellular carcinoma

(2014) Ke Zhang et al.   TUMOR BIOLOGY

Colon Cancer-Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins

(2013) S. Travica et al.   CLINICAL CANCER RESEARCH

Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity

(2013) Helen M. Sheldrake et al.   JOURNAL OF MEDICINAL CHEMISTRY

CYP2W1 polymorphism: functional aspects and relation to risk for colorectal cancer

(2013) Kristina Stenstedt et al.   PHARMACOGENOMICS

RNA Expression of Cytochrome P450 in Mexican Women with Breast Cancer

(2012) Cindy Bandala et al.   Asian Pacific Journal of Cancer Prevention

Bioactivation of Fluorinated 2-Aryl-benzothiazole Antitumor Molecules by Human Cytochrome P450s 1A1 and 2W1 and Deactivation by Cytochrome P450 2S1

(2012) Kai Wang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids

(2012) Yi Xiao et al.   JOURNAL OF LIPID RESEARCH

Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder

(2012) M. Sutherland et al.   MOLECULAR CANCER THERAPEUTICS

CYP2S1 and CYP2W1 Mediate 2-(3,4-Dimethoxyphenyl)-5-Fluorobenzothiazole (GW-610, NSC 721648) Sensitivity in Breast and Colorectal Cancer Cells

(2011) B. S. Tan et al.   MOLECULAR CANCER THERAPEUTICS

Efficient Hypoxic Activation of the Anticancer Agent AQ4N by CYP2S1 and CYP2W1

(2010) C. R. Nishida et al.   MOLECULAR PHARMACOLOGY

Colorectal Cancer-Specific Cytochrome P450 2W1: Intracellular Localization, Glycosylation, and Catalytic Activity

(2010) A. Gomez et al.   MOLECULAR PHARMACOLOGY

CYP2W1variant alleles in Caucasians and association of theCYP2W1G541A (Ala181Thr) polymorphism with increased colorectal cancer risk

(2010) Guillermo Gervasini et al.   PHARMACOGENOMICS

The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer – A pilot study

(2008) David Edler et al.   EUROPEAN JOURNAL OF CANCER