Article
Pharmacology & Pharmacy
Rhonda M. Cooper-DeHoff, Mikko Niemi, Laura B. Ramsey, Jasmine A. Luzum, E. Katriina Tarkiainen, Robert J. Straka, Li Gong, Sony Tuteja, Russell A. Wilke, Mia Wadelius, Eric A. Larson, Dan M. Roden, Teri E. Klein, Sook Wah Yee, Ronald M. Krauss, Richard M. Turner, Latha Palaniappan, Andrea Gaedigk, Kathleen M. Giacomini, Kelly E. Caudle, Deepak Voora
Summary: Statins are commonly prescribed medications that reduce cholesterol and prevent cardiovascular disease. However, statin-associated musculoskeletal symptoms can affect patient adherence and long-term effectiveness. Genetic variations in SLCO1B1, ABCG2, and CYP2C9 genes have been identified to impact the metabolism and adverse events of statins. This study summarizes the literature supporting these associations and provides therapeutic recommendations based on genotypes to improve the safety, adherence, and effectiveness of statin therapy.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Clinical Neurology
Osorio Lopes Abath Neto, Livija Medne, Sandra Donkervoort, Maria Elena Rodriguez-Garcia, Veronique Bolduc, Ying Hu, Eleonora Guadagnin, A. Reghan Foley, John F. Brandsema, Allan M. Glanzman, Gihan Tennekoon, Mariarita Santi, Justin H. Berger, Lynn A. Megeney, Hirofumi Komaki, Michio Inoue, Francisco Javier Cotrina-Vinagre, Aurelio Hernandez-Lain, Elena Martin-Hernandez, Linford Williams, Sabine Borell, David Schorling, Kimberly Lin, Konstantinos Kolokotronis, Uta Lichter-Konecki, Janbernd Kirschner, Ichizo Nishino, Brenda Banwell, Francisco Martinez-Azorin, Patrick G. Burgon, Carsten G. Bonnemann
Summary: This study identified seven individuals from six families with biallelic variants in the MLIP gene, shedding light on the genetic landscape of rhabdomyolysis. The findings solidify MLIP's role in maintaining normal and diseased skeletal muscle homeostasis.
Article
Pharmacology & Pharmacy
Blanca Gavilan-Carrera, Alberto Soriano-Maldonado, Juan Diego Mediavilla-Garcia, Carl J. Lavie, Jose Antonio Vargas-Hitos
Summary: Statin-associated muscle symptoms (SAMS) are common in patients using statin drugs, but not all symptoms are caused by the drugs, negative expectations could also play a role. Physical activity is important for managing cardiovascular disease risk, but the evidence of increased creatine-kinase levels in statin-treated athletes has been wrongly generalized. The potential of reducing sedentary behavior and resistance training has been overlooked in current guidelines.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Chunyan Wei, Wanhong Yin, Zhiyao He, Bin Wu
Summary: This study evaluated the muscular toxicity of the combination therapy of daptomycin and statins using a large pharmacovigilance database. The results showed that the combination of daptomycin with rosuvastatin, atorvastatin, and simvastatin increased the reporting frequency of myopathy. Additionally, the combination of daptomycin with these statins also increased the frequency of rhabdomyolysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alisha Sharma, Clio Musurakis, Nur Un Nisa Nabil, Bidhya Poudel, Angkawipa Trongtorsak
Summary: The use of statins for cardiovascular disease prevention has been increasing over the past decade, but it has also been associated with various side effects, including muscle-related complications. Among these, statin-induced necrotizing autoimmune myopathy (SINAM) stands out due to its unique characteristics and aggressive management. This article presents two cases of SINAM and discusses the clinical aspects of diagnosis, investigation, and treatment. SINAM typically presents with proximal myopathy and elevated creatinine kinase levels that do not improve with discontinuation of statins. Diagnosis is confirmed through biopsy and detection of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies. Additional investigations are necessary to rule out other causes of proximal myopathy. In most cases, rechallenging with statins is unsuccessful and immunosuppressive treatment is required.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Brian Lu, Laura Sun, Manuel Seraydarian, Thomas J. Hoffmann, Marisa W. Medina, Neil Risch, Carlos Iribarren, Ronald M. Krauss, Akinyemi Oni-Orisan
Summary: The study identified an association between the c.521T>C variant allele in the SLCO1B1 gene and statin-induced myotoxicity. Homozygous carriers of the C allele had increased risk of myopathy with simvastatin and lovastatin. The association with atorvastatin users was less clear and further research is needed to confirm this relationship.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Rheumatology
Maheswari Muruganandam, Ahsan Iqbal, Eyerusalem B. Akpan, Anthony C. Dolomisiewicz, Yvonne M. Waters, N. Suzanne Emil, Sharon E. Nunez, Matthew K. McElwee, Frank X. O'Sullivan, Roderick A. Fields, Wilmer L. Sibbitt
Summary: This study compared the manifestations of immune-mediated necrotizing myopathy (IMNM) to idiopathic inflammatory myositis (IIM) in Native Americans. It found that IMNM patients were older and more likely to have diabetes, hyperlipidemia, and statin exposure. They also had significantly higher levels of creatine kinase and anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) antibodies, and a higher prevalence of necrotizing myopathy. However, they had shorter disease duration and fewer cutaneous or vascular manifestations compared to IIM patients.
Review
Biochemistry & Molecular Biology
Pierandrea Vinci, Emiliano Panizon, Letizia Maria Tosoni, Carla Cerrato, Federica Pellicori, Filippo Mearelli, Chiara Biasinutto, Nicola Fiotti, Filippo Giorgio Di Girolamo, Gianni Biolo
Summary: Hyperlipidemia is a major risk factor for cardiovascular morbidity and mortality, and statins are the first-choice therapy for dyslipidemias. However, patient compliance is poor and statin-associated muscle symptoms are the most common side effect leading to treatment discontinuation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Karolina Piekarska, Pawel Radwan, Agnieszka Tarnowska, Michal Radwan, Jacek R. Wilczynski, Andrzej Malinowski, Izabela Nowak
Summary: This study aimed to assess the association of combined KIR genes and their HLA-C ligands, as well as ERAP1 and ERAP2 polymorphisms, with recurrent implantation failure after in vitro fertilization (RIF). The study found that in the combination of female ERAP1 and an HLA-C partner, the rs30187 C>T and rs27044 C>G polymorphisms played an important role in implantation failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Qingjie Li, Lei Bao, Meirong Liu, Ruixue Zhang, Hongjuan Shi, Hao Chen
Summary: This study presents a case series of hypernatremic myopathy, focusing on its clinical characteristics and pathogenesis. The results showed that all patients had hypothalamic lesions as the cause of the hypernatremia, with various clinical manifestations including muscle weakness and myalgia. Rhabdomyolysis frequently occurred, leading to acute kidney injury. Testing of hormone levels and brain magnetic resonance imaging is recommended.
Review
Biochemistry & Molecular Biology
Giulia Maria Camerino, Nancy Tarantino, Ileana Canfora, Michela De Bellis, Olimpia Musumeci, Sabata Pierno
Summary: Statins are effective drugs for treating cardiovascular diseases, but can lead to skeletal muscle toxicity which needs risk assessment and study of new biomarkers. Identifying a marker of toxicity is important to prevent or to cure statin induced myopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Ji Hyoun Kim, Jun Hyoung Kim, Chang Gok Woo
Summary: Unexpected side effects, such as myopathy, can occur after COVID-19 vaccination. This case study presents a 30-year-old male patient who developed myopathy in both extremities after receiving the Pfizer-BioNTech COVID-19 vaccine. Symptoms included swelling, pain, dysphagia, and dysarthria, and biopsy showed macrophage infiltration and degeneration of muscle fibers. The symptoms improved with glucocorticoid and immunosuppressive treatment.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Wahid Boukouaci, Mohamed Lajnef, Jean-Romain Richard, Ching-Lien Wu, Jihene Bouassida, Ismail Rafik, Marianne Foiselle, Celine Straczek, Esma Mezouad, Soumia Naamoune, Sofiane Salah, Mohamed Amin Bencharif, Arij Ben Chaaben, Caroline Barau, Philippe Le Corvoisier, Marion Leboyer, Ryad Tamouza
Summary: Research suggests that levels of HLA-E expression are significantly elevated in patients with schizophrenia and bipolar disorders, potentially serving as diagnostic biomarkers for these conditions. Additionally, stable schizophrenia patients and bipolar disorder patients experiencing depressive episodes also exhibit higher levels of HLA-E expression.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Mengyuan Liu, Fangfang Fan, Yan Zhang, Jianping Li
Summary: Statin-induced myopathy (SIM) is a common reason for discontinuation of statin therapy. This meta-analysis found that GATM polymorphism, including rs9806699 G>A, rs1719247 C>T, and rs1346268 T>C, may be protective factors of SIM. The association of rs9806699 G>A with decreased risk of SIM was significant, especially in mild cases.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Valerie Leclair, Angeles S. Galindo-Feria, Simon Rothwell, Olga Krystufkova, Sepehr Sarrafzadeh Zargar, Herman Mann, Louise Pyndt Diederichsen, Helena Andersson, Martin Klein, Sarah Tansley, Lars Ronnblom, Kerstin Lindblad-Toh, Ann-Christine Syvanen, Marie Wahren-Herlenius, Johanna K. Sandling, Neil McHugh, Janine A. Lamb, Jiri Vencovsky, Hector Chinoy, Marie Holmqvist, Matteo Bianchi, Leonid Padyukov, Ingrid E. Lundberg, Lina-Marcela Diaz-Galloc
Summary: In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific HLA genetic variants and clinical manifestations. Distinct HLA class II and I associations were observed for almost all autoantibody-defined subgroups, supporting the use of autoantibody profiles for classifying IIM.
Article
Pharmacology & Pharmacy
Keiko Maekawa, Ryosuke Nakamura, Nahoko Kaniwa, Seiho Mizusawa, Aya Kitamoto, Takuya Kitamoto, Maho Ukaji, Yumiko Matsuzawa, Emiko Sugiyama, Yoshimi Uchida, Kouichi Kurose, Mayumi Ueta, Chie Sotozono, Hiroko Ikeda, Akiko Yagami, Setsuko Matsukura, Shigeru Kinoshita, Masaaki Muramatsu, Zenro Ikezawa, Akihiro Sekine, Hirokazu Furuya, Yukitoshi Takahashi, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito
Article
Food Science & Technology
Kigen Takahashi, Koichi Kurose, Emiko Okazaki, Kazufumi Osako
LWT-FOOD SCIENCE AND TECHNOLOGY
(2016)
Article
Fisheries
Kigen Takahashi, Kouichi Kurose, Emiko Okazaki, Kazufumi Osako
NIPPON SUISAN GAKKAISHI
(2017)
Article
Pharmacology & Pharmacy
Kimie Sai, Kouichi Kurose, Tomoko Koizumi, Noriko Katori, Jun-ichi Sawada, Yasuhiro Matsumura, Nagahiro Saijo, Noboru Yamamoto, Tomohide Tamura, Haruhiro Okuda, Yoshiro Saito
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2014)
Article
Pharmacology & Pharmacy
Yuki Kondo, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Yoshinori Kanehama, Yoshiyuki Maki, Shin Enosawa, Kouichi Kurose, Takahiro Iwao, Katsunori Nakamura, Tamihide Matsunaga
DRUG METABOLISM AND PHARMACOKINETICS
(2014)
Article
Genetics & Heredity
Minoru Tada, Akiko Ishii-Watabe, Keiko Maekawa, Hiromi Fukushima-Uesaka, Kouichi Kurose, Takuo Suzuki, Nahoko Kaniwa, Jun-ichi Sawada, Nana Kawasaki, Takako Eguchi Nakajima, Ken Kato, Yasuhide Yamada, Yasuhiro Shimada, Teruhiko Yoshida, Takashi Ura, Miyuki Saito, Kei Muro, Toshihiko Doi, Nozomu Fuse, Takayuki Yoshino, Atsushi Ohtsu, Nagahiro Saijo, Haruhiro Okuda, Tetsuya Hamaguchi, Yoshiro Saito, Yasuhiro Matsumura
Article
Pharmacology & Pharmacy
Nahoko Kaniwa, Emiko Sugiyama, Yoshiro Saito, Kouichi Kurose, Keiko Maekawa, Ryuichi Hasegawa, Hirokazu Furuya, Hiroko Ikeda, Yukitoshi Takahashi, Masaaki Muramatsu, Masahiro Tohkin, Takeshi Ozeki, Taisei Mushiroda, Michiaki Kubo, Naoyuki Kamatani, Masamichi Abe, Akiko Yagami, Mayumi Ueta, Chie Sotozono, Shigeru Kinoshita, Zenro Ikezawa, Kayoko Matsunaga, Michiko Aihara
Article
Genetics & Heredity
M. Tohkin, N. Kaniwa, Y. Saito, E. Sugiyama, K. Kurose, J. Nishikawa, R. Hasegawa, M. Aihara, K. Matsunaga, M. Abe, H. Furuya, Y. Takahashi, H. Ikeda, M. Muramatsu, M. Ueta, C. Sotozono, S. Kinoshita, Z. Ikezawa
PHARMACOGENOMICS JOURNAL
(2013)
Article
Multidisciplinary Sciences
Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga
Article
Psychiatry
Kouichi Kurose, Kazuyuki Hiratsuka, Kazuya Ishiwata, Jun Nishikawa, Shinpei Nonen, Junichi Azuma, Masaki Kato, Masataka Wakeno, Gaku Okugawa, Toshihiko Kinoshita, Toru Kurosawa, Ryuichi Hasegawa, Yoshiro Saito
PSYCHIATRY RESEARCH
(2012)
Article
Pharmacology & Pharmacy
Maho Ukaji Nishikawa, Megumi Iwaki, Kosuke Tashiro, Kouichi Kurose
Article
Pharmacology & Pharmacy
Takahiro Iwao, Nao Kodama, Yuki Kondo, Tomoki Kabeya, Katsunori Nakamura, Takashi Horikawa, Takuro Niwa, Kouichi Kurose, Tamihide Matsunaga
DRUG METABOLISM AND DISPOSITION
(2015)
Meeting Abstract
Clinical Neurology
Hirokazu Furuya, Nahoko Kaniwa, Emiko Sugiyama, Yoshiro Saito, Kouichi Kurose, Keiko Maekawa, Ryuichi Hasegawa, Hiroko Ikeda, Yukitoshi Takahashi, Masaaki Muramatsu, Masahiro Tohkin
ANNALS OF NEUROLOGY
(2014)
Meeting Abstract
Pharmacology & Pharmacy
Kimie Sai, Kouichi Kurose, Tomoko Koizumi, Noriko Katori, Jun-ichi Sawada, Yasuhiro Matsumura, Nagahiro Saijo, Noboru Yamamoto, Tomohide Tamura, Haruhiro Okuda, Yoshiro Saito
DRUG METABOLISM REVIEWS
(2014)